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| | Atosiban |
 | | A total of 246 patients were randomized to receive atosiban and 246 to placebo; the primary endpoint was the time from the start of study drug to delivery or therapeutic failure. | | | The efficacy was analyzed by intention to treat and the safety according to the drug that the patient in fact received. | | | The incidence of adverse effects in both groups was comparable (thoracic pain, tachycardia and fetal distress) except for injection site reaction that was higher in the atosiban group. |
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http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijgo/vol2n1/atosiban.xml
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| | New drug |
| | Atosiban, originally piloted in 1987 to treat painful periods, is being heralded as a breakthrough in the development of tocolytics &; drugs used to delay labour — because it has no alarming side-effects. | | | Premature births account for more than two thirds of all neonatal fatalities worldwide, and those babies who survive a preterm delivery are often prone to disabilities that may dog them throughout their lives. | | | It was found to be as effective, but much less likely to cause cardiovascular problems. |
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http://www.kerri.thomas.btinternet.co.uk/drug.htm
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| | Data Sheet |
| | As an antagonist of oxytocin, atosiban may theoretically facilitate uterine relaxation and postpartum bleeding, therefore, blood loss after delivery should be monitored. | | | Admission to a neonatal intensive care unit (NICU) was similar for both treatment groups (approximately 30%), as was length of stay and ventilation therapy. | | | The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence (≤ 4 contractions/hour) for 12 hours. |
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http://www.medsafe.govt.nz/profs/Datasheet/t/Tractocileinj.htm
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| | Clinical Significance of Atosiban in the Treatment of Preterm Labour |
| | The favourable safety profile of atosiban in combination with equivalent tocolytic effectiveness would appear to represent an advance over current tocolytic therapy. | | | Neonatal outcomes were found to be comparable in both treatment groups. | | | What does atosiban offer for future clinical practice? |
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http://www.kenes.com/cogibook1999/Clinical_Significance_of_Atosiban_in_the_Treatment_of_Preterm_Labour.html
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| | OBLink Preterm Labor Resource - Head to Head: Nifedipine versus Atosiban - transcript |
| | Nifedipine is a drug that affects all vasculature, in fact that’s why we use it in obstetrics for pre-eclampsia, etc. And so it still has some side effects: flushing, headache, tachycardia, but they’re not usually a major problem at least in well people. | | | The other side of the equation in side effects is always the baby. | | | Atosiban is a drug that’s specific for uterine muscle and very little of it crosses the placenta so it has very few side effects. |
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http://www.oblink.com/display.asp?page=congresses_proceedings_COGI2003-Fisk
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| | Website Directory - Atosiban |
| | Evidence based resource for obstetricians and women on maternal fetal medicine and especially on epidemiology, prevention and treatment of preterm labour. | | | Home > Directory > Drugs and Medications > A > Atosiban | | | Some listings found within this directory have been supplemented with results from the DMOZ project. |
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http://www.supergreen.biz/lma/directory/Drugs_and_Medications/A/Atosiban/Atosiban.html
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| | HighBeam Research: Library Search: Results |
| | They combined this with revolutionary new fertility drug Atosiban (or Tractocila) which relaxes the womb so it doesn't constrict and tighten during pregnancy. | | | number of clinical trials are studying atosiban's pharmacokinetics and efficacy. | | | The effect of the oxytocin antagonist atosiban on preterm uterine activity in the human... |
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http://www.highbeam.com/library/search.asp?q=Atosiban&refid=healthcyclopedia
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| | p144 : Extracorporeal Perfusion of the Porcine Uterus |
| | The objective of the study was to establish an experimental model for the examination of the uterine function, using the extracorporeal perfusion of the swine uterus. | | | In order to examine viability and responsiveness to hormones the effect of Oxyroxin, Prostaglandin E2 and various tocolytic drugs (Fenoterol, Terbutaline, Ritodrine, Alcohol, Atosiban, Aspirin, Glyceroltrinitate, Verapamil and Propofol) were tested. | | | Our results demonstrate clearly that the perfused swine uterus can be maintained in a normal functional status and thus is a suitable experimental model to study the physiology of the pregnant and non pregnant uterus. |
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http://www.thieme.de/abstracts/eced/abstracts2002/daten/p144.html
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| | Atosiban - Health Information |
| | OBLink - Tractocile Description: Evidence based resource for obstetricians and women on maternal fetal medicine and especially on epidemiology, prevention and treatment of preterm labour. | | | home > pharmacy > medication > a > atosiban | | | This site is a web directory and does not offer medical advice. |
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http://www.healthcyclopedia.com/pharmacy/medication/a/atosiban.html
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| | Obstetrics |
| | Evaluation of the maternal and neonatal effects of the oxytocin antagonist, atosiban, in a cross-fostering study in rats. | | | Inhibitory effect of barusiban and atosiban on oxytocin-induced contractions of myometrium from preterm and term pregnant women | | | Molecular Modeling of the Neurohypophyseal Receptor Atosiban Complexes |
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http://www.ferring.com/randd/Publication+Lists/Obstetrics.htm
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| | Atosiban A Drugs and Medications Pharmacy Health |
| | OBLink - Tractocile - Evidence based resource for obstetricians and women on maternal fetal medicine and especially on epidemiology, prevention and treatment of preterm labour. | | | Top : Health : Pharmacy : Drugs_and_Medications : A : Atosiban : | | | Click here to add, change or remove your listing |
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http://www.iaswww.com/ODP/Health/Pharmacy/Drugs_and_Medications/A/Atosiban
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| | [No title] |
| | Also, 23% of women given atosiban and 31% on placebo had at least one subsequent iv therapy for recurrent PTL. | | | Therefore, atosiban prolonged the time interval to first recurrence of PTL and reduced the need for subsequent iv therapy. | | | These findings, which were dependent on gestational age, suggest a role for atosiban in the treatment of PTL. |
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http://www.kenes.com/cogibook1999/Us_Placebo_Controlled_Trials_of_Atosiban_in_the_Treatment_of_Preterm_Labour.doc
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| | Tractocile injection and infusion |
| | For the newborn, clinical trials did not reveal any specific undesirable effects of atosiban. |
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http://www.pharmj.com/Editorial/20000610/products/tractocile.html
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| | Journal of Perinatal Medicine - Abstract |
| | Conclusion: Atosiban may be an effective treatment of uterine hyperactivity during active labor. | | | Atosiban was well tolerated by all women and no side effects were noted. | | | Atosiban treatment for uterine hyperactivity during active labor: a pilot study |
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http://www.degruyter.de/journals/jpm/abs/13171.html
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| | New drug for delaying premature birth marketed |
| | The proportion of women who remained undelivered and not requiring alternative treatment within seven days of therapy initiation was 59.6 per cent for atosiban and 47.7 per cent for the beta-agonist. | | | The manufacturer, Ferring, reports that phase III clinical trials showed atosiban to be superior to a beta-agonist. | | | The drug has also been shown to inhibit the effects of vasopressin by binding to its receptor. |
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http://www.pharmj.com/Editorial/20000610/clinical/prematurebirth.html
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| | Obstetrics & Gynecology -- Table of Contents (September 1 1996, 88 [3]) |
| | Dose ranging study of the oxytocin antagonist atosiban in the treatment of preterm labor. | | | The effect of atosiban on uterine activity in preterm labor is enhanced by bolus infusion and is similar to ritrodrine. | | | Pregnancy predisposes women to an increase in intrapulmonary shunt. |
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http://www.greenjournal.org/content/vol88/issue3/index.shtml
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| | Obstetrics Products |
| | The active ingredient, atosiban, is an oxytocin antagonist that blocks the action of oxytocin and is able to prevent uterine contractions and relax the uterus. | | | TRACTOCILE (atosiban) is a novel treatment indicated to delay imminent pre-term birth, which is the main cause of death and disability in new-born infants. | | | Ferring is dedicated to advancing the treatment of pre-term labour supporting a reduction in the number of premature births and the high risk of death and serious disability associated with it. |
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http://www.ferring.com/therapeutic/obstetrics/Obstetrics+Products.htm
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| | DARE abstract992142 |
| | Tocolytics for the intervention group and placebo or no tocolytic for the control group. | | | Tocolytics used in the intervention group included: isxuprine, ethanol, terbutaline, ritodrine, indomethacin, magnesium sulfate and atosiban. | | | Betamimetics, indomethacin, atosiban and ethanol, but not magnesium sulfate, were associated with significant prolongations in pregnancy. |
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http://nhscrd.york.ac.uk/online/dare/992142.htm
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| | USPharmd - Drug Information |
| | Top » Pharmacist » Drug Information » Top » a » atosiban |
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http://www.uspharmd.com/pharmacist/druginfo/index/a/atosiban?thumb=thumb
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| | BBC NEWS Health Call for premature baby lifesaver |
| | If there's any treatment that is more effective and safer we would hope it can be used widely | | | It found Atosiban to be at least as effective in delaying premature labour. | | | A large-scale international trial has compared the beta agonists still used in many UK hospitals with an alternative called Atosiban. |
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http://news.bbc.co.uk/1/hi/health/2125640.stm
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| | Electric field stimulation |
| | atosiban) can be tested using pregnant uterine tissue from rat or guinea pig. | | | The investigations of the vasculature isolated from rat, guinea pig, rabbit, or human placental tissue are carried on in the presence of potassium chloride as contractile agent or vasodilators like the nitrite derivatives or angiotensine receptor agonists and antagonists (e.g. |
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http://www.sams-dodd.com/tds/T-A00085-00000.htm
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| | Medical Science Monitor - _MANUS |
| | We searched MEDLINE, EMBASE, the Cochrane Controlled Trials Register and Science Citation Index using the following Medical Subject Headings and textwords: oxytocin (antagonists and inhibitors), atosiban, antocin, oxytocin antagonists, oxytocin receptor antagonists and oxytocin inhibitors. | | | Side effect profile was substantially better for atosiban compared to beta-agonists. | | | All randomised controlled trials that compared effectiveness and safety of atosiban with a placebo or another tocolytic in women with threatened or actual preterm labour were included. |
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http://www.medscimonit.com/medscimonit/modules.php?name=Current_Issue&d_op=summary&id=2762
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| | Karger Publishers |
| | Our results do not support the contention that vasopressin is involved in the etiology of dysmenorrhea, plasma concentrations of vasopressin being similar in dysmenorrheic women and controls, and the vasopressin antagonist Atosiban having no effect on menstrual pain, intrauterine pressure or uterine artery pulsatility index in dysmenorrheic women. | | | We compared menstrual pain, uterine contractility and blood circulation, and plasma concentrations of vasopressin and prostaglandin F | | | metabolite in women with versus without primary dysmenorrhea, and determined the effects of a vasopressin antagonist, 1-deamino-2- D -Tyr(OEt)-4-Thr-8-Orn-oxytocin (Atosiban), on these parameters. |
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http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=goi50170
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| | Infusion with an oxytocin receptor antagonist delays parturition in a marsupial -- Renfree et al. 108 (1): 131 -- ... |
| | The oxytocin receptor antagonist [1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Om]-oxytocin (Atosiban) is a specific antagonist of both mesotocin- and oxytocin-induced myometrial contractions in late pregnant tammars in vitro. | | | In both the 3 day and 7 day infusion groups, all 15 control animals were pregnant and gave birth within the normal time (day 26.75 +/- 0.20, mean +/- SEM), during the infusion of saline. | | | Continuous intravenous infusion of Atosiban (1 mg kg-1 day-1) for 3 or 7 days from day 24 of the 26.5 day gestation significantly delayed births. |
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http://www.reproduction-online.org/cgi/content/abstract/108/1/131
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| | search atosiban websites - buy, sell or shop for atosiban discounts & resources |
| | Your last search covered atosiban topics - including information on atosiban, atosiban websites and atosiban resources. | | | Extend your web search for atosiban or narrow for results from the UK, Ireland, Canada, Australia | | | HaveASearch.com is a Directica production and has several Internet divisions. |
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http://www.haveasearch.com/search.php?keywords=atosiban
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| | Protein & Peptide Letters, Volume 10, No. 3, 2003 |
| | In this paper we describe a computer simulated docking pertinent to affinity of an oxytocin antagonist atosiban towards OT receptor, versus vasopressin V1a and V2 receptors. | | | Conversely, oxytocin antagonists blocking uterine OT receptor can suppress uterus contraction. |
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http://www.bentham.org/ppl/ppl10-3.htm
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