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| | a792.htm |
 | | In this study CD8 CTLs recognized the HSV-2 IE proteins ICP27 (expressed in autologous IFN-g pretreated, Vaccinia virus recombinant infected ECs) in all, ICP4 in 89% and ICP0 in 11% of subjects. | | | Specific CD8 cytotoxicity was enhanced by 48 to 67% when CD8 CTLs were co-incubated with combined monophosphoryl lipid A and QS21 adjuvants at the time of antigen presentation. | | | We have shown previously that IFN-g pretreatment of human epidermal cells (ECs) partially reverses downregulation of surface MHC class I by Herpes Simplex virus (HSV) infection allowing recognition by CD8 CTLs and that HSV immediate early (IE)/early (E) proteins are the predominant targets for CD8 CTLs. |
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http://www.portalmed.pl/res/serwisy/efis2000/cont/abs/a792.htm
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| | Protein Chemistry Core Laboratory - MHC Tetramer Laboratory |
| | With some tetramers but not most), their binding to the antigen-specific T lymphocytes is influenced by CD8 participation. | | | In some cases, the CD8 mediated non-specific tetramer binding has been observed (the tetramer binds to all CD8 | | | On contrary, other CD8 monoclonal antibodies could block the tetramer binding, such as the CT-CD8α antibody from Caltag. |
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http://research.bcm.tmc.edu/protein/mhcstaining.html
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| | Phenotypic analysis of lymphocyte subsets in a diffuse infiltrative lymphocytosis syndrome (DILS) associated with HIV infection. |
| | As CD4+CDW29+ cells are required for the differentiation of cytotoxic CD8 cells, the CD4-CDw29+ subset, which presumably defines the circulating CD8 population in DILS, is currently the subject of detailed characterization. | | | OBJECTIVE: To characterize a Sjogren's syndrome-like disorder in HIV-infected individuals with circulating and diffuse infiltrative CD8 lymphocytosis associated with HLA-DR5 (DILS) and to determine whether particular lymphocyte subsets are selectively expanded. | | | Paralleling the massive increase in CD8+ cells, patients with DILS had significantly higher numbers of CD4-CDw29+ cells, 1089/mm3 vs. 323 for HIV controls and 371 for healthy controls (p less than 0.01). |
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http://www.aegis.com/aidsline/1990/sep/M9094000.html
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| | CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection -- Matloubian et al. 68 (12): 8056 -- The Journal of Virology |
| | Khan, I. A., Casciotti, L. IL-15 Prolongs the Duration of CD8+ T Cell-Mediated Immunity in Mice Infected with a Vaccine Strain of Toxoplasma gondii. | | | Khan, I. A., Moretto, M., Wei, X.-q., Williams, M., Schwartzman, J. D., Liew, F. Treatment with Soluble Interleukin-15R{alpha} Exacerbates Intracellular Parasitic Infection by Blocking the Development of Memory CD8+ T Cell Response. | | | Khan, I. A., Green, W. R., Kasper, L. H., Green, K. A., Schwartzman, J. Immune CD8+ T Cells Prevent Reactivation of Toxoplasma gondii Infection in the Immunocompromised Host. |
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http://jvi.asm.org/cgi/content/abstract/68/12/8056
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| | Antiapoptotic Effects of IL-15 on Pulmonary Tc1 Cells of Patients with Human Immunodeficiency Virus Infection -- AGOSTINI et al. 163 (2): 484 -- American Journal of Respiratory and Critical Care Medicine |
| | Agostini C, Zambello R, Facco M, Perin A, Piazza F, Siviero M, Basso U, Bortolin M, Trentin L, Semenzato G. CD8 T-cell infiltration in extravascular tissues of patients with human immunodeficiency virus infection: interleukin-15 upmodulates costimulatory pathways involved in the antigen-presenting cells-T-cell interaction. | | | Agostini C, Trentin L, Sancetta R, Facco M, Tassinari C, Cerutti A, Bortolin M, Milani A, Siviero M, Zambello R, Semenzato G. Interleukin-15 triggers activation and growth of the CD8 T-cell pool in extravascular tissues of patients with acquired immunodeficiency syndrome. | | | Semenzato G, Agostini C, Ometto L, Zambello R, Trentin L, Chieco-Bianchi L, De Rossi A. CD8+ T lymphocytes in the lung of acquired immunodeficiency syndrome patients harbor human immunodeficiency virus type 1. |
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http://www.ajrccm.org/cgi/content/full/163/2/484
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| | Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment -- Wherry et al. 77 (8): 4911 -- The Journal of Virology |
| | Wherry, E. J., Barber, D. L., Kaech, S. M., Blattman, J. N., Ahmed, R. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. | | | Wherry, E. J., Blattman, J. N., Ahmed, R. Low CD8 T-Cell Proliferative Potential and High Viral Load Limit the Effectiveness of Therapeutic Vaccination. | | | Becker, T. C., Coley, S. M., Wherry, E. J., Ahmed, R. Bone Marrow Is a Preferred Site for Homeostatic Proliferation of Memory CD8 T Cells. |
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http://jvi.asm.org/cgi/content/abstract/77/8/4911
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| | Alpha beta TCR+ cells are a minimal fraction of peripheral CD8+ pool in MHC class I-deficient mice. |
| | Most of the CD8 alpha+ cells express CD11c and can be found in beta 2m/RAG-2 double-deficient mice, demonstrating that these cells do not require rearranged Ag receptors for differentiation and survival and may be of dendritic cell lineage. | | | Selective MHC class I expression by bone marrow-derived cells does not lead to an accumulation of CD8 beta+ cells in beta 2m-/- mice. | | | The mechanisms of the peripheral maintenance and the life span of residual CD8+ cells present in the periphery of beta 2-microglobulin-deficient (beta 2m-/-) mice are unknown. |
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http://www.aegis.com/aidsline/2000/nov/A00B0552.html
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| | Development and antigen specificity of CD8+ cytotoxic T lymphocytes in beta 2-microglobulin-negative, MHC class I-deficient mice in response to immunization with tumor cells. |
| | The rejection of tumor cells appears to be MHC class I directed because no rejection of tumors, no accumulation of CD8+ CTLs, and no survival of animals were observed when syngeneic tumor cells were used for injection with the notable exception of anti-minor Ag response. | | | beta 2-Microglobulin knockout mice (beta 2-m-/-) with MHC class I expression deficiency are able to develop functional TCR(+)-alpha beta, CD8+ CTLs in response to tumor cell injection. | | | The deficiency in MHC class I expression in beta 2-m/- mice is reflected in the delayed tumor rejection and CD8+ cell accumulation during the primary anti-tumor response in comparison with normal mice. |
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http://www.bioscience.org/knockout/ref/apasov.htm
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| | Hunter-Fleming • Newsroom |
| | Salmond, Robert J., Hirst, Tim R., and Williams, Neil A. Selective induction of CD8+CD4- thymocyte mediated by the B-subunit of Escherichia coli heat-labile enterotoxin. | | | Salmond, Robert J., Pitman, Richard S., Jimi, Eijiro., Soriani, Marco., Hirst, Tim R., Ghosh, Sankar, Rincon, Mercedes., and Williams, Neil A. CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-?B-dependent caspase activation. | | | Ong, K-W, Wilson, S.D., Hirst, T.R. and Morgan, A.J. The B subunit of Escherichia coli heat-labile enterotoxin enhances CD8+ cytotoxic-T-lymphocyte killing of Epstein-Barr virus-infected cell lines. |
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http://www.hunter-fleming.com/newsroom/publications/hf_publications.html
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| | T-Lymphocyte Helper/Suppressor Profile |
| | Enumeration of CD4 and CD8 T cells in HIV-1 seropositive patients may be used for prognostic purposes, to monitor disease progression and retroviral therapy. | | | HIV-1 infection results in a decrease of CD4 T cells, an increase in CD8 T cells, and a progressive destruction of immune function. | | | Absolute CD4 helper/inducer T cells; absolute CD8 suppressor/cytotoxic T cells; absolute lymphocyte count; absolute T cells (CD3); CBC with differential and platelet count; CD4:CD8 ratio |
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http://www.labcorp.com/datasets/labcorp/html/chapter/mono/ci006800.htm
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| | CD8 - Wikipedia, the free encyclopedia |
| | CD8 (cluster of differentiation 8) is a glycoprotein which serves as a co-receptor that is expressed on the surface of cytotoxic T cells. | | | CD8 consists of an α and a ß chain, which both resemble an immunoglobulin-like domain that is connected to the membrane by a thin stalk. | | | Cytotoxic T cells with CD8 surface protein are called CD8+ T cells. |
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http://en.wikipedia.org/wiki/CD8
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| | A comparative study on the efficacy of CD8-positive cells in enhancing allogeneic bone marrow engraftment: cell sorting vs microbead selection. |
| | The CD8+ cell population prepared by the microbead selection procedure was as effective as cell sorter purified CD8+ cells in enhancing T cell-depleted allogeneic bone marrow engraftment in lethally irradiated mice. | | | The functional ability of these cells to enhance allogeneic bone marrow engraftment was compared with that of fluorescence activated cell sorter purified CD8+ cells. | | | Phenotypic characterization of these cells shows that most of these CD8+ cells express CD3 and the T cell antigen receptor complex. |
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http://www.aegis.com/aidsline/1999/jan/A9910880.html
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| | Stricker NK Panel CD-57 |
| | For ease in communication, it was just simpler for people to refer to it as "the Stricker Panel" than "that WBC, Lymphocytes, % T cells (CD3+), % NK Subset (CD57+/CD8), % CD8+/CD57+, Total Lymphocytes, Total T cells (CD3), Total CD8+/CD57+, and Total NK subset (CD57+/CD8) panel." | | | And then there are people like me, who had a zero (that is, 0) NK count in while feeling significantly better (all things being relative) than some friends in severe flare, who had normal-high NK counts. | | | This panel is referred to as the "Stricker Panel" because Dr. Stricker and a couple of other doctors decided to look at this particular collection of data to see if they could see any patterns between the test results and how their patients were feeling and responding (or not) therapeutically. |
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http://www.anapsid.org/lyme/strickerpanel.html
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| | CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages. |
| | CD8+ T lymphocytes have been implicated in the protective immune response against human and murine tuberculosis. | | | CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages.However, the functional role that this cell subset plays during the resolution of infection remains controversial. | | | The presented data indicate that CD8+ T cells contribute to the protective immune response during M. tuberculosis infection by exerting cytotoxic function and lysing infected macrophages. |
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http://www.pdg.cnb.uam.es/UniPub/iHOP/gp/8401519.html
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| | Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression - Nature Medicine |
| | A phase I study of adoptive transfer of autologous CD8+ T lymphocytes in patients with acquired immunodeficiency syndrome (AIDS)-related complex or AIDS. | | | Jacobson, S., Shida, H., McFarlin, D.E., Fauci, A.S. and Koenig, S. Circulating HTLV-1 pX-specific CD8+ cytotoxic T lymphocytes in patients with HTLV-1 associated neurologic disease. | | | Slobod, K.S. and Allen, J.E. Parainfluenza type 1 virus-infected cells are killed by both CD8+ and CD4+ cytotoxic T cell precursors. |
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http://www.nature.com/doifinder/10.1038/nm0495-330
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| | Induction of murine gamma delta T cells cytotoxic for xenogeneic rat cells. |
| | Spleen cells obtained from CD4- and CD8-depleted animals rejecting W7TM-1 were examined by cytofluorometry, which demonstrated the presence of highly increased gamma delta type CD4-CD8- T cell population (30 to 50% of entire T cells). | | | C57BL/6 mice deprived or nondeprived of CD4+ and CD8+ T cells by mAbs were challenged with a rat T cell line, W7TM-1. | | | Induction of murine gamma delta T cells cytotoxic for xenogeneic rat cells. |
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http://www.aegis.com/aidsline/1995/apr/M9540400.html
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| | Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats. |
| | Thymus glands from old rats contained greater than 50% more CD4-CD8- cells and a reduced percentage of CD4+CD8+ lymphocytes compared to those of young rats (P less than 0.05). | | | Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats. | | | Although implantation of GH3 pituitary epithelial cells has been shown to reverse thymic aging in rats, the differentiation pattern of T-lymphocytes within the reconstituted thymus glands has not been investigated. |
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http://www.arclab.org/medlineupdates/abstract_1572290.html
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| | Project Inform's What's New? Memo - September 1996 [ HIV / AIDS Treatment Information ] |
| | Giorgi’s observations, however, have brought such questions to the forefront and numerous studies are now looking at CD38 expression on CD8+ cells to better understand the roll of this immune marker in HIV disease, and how various therapeutic interventions affect this marker. | | | Giorgi’s work, however, focused on the expression of CD38 on a particular subset of T cells, CD8+ T cells. | | | A researcher from southern California, Dr. Janis Giorgi, who has been following the Multicenter AIDS Cohort Study (MACS), recently published a paper in the Journal of Clinical Cytometry showing that CD38 expression on CD8+ cells is significantly correlated with HIV-disease progression, possibly even more strongly correlated than even CD4+ cell number and viral levels. |
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http://www.projinf.org/whatsnew/wn-9609.html
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| | The CD4/CD8 ratio in the blood does not reflect the response of this index in secondary lymphoid organs of weanling mice in models of protein-energy malnutrition known to depress thymus-dependent immunity. |
| | The objective of this investigation, therefore was to determine the CD4/CD8 ratio in peripheral lymphoid compartments of diverse murine models of protein-energy malnutrition which produce systemic wasting (loss of approximately 1.8% of initial body weight per day), lymphoid involution and (as shown in many previous studies) depression in thymus-dependent immunocompetence. | | | The CD4/CD8 ratio in the blood does not reflect the response of this index in secondary lymphoid organs of weanling mice in models of protein-energy malnutrition known to depress thymus-dependent immunity. | | | A low CD4/CD8 ratio is common in the blood in wasting protein-energy malnutrition, but appears uncharacteristic of the profoundly involuted lymphoid organs which generate acquired immune responses. |
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http://www.aegis.com/aidsline/1996/aug/M9681039.html
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| | Antiretroviral Therapy During Asymptomatic HIV Infection Saves Immune Function |
| | The researchers determined that treatment with zidovudine, lamivudine, and ritonavir in 15 asymptomatic patients resulted in a reduction of HIV RNA levels, memory CD8+/CD45RO+ cells, and activated CD4+/HLA-DR+, CD8+/HLA-DR+, and CD8+/CD38+ T cells. | | | The Swiss HIV Cohort Study has found that the administration of highly active antiretroviral therapy (HAART) to asymptomatic HIV-positive patients early in the course of infection can help preserve pre-therapy levels of immune function. | | | There was also an increase in the number of naive CD4+/CD45RA+ and memory CD4+/CD45RO+ T cells. |
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http://www.aegis.com/news/ads/1998/AD982254.html
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| | CD8+ T cell proliferation differs in HIV progressors and nonprogressors |
| | There does not seem to be a difference between progressors and nonprogressors in the frequency of HIV-specific CD8+ T cells, Dr. Connors said. | | | Since perforin is necessary "for killing by means of the granule exocytosis pathway," these findings may account for the very different outcomes of progressors and nonprogressors despite similar levels of circulating CD8+ cells, the investigators suggest. | | | Recently, another group of investigators showed that a set of anti-HIV proteins secreted by CD8+ cells from patients who experience slow disease progression are alpha-defensins, previously known as antibacterial peptides (see Reuters Health report September 26, 2002). |
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http://www.aidsmeds.com/news/20021007scie002.html
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| | Persistent immune activation in HIV-1 infection is associated with progression to AIDS |
| | In addition, fast progressors showed a significant decline in the number of naive CD8 T cells 5 years after seroconversion (P = 0.050), which was not observed in the slow-progressor group. | | | In slow progressors, Ki67 expression on CD4 and CD8 T cells stabilized over time, whereas fast progressors showed a significant increase in the proportion of CD4 and CD8 T cells expressing this antigen (Fig. | | | In agreement with previous observations, plasma HIV-1 RNA was higher in fast progressors than in slow progressors when measured 1 and 5 years after seroconversion (P < 0.05; data not shown). |
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http://www.natap.org/2003/sept/091503_3.htm
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| | Analytical Cellular Pathology. |
| | P.J.M. Philip, F. Baudouin, L. Depierre, J. Bayle, Simultaneous analysis of dual, triple and quadruple CD4/CD8 immunofluorescent staining from aids in flow cytometry, Analytical Cellular Pathology 10 (2) (1996) pp. | | | P.J.M. Philip, F. Baudouin, L. Depierre, J. Bayle, Comparative analysis of dual (CD4/CD8, CD2/CD20) and quadruple (CD4/CD8/CD2/CD20) flow cytometry immunofluorescent staining from 82 AIDS, Analytical Cellular Pathology 10 (2) (1996) pp. | | | P.J.M. Philip, F. Baudouin, J. Bayle, Determination of positive CD14+CD4+ lymphoid cell subpopulation in AIDS by using triple immunofluorescent staining, Analytical Cellular Pathology 10 (2) (1996) pp. |
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http://www.elsevier.com/cdweb/journals/09218912/viewer.htt?viewtype=authors&rangeselected=1
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