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| | [No title] |
 | | A third problem is that these cells do not replace themselves---thus the need for an easy surgical technique to keep replacing them and the need to keep the encapsulated cells alive as long as possible to reduce the frequency of surgery. | | | But in the healthy person, these cells are critical to the delivery of energy throughout the body. | | | There was one Type I, already on immunosuppression for an unrelated problem, a very young athlete, who managed to stay off insulin for 7 or so years, but that's as close to success as was found with immunosuppressive preventive therapy. |
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http://www.diabetic-help.com/mmfaqislet.txt
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| | MITACS Project Website, Research |
| | Starting with the "Copenhagen model", he is determining under what conditions this (normally harmless) process can lead to runaway inflammation and overt disease conditions. | | | Our models have been aimed at understanding (1) what leads to this faulty immune response and avidity maturation, and (2) under what conditions peptide therapy could subdue the deadly T cells. | | | The interrelated aspects include: (1) A project on periodic chronic myelogenous leukemia: in this condition, there are oscillations of leukocytes with periods from 30 to 100 days. |
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http://www.math.ubc.ca/~keshet/MITACS/temp
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| | Rednova NEWS Posters: Islet Biology-Beta Cell Growth and Differentiation |
| | The interaction partner of p8 was characterized as a novel splice variant of DDX18 expressed in human pancreatic islets using RT-PCR and sequencing analysis. | | | Insulin positive cells did not stain for p57KIP2 at any stage during rat development. | | | Our results suggest the important role of IRS signaling pathway on the regulation of [beta]-cell size and mass, and islet development at the embryonic stage. |
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http://www.rednova.com/modules/news/tools.php?tool=print&id=65444
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| | Understanding Digestion, Assimilation And Enzyme Nutrition |
| | We have found that this practice can lead to an acid/alkaline 'roller-coaster', leading to chronic antacid use and potentially causing greater digestive problems and body chemistry imbalances. | | | There are hundreds of kinds of biochemical enzymes in the body, constantly keeping our body functioning properly. | | | This is also known as having a food allergy attack. |
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http://www.extremehealthusa.com/digestive.html
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| | Cellml.org - Na/Ca Exchange in Models for Pancreatic Beta-Cells |
| | Pancreatic beta-cells have been the subject of both experimental and theoretical studies for several decades. | | | A major focus of theoretical work has been beta-cell dynamics, especially in the form of bursting electrical activity. | | | In addition, they examined a possible link between Na /Ca exchange activity and glucose metabolism, finding that Na /Ca exchange can provide a physiological mechanism to increase the plateau fraction as the glucose concentration is raised. |
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http://www.cellml.org/examples/repository/gall_model_1999_doc.html
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| | Restoring Pancreatic Function in Diabetes |
| | She called the study an important step, and much further research is already underway. | | | Moore, from the department of radiology at Massachusetts General Hospital, Harvard Medical School, has been focusing on developing imaging techniques. | | | As Anna Moore notes, researchers have lacked a noninvasive technique for assessing pancreatic beta cells. |
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http://www.nyas.org/ebriefreps/main.asp?intSubsectionID=752
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| | Exam 1A |
| | D. eliminate any T-cells that are incapable of being stimulated by any of the limited set of MHCs present in the body in which those T-cells are maturing | | | One reason why all of the patients in the DiaPep277 study were men is: | | | Cytokine "profiles" are used as one way to measure the activity of cells in involved in immune responses. |
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http://www.rit.edu/~gtfsbi/imm/012exam1a.htm
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| | World J Gastroenterol |
| | Wistar rats were bought from Animal Center, Tongji Medical College. | | | Table 2 Blood glucose level (mmol/L) changes in STZ-diabetic rats | | | Transdifferentiation of human islet cells in a long-term culture. |
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http://www.wjgnet.com/1007-9327/10/3016.asp
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| | JDRF Researchers Identify How New Beta Cells Form : Juvenile Diabetes Research Foundation International |
| | We are strongly committed to developing regeneration therapeutics, making it one of our six therapeutic targets for the next five years," Dr. Insel said. | | | The islet transplantation research structure JDRF has helped create may be useful in developing regeneration therapeutics by exploring regeneration in type 1 diabetes when the patient has good glucose regulation and control of the autoimmune response. | | | Further, regeneration research may provide approaches to grow, in the laboratory, beta cells taken from human cadavers. |
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http://www.jdrf.org/index.cfm?page_id=102791
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| | ANS 426: Pancreatic Hormones |
| | Cells may depolarize throughout the islet H. Peripheral "tricellular zone" intervated by autonomic afferent nerves. | | | Energy source through glycolytic pathway E. Stimulates K+ uptake by cells. | | | Glucose A. Enters Hepatic Cells B. Three pathways a. |
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http://www.siu.edu/departments/coagr/animal/tw3a/public_html/426pan.htm
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| | B Cells and T Cells |
| | It is one of the ways in which tolerance to self antigens is achieved. | | | Knockout mice that cannot make γδ T cells are slower to heal injuries to their skin. | | | Not only does the patient become hypersusceptible to pathogens that give all of us grief but also to microorganisms, especially viruses and fungi, that normally inhabit our tissues without harming us. |
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http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/B/B_and_Tcells.html
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| | Diabetes: Pancreatic [beta]-cells express phagocyte-like ... @ HighBeam Research |
| | The kinetics of production presented by the islet oxidase mimics that of vascular oxidase, which is low-output, in contrast to neutrophil oxidase (2). | | | The method used to disperse the cells of the pancreatic islets has been described elsewhere (18). | | | Recent studies have suggested, however, that other tissues and cells also present NAD(P)H oxidase activity, such as endothelial cells, vascular smooth muscle cells (VSMCs) (4), thyroid cells (5), fibroblasts (6), lymphocytes (7), spermatozoa (8), and osteoclasts (9). |
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http://www.highbeam.com/library/doc0.asp?DOCID=1G1:102836199&refid=holomed_1
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| | Functional Anatomy of the Endocrine Pancreas |
| | Its gross anatomy and the structure of pancreatic exocrine tissue and ducts are discussed in the context of the digestive system. | | | (D cells) secrete the hormone somatostatin, which is also produced by a number of other endocrine cells in the body. | | | The endocrine portion of the pancreas takes the form of many small clusters of cells called islets of Langerhans or, more simply, islets. |
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http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/pancreas/anatomy.html
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| | HUM-MOLGEN: Buckets Of Beta Cells |
| | Kobayashi, Yoon and colleagues got around this problem by manipulating and analyzing large numbers of human beta-cells. | | | Development Of Immune Cells Associated With Allergy And Asthma | | | Transplantation of insulin-producing pancreatic beta-cells shows great promise as a treatment for type 1 diabetes, but development of this therapy is hampered by a severe shortage of donor beta-cells, which are obtained from deceased human donors. |
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http://hum-molgen.org/NewsGen/10-2005/msg20.html
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| | BBC NEWS Health Stem cells 'could treat diabetes' |
| | There is a lot of work to be done before this procedure could be used in practice | | | "Transplantation of bone marrow stem cells already is a routine procedure for treating cancer and other diseases, and we could build on that experience." | | | They were the cells which had come from the bone marrow and they were behaving in exactly the same way as beta cells, producing insulin in response to glucose. |
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http://news.bbc.co.uk/1/hi/health/2849667.stm
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| | obesity - Columbia Encyclopedia® article about obesity |
| | Some weight-loss experts see obesity as based upon genetics and physiology rather than as a behavioral or psychological problem. | | | For example, rat studies have shown that fat cells secrete a hormone that helps the rat's brain assess the amount of body fat present. | | | The brain tries to keep the amount of that hormone (which also appears to act on the brain area that regulates appetite and metabolic rate) at a set level, resulting in the so-called set point—a weight that the body comes back to, even after resolute dieting. |
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http://columbia.thefreedictionary.com/obesity
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| | Archived News - News & Reviews - DrugDigest |
| | There still is room for a different approach, Zaret said. | | | One goal is a treatment that will supply new beta cells to replace those destroyed by the immune attack. | | | WEDNESDAY, May 5 (HealthDayNews) -- In a finding that might seem obscure but is nonetheless important to many people with diabetes, researchers have discovered where the body's insulin-making beta cells come from: other beta cells. |
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http://www.drugdigest.org/DD/Articles/News/0,10141,5187472,00.html
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| | Press Release: Diabetes Breakthrough: Unlimited Source of Healthy Beta Cells |
| | Advances in this field were presented by Aldo Rossini, MD, of the University of Massachusetts Medical Center in Worcester. | | | Because the same factors that enable their growth and reproduction might also increase the risk of cancer development, the research team developed genetic techniques to remove their malignant potential. | | | Because animal studies have shown that bone marrow stem cells increase tolerance to other transplanted cells, giving patients both islets and stem cells from the same cadaver source might help prevent rejection without immune suppressive drugs. |
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http://www.riskworld.com/PressRel/2000/00q2/PR00a172.htm
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| | Islets of Langerhans - Wikipedia, the free encyclopedia |
| | Electrical activity of pancreatic islets has been studied using the patch-clamp technique, and it has turned out that the behaviour of cells in intact islets differs significantly from the behaviour of dispersed cells | | | The paracrine feed-back system of the Islets of Langerhans has the following structure: | | | Islets can influence each other through paracrine and autocrine communication, and beta-cells are coupled electrically to beta-cells (but not to other cell-types!). |
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http://en.wikipedia.org/wiki/Islets_of_Langerhans
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| | July 17, 2002 Researchers identify hormone that prompts adult stem cells to differentiate into insulin-producing cells |
| | One current strategy being explored for treating type 1 diabetes is transplantation of beta cells, but these cells are in limited supply and may be rejected by the patients' immune systems. | | | ViaCell has licensed some of Habener's discoveries and has formed the subsidairy ViaCell Endocrine Science, Inc. to research and develop cellular medicines for human diseases including diabetes. | | | Habener is working with the cellular therapy company ViaCell to design preclinical studies that will test whether adult islet stem cells might actually prove to be a cure for diabetes. |
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http://www.massgeneral.org/news/releases/071702islets.htm
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| | Health: Conditions and Diseases - Open Site |
| | Disease is the state or process of abnormal function in an identifiable component of the body. | | | The affected region may include specific organs, such as the heart or lung; specific cells, such as the pancreatic beta cells or helper T cells; or specific molecules, such as in an enzyme deficiency. | | | Disease is most commonly associated with foreign agents, called pathogens. |
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http://www.open-encyclopedia.info/index.php/Health/Conditions_and_Diseases
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| | Joel Habener, M.D. |
| | We believe that an understanding of how the expression of IDX-1, Brn4, C/EBP-beta, and CHOP are regulated during pancreas development, islet cell neogenesis and apoptosis, as well as the properties of pancreatic stem cells, will provide opportunities for the development of future rational therapeutic approaches for the cure of diabetes. | | | This hypothesis states that specific transcriptional proteins, that regulate the expression of specific genes during pancreas development, are responsible for beta cell neogenesis and apoptosis and that malfunctioning of these proteins may curtail beta cell growth and function. | | | Specifically we are investigating the regulation of the expression of these transcription factors during the differentiation of beta cells in cell culture models in vitro and by genetic manipulations of mice in vivo. |
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http://weeds.mgh.harvard.edu/baderc/members/JoelHabener.html
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| | Hormones of the Pancreas |
| | However, late in the course of disease, patients may have to begin to take insulin. | | | may fail to be expressed properly at the cell surface or | | | may fail to transmit an effective signal to the interior of the cell. |
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http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Pancreas.html
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| | Welcome to Doctor's A-Z |
| | Autoimmune: Describing a condition in which antibodies attack the body's own tissues. | | | Analgesic: An agent that alleviates pain without causing loss of consciousness. | | | Biotin: A B vitamin produced in the small intestine by beneficial bacteria. |
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http://www.doctorsa-z.com/DAZ_Encyc/Glossary.html
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| | Role Of Pancreatic Beta Cells In The Pathophysiology Of Diabetes |
| | For example, it has recently been demonstrated that reductions in the activity of a specific calpain- or calcium-activated cysteine protease is associated with a substantial increase in the risk of developing diabetes. | | | The animals have elevations of blood glucose, and experiments are currently underway to determine the mechanisms responsible for this. | | | Faculty Research by Name: A B C D E F G H I J K L M N O P R S T U V W X Y Z |
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http://research.medicine.wustl.edu/ocfr/research.nsf/s/362E86506CA626C38625683A002F41ED
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| | Defeat Diabetes: Liver Cells Converted to Pancreas Beta Cells |
| | UK researchers have made tadpoles grow pancreas tissue from their liver cells, and turned human liver cells into pancreas cells in the lab | | | A study hints that one day portions of diabetics' livers might be converted into pancreas tissue in the lab to restore healthy, insulin-producing cells, so that their bodies can store nutrients properly. | | | During embryo development, liver and pancreas cells grow from similar, adjacent tissues. |
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http://www.defeatdiabetes.org/Articles/cells030205.htm
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| | children with DIABETES - Diabetes Dictionary: B |
| | Refers to a continuous supply of low levels of insulin, as in insulin pump therapy. | | | Glucose is the major source of energy for living cells and is carried to each cell through the bloodstream. | | | A measure to gauge total body fat which takes into account a person's weight and height. |
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http://www.childrenwithdiabetes.com/dictionary/b.htm
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| | Diabetes Self-Management - Beta Cells |
| | By discovering more about this immune system attack on the beta cells, researchers hope to devise ways of interrupting the process and preventing or delaying the onset of diabetes. | | | One recent breakthrough has been the identification of a key protein called glutamic acid decarboxylase, or GAD, found on the surface of beta cells, which seems to be an early target in this autoimmune response. | | | Once most of them are gone, the symptoms of diabetes begin to appear. |
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http://www.diabetes-self-mgmt.com/article.cfm?aid=741&sid=6
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| | Diabetes: Fas is Expressed on Beta Cells of NOD Mice but ... @ HighBeam Research |
| | Recent studies have suggested that Fas-mediated apoptosis of pancreatic beta cells may be involved in progression to autoimmune diabetes. | | | Islets from NOD mice 35 to 120 days of age were analyzed by flow cytometry for Fas and FasL expression. | | | Inhibition of nitric oxide production had no effect on either Fas expression or FasL-mediated cell death, eliminating the possibility that nitric oxide plays a role in the upregulation of Fas in murine beta cells. |
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http://www.highbeam.com/library/doc0.asp?DOCID=1G1:54770488&refid=ip_encyclopedia_hf
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| | Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells. |
| | The state of the art may have changed since the publication date. | | | Thus, SMG, an example of an IgA effector tissue, can be characterized as a Th2-dominant site. | | | Currently only limited information is available as to why dominant IgA isotype responses are supported by mucosal T cells in effector tissues. |
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http://www.aegis.com/aidsline/1996/feb/M9620651.html
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| | Diabetic Life |
| | "People have been intensely searching for pancreatic stem cells for a while now, and so our discovery of precursor cells within the adult pancreas that are capable of making new pancreatic cells is very exciting," researcher Simon Smukler, from the university's department of medical genetics and microbiology, said in a prepared statement. | | | The next step in their research, he added, is to prove that these precursor cells really are stem cells. | | | Potential stem cells may lead to new diabetes treatments |
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http://www.diabeticlife.org/ms/news/520776/main.html
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| | WebMD: Type 1 Diabetes Illustrated Guides - Death of Beta Cells |
| | In a person with type 1 diabetes, the insulin-producing beta cells in the pancreas are "mistakenly" killed by an immune-system reaction resulting from exposure to a foreign substance -- such as a virus. | | | This process kills so many beta cells that the pancreas loses its ability to produce insulin. | | | Activation of the immune response sends millions of infection-fighting "T" cells, along with antibodies produced from the foreign-substance exposure, to "fight" and kill the beta cells. |
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http://www.hipusa.com/eTools/webmd/IllustratedGuides/Diabetes1_animated_cons/causes2.html
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| | Alpha beta TCR+ cells are a minimal fraction of peripheral CD8+ pool in MHC class I-deficient mice. |
| | The state of the art may have changed since the publication date. | | | Most of the CD8 alpha+ cells express CD11c and can be found in beta 2m/RAG-2 double-deficient mice, demonstrating that these cells do not require rearranged Ag receptors for differentiation and survival and may be of dendritic cell lineage. | | | Selective MHC class I expression by bone marrow-derived cells does not lead to an accumulation of CD8 beta+ cells in beta 2m-/- mice. |
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http://www.aegis.com/aidsline/2000/nov/A00B0552.html
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | Post-test analysis of positive electrodes from CSPL Beta cells | | | Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. | | | Energy Citations Database (ECD) Document #5311083 - Post-test analysis of positive electrodes from CSPL Beta cells |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=5311083
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| | The source(s) for new pancreatic beta cells in adult life. |
| | The natural source for new pancreatic beta cells is an important issue both for understanding the pathogenesis of diabetes, and for possibly curing diabetes by increasing the number of beta cells. | | | The data conclusively showed that beta-cell replication was the only source for new beta cells without contributions from stem cells or other non-beta cells. | | | This underlines the capacity for beta-cell self-renewal and casts doubt that other cell types are able to generate new beta cells in the intact pancreas. |
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http://www.arclab.org/medlineupdates/abstract_15499581.html
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| | Miura: Electrical Activity in Pancreatic beta-cells |
| | Abstract: Bursting electrical activity (BEA) in cells, e.g., neurons and pancreatic beta-cells, consists of alternating active and silent phases in which the membrane potential exhibits rapid oscillations and slow changes, respectively. |
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http://math.vanderbilt.edu/meetings/97mmmhs/plenary/Miura.html
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| | seattletimes.com |
| | The story you have requested, "Report cites embryonic cells in possible cure for diabetes" has been moved to the seattletimes.com archive. | | | The story will appear automatically in ten seconds, or click here. |
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http://seattletimes.nwsource.com/html/health/2001925359_diabetes11.html
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| | Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. |
| | Despite this, gamma delta + T cells developed in normal numbers, and there was an increase in splenic B cells. | | | The precise influence of alpha beta + T cells on B cell development is poorly understood. | | | alpha beta + T cells respond to specific pathogens by collaborating with immunoglobulin-producing B cells in distinct lymphoid organs such as the spleen and Peyer's patches. |
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http://www.bioscience.org/knockout/ref/philpot.htm
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