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Topic: Atheroma



  
 Atheroma - Wikipedia, the free encyclopedia
However, the heart arteries, because (a) they are small (from about 5 mm down to invisible), (b) hidden deep within the chest and (c) never stop moving, have been a difficult target organ to track, especially clinically in individuals who are still asymptomatic.
However, though these methods are used in research, they are not widely available to most patients, still have mild to significant technical limitations, have not been widely accepted and generally are not covered by medical insurance carriers.
For most people, changing their internal physiologic behaviors, mostly hidden within, from the usual ones which promote atheroma progression (i.e.
http://en.wikipedia.org/wiki/Atheroma   (2034 words)

  
 Texas Heart Institute Journal - High-Grade Atherosclerosis of the Aorta
An extensive discussion of the clinical and therapeutic issues in patients with atheromas of the thoracic aorta can be found in an excellent review of this topic by Tunick and Kronzon.
The risk of development of thromboemboli is related to the thickness and anatomic structure of the atheroma.
There have been reports of surgical removal of highly mobile atheromas and thromboendarterectomy of the ascending aorta and arch; however, the risk of surgical intervention would appear to outweigh any benefits achieved.
http://www.bcm.edu/tmc/thi/siddi291.html   (1097 words)

  
 REVERSAL: Atorvastatin halts atheroma progression
Secondary end points of change in total atheroma volume and change in percent obstructive volume also both showed progression in the pravastatin group but no change in the atorvastatin group.
Subgroup analysis showed similar results for almost all subgroups, with progression of atheroma in most pravastatin subgroups but no change in any atorvastatin subgroup.
There were 167 patients in this group, and they achieved mean LDL levels of 88 mg/dL.
http://www.clevelandclinic.org/heartcenter/pub/news/archive/2003/reversal11_13.asp   (1544 words)

  
 Risk Factors for Progression of Aortic Atheroma in Stroke and Transient Ischemic Attack Patients -- Sen et al. 33 (4): ...
Tunick PA, Kronzon I. Atheromas of the thoracic aorta: clinical and therapeutic update.
aortic atheroma, and investigation of new treatment approaches
of stroke subtype with progression of aortic atheroma was explored
http://stroke.ahajournals.org/cgi/content/full/33/4/930   (3696 words)

  
 Clinical Trial: Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina
There is currently no in-vivo human evidence that androgen therapy inhibits or reduces levels of atheroma, although there is abundant evidence in animals to suggest a potential improvement.
Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina
http://www.clinicaltrials.gov/ct/gui/show/NCT00131183   (897 words)

  
 Cerebral embolization during cardiac surgery: impact of aortic atheroma burden -- Mackensen et al. 91 (5): 656 -- ...
Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients.
Fig 2 The relationship, defined using univariate linear regression, between transcranial Doppler-detected cerebral emboli and atheroma burden in the aortic arch in patients undergoing coronary artery bypass graft surgery.
Cerebral embolization during cardiac surgery: impact of aortic atheroma burden -- Mackensen et al.
http://bja.oxfordjournals.org/cgi/content/full/91/5/656   (2742 words)

  
 Apria - resources - Health Advisors
Removing an atheroma used to require opening the chest and the artery.
Your doctor will base his or her recommendation on the location and characteristics of the atheroma.
You and your doctor will decide whether to use the atherectomy technique after discussing the benefits and risk.
http://www.apria.com/resources/1,2725,48-51-A-820,00.html   (646 words)

  
 CRISP - Computer Retrieval of Information on Scientific Projects, Abstract Display
The results of this study may form the basis of a larger longitudinal evaluation of the progression of atherosclerosis as it relates to underlying cardiovascular risk factors and medical intervention, possible only with this noninvasive technique.
Abstract: DESCRIPTION (provided by applicant): The overall goal of this study is to elucidate the pathophysiology that underlies the development and composition of atherosclerosis by analyzing gadolinium-based contrast-enhanced MRI (CE-MRI) features of atheroma of the carotid artery.
Our preliminary studies have shown the unique ability of CE-MRI to characterize atherosclerotic changes in the wall of the carotid artery, both at early and advanced stages.
http://crisp.cit.nih.gov/crisp/CRISP_LIB.getdoc?textkey=6795598&p_grant_num=5R01HL069905-03&p_query=(atherosclerosis)&ticket=16289214&p_audit_session_id=76645215&p_audit_score=70&p_audit_numfound=66&p_keywords=atherosclerosis   (367 words)

  
 NEJM -- Peripheral Embolism from an Aortic-Arch Atheroma
Thromboembolism from an atheroma in the aortic arch is an important cause of stroke and peripheral embolism.
Transesophageal echocardiography is the technique of choice for the diagnosis of aortic-arch atheroma.
This article has been cited by other articles:
http://content.nejm.org/cgi/content/full/349/24/e23   (242 words)

  
 AtheroNews - 17 May 2004 - Recurrent ischemic stroke associated with severe aortic atherosclerosis
They do note that the incidence of stroke recurrence in patients with an atheroma >4.0 mm was lower than that found by the French Study of Aortic Plaques in Stroke Group [2], and that more patients in the present study were treated with anticoagulants (45% vs 20%) than in the French study.
Multivariate analysis of stroke recurrence by severity of aortic arch atheroma*
Recurrent ischemic stroke associated with severe aortic atherosclerosis
http://www.atherothrombosis.org/news/stroke/nh_17may04.cfm   (953 words)

  
 CRISP - Computer Retrieval of Information on Scientific Projects, Abstract Display
To study the feasibility of a larger study investigating the role of treatment measures that may be used to treat aortic atherosclerosis and prevent stroke/TIA.
Other locations will be examined for any new change.
Abstract: DESCRIPTION (Adapted From The Applicant's Abstract): Aims: To investigate the natural history of aortic athersclerosis in stroke/TIA patients over a period of 12 months.
http://crisp.cit.nih.gov/crisp/CRISP_LIB.getdoc?textkey=6748496&p_grant_num=5K23NS002177-05&p_query=(atherosclerosis)&ticket=16289214&p_audit_session_id=76645215&p_audit_score=26&p_audit_numfound=371&p_keywords=atherosclerosis   (395 words)

  
 The thyroid, blood flow and atheroma -- Fowler 93 (7): 477 -- QJM
Atheroma tends to develop where the blood flow is relatively
which are responsible for the development of atheroma, while
shown by the advanced atheroma in false channels of chronic
http://qjmed.oxfordjournals.org/cgi/content/full/93/7/477   (4407 words)

  
 Cholesterol Disorders Center --- HealthandAge
The most important measurement made was the change in the percentage volume of atheroma (the deposits of waxy material in the walls of the coronary arteries that occurs in atherosclerosis) after 5 weeks' therapy.
Certainly, anything that can clean out atheroma, and send the cholesterol back to the liver for disposal, is a potentially valuable addition to the medicine chest.
After the 5-week experimental treatment, the percentage volume of atheroma had increased a little (0.14%) in the placebo group, and was considerable decreased (-1.06%) in the low- and high-dose treatment groups, when their results were combined.
http://www.burtonsys.com/like_drano_for_the_arteries.htm   (840 words)

  
 Core aldehydes of alkyl glycerophosphocholines in atheroma induce platelet aggregation and inhibit ...
TLC conditions as given in Materials and Methods.
Isolation and identification of GroPCho core aldehydes from human atheromas
alkyl GroPCho core aldehydes in human atheroma, and to demonstrate
http://www.jlr.org/cgi/content/full/43/1/158   (4080 words)

  
 Expression of Neutrophil Collagenase (Matrix Metalloproteinase-8) in Human Atheroma: A Novel Collagenolytic Pathway ...
Expression of Neutrophil Collagenase (Matrix Metalloproteinase-8) in Human Atheroma: A Novel Collagenolytic Pathway Suggested by Transcriptional Profiling -- Herman et al.
Expression of Neutrophil Collagenase (Matrix Metalloproteinase-8) in Human Atheroma
the shoulder region of human atheroma, a frequent site of rupture
http://circ.ahajournals.org/cgi/content/full/104/16/1899   (3927 words)

  
 CD40 Signaling and Plaque Instability -- Schönbeck and Libby 89 (12): 1092 -- Circulation Research
with all three interstitial collagenases within human atheroma.
atheroma, we sought direct in vivo evidence that interruption
cytokine abundantly expressed in human atheroma, by several
http://circres.ahajournals.org/cgi/content/full/89/12/1092   (7044 words)

  
 Stroke Survivors of Ottawa (Canada)
This study compares antiplatelet therapies versus anticoagulant therapy.
This predisposes to a number of conditions, including thrombosis, angina, and stroke.
High recurrence rate of cerebral or peripheral emboli in patients with protruding atheromas of the aortic arch identified by transesophageal echocardiography.
http://www.strokesurvivors.ca/index.php?nav=atheromas   (448 words)

  
 On Target
Spontaneous recovery of some forms of epilepsy may be responsible for the illusion of therapeutic effectiveness and for the confirming statements by physicians who have commented on this cure.
The main outcome measure was the change in percent atheroma volume (follow-up minus baseline) in the combined ETC-216 cohort.
As a result, a study published in the Journal of the American Medical Association (2003;290:2292-2300), was performed to assess the effect of intravenous recombinant ApoA-I Milano/phospholipid complexes (ETC-216) on atheroma burden in patients with acute coronary syndromes (ACS).
http://www.targethealth.com/ontarget/2003/11092003.htm   (2181 words)

  
 Cardiovascular disease--linking pathology and epidemiology -- Meade 30 (5): 1179 -- International Journal of ...
as much to clinical CHD as atheroma were in due course strengthened
‘atheroma of coronary walls, no relationship with physical
may not be a function simply and directly of the atheroma or
http://ije.oxfordjournals.org/cgi/content/full/30/5/1179   (2860 words)

  
 Attenuation of Neointimal Vascular Smooth Muscle Cellularity in Atheroma by Plasminogen Activator Inhibitor Type 1 ...
VSMC migration into the neointima may predispose to vulnerability.
The objective of our study was to determine whether increased
PAI-1 in atheroma from patients with unstable angina or acute
http://www.jhc.org/cgi/content/full/52/8/1091   (4378 words)

  
 Cholesterol and strokes -- Oliver 320 (7233): 459 -- BMJ
incidence of stroke is due to large vessel atheroma.
Effect of simvastatin on coronary atheroma: a multicentre antiatheroma study.
All patients under 75 recovering from a stroke with evidence of carotid atheroma as the cause, or with a history of coronary
http://bmj.bmjjournals.com/cgi/content/full/320/7233/459   (1044 words)

  
 Complications of Diabetes - Understanding Atheroma
Plaques of atheroma lead to turbulent blood flow.
There is a lot that you can do to improve your ‘endothelial function’ and reduce risk of developing atheroma.
Think of this as a diffuse process affecting the entire circulation.
http://www.diabetesuffolk.com/Complications/Atheroma.asp   (611 words)

  
 AANOS, Fathie Shunt
In cases of internal carotid occlusion when there is no retrograde hemorrhage from behind the occlusion, there would be no need to apply the Fathie Shunt.
The surgical approach to the removal of the atheroma, called an endarterectomy, has not been consistently successful because long standing closure of the internal and common carotid artery presents a surgical hazard in resulting brain damage.
Application of conventional shunting has been basically ineffective for correct perfusion of the arteries and brain.
http://www.aanos.org/edctn_fathie_shunt.htm   (1556 words)

  
 Expression of the Elastolytic Cathepsins S and K in Human Atheroma and Regulation of their Production in Smooth Muscle ...
Previous reports of accumulation of the bone matrix
well with our findings that atheroma contain large clusters of
This study examined the expression of the potent elastases cathepsins
http://www.jci.org/cgi/content/full/102/3/576   (5545 words)

  
 Dorlands Medical Dictionary
(ath”ər-o´mə-təs) affected with or of the nature of atheroma.
athērē gruel] a combining form denoting fatty degeneration, or relationship to an atheroma.
(ath”ər-o-sklə-ro´sis) [athero- + sclerosis] a common form of arteriosclerosis with formation of deposits of yellowish plaques (atheromas) containing cholesterol, lipoid material, and lipophages in the intima and inner media of large and medium-sized arteries.
http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_a_70zPzhtm   (1469 words)

  
 ASSENT-3 Trial
had no change in atheroma burden, whereas patients treated with
Compared with baseline values, patients treated with atorvastatin
These differences may be related to the greater reduction in
http://www.courses.ahc.umn.edu/pharmacy/5822/REVERSAL.html   (326 words)

  
 Cholesterol - Patient UK
you already have angina, had a heart attack, had a stroke or TIA, have peripheral vascular disease, or have another atheroma related condition.
So, you may be advised to take cholesterol lowering treatment irrespective of your cholesterol level if you: have angina; have had a heart attack; have had a stroke or a TIA; have peripheral vascular disease; have another atheroma related condition.
This means if you have a father or brother who developed heart disease or a stroke before they were 55, or in a mother or sister before they were 65.
http://www.patient.co.uk/showdoc/23068704   (1402 words)

  
 Rapid Development of Vein Graft Atheroma in ApoE-Deficient Mice -- Dietrich et al. 157 (2): 659 -- American Journal of ...
of atheroma remain elusive and few effective techniques are
In the present study, we developed and characterized
One of the most important observations made in the current study
http://ajp.amjpathol.org/cgi/content/full/157/2/659   (4967 words)

  
 Use of Intraoperative Epiaortic Ultrasonography To Delineate Aortic Atheroma -- Bolotin et al. 127 (1): 60 -- Chest
patients’ surgical planning: 72% of atheromas led to changes
these five patients had an atheroma in the aorta, but were operated
Our findings of atheroma are reflected by the changes in the
http://www.chestjournal.org/cgi/content/full/127/1/60   (2303 words)

  
 [No title]
They, like Keeley and Higginson, said that it was high time more concern should be shown over the danger of thrombi and less concern about atheroma.
In 1968 Strong et al reported on a world-wide study showing that atheroma is as prevalent among women as it is among men, and further, that all populations of the world suffer from atheroma to about the same degree, even among populations such as the Bantus, who are known to suffer little from myocardial infarction.
Martin (1984) "The combined role of atheroma, cholesterol, platelets, the endothelium and fibrin in heart attacks and strokes" Med Hypoth 15, 305-22.
http://www.angelfire.com/pro/flavin/service28.html   (3842 words)

  
 Mild to Moderate Atheromatous Disease of the Thoracic Aorta and New Ischemic Brain Lesions After Conventional Coronary ...
mobile atheroma had good clinical outcomes and no neurological
The prevalence of these brain infarcts in patients with atheroma
the association between atheroma and MRI brain infarcts was
http://stroke.ahajournals.org/cgi/content/full/35/9/e356   (1406 words)

  
 Prostaglandin E2 Suppresses Chemokine Production in Human Macrophages through the EP4 Receptor -- Takayama et al. 277 ...
pathways in atheroma has received much less attention.
COX-2 can also exert an anti-inflammatory action in human atheroma
Atheroma, like other inflammatory lesions, display increased biosynthesis of eicosanoids such as prostacyclin (PGI
http://www.jbc.org/cgi/content/full/277/46/44147   (4212 words)

  
 Helicobacter pylori infection: a risk factor for ischaemic cerebrovascular disease and carotid atheroma -- Markus and ...
Patients were characterised into stroke subtypes based on pathogenic
Helicobacter pylori infection: a risk factor for ischaemic cerebrovascular disease and carotid atheroma
If further studies confirm that H pylori is a risk factor for cerebrovascular disease this has important clinical implications.
http://jnnp.bmjjournals.com/cgi/content/full/64/1/104   (3070 words)

  
 JAMA -- Abstract: Effect of Recombinant ApoA-I Milano on Coronary Atherosclerosis in Patients With Acute Coronary ...
Localization of Nitration and Chlorination Sites on Apolipoprotein A-I Catalyzed by Myeloperoxidase in Human Atheroma and Associated Oxidative Impairment in ABCA1-dependent Cholesterol Efflux from Macrophages
in atheroma volume in the combined treatment groups was -14.1
the change in percent atheroma volume (follow-up minus baseline)
http://jama.ama-assn.org/cgi/content/abstract/290/17/2292   (1587 words)

  
 Ultrasonic imaging of aortic atheroma -- DE BELDER 79 (2): 111 -- Heart
High risk for vascular events in patients with protruding aortic atheromas: a prospective study.
Protruding aortic atheromas predict stroke in elderly patients undergoing cardiopulmonary bypass: a review of our experience with intraoperative transesophageal echocardiography.
The study of embolism in the cerebral and peripheral circulation requires imaging methods that reveal pathology in some part
http://heart.bmjjournals.com/cgi/content/full/79/2/111   (1578 words)

  
 Vulnerable plaque - Wikipedia, the free encyclopedia
Repeated atheroma rupture and healing is one of the mechanisms, perhaps the dominant one, which creates artery stenosis.
Unfortunately, vulnerable plaques are not revealed by either cardiac stress testing or coronary angiography, the heart tests most commonly performed clinically with the goal of testing suspectibility to future heart attack.
A vulnerable plaque is an atheromatous plaque which is particularly prone to produce sudden major problems, such as a heart attack or stroke.
http://en.wikipedia.org/wiki/Vulnerable_plaque   (332 words)

  
 Peripheral Vascular Disease - Patient UK
However, if you have PVD it means that you are more likely to form atheroma in other arteries.
However, there are certain 'risk factors' which increase the chance of atheroma becoming worse and causing problems.
This helps to prevent a build-up of atheroma.
http://www.patient.co.uk/showdoc.asp?doc=23068800   (1776 words)

  
 Lipids Online Slides: plaque rupture, culprit lesion, fibrous cap, M-CSF
Increased expression of interstitial collagenase by smooth muscle cells and macrophages in human atheroma
Most coronary syndromes are caused by thrombosis of a disrupted atheroma, which can result from weakening of the fibrous cap and enhanced thrombogenicity of the lipid core.
In the coronary circulation, these manifestations include unstable angina and acute myocardial infarction; thrombotic complications of atheroma in the cerebrovascular or peripheral arteries include stroke and critical limb ischemia.
http://www.lipidsonline.org/slides/slide01.cfm?&tk=20&pg=3   (675 words)

  
 Risk Factors for Atheroma - WrongDiagnosis.com
About risk factors: Risk factors for Atheroma are factors that do not seem to be a direct cause of the disease, but seem to be associated in some way.
Having a risk factor for Atheroma makes the chances of getting a condition higher but does not always lead to Atheroma.
For general information and a list of risk factors, see the risk center.
http://www.wrongdiagnosis.com/a/atheroma/riskfactors.htm   (176 words)

  
 American College of Cardiology Clinical Expert Consensus Document on Standards for Acquisition, Measurement and ...
If EEM area increases during atheroma development, the process is termed “positive remodeling.” If the EEM decreases, the process is termed “negative” or “constrictive remodeling.” In positive remodeling, the EEM area increase may
Direct evidence of remodeling can be derived only from serial changes in the EEM CSA that have been determined by two or more measurements obtained at different times.
In practice, the inclusion of the media into the atheroma area does not constitute a major limitation of IVUS, because the media represents only a very small fraction of the atheroma CSA.
http://www.acc.org/clinical/consensus/standards/standard9.htm   (1979 words)

  
 Atheroma: links with antiphospholipid antibodies, Hughes syndrome and lupus -- Harats et al. 92 (1): 57 -- QJM
From the Institute of Lipid and Atherosclerosis Research,
(Hughes) syndrome, and has provided a new line of atheroma research.
Atheroma: links with antiphospholipid antibodies, Hughes syndrome and lupus -- Harats et al.
http://qjmed.oxfordjournals.org/cgi/content/full/92/1/57   (1398 words)

  
 BHF Heart Health - Heart Terms: Atheroma
When it affects the arteries to the brain, it may cause a stroke.
When atheroma affects the coronary arteries, it can cause angina, heart attack or sudden death.
Atheroma can build up silently for many years before it causes trouble.
http://www.bhf.org.uk/hearthealth/index.asp?secID=1&secondlevel=74&thirdlevel=255&artID=29   (89 words)

  
 Atheroma definition - Medical Dictionary definitions of popular medical terms
Atheroma definition - Medical Dictionary definitions of popular medical terms
Please consult your healthcare provider before beginning any course of supplementation or treatment.
MedicineNet Home > MedTerms medical dictionary A-Z List > Atheroma
http://www.medterms.com/script/main/art.asp?articlekey=25664   (149 words)

  
 Genes of Cholesterol Metabolism in Human Atheroma: Overexpression of Perilipin and Genes Promoting Cholesterol Storage ...
Methods and Results— We measured in human atheroma and
We measured in human atheroma and nearby tissue the expression
NCEH was clearly expressed in MIT and atheroma without difference
http://atvb.ahajournals.org/cgi/content/full/25/8/1711   (3956 words)

  
 atheroma - definition of atheroma in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and ...
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
atheroma - definition of atheroma in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
A deposit or degenerative accumulation of lipid-containing plaques on the innermost layer of the wall of an artery.
http://medical-dictionary.thefreedictionary.com/atheroma   (89 words)

  
 Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells -- Mach et ...
Analysis of 5–7 atheroma at each stage of lesion development from different donors showed similar results.
Analysis of 5–7 atheroma at each stage of lesion development from different donors, and normal tissue from 4 different donors showed similar results.
Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma.
http://www.jci.org/cgi/content/full/104/8/1041   (5410 words)

  
 Regression of a Donor Atheroma After Cardiac Transplantation: Serial Observations With Intravascular Ultrasound -- ...
in atheroma volume is accompanied by new calcification, a process
Regression of a Donor Atheroma After Cardiac Transplantation: Serial Observations With Intravascular Ultrasound -- Tsutsui et al.
Regression of a Donor Atheroma After Cardiac Transplantation
http://circ.ahajournals.org/cgi/content/full/104/23/2874   (393 words)

  
 Insulin resistance as a contributor to myocardial ischaemia independent of obstructive coronary atheroma: a role for ...
Keywords: endothelial dysfunction; insulin resistance; myocardial ischaemia; coronary atheroma
Insulin resistance as a contributor to myocardial ischaemia independent of obstructive coronary atheroma: a role for insulin sensitisation?
dyslipidaemia, as well as direct promotion of atheroma production.
http://heart.bmjjournals.com/cgi/content/full/90/12/1379   (2681 words)

  
 Vascular inflammation and activation: new targets for lipid lowering -- Aikawa and Libby 3 (2004): B3 -- European Heart ...
cap of rabbit atheroma expressed less MMP and tissue factor
features of atheroma related to their propensity to provoke
atheroma, dietary lipid lowering reduced accumulation of macrophages
http://eurheartjsupp.oxfordjournals.org/cgi/content/abstract/3/suppl_B/B3   (338 words)

  
 [No title]
The thickening in the center represents the atheroma.
The normal aorta is to each side; the smooth surface is the endothelium, the rougher surface, the adventitia.
The bulk of the atheroma is in the intima, but the atheroma extends into and thins the media.
http://www.uvm.edu/~jkessler/CV/CVSB/Slide253/253micro.htm   (183 words)

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