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| | Timmons & Hamilton: Drugs, Brains and Behavior - Ch 3 |
 | | The blood-brain barrier should not be viewed as a system which isolates the brain, but rather as one which buffers it from the changing conditions of the remainder of the body (see Fig. | | | The nature of the blood brain barrier poses a number of problems in terms of the behavioral response to drugs. | | | Finally, the blood brain barrier changes as a function of organismic variables, the most important of which is probably age. |
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http://www.rci.rutgers.edu/~lwh/drugs/chap03.htm
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| | Blood Brain Barrier Program |
| | Together with ongoing research, the BBB Program's comprehensive approach to patient care focuses not only on patients' medical concerns but also on their complex emotional, personal and psychological needs. | | | The OHSU Blood-Brain Barrier Program is a member of the OHSU Cancer Institute and has strong affiliations with the National Institutes of Health in Washington, D.C., including the National Cancer Institute and the National Institute of Neurological Disorders and Stroke. | | | We prefer that a patient is referred to the BBB Program by his or her physician. |
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http://www.ohsu.edu/bbb
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| | Breaching the Blood-brain barrier |
| | This approach, which has demonstrated increased brain delivery of carboplatin in rat studies, is targeted directly at the tumor and has been shown to “open and close” the BBB more rapidly than the osmotic approach. | | | Other BBB strategies follow more covert means of overtaking disease in the brain—sneaking through the natural pathways that already exist. | | | For a more general approach to brain therapy, however, less invasive tactics are much preferred. |
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http://pubs.acs.org/subscribe/journals/mdd/v05/i06/html/06filmore.html
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| | Blood Brain Barrier Group |
| | Our goals in the next few years are to identify the mechanisms of transcytosis of cytokines in the cerebral endothelial cells composing the BBB, to determine regulatory factors for intracellular trafficking, and to enhance drug delivery to treat cytokine-related disorders in the brain and spinal cord. | | | : To determine the role of the blood-brain barrier (BBB) in neuroendocrine control, particularly in feeding behavior and alcoholism. | | | The results illustrate how cytokines are involved in the development of hypoxia tolerance which is important in disease situations such as stroke. |
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http://labs.pbrc.edu/bloodbrainbarrier
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| | Reverse-blood brain barrier |
| | The results of this research substantiate the fact that there exist BBB both ways: blood circulation to brain and brain to body circulation. | | | The present research was undertaken to explore whether blood-brain barrier is effective in the reverse way. | | | Thus one way blood circulation to the brain is a well-established fact. |
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http://www.ophidia.com/bloodbr.htm
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| | BLOOD BRAIN BARRIER |
| | Brain capillaries are in contact with foot processes of astrocytes which essentially separate the capillaries from the neurones. | | | Nowhere in the body is there more need for homeostasis than in the brain. | | | There is no such movement in brain endothelial cells. |
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http://cal.man.ac.uk/student_projects/2002/MNQJ9PP2/Webpages/bloodbrainbarrier.htm
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| | BLOOD BRAIN BARRIER |
| | In addition the brain capillary wall is reinforced with as pericytes and astrocytic foot process. | | | Knowledge of drug permeability help in clinical practice. | | | These changes form the basis of higher uptake of isotopes and contrast media. |
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http://www.thamburaj.com/bloodbrain.htm
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| | Trojan Horse Delivers Drugs Across the Blood-Brain Barrier |
| | Pardridge bases the approach on the fact that while most molecules are excluded from the brain, some are allowed to enter. | | | But it also keeps out 98 percent of small-molecule drugs and all drugs made of large molecules, including new drugs designed to treat a variety of brain disorders such as cancer, Alzheimer’s, stroke, and spinal cord injury. | | | For example, he has delivered molecules that protect neurons, a feat that could pave the way for their use in patients with stroke or spinal cord injury. |
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http://www.genomenewsnetwork.org/articles/12_03/trojan_horse.shtml
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| | Blood-Brain Barrier Transport of Uranium |
| | Specific Aims: Characterize uranium transport in cultured bovine and rat brain endothelium models of the blood-brain barrier (BBB). | | | The studies have positioned the laboratory for controlled studies on the putative role of DMT-1 in the transport of uranium into the brain. | | | In vivo studies will be conducted in the rat with the microdialysis technique. |
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http://www.gulflink.osd.mil/medsearch/BrainNervous/NervousSystem/DOD126.shtml
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| | blood brain barrier disruption, brain tumor treatments |
| | The patient is then taken to the neurological intensive care unit where he or she is recovered during the critical period while the barrier is still open. | | | Kroll, R.A., and Neuwelt, E.A. Outwitting the blood-brain barrier for therapeutic purposes: Osmotic opening and other means. | | | Remsen, L.G., Pagel, M.A., McCormick, C.I., Fiamengo, S.A., Sexton, G., and Neuwelt, E.A. The influence of anesthetic choice, Paco2, and other factors on osmotic blood-brain barrier disruption in rats with brain tumor xenografts. |
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http://www.clevelandclinic.org/neuroscience/treat/brain/treatments/bbbd.htm
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| | Cancer Fighter Gets Past Blood-Brain Barrier - Cancer information on MedicineNet.com |
| | WEDNESDAY, Aug. 24 (HealthDay News) -- For decades, efforts to treat brain cancer have been stymied by the fact that the brain is protected with a natural shield called the blood-brain barrier -- making it tough for tumor-fighting drugs to get through. | | | "The bottom line is, if you can get drugs into the brain, you can cure brain cancer," research team member Dr. William A. Banks, a professor of geriatrics and of pharmacological and physiological science at St. Louis University School of Medicine, said in a prepared statement. | | | But now, researchers say they have identified a cancer-killing compound that can sneak past the barrier, a discovery that could help doctors better treat a range of invasive brain malignancies. |
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http://www.medicinenet.com/script/main/art.asp?articlekey=53085
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| | BLOOD-BRAIN BARRIER DRUG TARGETING: THE FUTURE OF BRAIN DRUG DEVELOPMENT -- Pardridge 3 (2): 90 -- Molecular ... |
| | The drug is taken up by all organs of the body except the brain and spinal cord. | | | There is no significant distribution of the drug to the contralateral side, and there is no significant penetration of the drug into brain parenchyma from the ependymal surface. | | | There is no reduction in stroke volume with the BDNF alone because the neurotrophin does not cross the BBB, even in the infarcted region of brain. |
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http://molinterv.aspetjournals.org/cgi/content/full/3/2/90
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| | Great Moments in Science - Blood Brain Barrier |
| | In general, surgeons use a knife to do their work, but physicians use drugs. | | | Now of course, we have been thinking about ways around this Blood Brain Barrier - and that's what I'll talk about, next time. | | | Listen to Karl talk about Blood Brain Barrier |
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http://www.abc.net.au/science/k2/moments/s981339.htm
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| | The Blood-Brain Barrier In Multiple Sclerosis Abstracts |
| | CNS Pericytes are an integral part of the Blood-Brain Barrier (BBB), but their function is not well understood. | | | Pericyte migration from the Vascular Wall in response to Traumatic Brain Injury | | | We examined, at the ultrastructural level, MicroVascular Pericyte responses in a well-defined model of Traumatic Brain Injury in the rat. |
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http://thjuland.net/bbb.html
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| | Blood-Brain Barrier |
| | Fortunately, investigations of the mechanisms of this blocking system are helping researchers perfect techniques that manipulate the system and transport therapeutic agents from the body's blood supply directly to the brain. | | | Other researchers found that another molecular combination technique transported therapies, including nerve cell-protecting molecules, to the brains of animals. | | | More than 450 patients have received this procedure to treat specific cancers in the central nervous system. |
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http://web.sfn.org/content/Publications/BrainBriefings/blood-brain.html
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| | OHSU News: Blood Brain Barrier |
| | The team is made up of physicians, nurses, pharmacists, neuropsychologists and preclinical researchers working to treat people with brain tumors by outwitting the brain's natural defense system. | | | Prior to the study, a neurosurgeon, neuroradiologist and nurse clinician from each participating hospital traveled to OHSU to study the technique for administering intraarterial chemotherapy in conjunction with disruption of the blood-brain barrier. | | | However, for patients with brain tumors, it also can reduce the effectiveness of chemotherapy. |
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http://www.ohsu.edu/news/archive/2000/020800bbb.html
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| | Excitotoxins - The Blood-Brain Barrier |
| | The authors of this study concluded that glutamate appears to be an important regulator of brain capillary transport and stability, and that overstimulation of NMDA (glutamate) receptors on the blood-brain barrier appears to play an important role in breakdown of the barrier system. | | | This, naturally, would be the situation seen when individuals consume, on a daily basis, foods high in the excitotoxins - MSG, aspartame and cysteine. | | | The list of condition associated with barrier disruption include: hypertension, diabetes, ministrokes, major strokes, head trauma, multiple sclerosis, brain tumours, chemotherapy, radiation treatments to the nervous system, collagen-vascular diseases (lupus), AIDS, brain infections, certain drugs, Alzheimer’s disease, and as a consequence of natural aging. |
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http://www.nisbett.com/nutrition/excitotoxins03.htm
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| | Blood-brain barrier - Wikipedia, the free encyclopedia |
| | Late-stage neurological trypanosomiasis, or sleeping sickness, is a condition in which trypanosoma protozoa have crossed the blood-brain barrier. | | | A major challenge for treatment of most brain disorders is overcoming the difficulty of delivering therapeutic agents to specific regions of the brain. | | | More research is needed to determine which strategies are most effective and how they can be improved for patients with e.g., brain tumors. |
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http://en.wikipedia.org/wiki/Blood-brain_barrier
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| | Breaching the Blood Brain Barrier - Malorye Allison |
| | The brain, however, is more exclusive: Only certain substances are admitted, and finding out how this is achieved is a major part of finding ways around it. | | | Scientists are hoping to use similar means to get drugs in. | | | The body has its own ways of delivering vital substances such as glucose to the brain, and some pathogens use trickery to slip through. |
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http://www.worldandi.com/specialreport/1992/october/Sa20653.htm
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| | The Blood Brain Barrier - Treatment's Biggest Obstacle |
| | The problem is the BBB does not differentiate what it keeps out. | | | Tam (Jan 23, 2004): I have an interest in what drugs get through the BBB. | | | I've have Narcolepsy and have come to observe over the years that my symptoms worsen with the use of various medications. |
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http://www.mcmanweb.com/article-172.htm
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| | Acublog: Western Research, Eastern Medicine: Beyond the Blood/Brain Barrier |
| | The point here is that traditional Chinese medicine recognizes a relationship between Jing which is the precursor to bone marrow and gray matter, and Blood which is the red blood cells among other things (capitalized to include those "other things"). | | | Acublog: Western Research, Eastern Medicine: Beyond the Blood/Brain Barrier | | | The relationship that is described in TCM is that Jing and Blood are inter-transforming. |
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http://gancao.net/weblogs/archives/acublog/000227.html
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| | About the Blood Brain Barrier |
| | BBB investigation is an ever growing and dynamic field studied by pharmacologists, neuroscientists, pathologists, physiologists, and clinical practitioners. | | | Thus the BBB is often the rate-limiting factor in determining permeation of therapeutic drugs into the brain. | | | Pericyte, Astrocyte and Basal Lamina Association with the BBB |
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http://users.ahsc.arizona.edu/davis/bbb.htm
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| | Neuroscience for Kids - Blood-Brain-Barrier |
| | Over 100 years ago it was discovered that if blue dye was injected into the bloodstream of an animal, that tissues of the whole body EXCEPT the brain and spinal cord would turn blue. | | | in the blood that may injure the brain. | | | However, lipid soluble molecules, such as barbituate drugs, rapidly cross through into the brain. |
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http://faculty.washington.edu/chudler/bbb.html
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| | Blood-Brain Barrier Deficient mdr1a Knockout |
| | Studies could examine resulting changes in pharmacokinetics and toxicity to the brain and other organs. | | | This barrier, which effectively blocks a wide variety of drugs and toxic compounds in the bloodstream from entering the brain, has for years hampered researchers' efforts to study the effects of drugs on the brain. | | | P-glycoprotein is a large plasma membrane-bound protein present in most murine tissues and expressed predominantly in brain, intestine, liver, testis, kidney, heart, lung and spleen tissues. |
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http://www.taconic.com/newsltrs/nov96/nov96.htm
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| | Blood Brain Barrier Compromise Neurohistology Stain |
| | We surmise that the extreme stress, induction of acidosis, and lack of oxygen during the several minutes before death, result in a breakdown of the BBB allowing the IgG serum proteins to enter the brain parenchyma. | | | The appearance of IgG staining in normal (mouse) brain shows only some tincture in periventricular structures and other areas known to have leaky BBB such as the median eminence and area postrema. | | | When conducting a BBB compromise study, the impact of this event could serve to give a "false" indication of brain penetration for a particular compound as the compound may not have crossed the BBB under normal circumstances. |
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http://www.neuroscienceassociates.com/Stains/bbb.htm
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| | Blood Brain Barrier |
| | This is unlike the skeletal muscles or other organs, which have different blood flow requirements depending on how they are being used. | | | With all of this blood coming in, what protects the brain from blood-borne drugs or other substances? | | | The brain receives a constant 50ml of blood per 100g of brain tissue, per minute, no matter what the conditions. |
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http://www.xecu.net/kiirenza/anatomy/bbb.htm
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| | Blood Brain Barrier Transport |
| | The development of many new drug delivery technologies focuses on AME (Pardridge, 1999). | | | This mechanism is involved in extruding drugs from the brain and is a major obstacle for many pharmacological agents, with the ABC (ATP binding cassette) transporter P-glycoprotein being the principle efflux mechanism of these agents (Cordon-Cardo et al., 1989). | | | Diffusion of substances into the brain can be divided into paracellular (i.e. |
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http://users.ahsc.arizona.edu/davis/bbbtransport.htm
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| | Blood Brain Barrier or Sieve? |
| | The molecules of Essential oils are all very tiny and most of which can pass through the Blood Brain Barrier. | | | Most of the molecules of the substances used in chemotherapy are too large to pass through the Blood-Brain Filter which is why doctors say that chemo doesn't work on brain cancer. | | | Hence they are oxygenating to human tissue and are especially effective in fighting cancer cells which cannot tolerate oxygen. |
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http://aromakat.com/training/bbrain.htm
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| | blood-brain barrier |
| | Please click here to learn more about our commitment to providing | | | It is also hard for some substances (like anti-cancer drugs) to get past the walls and into the brain. | | | The brain is surrounded by a special layer that protects it from infection. |
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http://www.breastcancer.org/dictionary/bloodbrainbarrier_t.html
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| | UM Researchers Discover "Key" To Blood-Brain Barrier |
| | This breakthrough could lead to a better understanding of this nearly impenetrable barrier and to treatment of diseases that affect the brain, such as Multiple Sclerosis, brain tumors, meningitis, Alzheimer's disease, and HIV infection. | | | Findings Could Lead to New Treatments for Brain Disorders | | | Researchers at the University of Maryland School of Medicine in Baltimore have identified a receptor in the human brain that regulates the interface between the bloodstream and the brain, which is known as the blood-brain barrier. |
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http://www.umm.edu/news/releases/bloodbrain.html
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| | Crossing the Blood-Brain Barrier |
| | The blood-brain barrier (BBB) is an important obstacle to the effectiveness of compounds that seek to act on the central nervous system (CNS). | | | The highly restrictive brain capillary bed represents a formidable barrier to many drugs. | | | It is also known that active transport mechanisms play a role in the absorption of drug compounds into the brain. |
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http://www.xenoport.com/technology/cross_bbb.htm
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| | Aluminum and Blood-Brain Barrier Permeability |
| | Either brain to blood (efflux) systems, such as that for Tyr-MIF-1/methionine enkephalin, blood to brain (influx) systems, such as that for interleukin-1 alpha, can be inhibited. | | | The degree to which uptake is increased correlates with the lipid solubility of the substance. | | | Al tends to enhance the blood to brain uptake of water soluble substances that cross the BBB by non-saturable processes. |
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http://www.trufax.org/general/aluminum3.html
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| | Blood brain barrier - Hutchinson encyclopedia article about Blood brain barrier |
| | Many drugs are unable to cross the blood–brain barrier. | | | Theoretical term for the defence mechanism that prevents many substances circulating in the bloodstream (including some germs) from invading the brain. | | | This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. |
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http://encyclopedia.farlex.com/Blood+brain+barrier
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| | blood-brain barrier. The New Dictionary of Cultural Literacy, Third Edition. 2002 |
| | The separation of the brain, which is bathed in a clear cerebrospinal fluid, from the bloodstream. | | | The cells near the capillary beds external to the brain selectively filter the molecules that are allowed to enter the brain, creating a more stable, nearly pathogen-free environment. | | | ‡ Oxygen, glucose, and white blood cells are molecules that are able to pass through this barrier. |
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http://www.bartleby.com/59/21/bloodbrainba.html
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| | fig001pgc: The blood–brain barrier (BBB) |
| | This, together with a generally muted immune environment within the brain itself, protects the fragile neuronal network from the risk of damage that could ensue from a full-blown immune response. | | | The BBB is created by the tight apposition of endothelial cells lining blood vessels in the brain, forming a barrier between the circulation and the brain parenchyma (e.g. | | | Thus, the BBB is crucial for preventing infiltration of pathogens and restricting antibody-mediated immune responses in the central nervous system, as well as for preventing disorganisation of the fragile neural network. |
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http://www-ermm.cbcu.cam.ac.uk/03006264h.htm
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| | blood-brain barrier |
| | a layer of tightly packed cells that make up the walls of brain capillaries and prevent substances in the blood from diffusing freely into the brain: passage across the cell membranes is determined by solubility in the lipid bilayer or recognition by a transport molecule. |
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http://www.infoplease.com/dictionary/blood-brain+barrier
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| | MP3Search.Ru » Aube » Blood Brain Barrier |
| | For downloading mark songs you want to download and press the "order selected songs" button. | | | 17.55 Mb Build Up 17.96 Mb Blood-Brain Barrier II 13.78 Mb Build Down |
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http://www.mp3search.ru/album.html?id=4249
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