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| | Antiretroviral drug - Wikipedia, the free encyclopedia |
 | | Intermittent therapy is an experimental approach designed to reduce exposure to antiretroviral drugs in an effort to mitigate side-effects. | | | Adverse effects of antiretroviral drugs vary by drug, by ethnicity, and by individual, and by interaction with other drugs, including alcohol. | | | Studies of such interruptions attempt to increase the sensitivity of HIV to antiretroviral drugs. |
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http://en.wikipedia.org/wiki/Antiretroviral_drug
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| | The prevalence of antiretroviral drug resistance in the United States |
| | By diminishing the efficacy of antiretroviral therapy, HIV drug resistance has negative implications both for treatment of individuals, for whom effective therapy has been shown to reduce morbidity and mortality, and for public health, since effective therapy can reduce transmissibility. | | | For example, 2 years later, resistance to any drug was estimated to be present in 87, 82, and 43% of these subpopulations, respectively, and resistance to all three drug classes was present in 27, 11, and 2%. | | | These first estimates of the prevalence of HIV drug resistance in adults across the United States have several clinical and public health implications, mostly deriving from the fact that suppression of circulating HIV is an important goal for improving patient outcomes and reducing transmission. |
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http://www.natap.org/2004/HIV/062204_02.htm
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| | Role of HIV Drug Resistance Testing in Antiretroviral Drug Development |
| | Drug susceptibility (IC values) for resistant variants and the fold change in IC values relative to the parent virus should be determined (see section IV.E Characterization of Phenotypic and Genotypic Assays). | | | The Division believes that characterization of resistance/cross-resistance should be a part of antiretroviral drug development so that clinically relevant information will be available at the time of approval. | | | This guidance is intended to assist sponsors in the clinical development of drugs for the treatment of human immunodeficiency virus (HIV) infection. |
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http://www.fda.gov/cder/guidance/5879dft.htm
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| | Antiretroviral drugs |
| | Fifty percent of patients who fail antiretroviral therapy are resistant to one class of drug. | | | Because of the high frequency of drug interactions associated with AIDS therapy, specialized references should be consulted. | | | Williams, Ann B. "New Horizons: Antiretroviral Therapy in 1997." Journal of the Association of Nurses in AIDS Care 8 (July-August 1997): 26. |
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http://www.healthatoz.com/healthatoz/Atoz/ency/antiretroviral_drugs.jsp
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| | Rates of Antiretroviral Resistance Among HIV-Infected Patients With and Without a History of Injection Drug Use |
| | This is of particular clinical importance since there is substantial cross-resistance within antiretroviral drug classes [6], and there are a major challenges in treating patients with multi-drug resistant HIV [7,8]. | | | As a result, there has been substantial public health concern regarding the transmission of antiretroviral-resistant HIV in the community [9-12], and studies have consistently identified physician concerns regarding antiretroviral resistance as the primary reason for withholding HAART from patients perceived to be at risk of non-adherence [13-15]. | | | Briefly, the Centre is the only free source of antiretroviral medications in the province of British Columbia and pharmaceutical sales suggest that < 1% of HIV-infected patients obtain antiretroviral drugs outside the program [22]. |
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http://www.hivdent.org/drugs1/drugRARA0705.htm
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| | Drug-Drug Interactions with HIV-Related Medications (Veterans Affairs) |
| | Patients taking HIV medications often have complex drug profiles, and the interaction of only 2 drugs is rarely the concern; more often, patients are on 3 or more medications that could influence interactions. | | | Suggests that a high level of evidence is available regarding the drug combination, that the clinical significance of the interaction is well understood, and that consensus exists regarding the management strategy (eg, on dosage adjustments). | | | Even when pharmacokinetic data exist for specific drug combinations, the clinical significance of any changes in pharmacokinetic parameters may not be clear. |
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http://www.hiv.va.gov/vahiv?page=prtyp-wp-312_drug
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| | Examining the Probable Consequences of Alternative Patterns of Widespread Antiretroviral Drug Use in ... |
| | As private, bilateral, and multilateral initiatives begin to fund antiretroviral therapy programs for HIV/AIDS patients living in resource-constrained settings, scientists and practitioners have cautioned that the clinical and epidemiological effects of implementing such programs must be considered. | | | Workshop on Antiretroviral Drug Use in Resource-Constrained Settings | | | Examining the Probable Consequences of Alternative Patterns of Widespread Antiretroviral Drug Use in Resource-Constrained Settings - Institute of Medicine |
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http://www.iom.edu/project.asp?id=17080
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| | hiv drug treatment |
| | However, single drug treatment allows the development of drug resistance... | | | Information on the range of treatment options and drug interactions for HIV+ intravenous drug users who... | | | Active Antiretroviral Therapy (HAART) and Other HIV/AIDS Fighting Drugs. |
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http://www.go-shopping.us/drug%20treatment/hiv-drug-treatment.html
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| | AIDS - HIV Drug |
| | Updated regularly, Drug War Facts provides reliable information and credible citations on important criminal justice and public health issues. The goal is to introduce facts cited by authoritative sources to a debate which is often characterized by myths, erroneous information and emotion. | | | Drug use and transmission of HIV through unsafe sex and shared equipment. Drug interactions and needle exchange. | | | This report is an update on the prevalence of HIV drug resistance in the United Kingdom (UK) in both antiretroviral-experienced individuals and antiretroviral naive individuals |
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http://www.aidshq.com/hivdrug
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| | Database of Antiretroviral Drug Interactions |
| | Select an FDA-approved antiretroviral and view interactions with other drugs specified by drug name or drug class, or view "all interactions". | | | Select any drug in the database and view all interactions with FDA-approved antiretrovirals. | | | Select any drug class in the database and view all interactions with FDA-approved antiretrovirals. |
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http://hivinsite.ucsf.edu/arvdb?page=ar-00-02&post=1
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| | norvir search result |
| | Complete and easy-to-read information on treating HIV & AIDS, including guided treatment lessons, info on drugs, recent news, community forums, & a drug interactions checker. | | | Complete and easy-to-read information on treating HIV and AIDS, including guided treatment lessons, info on drugs, recent news, community forums, great links, and more. | | | Complete and easy-to-read info on treating HIV andAIDS, including guided treatment lessons, info on drugs, recent news, community forums, a drug interactions checker, andGraph My Labs. |
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http://www.bt2search.net/norvir
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| | The Epidemiology of Antiretroviral Drug Resistance among Drug-Naive HIV-1--Infected Persons in 10 US Cities: resistance ... |
| | Although the epidemiology of antiretroviral-drug resistance may reflect the HIV-infected populations that are seeking and receiving antiretroviral therapy, it also reflects, as others have noticed, the health care system's failures to prevent HIV transmission from these treated populations. | | | As a better understanding of patterns of antiretroviral-drug resistance in persons presenting for care emerges, this kind of information may help to guide recommendations for baseline resistance testing and, possibly, the selection of initial antiretroviral regimens. | | | The following antiretroviral drugs approved by the Food and Drug Administration were tested: zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir, nevirapine, delavirdine, efavirenz, saquinavir, ritonavir, indinavir, and nelfinavir. |
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http://www.natap.org/2004/HIV/060704_08.htm
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| | Antiretroviral drug |
| | Discontinue antiretroviral therapy if signs/symptoms of lactic acidosis/hepatic steatosis. | | | See drug class effects for all drugs (text and Table 10). | | | See drug class effects for all drugs (text and Table 10) |
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http://www.who.int/docstore/hiv/scaling/anex11b.html
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| | Science & Medicine NIAID Halts Trial on Antiretroviral Drug Conservation Strategy After Findings Show Method Increases ... |
| | The Strategies for Management of Antiretroviral Therapy trial -- which involved 318 sites in 33 countries -- began enrolling patients in January 2002 and included 5,472 HIV-positive participants when the trial was suspended on Jan. 11 (NIAID release, 1/18). | | | "We were surprised to learn that in the short term, episodic antiretroviral therapy carries such an increased risk without evidence of sparing patients the known side effects associated with [antiretroviral therapy]," Wafaa El-Sadr of the Harlem Hospital Center and Columbia University in New York, who was working on the trial, said. | | | Patients taking episodic treatment also were more likely to experience cardiovascular and kidney complications as well as liver disease, all of which also have been related to antiretroviral drug use (Smith, |
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http://www.kaisernetwork.org/daily_reports/rep_index.cfm?DR_ID=34861
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| | Hepatic Steatosis and Antiretroviral Drug Use among Adults Coinfected with HIV and Hepatitis C Virus |
| | · Liver histology was assessed in 112 patients, 74% of whom were taking antiretroviral therapy at the time of biopsy; | | | See also Interplay between hepatitis C, liver steatosis and antiretroviral therapy in HIV-infected patients | | | Accordingly, the objectives of the current study were to determine the prevalence and severity of hepatic steatosis among treatment-experienced, HIV-HCV-coinfected patients, to investigate if steatosis is associated with greater liver disease, and to identify factors that might contribute to the process. |
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http://www.hivandhepatitis.com/hiv_hcv_co_inf/2005/040805_a.html
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| | Search Results in the Bio Netbook [ medicine] |
| | 2001 KDD Cup will focus on data from genomics and drug design. | | | EuroSCAR: an epidemiological study aimed at evaluating the role of Drugs and Infections as risk factors for Severe Cutaneous Adverse drug Reactions (SCAR) | | | geno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes |
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http://www.pasteur.fr/cgi-bin/biology/bnb_s.pl?bool=et&bio=medicine&english=...
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| | Campus Library New Books - 5/27/2005 |
| | Committee on Examining the Probable Consequences of Alternative Patterns of Widespread Antiretroviral Drug Use in Resource-Constrained Settings | | | THE GUIDE TO COMMUNITY PREVENTIVE SERVICES : WHAT WORKS TO PROMOTE HEALTH? | | | INSIDE THE FDA : THE BUSINESS AND POLITICS BEHIND THE DRUGS WE TAKE AND THE FOOD WE EAT |
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http://www.bothell.washington.edu/library/newbooks/new050527.html
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