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| | Beta-lactamase - Wikipedia, the free encyclopedia |
 | | The structure of a Streptomyces β lactamase is given by PDB 1BSG. | | | These antibiotics have a common element in their molecular structure, a four-atom ring known as a beta-lactam. | | | The lactamase enzyme breaks that ring open, deactivating the molecule's properties. |
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http://en.wikipedia.org/wiki/Beta-lactamase
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| | OhioLINK ETD: Murphy, Deirdre |
| | This 2-azetidinone was found to be a covalent, irreversible inhibitor of the metallo beta lactamase CCrA from Bacteriodes fragilis. | | | The Class A beta lactamases (termed serine enzymes) are inhibited by clinically available compounds such as sulbactam, tazobactam and clavulanic acid. | | | MALDI-TOF analysis of an in-gel tryptic digest of the CCrA beta lactamase gave eight peptides (MH+) that corresponded to the masses of theoretical peptides: 775.398, 1433.651, 1505.730, 1637.778, 1765.912, 2070.961, 2101.977, and 2483.065. |
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http://www.ohiolink.edu/etd/view.cgi?ucin990561318
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| | beta - definition of beta in Computer |
| | Beta versions of non-commercial software are more often freely available to anyone who has an interest. | | | Beta: A beta version of something is not yet ready for prime time but still possibly useful to related developers and other interested parties. | | | Traditionally beta versions (of commercial software) are distributed only to selected testers who are often then given a discount on the proper version after its release in exchange for their testing work. |
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http://computer.laborlawtalk.com/beta
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| | Online Pharmacy, Tramadol, Paxil, antibiotics, amoxicillin, zithromax, Rx Online, pharmaceuticals, DHEA, prescription medications, prescription drugs. |
| | beta Lactamasic profile determination according to Rolfe and Finegold modified method allowed to show five different beta lactamase types. | | | Clindamicin and cefotaxin were active from only 70% and 65% of clinical isolates, and 71% of them were found resistant to cefotaxin with minimal inhibitory concentration above 32 ug/ml. | | | The isoelectric points (pI) vary between 4.3 and 7.5 according to the enzymatic extracts of the clinical isolates. |
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http://www.hairmillion.com/rx-online-info/amoxicillin-online-rx/amoxicillin-online-rx.50.html
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| | Beta-lactamase |
| | This structure of beta-lactamase came from Straphylococcus aureus. | | | It is formed by Ser70 and Gln237 on the edge of the beta strand on the major beta sheet. | | | Beta sheets are shown in red and alpha helices are in green. |
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http://www.creighton.edu/~jbean/jbRasMol.html
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| | Advertise |
| | The term Extended-spectrum beta-lactamase (ESBL) refers to beta lactamase enzymes produced mainly by Klebsiella sp and E. coli that confer resistance to beta-lactam antibiotics | | | Moreover, detection of organisms with multiple-lactamases that may interfere with the phenotypic confirmatory test can only be accomplished using isoelectric focusing and DNA sequencing | | | Some organisms with ESBLs contain other lactamases that can mask ESBL production in the phenotypic test, resulting in a false-negative test. |
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http://www.pjms.com.pk/issues/aprjun02/article11.html
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| | "Secretion cloning vectors in Escherichia coli" |
| | Using oligonucleotide-directed site- specific mutagenesis, we have also removed the linker sequence and upon induction of gene expression, beta-lactamase with the authentic NH2- terminal sequence was produced, in even larger amounts than the beta- lactamase with the linker sequence. | | | After a 3-h induction, beta-lactamase was accumulated to 20% of total cellular protein without any detectable accumulation of pro-beta-lactamase. |
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http://www.biotech-info.net/cloning_vectors.html
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| | Selection and Characterization of beta -Lactam-beta -Lactamase Inactivator-Resistant Mutants following PCR Mutagenesis of the TEM-1 beta -Lactamase Gene -- Vakulenko et al. 42 (7): 1542 -- Antimicrobial Agents and Chemotherapy |
| | Stapleton, P. D., Shannon, K. P., French, G. Construction and Characterization of Mutants of the TEM-1 beta -Lactamase Containing Amino Acid Substitutions Associated with both Extended-Spectrum Resistance and Resistance to beta -Lactamase Inhibitors. | | | Bermudes, H., Jude, F., Chaibi, E. B., Arpin, C., Bebear, C., Labia, R., Quentin, C. Molecular Characterization of TEM-59 (IRT-17), a Novel Inhibitor-Resistant TEM-Derived beta -Lactamase in a Clinical Isolate of Klebsiella oxytoca. | | | Selection and Characterization of beta -Lactam-beta -Lactamase Inactivator-Resistant Mutants following PCR Mutagenesis of the TEM-1 beta -Lactamase Gene -- Vakulenko et al. |
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http://aac.asm.org/cgi/content/abstract/42/7/1542
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| | Molecular epidemiology of Klebsiella pneumoniae producing SHV-5 beta- lactamase: parallel outbreaks due to multiple plasmid transfer -- Prodinger et al. 34 (3): 564 -- Journal of Clinical Microbiology |
| | Villa, L., Pezzella, C., Tosini, F., Visca, P., Petrucca, A., Carattoli, A. Multiple-Antibiotic Resistance Mediated by Structurally Related IncL/M Plasmids Carrying an Extended-Spectrum beta -Lactamase Gene and a Class 1 Integron. | | | Molecular epidemiology of Klebsiella pneumoniae producing SHV-5 beta- lactamase: parallel outbreaks due to multiple plasmid transfer -- Prodinger et al. | | | Molecular epidemiology of Klebsiella pneumoniae producing SHV-5 beta- lactamase: parallel outbreaks due to multiple plasmid transfer |
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http://jcm.asm.org/cgi/content/abstract/34/3/564?maxtoshow=&HITS=10&...
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| | Characterization of SFO-1, a Plasmid-Mediated Inducible Class A beta -Lactamase from Enterobacter cloacae -- Matsumoto and Inoue 43 (2): 307 -- Antimicrobial Agents and Chemotherapy |
| | Giakkoupi, P., Tzouvelekis, L. S., Tsakris, A., Loukova, V., Sofianou, D., Tzelepi, E. IBC-1, a Novel Integron-Associated Class A beta -Lactamase with Extended-Spectrum Properties Produced by an Enterobacter cloacae Clinical Strain. | | | Decousser, J. W., Poirel, L., Nordmann, P. Characterization of a Chromosomally Encoded Extended-Spectrum Class A beta -Lactamase from Kluyvera cryocrescens. | | | Poirel, L., Le Thomas, I., Naas, T., Karim, A., Nordmann, P. Biochemical Sequence Analyses of GES-1, a Novel Class A Extended-Spectrum beta -Lactamase, and the Class 1 Integron In52 from Klebsiella pneumoniae. |
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http://aac.asm.org/cgi/content/abstract/43/2/307
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| | SCOP: Fold: LuxS/MPP-like metallohydrolase |
| | Common fold elaborated with many additional structures; duplication: each family member consists of two similar domains of beta(2)-alpha(2)-beta(2)-alpha(5)-beta structure, but only the N-terminal domain of MPP beta chain binds the catalytic metal | | | Mainly antiparallel beta sheets (segregated alpha and beta regions) | | | Share the same "active site motif" HxxEH located in the first core helix, but differ in one of the zinc-binding residues |
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http://scop.bic.nus.edu.sg/data/scop.b.e.bbg.A.A.A.html
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| | beta Lactamase: AB3738 |
| | Beta Lactamase purified from an E.coli strain containing the pT7-3 vector. | | | Reactivity with other species has not been confirmed. | | | Maintain at -20°C in undiluted aliquots for up to 6 months. |
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http://www.chemicon.com/Product/ProductDataSheet.asp?ProductItem=AB3738
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| | Definition of beta - Merriam-Webster Online Dictionary |
| | For More Information on "beta" go to Britannica.com | | | Get the Top 10 Search Results for "beta" | | | Etymology: Middle English betha, from Latin beta, from Greek bEta, of Semitic origin; akin to Hebrew bEth beth |
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http://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=beta
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| | 66053.030814&ELEMENT_SET=DECL |
| | The physical dispersion of the beta-lactam antibiotic and/or the beta-lactamase inhibitor (or the pharmaceutically acceptable salt thereof) within the polymer backbone can be accomplished using any suitable technique known to those of skill in the art, provided the resulting polymer matrix can effectively degrade under physiological conditions to release the beta-lactam antibiotic | | | In the polymers of the invention, the beta-lactam antibiotic and the beta- lactamase inhibitor are not the same compound (i. | | | A beta-lactamase inhibitor or beta- lactam antibiotic that possesses one reactive functional group can be appended to the polymer of the invention by a hydrolyzable bond, or can be dispersed in the polymer of the invention. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=03/66053.030814&ELEMENT_SET=DECL
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| | Beta-lactam antibiotic - Wikipedia, the free encyclopedia |
| | If β-lactamase production is inducible, then failure to use the most appropriate β-lactam antibiotic therapy at the onset of treatment will result in induction of β-lactamase production, thereby making further efforts with other β-lactam antibiotics more difficult. | | | In particular, choosing appropriate β-lactam antibiotic therapy is highly important against organisms with inducible β-lactamase expression. | | | Anaphylaxis will occur in approximately 0.01% of patients. |
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http://www.wikipedia.org/wiki/Penicillin_derivatives
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| | PHA 421 - Infectious Disease Module |
| | However, these modifications cause a general decrease in the effectiveness of beta lactams, and almost all clinically available beta-lactamase resistant penicillins are less potent than the parent molecules. | | | Thus the drug methacillin is a beta-lactamase resistant antibiotic. | | | Beta lactamases are not particularly tolerant to steric hinderance when it occurs at the sidechain amide, even though they act to cleave the beta lactam amide bond. |
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http://wiz2.pharm.wayne.edu/module/betalactam.html
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| | Datamonitor - MethylGene and Merck-Frosst Canada enter worldwide licensing agreement - News |
| | MethylGene has designed and developed small molecules that inhibit the beta-lactamase enzymes, which are a major cause of resistance to these widely utilized antibiotics and these small molecules may be combined with any beta-lactam antibiotic. | | | In addition, MethylGene's compounds appear to inhibit a broader spectrum of beta-lactamase enzymes compared to currently available therapies. | | | Beta-lactamases are bacterial enzymes that destroy beta-lactam-containing antibiotics, such as the penicillins, cephalosporins, carbapenems, and monobactams. |
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http://www.datamonitor.com/all/news/product.asp?pid=98F8A24F-2AFC-4986-85EA-DBB28285128C
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| | ANTIBIOTIC_RESISTANCEm.html |
| | Resistance to penicillin is due to inactivation of antibiotic by beta-lactamase, alteration in target PBPs, and permeability barrier preventing penetration of antibiotic to target. | | | When the beta-lactam antibiotic binds to the PBPs, transpeptidation is inhibited, peptidoglycan synthesis is blocked, and the cell dies. | | | This process occurs as an adaptive mechanism that arises in response to antibiotics. |
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http://sun.science.wayne.edu/~bio340/StudentPages/Raphael/ANTIBIOTIC_RESISTANCEm.html
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| | Antibiotic composition with inhibitor - US Patent 6565882 |
| | Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. | | | Numerous modifications and variations of the present invention are possible in light of the above teachings, therefore, within the scope of the appended claims, the invention may be practiced otherwise than as particularly described. | | | The composition of the aqueous Eudragit L30D-55 dispersion applied to the antibiotic matrix pellets and to the inhibitor matrix pellets is provided below in Table 2. |
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http://www.patentstorm.us/patents/6565882.html
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| | 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives - Patent 4675186 |
| | By this mechanism they increase their own antibacterial effectiveness or the antibacterial effectiveness of a conventional beta-lactam antibiotic (penicillin or cephalosporin) against many microorganisms, particularly those which produce a beta-lactamase. | | | R is hydrogen, a radical group forming an ester hydrolyzable under physiological conditions, or an acyloxymethyl or 1-(acyloxy)ethyl radical derived from a conventional beta-lactam antibiotic; and | | | A pharmaceutical composition for treating bacterial infections which comprises, in a weight ratio of 10:1 to 1:3, a conventional beta-lactam antibiotic and a compound of claim 4 wherein R is hydrogen or a radical group forming an ester which is hydrolyzable under physiological conditions. |
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http://www.freepatentsonline.com/4675186.html
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| | Research Corporation Technologies News |
| | Researchers have identified more than 250 different beta-lactamases that fit into four structural classes--A, B, C and D. To overcome bacterial resistance to beta-lactams, current drugs combine a beta-lactam antibiotic and a beta-lactamase inhibitor. | | | A two-component drug containing an AlamX inhibitor and a beta-lactam antibiotic have the potential to treat a broad spectrum of microorganisms for which no effective therapies currently exist. | | | Beta-lactams, which include penicillins and cephalosporins, have been among the most useful of all antibiotics, but overuse and misuse have endangered their effectiveness. |
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http://www.rctech.com/news/rct-news.php?articleID=47&articleYear=2000
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| | OhioLINK ETD: Murphy, Deirdre |
| | This 2-azetidinone was found to be a covalent, irreversible inhibitor of the metallo beta lactamase CCrA from Bacteriodes fragilis. | | | The Class A beta lactamases (termed serine enzymes) are inhibited by clinically available compounds such as sulbactam, tazobactam and clavulanic acid. | | | Due to their ability to hydrolyze the lactams, the beta lactamases constitute the major mechanism by which bacteria become resistant to beta lactam antibiotics. |
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http://www.ohiolink.edu/etd/view.cgi?ucin990561318
(324 words)
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| | PHA 421 - Infectious Disease Module |
| | However, these modifications cause a general decrease in the effectiveness of beta lactams, and almost all clinically available beta-lactamase resistant penicillins are less potent than the parent molecules. | | | Beta lactamases are not particularly tolerant to steric hinderance when it occurs at the sidechain amide, even though they act to cleave the beta lactam amide bond. | | | The reactive nature of the beta lactam ring system makes penicillins and related compounds susceptible to a variety of degradative processes. |
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http://wiz2.pharm.wayne.edu/module/betalactam.html
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| | Beta-Lactam Antibiotics |
| | The second area of interest has been in the development of beta-lactamase resistant antibiotics. | | | Due to emergence of beta-lactamase enzymes, the newer classes of beta lactam antibiotics are either resistant to or at least partially resistant to this form of enzyme degradation. |
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http://www.fhsu.edu/nursing/otitis/b-lactam.html
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| | Advertise |
| | The term Extended-spectrum beta-lactamase (ESBL) refers to beta lactamase enzymes produced mainly by Klebsiella sp and E. coli that confer resistance to beta-lactam antibiotics | | | Soon after the first detection of multiple transferable drug resistant strains in Japan its importance in microbial genetics have launched wider searches for it in different bacteria. |
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http://www.pjms.com.pk/issues/aprjun02/article11.html
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