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| | [No title] |
 | | autoantibody in said sample of body fluid from said patient. | | | It is a further object of the present invention to provide an assay method that can be carried out near the point of patient care by personnel who do not have experience in laboratory procedures. | | | Advantageously, the monitoring means employed in a kit according to the present invention comprise means for observing a colorimetric change dependent on the binding of the autoantibody and the antigen present in said mixture substantially as hereinbefore described, although other monitoring means can be employed also substantially as hereinbefore described. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=00/25137.000504&ELEMENT_SET=DECL
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| | Stanford NHLBI Proteomics Center |
| | We anticipate that proteomic monitoring of blood autoantibody responses will revolutionize care for patients with autoimmune disease by enabling identification of ‘biosignatures’ for diagnosis, prognostication, and guiding therapy. | | | To characterize the evolution of autoantibody profiles for prognostication and monitoring therapy: analysis of autoantibody specificity and isotype usage. | | | We demonstrated the feasibility of this approach by applying first-generation ‘connective tissue disease’ (CTD) arrays to profile autoantibody responses in human SLE and RA, and ‘myelin proteome’ arrays to study, develop therapies for, and monitor therapeutic responses in, an animal model for multiple sclerosis (MS) |
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http://www.stanford.edu/group/nolan/proteomics/PlanarArray.htm
(428 words)
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| | Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine ... |
| | Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect -- Bleeker et al. | | | Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect | | | In summary, our study shows that IVIG therapy induces a relatively long-lasting, but modest, reduction of autoantibody levels |
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http://www.bloodjournal.org/cgi/content/full/98/10/3136
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| | Origin and age-associated changes in the expression of a physiologic autoantibody. |
| | The potential of human subjects to secrete this autoantibody and the age-related changes in its expression by human peripheral blood and bone marrow lymphocytes have been investigated. | | | Much evidence indicates that this autoantibody plays a physiologic role in the immune response. | | | Origin and age-associated changes in the expression of a physiologic autoantibody. |
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http://www.arclab.org/medlineupdates/abstract_3876969.html
(180 words)
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| | Autoantibody Profiles and Neurological Correlations of Thymoma -- Vernino and Lennon 10 (21): 7270 -- Clinical Cancer ... |
| | Autoantibody Profiles and Neurological Correlations of Thymoma -- Vernino and Lennon 10 (21): 7270 -- Clinical Cancer Research | | | of neuronal and muscle autoantibodies may aid in preoperative | | | Strauss AJLH, Smith CW, Cage GW, van der Geld HW, McFarlin DE, Barlow M. Further studies on the specificity of presumed immune associations of myasthenia gravis and consideration of possible pathogenic implications. |
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http://clincancerres.aacrjournals.org/cgi/content/full/10/21/7270
(2992 words)
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| | Veterinary Information - Immune Mediated Disorders of Dogs |
| | autoantibodies are more likely to develop hypothyroidism than dogs without | | | dogs with autoantibodies develop the disorder) but dogs that are producing | | | This is the condition that leads to hypothyroidism in many |
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http://www.vetinfo.com/dimmune.html
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| | Autoantibody against prothrombin aberrantly alters the proenzyme to facilitate formation of a complex with its ... |
| | and undergo replacement therapy, or as autoantibodies in patients | | | From the Division of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical School, Minamikawachi-machi; the Third Department of Internal Medicine, Dokkyo University School of Medicine, Mibu-machi, Tochigi; and the First Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan. | | | Autoantibody against prothrombin aberrantly alters the proenzyme to facilitate formation of a complex with its physiological inhibitor antithrombin III without thrombin conversion -- Madoiwa et al. |
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http://www.bloodjournal.org/cgi/content/full/97/12/3783
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| | Ovid: Njoku: Anesth Analg, Volume 94(2).February 2002.243-249 |
| | Furthermore, the autoantibody levels of pediatric anesthesiologists did not depend on age or work experience. | | | Address correspondence and reprint requests to Dolores B. Njoku, MD, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, Blalock 906A, 600 N Wolfe St., Baltimore, MD 21287. | | | The median for the general anesthesiologist autoantibody levels was significantly lower than that for the pediatric anesthesiologists and halothane hepatitis patients, but it was not different from control patients. |
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http://www.uic.edu/com/mcas/auto-antibodies.html
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| | [No title] |
| | Efforts to stabilize the acridinium ester-labeled TPO by classical methods, discussed in more detail below, failed. | | | Such autoantibodies can cause significant health problems for the organism. | | | Detailed Description of the Invention As depicted in Figure 1, there is a detectable molecular complex 8 which includes a number of elements as follows: a TPO autoantibody 10 which is the analyte being assayed for in a specimen from a subject, typically a human medical patient. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=00/31535.000602&ELEMENT_SET=DECL
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| | Balance of Th1/Th2 cytokines in thyroid autoantibody synthesis in vitro. |
| | Our observations suggest that "immune deviation" towards Th2 as a form of therapy in Graves' disease could project the patient from the frying pan into the fire. | | | The state of the art may have changed since the publication date. | | | The shift towards Th1 in the target organ is associated with reduced autoantibody synthesis. |
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http://www.aegis.com/aidsline/1999/nov/A99B1069.html
(469 words)
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| | Dummies::Exploring Autoantibody Production |
| | Home > Health, Mind & Spirit > Mind & Body Health > Exploring Autoantibody Production | | | It may be that people who form thyroid autoantibodies are deficient in those protective cells at some point early in life. | | | Another possibility is that the body is attacked at some point by a foreign invader (like a virus) that has antigens similar to those found in thyroid tissue. |
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http://www.dummies.com/WileyCDA/DummiesTip/id-3087.html
(148 words)
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| | Links to Major Medical and Research Sites MDA Research |
| | The site of the Department of Neurology at the University of Rochester Medical Center provides information on faculty, training programs, clinics and neuromuscular research, both basic research and clinical trials. | | | The Washington University School of Medicine Neuromuscular Disease Center contains information on neuromuscular, spinal and cerebral disorders and syndromes, guidelines for neuromuscular evaluation, autoantibody testing and patient information. | | | The World Federation of Neurology Amyotrophic Lateral Sclerosis (WNF/ALS) Web site is sponsored by the World Federation of Neurology to link researchers and clinicians worldwide. |
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http://www.mdausa.org/research/links.html
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| | A Marker Autoantibody of Neuromyelitis Optica (NMO) also known as Devic's Disease |
| | The antigen for the autoantibody has also been discoverd which could be useful for NMO therapy. | | | The assay allows for early stage diagnosis and appropriate therapy before irreversible damage is done and serves as a biomarker for monitoring disease progression and response to therapy. | | | The current assay detects NMO-IgG in 70% of patients with a diagnosis of definite NMO and less than 2% of patients with a diagnosis of definite MS. |
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http://www.mayoclinictechnology.com/tc/diagnostics/MMV-03-132-330.html
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| | News - Autoantibody Positive Gestational Hyperglycaemic Women Need Insulin More Often |
| | Autoantibody positivity was 8.9% in patients with diabetes, 17.9% in patients with impaired tolerance and 0.3% in patients with normoglycaemia. | | | These values were inversely related to the presence of autoantibodies, with the lowest values in patients who were positive for anti-glutamic acid decarboxylase. | | | One hundred and twenty three patients with gestational diabetes, 84 patients with impaired glucose tolerance and 290 normoglycaemic patients were all assessed for anti-islet cell antibodies, glutamic acid decarboxylase autoantibodies and the components of the metabolic syndrome. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256CAB002497D6
(450 words)
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| | Autoantibody - Wikipedia, the free encyclopedia |
| | Many autoimmune diseases in humans, most notably lupus erythematosus, are caused by such autoantibodies. | | | Note: the sensitivity and specificity of various autoantibodies for a particular disease is different for different diseases. | | | List of some autoantibodies and commonly associated diseases |
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http://en.wikipedia.org/wiki/Autoantibody
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| | News - Prolonged Treatment With Infliximab Causes Autoantibody Formation |
| | The researchers assessed correlation of these autoantibody levels with pharmacologic treatments, response to infliximab, and adverse events. | | | In early reports, the formation of autoantibodies was noted in a small number of patients; however, the extent of autoantibody formation and the association with treatment efficacy and adverse effects have not been fully evaluated. | | | Of the patients, 76% developed new autoantibodies, and these autoantibodies persisted in 57%. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256E1C0038E452
(528 words)
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| | Glutamic Acid Decarboxylase (GAD) Autoantibody |
| | autoantibodies are often markedly elevated in patients with the stiff-person syndrome (also referred to as stiff-man syndrome), a condition that is associated with fluctuating stiffness and paroxysmal spasms of the trunk and legs. | | | This is consistent with the hypothesis that IDDM is an autoimmune disease and that autoantibody production is an early step in the development of IDDM. | | | A number of recent studies indicate that patients with insulin-dependent diabetes mellitus (IDDM) often have antibodies to GAD |
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http://www.labcorp.com/datasets/labcorp/html/chapter/mono/sr016400.htm
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| | Anti-Calpastatin Autoantibody Detection Elisa available from Research Diagnostics Inc |
| | Furthermore an increased incidence of calpastatin autoantibodies was found for a subgroup of patients with rheumatoid arthritis (7). | | | Autoantibodies reactive against human calpastatin were detected by screening a cDNA expression library with the serum of a patient with the history of venous thrombosis and suspected antiphospholipid syndrome. | | | Also observed was the presence of calpastatin autoantibodies in some cases of infertility (8,9). |
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http://www.researchd.com/rdikits/calpaskt.htm
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| | Pathogenic Autoantibody Interactions in Lupus Nephritis |
| | Furthermore, it is postulated that the nature and location of the target antigen influences the nature of the subsequent inflammatory response through direct effects on the local cell biology through direct effects on cell-matrix, cell-cell, and intracellular processes. | | | Previous work involved identification of monoclonal autoantibodies with pathogenic properties; the nephritogenic IgG reproducibly formed glomerular immune deposits, accompanied by clinical and histologic evidence of nephritis after transfer to normal mice. | | | With the information and reagents derived from these studies, our long-term goal is to design specific therapies aimed at modulation of anti-GBM antibody mediated diseases by either eliminating pathogenic B cells and/or inhibiting the deposition of anti-GBM antibodies, in vivo. |
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http://renal2.med.upenn.edu/RehdWeb/madaiores.html
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| | Developing New Standards for Autoantibody Measurement; Bringing Metrology to Serology |
| | The determination of circulating autoantibodies has long been a part of clinical medicine in autoimmune disease and there are many FDA approved autoantibody tests currently marketed. | | | However, there is enormous variability in these tests that has led to confusion over results, variable degrees of confidence in their utility and even misdiagnosis of patients' disease. | | | Two of the largest health problems in the country are autoimmune disease and cancer, which combined, affect almost half of all Americans. |
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http://usms.nist.gov/workshops/antibody.htm
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| | Autoantibody interpretations |
| | Assays for anti-proteinase-3 autoantibodies are useful for corroborating positive C-ANCA assays. | | | This patient was previously shown to produce low titer P-ANCA autoantibody. | | | All sera are stored frozen for six weeks for additional testing. |
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http://dpalm.med.uth.tmc.edu/clinicalservices/Interps/autoAB.html
(937 words)
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| | Platelet Immunology Laboratory Platelet Autoantibody Test |
| | In approximately 85% of patients with ITP the presence of an autoantibody can be detected. | | | Idiopathic Thrombocytopenic Purpura (ITP) is a diagnosis associated with elevated platelet associated IgG, IgM or both. | | | Patients who require autoantibody testing must be platelet transfusion independent for approximately 5 days to ensure that the platelets being tested are the patient’s own platelets and not circulating donor platelets. |
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http://www.psbc.org/lab_platelet/test01.htm
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| | NEJM -- Autoantibody-mediated acquired deficiency of C1 inhibitor |
| | Two patients with recurrent angioedema but no associated diseases were found to have IgG1 autoantibodies against C1 inhibitor. | | | We report another type of acquired C1-inhibitor deficiency with angioedema. |
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http://content.nejm.org/cgi/content/abstract/316/22/1360
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| | ScienceDaily: New Blueprint To Aid Physicians In Predicting Risk For Type 1 Diabetes |
| | Those who tested positive for the two most commonly recognized autoantibodies had a 14 percent risk of developing type 1 diabetes after 10 years. | | | Newer tests use biochemical markers to detect islet autoantibodies, and these autoantibody responses signify a cause and effect relationship between type 1 diabetes and autoimmune phenomena targeting pancreatic insulin-producing cells. | | | However, those who displayed those two autoantibodies along with islet cell antibodies had an 80 percent risk after just 6.7 years. |
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http://www.sciencedaily.com/releases/2005/10/051031080519.htm
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| | Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule. |
| | The state of the art may have changed since the publication date. | | | The treatment with a combination of anti-CD80 and CD86 mAb before the onset of lupus completely prevented autoantibody production and nephritis, and prolonged survival. | | | However, the blockade of both CD80 and CD86 are required for preventing the development and progression of lupus. |
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http://www.aegis.com/aidsline/1996/mar/M9630716.html
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| | NEJM -- Autoantibody Signatures in Prostate Cancer |
| | Disis, M. L., Lyerly, H. Global Role of the Immune System in Identifying Cancer Initiation and Limiting Disease Progression. | | | This article has been cited by other articles: | | | Arul M. Chinnaiyan, M.D., Ph.D. Background New biomarkers, such as autoantibody signatures, |
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http://content.nejm.org/cgi/content/short/353/12/1224
(401 words)
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