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ARUP: Epithelial Basementb> Membrane Zone IgG Antibodies

Basementb> membrane zone antibody testing by IFA is a well established test and can be used to distinguish pemphigoid from linear IgA disease (linear IgA bullous disease and childhood immunobullous disease) and epidermolysis bullosa acquisita, as well as other immunobullous diseases such as pemphigus and dermatitis herpetiformis.
IgG and complement are found at the basementb> membrane zone in perilesional tissue, and IgG basementb> membrane zone antibodies are present in sera in up to 80 percent of patients with localization on the epidermal side of split skin.
Antibodies to two basementb> membrane zone-containing substrates, human epidermis split at the basementb> membrane zone and monkey esophagus epithelium, are detected by indirect immunofluorescence (IFA).

http://www.aruplab.com/guides/clt/tests/clt_a236.jsp (667 words)



Thesis

Normal human salt split skin has been used to characterize basementb> membrane zone autoantibodies.
There is a separation of the basementb> membrane from the epithelium, with some portions of the basementb> membrane attached to the epithelium occasionally found.
Cross-reactivity between the basementb> membrane components (BMCs) tested and the bacterial antigens, and between the monoclonal antibodies to the BMCs was observed.

http://www.dent.ucla.edu/pic/visitors/honigman.thesis.html (7346 words)



Handbook of Ocular Disease Management - Epithelial Basementb> Membrane Dystrophy

EBMDs are bilateral, often asymmetrical corneal basementb> membrane disorders usually occurring in individuals over 30.
In EBMD disorders, the basal epithelial cells manufacture abnormal finger-like projections that protrude from the abnormally thickened basementb> membrane.
Anterior stromal puncture (ASP) under topical anesthesia involves the use of a 25g needle to place 0.1mm deep perforations, breaching Bowmans's membrane, at 0.25mm intervals in a chronic RCE zone in an attempt to initiate scar formation and healing.

http://www.revoptom.com/handbook/sect3i.htm (608 words)



Agarose-Dextran Gels as Synthetic Analogs of Glomerular Basementb> Membrane: Water Permeability -- White and Deen 82 (4): 2081 -- Biophysical Journal

Characterization of the glycosaminoglycan component of the renal glomerular basementb> membrane and its relationship to the peptide portion.
Glomerular basementb> membrane: in vitro studies of water and protein permeability.
Assessment of the charge-selectivity of glomerular basementb> membrane using Ficoll sulfate.

http://www.biophysj.org/cgi/content/full/82/4/2081 (4303 words)



Decreased Glomerular Basementb> Membrane Heparan Sulfate Proteoglycan in Essential Hypertension -- Heintz et al. 25 (3): 399 -- Hypertension

in the glomerular basementb> membranes of the kidney in hypertension.
and, to a lesser extent, in the basementb> membrane of tubuli.
The small heparan sulfate proteoglycan is located predominantly in the glomerular basementb> membrane and, to a lesser extent, in the basementb> membrane of tubuli but also in the mesangium.

http://hyper.ahajournals.org/cgi/content/full/25/3/399 (3697 words)



Dr. Koop - Anti-glomerular basementb> membrane

This is a blood test that detects the presence of antibodies to glomerular (kidney) basementb> membrane proteins.
This test is used when the presence of antibodies against the glomerular basementb> membrane (part of the kidney filtering system) is suspected as the cause of kidney disease.
In the first case, formation of antibodies against the basementb> membrane of the filtering system results in damage to the basementb> membrane and kidney failure.

http://www.drkoop.com/ency/43/003524.html (561 words)



cDNA Cloning of the Basementb> Membrane Chondroitin Sulfate Proteoglycan Core Protein, Bamacan: A Five Domain Structure Including Coiled-Coil Motifs -- Wu and Couchman 136 (2): 433 -- The Journal of Cell Biology

and stained rat and human tissue sections in a basementb> membrane-specific
Basementb> membrane specific chondroitin sulfate proteoglycan is abnormally associated with the glomerular capillary basementb> membrane in diabetic rats.
Basementb> membrane proteoglycans in glomerular morphogenesis: chondroitin sulfate proteoglycan is temporally and spatially restricted during development.

http://www.jcb.org/cgi/content/full/136/2/433 (6221 words)



Basementb> Membrane-Dependent Survival of Retinal Ganglion Cells -- Halfter et al. 46 (3): 1000 -- Investigative Ophthalmology & Visual Science

Basementb> Membrane-Dependent Survival of Retinal Ganglion Cells -- Halfter et al.
Articles by Halfter, W. Articles by Mayer, U. Basementb> Membrane–Dependent Survival of Retinal Ganglion Cells
limiting membrane (ILM) in the survival of ganglion cells (GCs)

http://www.iovs.org/cgi/content/abstract/46/3/1000 (344 words)



LaserMyEye :: Encyclopedia :: Basementb> membrane

For patients getting LASIK, it is very important that the basementb> membrane be in good condition.
A poor basementb> membrane resulting in loosely adhering epithelium will put LASIK patients at far higher risk of serious epithelial defects, extremely slow healing and severe chronic dry eye after surgery.
The basementb> membrane is a membrane of tissue beneath the epithelium which helps the epithelium adhere to the Bowman's layer or stromal tissue.

http://www.lasermyeye.org/encyclopedia/basementmembrane.html (147 words)



Tumor Necrosis Factor-{alpha}-Induced Matrix Proteolytic Enzyme Production and Basementb> Membrane Remodeling by Human Ovarian Surface Epithelial Cells: Molecular Basis Linking Ovulation and Cancer Risk -- Yang et al. 64 (4): 1534 -- Cancer Research

that lead to basementb> membrane breakdown during neoplastic transformation
Stenbeck F., Wasenius V-M. Basementb> membrane structures in tumors of the ovary.
Evidence for a role as a potent basementb> membrane degrading enzyme.

http://cancerres.aacrjournals.org/cgi/content/full/64/4/1534 (4539 words)



Isoform Switching of Type IV Collagen Is Developmentally Arrested In X-Linked Alport Syndrome Leading to Increased Susceptibility of Renal Basementb> Membranes to Endoproteolysis -- Kalluri et al. 99 (10): 2470 -- Journal of Clinical Investigation

Martin, and D.H. Lovett (1988) The purification and characterization of a glomerular-basementb>-membrane-degrading neutral proteinase from rat mesangial cells.
Sanders, and G.A. Coles (1978) The degradation of human glomerular basementb> membrane with purified lysosomal proteinases: evidence for the pathogenic role of the polymorphonuclear leucocyte in glomerulonephritis.
Timoneda, A.M. Chonko, S.J. Edwards, M.E. Noelken, and B.G. Hudson (1991) Glomerular basementb> membrane: identification of dimeric subunits of the noncollagenous domain (hexamer) of collagen IV and the Goodpasture antigen.

http://www.jci.org/cgi/content/full/99/10/2470 (4938 words)



Basementb> Membrane Pores in Human Bronchial Epithelium : A Conduit for Infiltrating Cells? -- Howat et al. 158 (2): 673 -- American Journal of Pathology

at the boundary of the lamina reticularis and basementb> membrane
In summary, pores are present in the basementb> membrane of bronchial epithelium.
A: The pore (arrowheads) traverses the full thickness of the basementb> membrane with epithelium (E) intact and connects with what appears to be a cell-filled channel at the lamina reticularis/lamina propria boundary (star).

http://ajp.amjpathol.org/cgi/content/full/158/2/673 (3957 words)



THE MERCK MANUAL, Sec. 6, Ch. 77, Goodpasture's Syndrome

Heredity may also play a role: HLA-DRw2 is associated with anti-glomerular basementb> membrane disease.
148) of unknown cause, characterized by circulating anti-glomerular basementb> membrane antibodies in the blood and linear deposition of immunoglobulin and complement in the glomerular basementb> membrane and causing pulmonary hemorrhage with severe and progressive glomerulonephritis.
Circulating anti-glomerular basementb> membrane antibodies are present in the blood.

http://www.merck.com/pubs/mmanual/section6/chapter77/77a.htm (439 words)



[Frontiers in Bioscience 2, d343-352, July 15, 1997]

Skin basementb> membrane zone (BMZ) is an ultrastructurally defined area situated between the outer layer of skin, the epidermis, and the inner layer of skin, the dermis.
Kirtschig, M.P. Marinkovich, R.E. Burgeson and K.B. Yancey: Anti-basementb> membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the
L.S. Chan and D.T. Woodley: The 105-kDa basementb> membrane autoantigen p105 is N-terminally homologous to a tumor-associated antigen.

http://bioscience.org/1997/v2/d/chan/343-352.htm (5510 words)



D'Eyealogues - Fixing Epithelial Basementb> Membrane Dystrophy

In patients who present with mild and asymptomatic epithelial basementb> membrane dystrophy, laser in situ keratomileusis should be performed with caution, or photorefractive keratectomy may be the preferred refractive procedure.
Sloughing of corneal epithelium and wound healing complications associated with laser in situ keratomileusis in patients with epithelial basementb> membrane dystrophy.
Transmission electron microscopy of all epithelial debridement specimens disclosed consistent abnormality of the basementb> membrane adhesion complex, as thickened and multilaminated basementb> membrane remained adherent to the intact epithelial sheet.

http://www.lasermyeye.org/forums/printthread.php?t=219 (1261 words)



Coordinated Reassembly of the Basementb> Membrane and Junctional Proteins during Corneal Epithelial Wound Healing -- Suzuki et al. 41 (9): 2495 -- Investigative Ophthalmology & Visual Science

This observation that the re-establishment of the basementb> membrane
Coordinated Reassembly of the Basementb> Membrane and Junctional Proteins during Corneal Epithelial Wound Healing -- Suzuki et al.
for laminin-1 was detected in the basementb> membrane region beneath

http://www.iovs.org/cgi/content/full/41/9/2495 (2996 words)



eMedicine - Antiglomerular Basementb> Membrane Disease : Article by Ramesh Saxena, MD, PhD

Immunofluorescent examination of a kidney biopsy specimen from a patient with antiglomerular basementb> membrane nephritis showing a linear deposition of immunoglobulin G along the glomerular basementb> membrane.
The syndrome was subsequently shown to be caused by an antibody response against antigens present in the glomerular basementb> membrane (GBM).
The alpha-3 chain of type IV collagen has a limited distribution in the body; it is found only in a few specialized basementb> membranes, including the glomerular and alveolar basementb> membranes.

http://www.emedicine.com/med/topic149.htm (5053 words)



Basementb> Membrane-Dependent Modification of Phenotype and Gene Expression in Human Retinal Pigment Epithelial ARPE-19 Cells -- Turowski et al. 45 (8): 2786 -- Investigative Ophthalmology & Visual Science

Basementb> Membrane-Dependent Modification of Phenotype and Gene Expression in Human Retinal Pigment Epithelial ARPE-19 Cells -- Turowski et al.
Articles by Turowski, P. Articles by Greenwood, J. Basementb> Membrane-Dependent Modification of Phenotype and Gene Expression in Human Retinal Pigment Epithelial ARPE-19 Cells
on either porous polyester filters or PLC membranes and characterized

http://www.iovs.org/cgi/content/abstract/45/8/2786 (242 words)



Arch Ophthalmol -- Abstract: Phototherapeutic Keratectomy for Anterior Basementb> Membrane Dystrophy After Laser In Situ Keratomileusis, June 2002, Rojas and Manche 120 (6): 722

Arch Ophthalmol -- Abstract: Phototherapeutic Keratectomy for Anterior Basementb> Membrane Dystrophy After Laser In Situ Keratomileusis, June 2002, Rojas and Manche 120 (6): 722
with no evidence of anterior basementb> membrane dystrophy, and
Phototherapeutic Keratectomy for Anterior Basementb> Membrane Dystrophy After Laser In Situ Keratomileusis

http://archopht.ama-assn.org/cgi/content/abstract/120/6/722 (269 words)



Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations

In vitro degradation of radiolabelled, intact basementb> membrane mediated by cellular plasminogen activator
Energy Citations Database (ECD) Document #6727058 - In vitro degradation of radiolabelled, intact basementb> membrane mediated by cellular plasminogen activator
550301 -- Cytology-- Tracer Techniques ;550901 -- Pathology-- Tracer Techniques; ;CELL MEMBRANES-- DECOMPOSITION;CELL MEMBRANES-- LABELLING; CARCINOGENESIS;HAMSTERS;IN VITRO;LUNGS;RADIOASSAY;TRITIUM COMPOUNDS;TUMOR CELLS

http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=6727058 (105 words)



Basementb> membrane chondroitin sulfate proteoglycan alterations in a rat model of polycystic kidney disease.

These results suggest that BM-CSPG, which was rapidly altered in distribution through the onset and recovery phases, may be a sensitive marker of the cystic state, and in addition, the expression of basementb> membrane proteoglycans may be specifically and separately regulated in this disease.
Staining with antibody to a basementb> membrane heparan sulfate proteoglycan core protein related to perlecan did not diminish but rather stained affected tubules intensely, whereas laminin, on the other hand, was apparently diminished in the basementb> membranes of the cystic tubules.
Staining of tissue sections with two mouse monoclonal antibodies to a recently described basementb> membrane chondroitin sulfate proteoglycan (BM-CSPG) core protein was markedly diminished in the basementb> membranes of dilated cystic tubules.

http://www.arclab.org/medlineupdates/abstract_7510458.html (310 words)



Airway Inflammation in Childhood Asthma -- Barbato et al. 168 (7): 798 -- American Journal of Respiratory and Critical Care Medicine

Individual values for reticular basementb> membrane thickness in bronchial biopsies of children with asthma, children with atopy, and children who were control subjects.
Microphotograph showing bronchial biopsies from a child with asthma (A) and a control child (B), demonstrating an increased basementb> membrane thickness in the child with asthma.
Early thickening of the reticular basementb> membrane in children with difficult asthma.

http://ajrccm.atsjournals.org/cgi/content/full/168/7/798 (3813 words)



Leung, Mol Vis 2000; 6:15-23.

This membrane is called the basementb> membrane of the corneal endothelium because of its location and ultrastructral appearance.
The retrocorneal fibrous membrane (RCFM), first described by Fuchs in 1901 [1], has been observed in various clinical conditions associated with disease and damage to the corneal endothelium [2-4].
This pathological membrane consists of fibrous ECM and elongated cells that are responsible for the fibrillar phenotypes.

http://www.molvis.org/molvis/v6/a4 (4367 words)



ARUP: Glomerular Basementb> Membrane Antibodies

Goodpasture's syndrome is a rapidly progressive autoimmune disease associated with glomerular and tubular basementb> membrane antibodies, pulmonary hemorrhages, and acute glomerulonephritis, commonly of the rapidly progressive type.
FAQE-->): Biochemical studies have shown that the antigen involved in Goodpasture's syndrome is a part of the globular domain of the collagen IV chains in the glomerular basementb> membrane.
A rapid assay for circulating anti-glomerular basementb> membrane antibodies in Goodpasture syndrome.

http://www.aruplab.com/guides/clt/tests/clt_a282.jsp (984 words)



Antibody Response Against the Glomerular Basementb> Membrane Protein Agrin in Patients with Transplant Glomerulopathy

Antibody Response Against the Glomerular Basementb> Membrane Protein Agrin in Patients with Transplant Glomerulopathy
Continue to Antibody Response Against the Glomerular Basementb> Membrane Protein Agrin in Patients with Transplant Glomerulopathy on Medscape Headlines.
The structure of the membrane protein NhaA has been revealed by researchers at the Hebrew University of Jerusalem and the Max Planck Institute of Germany.

http://www.medical-buzz.com/antibody-response-against-the-glomerular-basement-membrane-protein-agrin-in-patients-with-transplant-glomerulopathy,46770.html (184 words)



Basementb> membrane components -- Li and Thompson 56 (12): 885 -- Journal of Clinical Pathology

Basementb> membrane components -- Li and Thompson 56 (12): 885 -- Journal of Clinical Pathology
of the basementb> membrane, laminin and collagen IV, in 170 patients
Deficiency of epithelial basementb> membrane laminin in ulcerative colitis affected human colonic mucosa.

http://jcp.bmjjournals.com/cgi/content/full/56/12/885 (1713 words)



Basementb> Membrane of the Skin

The basementb> membrane zone (BMZ) of the skin is a dynamic area of research.
Collagen VII-Collagen variant present in the skin basementb> membrane within the anchoring fibrils.
Localizes to the anchoring filaments of the lamina lucida and also within the lamina densa of the basementb> membrane zone.

http://www.thedoctorsdoctor.com/bodysites/skin_bm.htm (457 words)



Collagen IV is essential for basementb> membrane stability but dispensable for initiation of its assembly during early development -- Pöschl et al. 131 (7): 1619 -- Development

Basementb> membrane-like structures are deposited in the absence of collagen IV.
function of basementb> membrane-like structures during early development.
in all basementb> membranes and are characterized by their ability

http://dev.biologists.org/cgi/content/full/131/7/1619 (5812 words)



Basal lamina -- Facts, Info, and Encyclopedia article

The basal lamina (previously called basementb> membrane) is a layer on which (Membranous tissue covering internal organs and other internal surfaces of the body) epithelium sits.
This layer is approximately 40-50 (A state in southwestern United States on the Mexican border) nm thick and composed of the lumina lucida and the lumina densa.

http://www.absoluteastronomy.com/encyclopedia/b/ba/basal_lamina.htm (134 words)



Glomerular basementb> membrane (GBM) disorders

On this page we describe the normal glomerular basementb> membrane (GBM) and then some of the diseases that involve it.
Some specialized subtypes of these molecules are only found in specialised basementb> membranes such as the GBM.
The GBM is thickened with normal basementb> membrane material in two common kidney disease, membranous nephropathy and diabetic nephropathy (kidney disease caused by diabetes).

http://renux.dmed.ed.ac.uk/EdREN/EdRenINFObits/GBMdisorders.html (1035 words)

Topic: Basement <b>membrane<

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