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Topic: Bradykinin



  
 Bradykinin - Wikipedia, the free encyclopedia
Bradykinin is a potent endothelium-dependent vasodilator, causes contraction of non-vascular smooth muscle, increases vascular permeability and also is involved in the mechanism of pain.
In some aspects, it has similar actions to that of histamine, and like histamine is released from venules rather than arterioles.
Bradykinin was to prove a new autopharmacological principle, i.e., a substance that is released in the body by a metabolic modification from precursors, which are pharmacologically active.
http://en.wikipedia.org/wiki/Bradykinin   (454 words)

  
 A Role for TRPV1 in Bradykinin-Induced Excitation of Vagal Airway Afferent Nerve Terminals -- Carr et al. 304 (3): 1275 ...
Concordance of Responsivity of Afferent Fibers to Capsaicin and Bradykinin.
inasmuch as responses to bradykinin were markedly attenuated in
McGuirk SM and Dolphin AC (1992) G-protein mediation in nociceptive signal transduction: an investigation into the excitatory action of bradykinin in a subpopulation of cultured rat sensory neurons.
http://jpet.aspetjournals.org/cgi/content/full/304/3/1275   (3432 words)

  
 Bradykinin stimulates respiratory drive by activating pulmonary sympathetic afferents in the rabbit -- Soukhova et al. ...
Bradykinin-induced depolarization of primary afferent nerve terminals in the neonatal rat spinal cord in vitro.
Bradykinin is a naturally occurring nanopeptide and a common
Differences in expiratory responses to hypertonic saline (A) and bradykinin (B).
http://jap.physiology.org/cgi/content/full/95/1/241   (3839 words)

  
 Bradykinin induces tubulin phosphorylation and nuclear translocation of MAP kinase in mesangial cells -- Jaffa et al. ...
substrates that are tyrosine phosphorylated in response to bradykinin
microtubules are tyrosyl phosphorylated in response to bradykinin
Blot is a representative of 3 separate experiments.
http://ajprenal.physiology.org/cgi/content/full/273/6/F916   (3796 words)

  
 Cardiac interstitial bradykinin release during ischemia is enhanced by ischemic preconditioning -- Pan et al. 279 (1): ...
Bradykinin and endothelial-cardiac myocyte interactions in ischemic preconditioning.
In summary, a cardiac microdialysis technique was used in the present study to determine bradykinin levels in the myocardial
Therefore, it is feasible to use this approach to assess myocardial
http://ajpheart.physiology.org/cgi/content/full/279/1/H116   (3734 words)

  
 Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans -- Kellogg et al. 93 (4): 1215 ...
Bradykinin formation in human skin as a factor in heat vasodilation.
Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans -- Kellogg et al.
Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans
http://jap.physiology.org/cgi/content/full/93/4/1215   (3982 words)

  
 Sympathoexcitation by Bradykinin Involves Ca2+-Independent Protein Kinase C -- Scholze et al. 22 (14): 5823 -- Journal ...
Activation of PKC isoforms in rat SCG neurons by phorbol esters and bradykinin.
of bradykinin, several types of experiments were performed.
the present experiments demonstrate that bradykinin excites sympathetic
http://www.jneurosci.org/cgi/content/full/22/14/5823   (6548 words)

  
 Effect of chronic bradykinin administration on insulin action in an animal model of insulin resistance -- Henriksen et ...
Bradykinin enhances GLUT4 translocation in dog skeletal muscle and rat L6 myoblasts (Abstract).
There were no changes induced by bradykinin treatment of lean or obese animals in the epitrochlearis
in insulin-resistant skeletal muscle from aged rats that bradykinin
http://ajpregu.physiology.org/cgi/content/full/275/1/R40   (3432 words)

  
 Increase of Bradykinin in Plasma of Patients Undergoing Cardiopulmonary Bypass : The Importance of Lung Exclusion -- ...
bradykinin levels were not correlated with any of the other
in patients during CPB and the physiologic elimination of bradykinin
Baseline bradykinin levels in our patients with coronary
http://www.chestjournal.org/cgi/content/full/120/6/1776   (3699 words)

  
 Diabetes: Effect of captopril, losartan, and bradykinin o... @ HighBeam Research
Effect of acute captopril treatment on the 15-min ITT in aging rats and mean blood pressure.
Rats received captopril (2 mg/kg body wt) or losartan (15 mg/kg body wt) orally 6 and 1 h before the experiment, or bradykinin (100 [Mu]g i.p.), as described in figure legends, before the experiment.
(52) demonstrated in isolated rat heart that bradykinin, at a concentration that does not affect coronary flow, mimics the insulin-induced translocation of both GLUT4 and GLUT1, and Isami et al.
http://www.highbeam.com/library/doc0.asp?DOCID=1G1:20153520&refid=holomed_1   (5374 words)

  
 In vivo bradykinin B2 receptor activation reduces renal fibrosis -- Schanstra et al. 110 (3): 371 -- Journal of ...
B and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts.
the rapid tPA release upon bradykinin treatment in humans (29).
Values are mean ± SEM of five different experiments.
http://www.jci.org/cgi/content/full/110/3/371   (4714 words)

  
 Smoking Impairs Bradykinin-Stimulated t-PA Release -- Pretorius et al. 39 (3): 767 -- Hypertension
bradykinin was compared with responses to methacholine (an endothelium-dependent
The t-PA response to bradykinin was significantly greater in nonsmokers (P=0.037)
bradykinin in the nonsmokers, even though the flow response
http://hyper.ahajournals.org/cgi/content/full/39/3/767   (2691 words)

  
 Virus- and Bradykinin-Induced Airway Hyperresponsiveness in Guinea Pigs -- FOLKERTS et al. 161 (5): 1666 -- American ...
Receptors for bradykinin and related kinins: a critical analysis.
Another pathway in which Hoe 140 could interfere with AHR can be deduced from other actions of bradykinin observed in the
The bradykinin RIA was from Peninsula Laboratories (St. Helens,
http://ajrccm.atsjournals.org/cgi/content/full/161/5/1666   (3827 words)

  
 Bradykinin Antagonism Inhibits the Antigrowth Effect of Converting Enzyme Inhibition in the Dog Myocardium After ...
The importance of bradykinin levels not augmented by CEI therapy
bradykinin by CEI therapy is the major mechanism by which these
indicating that the addition of a bradykinin antagonist to CEI therapy
http://circ.ahajournals.org/cgi/content/full/91/7/2043   (5199 words)

  
 Involvement of Bradykinin Generation in Intravascular Dissemination of Vibrio vulnificus and Prevention of Invasion by ...
A three-year study of positive blood cultures, with emphasis on prognosis.
The results obtained in the present experiments provide evidence that bradykinin generation facilitates movement of bacteria
) and the infected group treated with the bradykinin antagonist (
http://iai.asm.org/cgi/content/full/66/2/866   (2310 words)

  
 Metabolism of Bradykinin In Vivo in Humans: Identification of BK1-5 as a Stable Plasma Peptide Metabolite -- Murphey et ...
Dikler S, Kelly JW and Russell DH (1997) Improving mass spectrometric sequencing of arginine-containing peptides by derivatization with acetylacetone.
will allow for further elucidation of the role of bradykinin in
Bradykinin is a vasoactive nonapeptide that has cardioprotective effects.
http://jpet.aspetjournals.org/cgi/content/full/294/1/263   (3632 words)

  
 Chronic Angiotensin II Infusion But Not Bradykinin Blockade Abolishes the Antiproteinuric Response to ...
groups allocated to bradykinin antagonist and vehicle, respectively.
Groningen Institute of Drug Studies (GIDS), Department of Medicine, Division of Nephrology, University Hospital and Groningen School of Medicine, The Netherlands.
Twelve rats received lisinopril 5 mg/kg per 24 h as of
http://jasn.asnjournals.org/cgi/content/full/11/3/490   (3741 words)

  
 Localization of Bradykinin B2 Receptor in the Follicles of Porcine Ovary and Increased Expression of Matrix ...
the roles of bradykinin in the ovary, the current studies were
bradykinin in ovarian function has been repeatedly documented
The expression of MT1-MMP was also affected by bradykinin treatment.
http://www.biolreprod.org/cgi/content/full/65/5/1462   (4964 words)

  
 Effect of bradykinin on allergen induced increase in exhaled nitric oxide in asthma -- Ricciardolo et al. 58 (10): 840 ...
explanation for the action of bradykinin is vasodilation
indirect influence of bradykinin on NOS at the post-transcriptional
Effect of bradykinin on allergen induced increase in exhaled nitric oxide in asthma
http://thorax.bmjjournals.com/cgi/content/full/58/10/840   (3430 words)

  
 Detection of Bradykinin and Bradykinin-{beta}2 Receptors in the Porcine Endometrium During the Estrous Cycle and Early ...
Further supporting evidence for a role of bradykinin in the
The objective of the current investigation was to determine
The sensitivity of the bradykinin RIA assay was
http://www.biolreprod.org/cgi/content/full/66/3/574   (3837 words)

  
 Thrombin-, bradykinin-, and arachidonic acid-induced Ca2+ signaling in Ehrlich ascites tumor cells -- Jørgensen ...
Data are from 1 experiment, representative of a total of 5 experiments.
Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.
Bradykinin has a wide range of effects in both neuronal and nonneuronal
http://ajpcell.physiology.org/cgi/content/full/276/1/C26   (6805 words)

  
 731 - Abstract (11th CROI)
In contrast, infusion into animals treated with PI (3 days or 6 weeks) did not promote a decrease in blood pressure (85±5 mm Hg).
HIV Protease Inhibitors Impair Endothelial Nitric Oxide Synthase-mediated Vasodilation in Response to Acetylcholine and Bradykinin
Conclusions:  We conclude that HIV PI promote the up-regulation of caveolin in endothelial cells which subsequently inhibits endothelial nitric oxide synthase activity and contributes to endothelial-mediated dysfunction of blood pressure.
http://www.retroconference.org/2004/cd/Abstract/731.htm   (419 words)

  
 HON Allergy Glossary Bradykinin
Bradykinin increases vascular permeability, dilates blood vessels, contracts non-vascular smooth muscle, and causes pain.
The kinin system is a group of proteins, which ultimately produce the nonapeptide bradykinin.
http://www.hon.ch/Library/Theme/Allergy/Glossary/bradykinin.html   (28 words)

  
 Globeinvestor.com: Jerini`s Bradykinin Antagonist Icatibant Shows Promise in Treatment of Refractory Ascites in Liver ...
Administration of a Bradykinin antagonist such as Icatibant is therefore expected to be of therapeutic benefit in this patient population.
In patients with liver cirrhosis, the kallikrein-kinin system is considerably activated with Bradykinin being one of the most important inducers of microvascular leakage.
Jerini`s Bradykinin Antagonist Icatibant Shows Promise in Treatment of Refractory Ascites in Liver Cirrhosis in a Phase II Study
http://globeinvestor.com/servlet/ArticleNews/story/BWIRE/20031202/233365049   (864 words)

  
 Methotrexate potentiates bradykinin-induced increase in macromolecular efflux from the hamster oral mucosa -- Gao and ...
relative to that associated with suffusion of bradykinin, it nonetheless
of bradykinin and methotrexate used in these studies were based
and bradykinin was associated with significant increases in nitrites
http://ajpregu.physiology.org/cgi/content/full/273/4/R1254   (4303 words)

  
 Preparation of a Photoactivable Ligand for Bradykinin Receptors
Most of physiological effects of bradykinin is due to its effect on bradykinin B2 receptors.
There is no reports of preparation of a photoactivatable analogue of bradykinin reactive; with solubilized bradykinin B2 receptors.
In this study we report preparation of a photoactivatable iodinatable analogue of bradykinin reactive with soluble bradykinin B2 receptors.
http://www.gums.ac.ir/magazin/abstract78_1.htm   (238 words)

  
 Bradykinin and Renal Fibrosis: Have We ACE'd it? -- Bascands and Schanstra 15 (9): 2504 -- Journal of the American ...
Witherow FN, Helmy A, Webb DJ, Fox KA, Newby DE: Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure.
Silva JA Jr, Araujo RC, Baltatu O, Oliveira SM, Tschope C, Fink E, Hoffmann S, Plehm R, Chai KX, Chao L, Chao J, Ganten D, Pesquero JB, Bader M: Reduced cardiac hypertrophy and altered blood pressure control in transgenic rats with the human tissue kallikrein gene.
Pitt B, Poole-Wilson PA, Segal R, Martinez FA, Dickstein K, Camm AJ, Konstam MA, Riegger G, Klinger GH, Neaton J, Sharma D, Thiyagarajan B: Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial– the Losartan Heart Failure Survival Study ELITE II.
http://jasn.asnjournals.org/cgi/content/full/15/9/2504   (1566 words)

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