|
| |
| | Characteristics of C. elegans |
 | | It is also a good model organism for students to watch animal behavior, because C. elegans shows a diversity of behaviors. | | | With the awareness of how important model systems are in biological research, he introduced Caenorhabditis elegans (C. | | | elegans a good experimental organism for students to study behavior (Aamodt, 1999; DeStasio, 1999). |
|
http://www.nbr.wisc.edu/outreach/text/celegans.html
(1783 words)
|
|
| |
| | daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 ... |
| | elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. | | | Birnby, D.A., Link, E.M., Vowels, J.J., Tian, H., Colacurcio, P.L., and Thomas, J.H. A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans. | | | L3 larval stage to form a dauer larva (Cassada and Russell 1975 |
|
http://www.genesdev.org/cgi/content/full/17/7/844
(7827 words)
|
|
| |
| | CPC: Worm Protocols |
| | Development of techniques for primary culture of C. |
|
http://www.dartmouth.edu/~ambros/protocols/worm_protocols.html
(42 words)
|
|
| |
| | HHMI News: New Brain-Signaling Chemical Identified in C. elegans |
| | Also, since the roundworm has only 302 well-characterized neurons, the behavioral consequences of genetic manipulations can be traced to the responsible neurons, he said. | | | Alkema, Horvitz and their colleagues began their studies of tyramine in the context of their analysis of the role of octopamine in C. | | | The studies show that the chemical tyramine controls neurons responsible for important behaviors in the roundworm. |
|
http://www.hhmi.org/news/horvitz4.html
(751 words)
|
|
| |
| | C. elegans |
| | The major process tracts of the worm are the nerve ring, the ventral nerve cord and the dorsal nerve cord. | | | When conditions are unfavorable (low food or crowding) an the alternate dauer developmental pathway insues. | | | Most sensory neurons, such as ASI, of C. |
|
http://thalamus.wustl.edu/nonetlab/ResearchF/elegans.html
(1650 words)
|
|
| |
| | Press Release: The 2002 Nobel Prize in Physiology or Medicine |
| | elegans, being multi-cellular, yet relatively simple, was therefore chosen as the most appropriate model system, which has then led to characterization of these processes also in humans. | | | elegans as a novel experimental model system, the characterization of its invariant cell lineage, and the possibility to link this to genetic analysis have proven valuable for many research disciplines. | | | elegans and developed techniques to study all cell divisions in the nematode, from the fertilized egg to the 959 cells in the adult organism. |
|
http://nobelprize.org/medicine/laureates/2002/press.html
(1590 words)
|
|
| |
| | Worm Development |
| | These links will provide information that outlines various aspects of worm development for which you will be responsible. | | | elegans development by becoming acquainted with the worm itself. | | | Notice that all organ systems are easily seen through the body wall. |
|
http://www.ucalgary.ca/UofC/eduweb/virtualembryo/worms.html
(711 words)
|
|
| |
| | Amazon.com: Books: C. elegans: A Practical Approach |
| | Customers interested in C. elegans: A Practical Approach may also be interested in | | | Caenorhabditis Elegans has been a popular model organism for biological research for over thirty years and has been used to investigate many aspects of animal development, for example apoptosis, the Hox genes, signal transduction pathways, and the development of the nervous system. | | | Caenorhabditis Elegans: A Practical Approach will therefore provide all the background information necessary for use of C. elegans as a model system. |
|
http://www.amazon.com/exec/obidos/tg/detail/-/0199637385?v=glance
(1000 words)
|
|
| |
| | Center For C. elegans Anatomy |
| | Our primary focus is to aid the funded research aims of the C. | | | However, we are also available to help research groups with other funding sources by arrangement. | | | elegans community, particularly those groups with NIH or NSF support. |
|
http://www.aecom.yu.edu/wormem
(145 words)
|
|
| |
| | The Intronerator |
| | elegans with a special emphasis on alternative splicing. | | | elegans," Nucleic Acids Research Jan. 1, 2000; 28(1):91-93 and "Conservation, Regulation, Synteny, and Introns in a Large-scale C. | | | Worm Align - Paste in a piece of cDNA and see where it aligns with the C. elegans genome. |
|
http://www.soe.ucsc.edu/~kent/intronerator
(252 words)
|
|
| |
| | Science -- Table of Contents {Dec 11 1998; 282 (5396)} |
| | Zinc Fingers in Caenorhabditis elegans: Finding Families and Probing Pathways | | | A 3.3-Ma Impact in Argentina and Possible Consequences | | | The Taxonomy of Developmental Control in Caenorhabditis elegans |
|
http://www.sciencemag.org/content/vol282/issue5396
(569 words)
|
|
| |
| | Caenorhabditis Genetics |
| | elegans genes and those of other organisms such as humans. | | | This allows the effects of disruption of embryonic development (by physical manipulation or mutation) to be traced with relative ease. | | | elegans develops through four larval stages (also called juveniles in some nematode literature) which are separated by moults. |
|
http://nema.cap.ed.ac.uk/Caenorhabditis/C_elegans.html
(825 words)
|
|
| |
| | Blaxter Lab |
| | Caenorhabditis elegans is a small, freeliving nematode that is the subject of an extensive integrated analysis of the genetics of development. | | | elegans extensively in our parasitic nematode biology research. | | | As a nematode it is also an excellent model nematode, and we use C. |
|
http://nema.cap.ed.ac.uk/C_elegans.html
(136 words)
|
|
| |
| | http://eatworms |
| | elegans ortholog of the human gene WRN1, responsible for Werner’s syndrome. | | | elegans gene or part thereof fused to a reporter such as lacZ or GFP are indicated by the | | | elegans as the organism of origin can be specified with a prefix ( |
|
http://biosci.umn.edu/CGC/Nomenclature/nomenguid.htm
(2842 words)
|
|
| |
| | Caenorhabditis elegans WWW Server |
| | Sydney Brenner began using it to study the genetics of development and neurobiology. | | | The Genetics of Caenorhabditis elegans, An Introduction for more information. | | | Since then the community of C elegans researchers has expanded several thousands. |
|
http://elegans.swmed.edu
(68 words)
|
|
| |
| | Origins: Cold Spring Harbor: Tools |
| | elegans as a model organism, see the C. | | | Caenorhabditis elegans can be grown in a Petri dish and is used for studying the genetics of development and other physiological processes including nerve function and aging. | | | Its transparent body allowed researchers to image stages of development in the worm. |
|
http://www.exploratorium.edu/origins/coldspring/tools/nematode.html
(311 words)
|
|
| |
| | Ask a C.elegans Expert a question! |
| | elegans and developed links to human physiology (The branch of the biological sciences dealing with the functioning of organisms and the study of internal processes and functions in humans) in space. | | | The First International Caenorhabditis (pronounced SEE-NO-RAB-DIT-IS) elegans Experiment (commonly referred to as ICE) consisted of several experiments that investigated the effects of spaceflight on C. | | | We invite you to experience the excitement of sending experiments into space. |
|
http://weboflife.nasa.gov/celegans
(132 words)
|
|
| |
| | Caenorhabditis elegans |
| | The diagrams below show the pathway by which each of the 556 cells in the larva of C. elegans has developed from the zygote. | | | Neighboring cells may not compensate for the loss as they do so freely in mammals. | | | In contrast to other eukaryotes, some 13 - 15% of its genes are grouped in operons containing 2 - 8 genes each. |
|
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Caen.elegans.html
(755 words)
|
|
| |
| | About C. elegans and WormBase |
| | elegans is a major model organism for biomedical research and for nematology research. | | | The Structure of the Nervous System of the Nematode Caenorhabditis elegans by J.G. White, E. Southgate, J.N. Thomson and S. Brenner 1986. | | | Studies on the Development and Organisation of the Nervous System of Caenorhabditis elegans by R. Durbin 1987 HTML and PDF formats. |
|
http://www.wormbase.org/about/about_Celegans.html
(183 words)
|
|
| |
| | The Nonmuscle Myosin Regulatory Light Chain Gene mlc-4 Is Required for Cytokinesis, Anterior-Posterior Polarity, and ... |
| | The Caenorhabditis elegans nonmuscle myosin genes nmy-1 and nmy-2 function as redundant components of the let-502/Rho-binding kinase and mel-11/myosin phosphatase pathway during embryonic morphogenesis | | | Maternal UNC-45 is involved in cytokinesis and colocalizes with non-muscle myosin in the early Caenorhabditis elegans embryo | | | A ubiquitin C-terminal hydrolase is required to maintain osmotic balance and execute actin-dependent processes in the early C. elegans embryo |
|
http://www.jcb.org/cgi/content/abstract/146/2/439
(842 words)
|
|
| |
| | C. elegans expression topomap |
| | C, D. Correlation of VxInsight mountains with biological functions | | | Heat shocks were for 15 minutes at 33 °C, and RNA expression levels were measured 30 minutes after heat shock. | | | This figure shows that the gene mountains formed by VxInsight (based on expression data) correlate with sets of genes that have similar biochemical functions. |
|
http://cmgm.stanford.edu/~kimlab/topomap/c._elegans_topomap.htm
(720 words)
|
|
| |
| | Evolutionary Conservation Of A Mechanism Of Longevity From Worms To Mammals |
| | Though the study of aging in the nematode model organism C. elegans has provided much insight into this complex process, it is not yet clear whether genes involved in aging in the worm have a similar role in mammals. | | | Though the aging process of different organisms will most likely differ due to different physiologies and environments, Dr. Hekimi summarizes the relevance of their findings by concluding that "... | | | Rutgers And Albert Einstein College Of Medicine Researchers Seek Fountain Of Youth Among The Worms (October 24, 2002) -- In the pursuit of longer, healthier lives, scientists are studying the lowly roundworm Caenorhabditis (C.) elegans to better understand the molecular mechanisms of human aging. |
|
http://www.sciencedaily.com/releases/2005/10/051004083842.htm
(539 words)
|
|
| |
| | nature genome gateway - papers - Caenorhabditis elegans |
| | Research had already revealed the cell lineage map of this nematode worm and all the connections of the 302 neurons in the adult hermaphrodite (the wiring diagram), and had developed a number of genetic techniques that allowed researchers to manipulate the genes of C. | | | In News and Views articles published in Nature and Nature Genetics Martin Chalfie and Ronald Plasterk marked this milestone and discussed the implications of the research. | | | The genome sequence therefore completed the "genetic tool-box" for this versatile model organism. |
|
http://www.nature.com/genomics/papers/c_elegans.html
(217 words)
|
|
| |
| | Caenorhabditis elegans Genetics and Genomics |
| | European Bioinformatics Institute: Proteome analysis of Caenorhabditis elegans | | | National Bioresource Project for the Experimental Animal C elegans | | | C elegans Genome Project WWW Site (Sanger Centre, UK) |
|
http://elegans.swmed.edu/genome.shtml
(37 words)
|
|
| |
| | [No title] |
| | elegans is controlled hormonally by an insulin/IGF-1 like signaling system. | | | Our lab studies genes that control aging in C. | | | We are also starting to investigate the role of these genes in mammals, in hopes of staying youthful ourselves. |
|
http://wormworld.ucsf.edu/Kenyonintro.html
(108 words)
|
|
| |
| | Welcome to Wormatlas |
| | Assembly of body wall muscle and muscle cell attachment structures in C. elegans-pdf | | | The Posterior Nervous System of the Nematode C. | | | This project is funded by a grant from the NIH Division of Research Resources for the Center for Anatomical Studies of C. |
|
http://www.wormatlas.org
(563 words)
|
|
| |
| | Trans-NIH C. elegans Initiative |
| | RFA on Genetic Studies of Obesity-Related Traits in Model Organisms (DK-03-018) | | | elegans meeting, announcements, links to the Bionet.celegans newsgroup, information and links to information on other nematodes, methods for C. | | | elegans research, lineage map information, genomics information and links to other genomics information sites, software useful for C. |
|
http://www.nih.gov/science/models/c_elegans
(237 words)
|
|
| |
| | Celegans Gene Knockout Lab OMRF |
| | The C. elegans gene knockout facility at the Oklahoma Medical Research Foundation was established in 1998 with funding from the National Institutes of Health. | | | This site has been created to contribute information related to the C. elegans Gene Knockout Project. | | | This gene knockout facility strives to further advance C. elegans reverse genetics by establishing efficient production methods, innovative protocols in a cooperative effort with consortium members. |
|
http://www.mutantfactory.ouhsc.edu
(132 words)
|
|
| |
| | SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A -- Anders ... |
| | Serin,G., Gersappe,A., Black,J.D., Aronoff,R. and Maquat,L.E. (2001) Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). | | | Morrison,M., Harris,K.S. and Roth,M.B. smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans. | | | Dunckley,T. and Parker,R. (1999) The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. |
|
http://embojournal.npgjournals.com/cgi/content/full/22/3/641
(5657 words)
|
|
| |
| | Kim lab C. elegans microarrays |
| | We are collaborating with any C. elegans lab by hybridizing their RNA samples to C. elegans microarrays, and we are also helping to provide needed tools and reagents so that other labs can establish their own microarraying facilities. | | | previous message: Our general goal is to develop C. elegans microarray technology, and to make this technology available to all other C. elegans labs. | | | After June, you should contact Stuart Kim to discuss possible ways to collaborate to do DNA microarray experiments (kim@cmgm.stanford.edu). |
|
http://cmgm.stanford.edu/~kimlab/wmdirectorybig.html
(283 words)
|
|
| |
| | C. elegans Movies |
| | This page has links to timelapse films made by C. elegans researchers worldwide. | | | The worm that crawls out of its eggshell has a functioning feeding apparatus, gut, nervous system and muscles. | | | For more information about the worms, see the |
|
http://www.bio.unc.edu/faculty/goldstein/lab/movies.html
(127 words)
|
|
| |
| | The Sanger Institute: C. elegans Project |
| | elegans genome sequence is represented by over 3,000 individual clone sequences which can be accessed through this site (or through WormBase). | | | The Sanger Institute and the Genome Sequencing Center at the Washington University School of Medicine, St. Louis have collaborated to sequence the genomes of both C. | | | The assembly sequences can be searched using our C. |
|
http://www.sanger.ac.uk/Projects/C_elegans
(339 words)
|
|
| |
| | WormBase - Home Page |
| | The Genetics Society of America is having their first meeting focusing on model organisms: Genetic Analysis: Model Organisms to Human Biology, January 5-7, 2006. | | | These data are based on a preliminary assembly of the genome; users are urged to treat this data in accord with its pre-release status. | | | elegans II book (1997), The Mind of a Worm (White et al, 1986), The Genetics of C. |
|
http://www.wormbase.org
(661 words)
|
|
| |
| | Vancouver Lab Home |
| | Significant conservation between nematode and human genes may provide answers to vexing biological and genetic questions in our own species. | | | elegans DNA sequence makes possible the targeting of all genes in this organism, which in turn will help elucidate the detailed information necessary to build a worm. | | | elegans Gene Knockout Laboratory is part of an international consortium, working to produce null mutations in all identified and predicted genes in the C. elegans genome. |
|
http://ko.cigenomics.bc.ca
(107 words)
|
|
| |
| | C. elegans Gene Knockout Consortium |
| | However, if you indicate that an existing allele is not satisfactory for your research, (for whatever reason), you may request that we generate another allele for the same target. | | | elegans Gene Knockout Consortium is to facilitate genetic research of this important model system through the production of deletion alleles at specified gene targets. | | | Any information generated by the Consortium is entered into the official C. |
|
http://www.celeganskoconsortium.omrf.org
(215 words)
|
|
| |
| | The Sanger Institute: C. elegans Project |
| | Wormpep contains the predicted proteins from the Caenorhabditis elegans genome sequencing project, which is carried out jointly by the Sanger Institute in Cambridge, UK and the Genome Sequencing Center in St. Louis, USA. | | | You can search the database for protein entries, or for their corresponding "cDNA" (not containing any UTR's). | | | The current Wormpep database, wormpep149 (released 28 09 2005), contains 10,042,409 residues in 22,841 protein sequences (of which 1969 have splice variants) - wormpep149 is based on the current WS149 release of the C. |
|
http://www.sanger.ac.uk/Projects/C_elegans/wormpep
(204 words)
|
|
| |
| | Affymetrix - C. elegans Genome Array |
| | This whole genome GeneChip array represents 22,500 transcripts from Caenorhabditis elegans, a model organism for developmental biology and functional genomics. | | | Find individual probe sets on all GeneChip® expression arrays with Array Finder. | | | For more information, please review the data sheet (pdf, 317 KB). |
|
http://www.affymetrix.com/products/arrays/specific/celegans.affx
(97 words)
|
|
| |
| | Genome Sciences Centre - C. elegans Resources - Home |
| | elegans gene expression using promoter::GFP fusions and serial analysis of gene expression (SAGE). | | | Provided are tag to gene mappings, various filters (e.g.: sequence quality, minimum tag count), and search by keyword or tag. | | | Genome Sciences Centre - C. elegans Resources - Home |
|
http://elegans.bcgsc.bc.ca
(90 words)
|
|
| |
| | Ward Lab C. elegans Links |
| | WormBase a repository of mapping, sequencing and phenotypic information about the C. elegans nematode. | | | elegans Server at University of Texas Southwestern Medical Center | | | ACEDB, a database of C. elegans genomic and biological data |
|
http://www.mcb.arizona.edu/wardlab/celegans.html
(63 words)
|
|
| |
| | The Sanger Institute: C. elegans Blast Server |
| | Also available are the current database of C. | | | Search the DNA database containing sequence data from both the Cambridge and St. Louis Sequencing groups. |
|
http://www.sanger.ac.uk/Projects/C_elegans/blast_server.shtml
(50 words)
|
|
| |
| | NCBI/xpubmed4 - WWW Error 404 Diagnostic |
| | NOTE: The above may be an internal URL which differs from the one you used to address the page. | | | g o v / P M G i f s / G e n o m e s / c e. |
|
http://www.ncbi.nlm.nih.gov/PMGifs/Genomes/ce.html
(191 words)
|
|
|
