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| | Apoptosis - Wikipedia, the free encyclopedia |
 | | It must be advised, however, that the apoptotic pathways that have been summarily described are subject to regulatory mechanisms, and that there is not a one-to-one relationship between the reception of TNF or FasL and the complete execution of an apoptotic pathway. | | | Beyond the physiological importance, understanding these patterns will be relevant to maintaining the vitality of cells used for cell therapy. | | | Wang and his team identified and reconstituted the mitochondrial pathway to apoptosis (see Biochemical execution, above). |
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http://en.wikipedia.org/wiki/Apoptosis
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| | Cell Suicide in Health and Disease |
| | Researchers are exploring genetic therapies for overcoming resistance to apoptosis. | | | For example, they indeed found signs that apoptosis is ongoing and that its failure can contribute to cancer. | | | Internal organelles retain their structure, but the nucleus, which is altered little during necrosis, invariably changes dramatically during apoptosis. |
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http://www.critpath.org/aric/library/art006.htm
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| | Cell Biology - Apoptosis |
| | Apoptosis can be triggered in a cell through either the extrinsic pathway or the intrinsic pathway. | | | The intrinsic and extrinsic pathways leading to apoptosis. | | | Cancer may arise from the dysfunction in the apoptotic pathway. |
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http://www.bioteach.ubc.ca/CellBiology/Apoptosis
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| | Apoptosis in cancer -- Lowe and Lin 21 (3): 485 -- Carcinogenesis |
| | of apoptosis, and its contribution to cancer and cancer therapy. | | | Oncogenes such as E1A and c-myc induce apoptosis through p53-dependent and independent pathways, and both pathways may facilitate cytochrome c release from mitochondria. | | | Yoshida,H., Kong,Y.Y., Yoshida,R., Elia,A.J., Hakem,A., Hakem,R., Penninger,J.M. and Mak,T.W. (1998) Apaf1 is required for mitochondrial pathways of apoptosis and brain development. |
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http://carcin.oxfordjournals.org/cgi/content/full/21/3/485
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| | Apoptosis |
| | Apoptosis is involved in a wide range of physiological and pathological processes. | | | Research is already underway to harness apoptosis as a therapeutic tool in modern medicine. | | | In the last decade there has been an explosion of interest with apoptosis becoming one of the most widely used words in medicine and biology today, with ever increasing levels of funding being made available for research into the subject. |
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http://www.portfolio.mvm.ed.ac.uk/studentwebs/session2/group28/apoptosis.html
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| | C26 |
| | Could the authors please clear this point up for the readers, and if a biphasic response is present show error bars to support this statement or make a statemnt about the error present in their system. | | | I believe the authors mean biphasic in the kinetic sense, but they may be reffering to biphaisc in the mechanistic sense. | | | Second, the authors state that there is a biphasic response demonstrated in figures 2 and 3, but I do not see two peaks or anything that resembles another peak. |
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http://www.netsci-journal.com/97v3/discussion/0000003c.htm
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| | Search results : apoptosis : Nature |
| | SUMMARY: The onset of resistance to drug-induced apoptosis of tumour cells is a major problem in cancer therapy. | | | Especially the pathways of IR-induced apoptosis are not well understood so far. | | | As a consequence, the onset of resistance to apoptosis can result either in a metastatic... |
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http://search.nature.com/search?sp_q=apoptosis&sp_a=sp1001702d&sp_sfv1_field=subjectujournal&sp_t=results&sp_x_1=ujournal&sp_p_1=phrase&sp_s=pubdate_des
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| | Apoptosis in Lung Fibrosis and Repair -- Uhal 122 (6 Supplement): 293 -- Chest |
| | Bardales, RH, Xie, SS, Schaefer, RF, et al Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury. | | | For this reason, the manipulation of apoptosis could be | | | Apoptosis in Lung Fibrosis and Repair -- Uhal 122 (6 Supplement): 293 -- Chest |
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http://www.chestjournal.org/cgi/content/full/122/6_suppl/293S
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| | Apoptosis in Development |
| | Those that fail to reach the genital ridges are eliminated, presumably because they are deprived of the signal (Steel factor) that is required for their survival in the genital ridges (De Felici and Pesce, 1994). | | | elegans and their characterization have led to considerable understanding of the molecular events of apoptosis and to the identification of mammalian homologues of the apoptotic effectors. | | | As soon as the lamins are removed by caspases, the nucleus undergoes the characteristic morphological changes that are associated with apoptosis (described above). |
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http://www.ucalgary.ca/UofC/eduweb/virtualembryo/death.html
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| | Apoptosis -- Miller and Marx 281 (5381): 1301 -- Science |
| | Because of the importance of apoptosis and the recent explosive progress toward dissecting its molecular basis, we have asked some of the leaders in the field to describe the insights gained from these advances, point out the questions that remain unanswered, and discuss the directions that new research should take. | | | If so, it might be possible to develop new therapies for the conditions that work by inhibiting apoptosis. | | | As noted in the Editorial on page 1283, apoptosis is critical to the health of many organisms, needed to sculpt the nervous system during development and to maintain the normal functioning of the immune system. |
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http://www.sciencemag.org/cgi/content/summary/281/5381/1301
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| | Apoptosis |
| | Therefore, it is thought that understanding how the cell death program is initiated by these drugs or any other kind of insults, and hence why it fails to work for certain drugs, offers a novel approach to overcoming the clinical problem of drug resistance (Makin and Hickman, 2000). | | | It is thought that understanding how the cell death program is initiated by following these drugs or any other kind of insults, and hence why it fails to work for certain drugs, offers a novel approach to overcoming the clinical problem of drug resistance (Makin and Hickman, 2000). | | | Apoptosis is different to necrosis in some ways. |
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http://www20.uludag.edu.tr/~eulukaya/apopANDcancer.html
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| | A Brief Introduction to Apoptosis |
| | Recently, considerable research has focused on identifying the molecular sensors or triggers of apoptosis. | | | elegans, while ectopic/over expression of ice causes apoptosis in rat fibroblasts (Yuan et al. | | | This information may lead to therapeutic agents that can modulate this process in the treatment of degenerative diseases such as neurodegenerative disorders or proliferative diseases such as cancer. |
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http://www.ucalgary.ca/~browder/apo_intro.html
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| | Apoptosis - BioChemWeb.org |
| | Apoptosis - Overview of the process with a particular emphasis on the role of nitric oxide. | | | Kimball's Biology Pages: Apoptosis - Basic information on apoptosis ("death by suicide" as opposed to "death by injury" or necrosis). | | | Cancer Research UK FACS Laboratory: Apoptosis - Methods for detection of apoptosis using flow cytometry. |
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http://www.biochemweb.org/apoptosis.shtml
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| | Apoptosis |
| | Apoptosis triggered by internal signals: the intrinsic or mitochondrial pathway | | | Radiation and chemicals used in cancer therapy induce apoptosis in some types of cancer cells. | | | Apoptosis triggered by external signals: the extrinsic or death receptor pathway |
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http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/Apoptosis.html
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| | [6G] Apoptosis |
| | The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis - Circulation Research, 2004. | | | Inhibitor of Apoptosis Proteins: Translating Basic Knowledge into Clinical Practice - Cancer Research, 2004. | | | Apoptosis is an important process during normal development. |
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http://www.web-books.com/MoBio/Free/Ch6G.htm
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| | Dr Karl - Apoptosis Part 3 |
| | Apoptosis is also responsible for other unique structures, such as the natural curvatures of the spine. | | | This apoptosis has turned out to be a very basic phenomenon. | | | As a human heart gradually develops, it grows as a solid blob of cells. |
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http://www.abc.net.au/science/k2/moments/gmis9850.htm
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| | National Cancer Institute : Plans & Priorities for Cancer Research |
| | NCI and Genta are cosponsoring clinical trials in lung cancer and leukemia patients to determine whether pretreatment with this drug followed by state-of-the-art chemotherapies improves treatment outcome. | | | Velcade may prove to be a versatile cancer treatment because it appears to be equally effective against cancers that do or do not overexpress the bcl-2 gene and seems to overcome a tumors ability to develop chemoresistance. | | | Scientists now are working to develop a complete picture of how bcl-2 acts so that they can improve the suicide-provoking effects of cancer treatments as well as thwart a cancer cell's ability to evade these drugs. |
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http://plan2004.cancer.gov/discovery/apoptosis.htm
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| | Apoptosis |
| | The conclusions are that it is generally difficult to establish a functionally specific TUNEL technique for skin sections and that the choice of a kit is absolutely crucial for obtaining reliable results. | | | Further, it is necessary to combine the TUNEL technique with the investigation of other apoptotic markers. | | | In some diseases, such as spinal muscle atrophy, there are mutations in some inhibitors of apoptosis such as neuronal apoptosis inhibitory protein (NAIP) which suppresses TNF-induced cell death, promoting survival. |
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http://www.thedoctorsdoctor.com/labtests/apoptosis.htm
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| | Gruppo di Cooperazione in Immunologia |
| | Detection of apoptosis in situ with immunocytochemistry and TUNEL Daniela Barbieri and Enzo Ottaviani | | | Fluorescence microscopy analysis of nuclear alterations during apoptosis Ildo Nicoletti and Roberta Mannucci | | | Morphological aspects of apoptosis Walter Malorni, Stefano Fais and Carla Fiorentini |
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http://www.cyto.purdue.edu/flowcyt/research/cytotech/apopto/data
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| | APOPTOSIS |
| | Among the predisposing factors are light skin tone and red or blonde hair, excessive sun exposure, xeroderma pigmentosum, dysplastic nevus syndrome, and a family history or previous personal history of melanoma. | | | Hahne et al, report in the Nov 22, 96 issue of Science that melanoma cells express FasL on their surfaces both in vivo and in vitro. | | | Therefore, it was hypothesized that the tumor cells may escape from the attack by the effector cells of the immune system within the tumor microenvironment by virtue of expression of FasL |
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http://www.bioscience.org/news/scientis/melanoma.htm
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| | ADB welcome |
| | Includes a pathway diagram and links to many other sites. | | | Apoptosis site with an Apoptopedia containing over entries related to the field |
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http://www.apoptosis-db.org/welcome.html
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| | Apoptosis |
| | Post-Doc position available in our group - please click here for more details | | | Apoptosis, or programmed cell death, is a normal component of the development and health of multicellular organisms. | | | Apoptosis, by contrast, is a process in which cells play an active role in their own death (which is why apoptosis is often referred to as cell suicide). |
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http://www.sgul.ac.uk/depts/immunology/~dash/apoptosis
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| | Apoptosis and Cell Death |
| | Regulation of Trophoblast Apoptosis, With Particular Emphasis on the Role of Nitric oxide (NO). | | | Pediatric Flow Cytometric Enumeration of Apoptosis Cells Using the Tunel Assay | | | NIH Special Interests Groups - Apoptosis Interest Group |
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http://www.ihcworld.com/apoptosis.htm
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| | Apoptosis |
| | Apoptotic cells are detected in the brain of ischemia or Alzheimer patients, suggesting that apoptosis is at least in part responsible for the disease manifestification of these patients. | | | It is hoped that elucidation of the molecular mechanism of apoptosis leads to development of an efficient cancer therapy. | | | Cellular and Molecular Regulation: Apoptosis is mediated by a family of proteases called caspases that are activated by processing from its inactive precursor (zymogen). |
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http://claim.springer.de/EncRef/CancerResearch/samples/0003.htm
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| | AIG - About apoptosis |
| | Apoptosis was distinguished from necrosis, which was associated with acute injury to cells. | | | most terms used in biomedical science, the term apoptosis is not simple to define, and this has led to some confusion and controversy. | | | Cancer 26:239) in 1972 as a means of distinguishing a morphologically distinctive form of cell death which was associated with normal physiology. |
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http://www.nih.gov/sigs/aig/Aboutapo.html
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| | Apoptosis |
| | Apoptosis consists of a cascade of events leading to the ordered dismantling of critical cell survival components and pathways. | | | This can prevent undesirable effects to the organism such as inflammation. | | | In addition to providing an overview of apoptosis, this site provides links to a variety of resources to aid investigators that are interested in measuring apoptosis in their own model systems. |
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http://www.apoptosisworld.com
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| | BioCarta - Charting Pathways of Life |
| | Activation of the Jun N-Terminal kinase, a regulator of apoptosis, may be one of the mechanisms. | | | The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. | | | Induction of apoptosis through DR3 and DR4/5 Death Receptors |
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http://www.biocarta.com/genes/catApoptosis.asp
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| | APOPTOSIS |
| | This insight would be useful for devising strategies in the treatment of cancer and inflammatory responses that involve TNF-alpha. | | | Apoptosis is a selective process for deletion of cells in various biological systems. | | | and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kB. |
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http://www.bioscience.org/news/scientis/apoptos.htm
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| | Apoptosis definition - Medical Dictionary definitions of popular medical terms |
| | Strictly speaking, the term apoptosis refers only to the structural changes cells go through, and programmed cell death refers to the complete underlying process, but the terms are often used interchangeably. | | | Apoptosis definition - Medical Dictionary definitions of popular medical terms | | | Apoptosis plays a crucial role in developing and maintaining health by eliminating old cells, unnecessary cells, and unhealthy cells. |
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http://www.medterms.com/script/main/art.asp?articlekey=11287
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| | Apoptosis |
| | DeadEnd™ Colorimetric Apoptosis Detection System for the Analysis of Retinal | | | DeadEnd™ Colorimetric Apoptosis Detection System: Applications in Pathology | | | Homogeneous Caspase-3/7 Assay: A Rapid, Sensitive and Flexible |
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http://www.promega.com/techserv/apps/apoptosis
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| | Turns of Phrase: Apoptosis |
| | An understanding of the mechanisms by which cells are instructed to remain alive or die has profound implications for finding cures for cancerous conditions and auto-immune diseases. | | | Recently researchers have found the genes which cause cell death in some simple organisms and New Scientist has reported on research which shows how the drug cisplatin cures testicular cancer by blocking repair mechanisms that prevent apoptosis. |
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http://www.worldwidewords.org/turnsofphrase/tp-apo1.htm
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| | Apoptosis |
| | Lockshin, R. & Zakeri, Z. Programmed cell death and apoptosis: origins of the theory. | | | Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. | | | p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. |
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http://www.nature.com/celldivision/library/apoptosis.html
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| | Promega - Apoptosis |
| | A fast, sensitive and flexible apoptosis detection system. | | | The most up-to-date Promega Protocols & Applications Guide is now available! | | | Monitor toxic effects of compounds at high throughput capacities, or one sample at a time, in as little as 15 minutes to 1 hour. |
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http://www.promega.com/applications/apoptosis
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| | Apoptosis |
| | Enlarged and malformed cerebrum: Caused by reduced apoptosis during brain development | | | Lymphadenopathy, splenomegaly and defective CD95-induced apoptosis of peripheral blood lymphocytes | | | Caspase types: Based on sequence of activation in apoptosis |
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http://www.neuro.wustl.edu/neuromuscular/mother/apoptosis.htm
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| | Apoptosis: How Cells Commit Suicide |
| | Apoptotic cells break into smaller pieces called apoptotic bodies that other body cells recognize and eat. | | | For the current science on this subject, two good sources are John W. Kimball's Apoptosis Page and the APOPTOSIS/PROGRAMMED CELL DEATH HOME PAGE. | | | A version of this video may be purchased and downloaded for classroom use. |
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http://www.cellsalive.com/apop.htm
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| | Apoptosis - Biocompare Buyer's Guide |
| | H2A.X Phosphorylation Assay Kit (Flow Cytometry) by Upstate | | | Apoptosis Detection Products Ensure Cells Are Caught — Dead Or Alive | | | What To Look For In An Apoptosis Detection Kit |
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http://www.biocompare.com/jump/164/Apoptosis.html
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| | MBL International Corporation |
| | Click here to view supplemental data and a short video of nuclear import and export of a CoralHue Dronpa-ERK1 fusion protein in COS7 cells stimulated with EGF. | | | Make any on-line purchase and receive a free Apoptosis poster with your order. | | | Also, on-line orders receive an additional 10% discount! |
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http://www.mblintl.com/mbli/index.asp
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