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| | Magic bullet - Wikipedia, the free encyclopedia |
 | | The term used by bacteriologist Paul Ehrlich to describe his sought-for goal: a specific cure for syphilis which would attack the syphilis spirochaete while having no effect whatsoever on human tissue. | | | He also applied the term to the drug he developed circa 1910, Salvarsan (arsphenamine). |
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http://www.wikipedia.org/wiki/Magic_bullet
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| | Arsphenamine - Wikipedia, the free encyclopedia |
| | Arsphenamine is a drug that was used to treat syphilis and trypanosomiasis. | | | After leaving Erlich's laboratory, Hata continued parallel investigation of the new medicine in Japan. | | | but in 2005, researchers determined Arsphenamine's structure to be a compound of a cyclic trimer and a pentamer[2]. |
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http://en.wikipedia.org/wiki/Arsphenamine
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| | Syphilis: Chapter X |
| | Instead of his last sentences being a defense of the use of arsenic, as he intends them to be, it is an indictment of the whole drug practice, not alone in "syphilis," but in all forms of disease. | | | This is the drug that is recommended through the whole of pregnancy, notwithstanding the fact that arsphenamine is especially harmful to infants. | | | The renal irritation resulting from combined arsphenamine and mercury is practically equivalent to that produced by the two drugs given separately," says the "Practical Medicine Series. |
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http://www.soilandhealth.org/02/0201hyglibcat/020134syphilis/020134syphilis-ch10.htm
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| | Encyclopedia: Arsenic |
| | Arsphenamine is a drug that was used to treat syphilis and trypanosomiasis. | | | The FDA in 2000 approved this compound for the treatment of patients with acute promyelocytic leukemia that is resistant to ATRA. | | | Arsenic trioxide has been used in a variety of ways over the past 200 years, but most commonly in the treatment of cancer. |
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http://www.nationmaster.com/encyclopedia/Arsenic
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| | Encyclopedia: Paul Ehrlich |
| | Arsphenamine is a drug that was used to treat syphilis and trypanosomiasis. | | | Depression-era U.S. poster advocating early syphilis treatment Syphilis (historically called lues) is a sexually transmitted disease (STD) that is caused by a spirochaete bacterium, Treponema pallidum. | | | His life is depicted in the movie The Magic Bullet, which focused on Salvarsan® (arsphenamine, "compound 606"), his cure for syphilis. |
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http://www.nationmaster.com/encyclopedia/Paul-Ehrlich
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| | Silver (CASRN 7440-22-4), IRIS, Environmental Protection Agency |
| | However, since body accumulates silver throughout life, it is theoretically possible for amounts less than this (for example, 4 g silver arsphenamine) to result in argyria. | | | Also, the critical study reports on only 1 individual who developed argyria following an i.v. | | | Another important factor predisposing to the development of argyria is the exposure of the skin to light. |
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http://www.epa.gov/iris/subst/0099.htm
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| | Julius Wagner-Jauregg - Nobel Lecture |
| | Yet it seems indeed, disregarding rare exceptions, that sooner or later a point is reached where arsphenamine treatment is unable to halt the fatal progression. | | | The results in respect of the readjustment of the cerebrospinal fluid, which in such cases with other methods of treatment is on the contrary frequently very refractory, were so gratifying that already a large number of syphilologists have become acquainted with these methods. | | | It was ascertained by means of a preliminary experiment of a large number of paralytics that those treated with tuberculin (with a maximum dose at that time of 0.1) showed more and longer-lasting remissions and a longer duration of life than an equal number of untreated paralytics. |
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http://nobelprize.org/medicine/laureates/1927/wagner-jauregg-lecture.html
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| | In Their Own Words |
| | He did 300 experiments–most of them failures–and then, of course, with the success of 606, he developed Salvarsan (arsphenamine) as a treatment. | | | The drug cured the experimental infection in the rabbit. | | | There was criticism, terrible criticism, that they were making too much money, that the drug cost too much, and that Ehrlich was profiting from it. |
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http://history.nih.gov/NIHInOwnWords/docs/krause1_05.html
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| | Systemic argyria associated with ingestion of colloidal silver |
| | After observing Dr. Halstead of Johns Hopkins University apply silver foil and gauze to wounds to prevent infection in 1897, Crede popularized the use of silver as an anti-infective measure [1]. | | | In a subset of twelve patients treated with 4-20 gm IV arsphenamine, argyria becomes clinically apparent after the patient has been exposed to a total IV arsphenamine dose of 8 gm. | | | However, this number does not take into account the silver exposure a patient may have had from other sources throughout life. |
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http://dermatology.cdlib.org/111/case_reports/argyria/wadhera.html
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| | Syphilis: Chapter XIII |
| | Today, the world over, syphilis is treated largely with arsphenamine and bismuth. | | | Accordingly, the results of malarial therapy, and the established incompetence of arsphenamine, its numerous modifications, and bismuth and mercury compounds created among syphilologists a receptive mood for a new method of treatment. | | | A sufficient time has not elapsed since the discovery of arsphenamine in 1909 to determine whether or not the patients really are cured." |
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http://www.soilandhealth.org/02/0201hyglibcat/020134syphilis/020134syphilis-ch13.htm
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| | SWGC Art Gallery - Digital Gallery |
| | The only limitations that I have placed on myself has been to keep the works concise and to the point, to develop my skill at manipulating narratives, and to improve my technical skill at rendering video for the Internet. | | | Digital art has become an integral faucet of that expression, therefore, I explore it as best I can. | | | A section of penname pov was an on-line component of between arsphenamine and artefact, the fourth-year students exhibition which was held at Sir Wilfred Grenfell College Art Gallery from April 28 to June 7, 2003. |
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http://www.swgc.mun.ca/artgallery/digital.html
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| | colloidal silver article by James South |
| | The total silver amounts used in this experiment would equate to a minimum of 2304 mg Silver to a maximum of 23.98 grams Silver for a 70kg human. | | | Thus the risk of developing argyria from occasional use of Silver to treat specific infectious conditions must be considered virtually non-existent. | | | Only 16 cases occurred from less than one year's chronic use of Silver ; about half occurred with 3 years or less of chronic Silver use; and about half of all cases involved chronic Silver use ranging from 3 to 25 years. |
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http://www.smart-drugs.com/_vti_bin/shtml.exe/JamesSouth-silver.htm/map
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| | Arsphenamine - encyclopedia article about Arsphenamine. |
| | Arsphenamine is a drug A drug is any substance that can be used to modify a chemical process or processes in the body, for example to treat an illness, relieve a symptom, enhance a performance or ability, or to alter states of mind. | | | , researchers determined Arsphenamine's structure to be a compound of a cyclic trimer and a pentamer[1]. | | | The word "drug" is etymologically derived from the Dutch/Low German word "droog", which means "dry", since in the past, most drugs were dried plant parts. |
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http://encyclopedia.thefreedictionary.com/Arsphenamine
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| | Arsphenamine - Encyclopedia.WorldSearch |
| | Arsphenamine, also known under its trade name Salvarsan, is a drug that was used to treat syphilis. | | | A consideration of arsphenamine and certain other organic arsenic compounds used in the treatment of syphilis, | | | Paul Ehrlich, in his search for a magic bullet that would attack a disease-causing agent, and leave human tissue untouched, found this drug (the 606th he tested) in 1909. |
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http://encyclopedia.worldsearch.com/arsphenamine.htm
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| | BioMedicine - antibioticevolution |
| | Although arsphenamine was used to treat many syphilitic patients, it was extremely toxic and some patients died from it. | | | At the time syphilis was a fatal and incurable sexually transmitted infection, just as AIDS is today, and so the discovery of an effective treatment had a huge impact on the medical community | | | In total, Elrich tested 606 arsenic compounds, and in 1909, compound number 606, arsphenamine (later called salvarsen) was shown to destroy the syphilis-causing pathogen Treponema pallidum, and was successfully used to treat cases of syphilis |
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http://www.bioteach.ubc.ca/Biomedicine/antibioticsagain
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| | Untitled Document |
| | a virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, or analogous product, or arsphenamine or derivative of arsphenamine (or any other trivalent organic arsenic compound), applicable to the prevention, treatment, or cure of a disease or condition of human beings. |
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http://www.saetool.com/biologic.htm
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| | Arsphenamine jaundice and the recognition of instrument-borne virus infection. |
| | Soon after its introduction in 1910, intravenous arsphenamine treatment for syphilis was found to be complicated by jaundice. | | | The state of the art may have changed since the publication date. | | | The infection most often transmitted was probably hepatitis B virus (HBV), but the high mortality in a few of the outbreaks of arsphenamine jaundice suggests that variants of HBV, or other hepatitis viruses, were sometimes involved. |
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http://www.aegis.com/aidsline/1995/aug/M9580494.html
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| | Caf Chemotherapy |
| | The first modern chemotheraputic agent was Paul Ehrlich 's arsphenamine, an arsenic compounddiscovered in 1909 and used to treat syphilis. | | | Chemotherapy (pronounced keem-o-therapy) is the use of certain drugs totreat disease, as distinct from other forms of treatment, such as surgery.Chemotherapy dates at least as far back as the use, by the Indians of Peru, of cinchona bark in the treatment of fevers, such as malaria. |
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http://www.swingdancemusic.com/send/46036-caf%20chemotherapy.html
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| | ARSPHENAMINE ::catalogue:: |
| | Words similar to arsphenamine -Angarsk arrears arse arsenate arsenic arsenical arsenide arsenious arsenite arsenopyrite arsis arson arsonist arsonous arsphenamine Barsac Barstow bearskin Boarsh bugbears |
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http://www.mainseek.com/arsphenamine.html
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| | HENDECASYLLABLE ::catalogue:: |
| | Words similar to hendecasyllable -Aachen abhenry acetaminophen acetophenetidin achene akhenaten aminophenol antisthenes apprehensible apprehensibly archenemy archenteron Arrhenius arsphenamine asantehene asthenia asthenic asthenosphere athenaeum atheneum |
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http://www.mainseek.com/hendecasyllable.html
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| | Merck Vet. Edition - Organic Arsenicals |
| | Aromatic organic arsenicals include trivalent phenylorganicals such as thiacetarsamide and arsphenamine for the treatment of adult heartworms in dogs and pentavalent compounds such as phenylarsonic acids and their salts. | | | Thiacetarsamide and arsphenamine are no longer used commonly. | | | Phenylarsonic compounds are used as feed additives to improve production in swine and poultry rations and also to treat dysentery in pigs. |
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http://www.merckvetmanual.com/mvm/htm/bc/210303.htm
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| | Syphilis, neurosyphilis, penicillin, and AIDS. |
| | Early neurosyphilis, characterized by meningitis, cranial nerve abnormalities, and cerebrospinal accidents, was first described in patients with syphilis who received inadequate courses of arsphenamine. | | | Although more effective, penicillin at conventional doses does not yield treponemacidal levels in the central nervous system and probably does not eradicate the infecting organisms, suggesting that it works synergistically with the host's immune response in preventing neurosyphilis. | | | Musher DM; Infectious Diseases Section, Veterans Affairs Medical Center,; Houston, TX 77030. |
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http://www.aegis.com/aidsline/1991/sep/M9190577.html
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| | Definitions - Academic Health Center, University of Minnesota |
| | Botanical drug are products intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in humans. | | | Biological product means a virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, or analogous product, or arsphenamine or derivative of arsphenamine (or any other trivalent organic arsenic compound), applicable to the prevention, treatment, or cure of a disease or condition of human beings. | | | The IND/IDE Assistance Program has templates (annual report template) available to assist in the compliance of submitting the annual report in a timely manner. |
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http://www.ahc.umn.edu/research/indide/generalinfo/definitions/home.html
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| | BIOL 211: MICROBIOLOGY |
| | Chemotherapeutics involves the treatment of disease through the use of drugs (chemicals), most of which have been synthesized or modified in the laboratory; many treat the signs and symptoms of disease, not the causative agent | | | Antibiotics are naturally occurring products of microbial metabolism, some of which have been synthesized or altered in the laboratory; all have antimicrobial action; used by microbes as a way of reducing competition for nutrients | | | The first chemotherapeutic agent recognized was an arsenical compound called Salversan (arsphenamine #606), isolated by Paul Ehrlich and Sahachiro Hata, for the treatment of syphilis - 1910 |
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http://www.centralia.ctc.edu/Depts/Science/Biol211/antibiotics.html
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| | Nat' Academies Press, Biographical Memoirs V.66 (1995) |
| | As with chloroform liver injury, arsphenamine liver injury was not prevented by nonsulfur-containing amino acids. | | | ity to arsphenamine liver injury in protein-depleted dogs that could be prevented by prior feeding of protein or the sulfur-containing amino acids. | | | This led Whipple to emphasize the importance of body protein stores and their content of S-containing amino acids in protecting the liver against toxic agents, but the exact mechanism of the protective action was not established. |
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http://www.nap.edu/openbook/0309052378/html/388.html
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| | Total Arsenic |
| | However, the advent of penicillin and other drugs nearly eliminated the use of organic arsenicals as human therapeutic agents (EPA, 1980). | | | The introduction of arsphenamine, an organoarsenical, to control venereal disease earlier this century gave rise to intensive research by organic chemists, which resulted in the synthesis of at least 32,000 arsenic compounds. | | | In 1938, it was established that arsenic can counteract selenium toxicity (NRCC, 1978). |
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http://sposerver.nos.noaa.gov/projects/gomexico/as.html
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| | Jay Frank Schamberg (www.whonamedit.com) |
| | During World War I, when the supply of arsphenamine was cut off from Germany, with Raiziss and Kolmer, he was able to synthesize and supply this medication — the first Salvarsan in the United States — for thousands of patients suffering from syphilis. | | | When that affiliated with the University of Pennsylvania, he was appointed vice-dean and professor at the graduate school of that university until his death. |
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http://www.whonamedit.com/doctor.cfm/1876.html
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| | Silver Bullet in Medicine - Health and Medical Information produced by doctors - MedicineNet.com |
| | Ehrlich's best known magic bullet was arsphenamine (Salvarsan, or compound 606), the first effective treatment for syphilis. | | | At a meeting in 1910, Ehrlich and his colleagues announced the remarkable effects of their treatment of syphilis with this magic bullet. | | | He then reused the concept of a magic bullet to apply to a chemical that binds to and specifically kills microbes or tumor cells. |
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http://www.medicinenet.com/script/main/art.asp?articlekey=31953
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| | US CODE: Title 42,262. Regulation of biological products |
| | In this section, the term “biological product” means a virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, or analogous product, or arsphenamine or derivative of arsphenamine (or any other trivalent organic arsenic compound), applicable to the prevention, treatment, or cure of a disease or condition of human beings. | | | Application of Federal Food, Drug, and Cosmetic Act |
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http://www4.law.cornell.edu/uscode/42/262.html
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| | arsphenamine - OneLook Dictionary Search |
| | arsphenamine : The On-line Medical Dictionary [home, info] | | | arsphenamine : Dorland's Illustrated Medical Dictionary [home, info] | | | arsphenamine : Stedman's Online Medical Dictionary, 27th Edition [home, info] |
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http://www.onelook.com/?w=arsphenamine
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| | Re: Why is Thimerosal a necessary component of vaccines? |
| | Remember, in the 1930s syphilis was treated by giving patients an arsenic containing compound (arsphenamine), and skin infections were treated with mercurichrome and gentian violet (a violet colored dye that bound to bacteria and either killed them or prevented growth). | | | The problem with adding antibiotics to vaccines is that the antibiotics can degrade and/or the antibiotics could potentially contribute to developing drug resistant bacteria. | | | It was added to keep bacterial growth down and it works. |
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http://www.madsci.org/posts/archives/2005-07/1121272471.Me.r.html
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| | What Happened to Carl Fedayeeno ? |
| | arsphenamine wrote: = = Les Cargill wrote: = = Ham Taylor wrote: = = = He'll spend the rest of his life out in San Berdino. |
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http://www.thehobbyarchive.com/new-311427-30.html
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| | Dorlands Medical Dictionary |
| | It is carcinogenic and also causes hemolysis, jaundice, gastroenteritis, and nephritis. | | | , which acts in combination like the ammonium ion, NH arsphenamine |
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http://www.merckmedicus.com/pp/us/hcp/thcp_dorlands_content.jsp?pg=/ppdocs/us/common/dorlands/dorland/dmd-a-058.htm
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| | Merriam-Webster Online |
| | For More Information on "arsphenamine" go to Britannica.com | | | Get the Top 10 Search Results for "arsphenamine" |
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http://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=arsphenamines
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| | NEOARSPHENAMINE definition |
| | Sodium arsphenamine methylenesulfoxylate;formerly used as an antisyphilitic agent. |
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http://www.books.md/N/dic/neoarsphenamine.php
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| | art from On-line Medical Dictionary |
| | Published at the Centre for Cancer Education, University of Newcastle upon Tyne | | | Previous: arsenoxides, arsine, arsonic acid, arsonium, arsphenamine, arsthinol |
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http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=art&action=Search+OMD
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| | search result |
| | A very good ex-library copy with the usual markings. | | | Contains chapters on Hoffmann and LSD; Sertüner and morphine; Beaumont and hydrochloric acid; Abel and epinephrine, Withering and digitalis; Banting, Best and insulin; Ehrlich and Arsphenamine; etc. 15 ounces = 435 grams. |
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http://www.ilabdatabase.com/member/search.php3?membernr=1572&ordernr=GACH075848
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| | JEM -- Table of Contents (33 [5]) |
| | To see one abstract at a time, click its [Abstract] link. | | | SUPERINFECTION IN EXPERIMENTAL SYPHILIS FOLLOWING THE ADMINISTRATION OF SUBCURATIVE DOSES OF ARSPHENAMINE OR NEOARSPHENAMINE |
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http://www.jem.org/content/vol33/issue5/index.shtml
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