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| | Fool.com: Antisense Making Sense? [Commentary] February 17, 2004 |
 | | There is promise in the antisense horizon, with the FDA agreeing to review a new drug application for what is potentially the first antisense-based therapy approved for cancer. | | | Correction: Macugen was erroneously referred to as an "antisense therapy" in the first version of this article. | | | The best hope for antisense therapies lie in second- and third-generation drug candidates. |
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http://fool.com/news/commentary/2004/commentary040217dn.htm?logvisit=y&...
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| | Hospital Practice: Antisense Therapy |
| | First, the antisense therapy must evade breakdown, notably by nucleases, which cleave unprotected nucleic acids into their nucleotide building blocks (also called bases). | | | For researchers working on antisense therapy, chronic myelogenous leukemia (CML) has been a paradigm for such efforts, and perhaps, too, a lightning rod. | | | This is the idea underlying current hopes that short spans of "antisense" will be genetic therapy for various diseases. |
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http://www.hosppract.com/genetics/9909mmc.htm
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| | Isis Pharmaceuticals Antisense Technology |
| | The consistency of the behavior of antisense drugs allows Isis scientists to apply what they learn from the testing of one drug to future drugs, thus reducing the potential for failure in the early stages of development and creating significant competitive advantage for the platform. | | | Antisense drug discovery is more rational than any other type of drug discovery because: | | | Isis scientists have performed hundreds of experiments to determine how and where antisense drugs distribute throughout the body. |
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http://www.isispharm.com/antisense_tech.html
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| | Molecular Biology - Antisense RNA |
| | Antisense RNA is also being investigated for use in cancer therapy. | | | Antisense oligodeoxynucleotides (ODNs) are also being studied for human therapy. | | | Injecting aRNA that is complementary to the proto-oncogene BCL-2 may be useful for treating some B-cell lymphomas and leukemias. |
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http://www.bioteach.ubc.ca/MolecularBiology/AntisenseRNA
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| | Antisense therapy - Encyclopedia.WorldSearch |
| | Combo Tx may help fight metastatic melanoma: add antisense therapy.(Dermatologic Therapy) : An article from: Skin & Allergy News | | | Antisense-From Technology to Therapy: Lab Manual and Textbook | | | Antisense therapy is a theoretical form of treatment for genetic disorders. |
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http://encyclopedia.worldsearch.com/antisense_therapy.htm
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| | B-170 Antisense Products: Technologies, Markets |
| | The use of antisense compounds as therapeutics is beginning to gain momentum. | | | Vitravene gave creditability to all antisense therapeutics and launched them into the competitive world of therapeutics development. | | | This is about 3.1% of the combined total market for all applications of antisense therapeutics. |
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http://www.bccresearch.com/biotech/B170.html
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| | Antisense RNA |
| | Antisense RNA that is complementary to the proto-oncogene BCL-2 is being examined as a possible therapy for certain B-cell lymphomas and leukemias. | | | Surprisingly, preparations of sense RNA often turn out to be as effective an inhibitor as antisense RNA. | | | But getting the antisense RNA into the correct cells is a difficult problem. |
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http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/AntisenseRNA.html
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| | Antisense Treatment Promising For Deadly Brain Tumors |
| | If the trial for this therapy eventually re-opens, the researchers may continue the IGF-1R antisense strategy as a treatment after traditional therapies fail. | | | Researchers at Jefferson Medical College have used DNA therapy known as antisense to treat patients with usually fatal brain tumors. | | | Antisense therapy is designed to target and to turn off the mutated genes that cause cancer. |
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http://www.sciencedaily.com/releases/2001/04/010417074841.htm
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| | What is antisense |
| | This is an undesired result that must be carefully monitored during antisense experiments. | | | The antisense polygalacturonase cDNA sequence is cut with restriction enzymes and fused in the inverted orientation to a plasmid (i.e. | | | This means the cell has readily large supply of antisense mRNA present. |
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http://dragon.zoo.utoronto.ca/~jlm-gmf/T0501D/methods.html
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| | Market Research Reports: Antisense |
| | REASONS FOR THE STUDY The use of antisense compounds as therapeutics has become increasing popular in the past few years. | | | Antisense therapeutics are the buzz of the biotech sector, promising to effectively treat many intractable diseases, including cancer, viral infections, and autoimmune diseases. | | | This report from BCC focuses on three of the emerging "stars" of biotechnology: genomics (including proteomics, pharmacogenomics and bioinformatics), gene therapy, antisense drugs and antibodies. |
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http://www.mindbranch.com/catalog/find.jsp?cat=bt-ants
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| | ANTISENSE :: Bio Help Network News Events Videos Search |
| | The first new drug in 20 years for advanced melanoma could make its way into doctors' hands this summer. | | | Combined with chemotherapy, Genta's antisense drug Genasense (G3139) appreciably extends lives in patients with this almost untreatable cancer, and shows promise against other tumors... | | | A feedback forms will be provided and we'd like to hear your comments. |
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http://antisense.biohelp.com
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| | antisense on Encyclopedia.com |
| | Multiple Second-Generation Antisense Drugs Show Potential as New Treatments for Asthma. | | | Antisense has applications in agricultural biotechnology, where it has been used to deactivate the gene that causes softening in tomatoes, and in medicine, especially in cancer and antiviral therapy. |
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http://www.encyclopedia.com/html/a1/antisense.asp
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| | Antisense Genes |
| | The antisense molecule may have other unexpected effects on the organism. | | | The antisense strategy is an alternative to the knock-out strategy, particularly in organisms in which homologous recombination is difficult to achieve. | | | Antisense transgenes are usually dominant in their effects. |
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http://opbs.okstate.edu/~melcher/MG/MGW1/MG1234.html
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| | AVI BioPharma - NeuGene Antisense |
| | This is referred to as the antisense backbone. | | | In treating more than 200 patients, no drug-related adverse event has been observed. | | | This is called antisense technology because the strands of genetic material that get translated into a protein are called "sense" strands, and so "antisense" drugs are meant to stop that translation process. |
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http://www.avibio.com/neugene.html
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| | Antisense - An in Depth Exploration |
| | Many traditional drugs dealt with diseases by focusing on the faulty proteins themselves. | | | Antisense technology focuses on defeating diseases before the proteins which cause them can even be formed. | | | Many researchers do not consider this a true antisense compound. |
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http://www.cem.msu.edu/~cem181h/projects/97/antisense/anti.htm
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| | Antisense Therapeutics Limited |
| | Antisense Therapeutics Limited (ASX code: ANP) is an Australian publicly traded pharmaceutical drug discovery and development company whose mission is to create, develop and commercialise novel antisense therapeutics. | | | Animal Data Supports Therapeutic Potential of ATL1103 in eye diseases |
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http://www.antisense.com.au
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| | genome.gov Talking Glossary: "antisense" |
| | Dr. Richard Morgan, of the National Human Genome Research Institute's Clinical Gene Therapy Branch, defines antisense. | | | The antisense strand serves as the template for mRNA synthesis. |
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http://www.genome.gov/glossary.cfm?key=antisense
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| | Affymetrix - E. coli Antisense Genome Array |
| | In addition, over 1,350 intergenic sequences can be interrogated in both directions permitting functional characterization of potentially important shorter expressed sequences. | | | coli Antisense Genome Array can be used for examining expression of all known E. | | | Find individual probe sets on all GeneChip® expression arrays with Array Finder. |
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http://www.affymetrix.com/products/arrays/specific/ecoli_antisense.affx
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| | siRNA, antisense, RNAi, siRNA custom, siRNA design, antisense design, synthesis, transfection, IPTG, target, protein ... |
| | siRNA, antisense, RNAi, siRNA custom, siRNA design, antisense design, synthesis, transfection, IPTG, target, protein expression by Molecula |
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http://www.molecula.com
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