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| | Opioids In Pain Therapy |
 | | Antidopaminergic, antihistaminergic and antiserotinergic drug regimens for the prevention of opioid nausea are numerous and the efficacy of each regimen depends very much on the individual situation. |
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http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ija/vol4n4/opioids.xml
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| | Anticholinergic - Wikipedia, the free encyclopedia |
| | Many other drugs have anticholinergic properties, including cyclic antidepressants and the common allergy medications diphenhydramine (Benadryl) and its 8- chlorotheophylline salt dimenhydrinate (Dramamine), which are used medically for antihistaminergic purposes, and sometimes recreationally for their psychoactive effects. | | | This page was last modified 17:28, 8 Jul 2004. |
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http://wikipedia.startplane.com/Anticholinergic
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| | Antihistaminergic - encyclopedia article about Antihistaminergic. |
| | A (Aus) Hydroxyzine is piperazine derivative that is used as an antihistamine (especially for pruritus), anti-emetic, and anxiolytic drug. | | | Tricyclic antidepressants are a class of antidepressant drugs first used in the 1950s. | | | In addition to these drugs, which are used for their antihistaminergic effect, there are also drugs which possess unwanted antihistaminergic activity. |
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http://encyclopedia.thefreedictionary.com/Antihistaminergic
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| | Cocaine-induced anxiety |
| | In summary, benzodiazepines alleviated cocaine-induced anxiety, while future research on the ability of serotonergic and antihistaminergic drugs to alleviate these anxiety states is warranted. | | | Buspirone, dimenhydrinate and diphenhydramine did not consistently alleviate the anxiety caused by either cocaine pre-treatment regime; in the saline conditions, however, each of these treatments was anxiogenic. |
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http://www.cocaine.org.uk/anxiety/diazvbusp.html
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| | Antihistamine - Wikipedia, the free encyclopedia |
| | Many drugs, used for other indications, possess unwanted antihistaminergic activity. | | | These are experimental agents and do not yet have a defined clinical use. | | | Only agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines - other agents may have antihistaminergic action but are not true antihistamines. |
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http://en.wikipedia.org/wiki/Antihistamine
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| | CMC Contents and Abstracts, Vol 5, No. 5 |
| | Fluoxetine is an antidepressant drug, a potent and specific inhibitor of serotonin reuptake (SSRI). | | | Chronic treatment with fluoxetine was not reported to affect the electrocardiogram (ECG). | | | Evidence suggests that being compared with tricyclic antidepressants, fluoxetine may cause significantly fewer anticholinergic, antihistaminergic and cardiotoxic side effects in the treatment of major depressive disorders. |
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http://www.bentham.org/cmc/vol5-5.html
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| | Zyrtec update |
| | In this Commentary, we examine somebiological properties of cetirizine and levocetirizine, namelyenantioselectivity in pharmacological activity and pharmacokinetic properties, with emphasis on the possibility of racemization, the compared behavior of the two enantiomers, and the potential for interactions with other drugs. | | | Recent data demonstrate that the antihistaminergic activity of the racemate is primarily due to levocetirizine. |
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http://www.life-extension-drugs.com/zyrtec_3.htm
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| | Brain Explorer - Focus on Brain Disorders - Anxiety Disorders - Treatment |
| | From the third week onwards, however, imipramine became more effective in reducing the psychic symptoms. | | | TCAs with strong antihistaminergic properties, such as doxepin and amitriptyline, have sedating properties that are useful when treating people with anxiety disorders who have insomnia. | | | It was hypothesised that the sedative effect of some TCAs would be an advantage in the early treatment of anxiety, but this has not been demonstrated in controlled trials (Kasper, 1994). |
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http://www.brainexplorer.org/anxiety/Anxiety_Treatment.shtml
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| | 587D1 |
| | Waguespack Note: This is a 1990 article but relevant to undertanding the scientific progress of developing antidepressants. Effexor, a popular drug today is works as a serotonin-norepinephrine reuptake inhibitor. | | | As with the TCAs, the antidepressant activity of SNRIs is based on inhibition of norepinephrine and serotonin reuptake, but unlike TCAs they do not have anticholinergic, antihistaminergic, and ______________ effects. | | | The next step was the development of mixed serotonin-norepinephrine reuptake inhibitors (SNRIs), exemplified by venlafaxine and milnacipran. |
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http://www.homestead.com/adjunct_college/687D1.html
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| | Pain: Clinical Updates - Dec 1994 - Neurogenic Pain: Diagnosis and Treatment |
| | Antidepressants in general, and amitriptyline in particular, provide analgesia in a subgroup of patients with peripheral | | | The anticholinergic and antihistaminergic effects of antidepressants may also contribute to the analgesic effects of these drugs. | | | Antidepressants are believed to potentiate the effect of biogenic amines in endogenous pain-relieving systems. |
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http://www.iasp-pain.org/PCU94c.html
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| | [No title] |
| | Following chronic administration of sibutramine to rats no depletion of brain monoamines has been observed | | | Sibutramine M1 and M 2 exhibit no evidence of anticholinergic or antihistaminergic actions. | | | In addition receptor binding profiles show that sibutramine M1 and M 2 have low affinity for serotonin (5-HT) norepinephrine beta, beta1, beta3 ; alfa1 and alfa2), dopamine (D1 and D2) benzodiazepine, and glutamate (NMDA) receptors. |
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http://www.best-meds.com/drugdescription/meridia_clinical.htm
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| | Program Objectives |
| | The objectives of Nasonex and Aerius: Report on Effectiveness and Symptom Control (NARES) are to assess the effectiveness of regular intranasal steroid use (Nasonex) in alleviating nasal and extranasal symptoms in patients with SAR when used alone or in combination with an oral antihistamine with demonstrated antihistaminergic, anti-allergic and anti-inflammatory properties (Aerius). |
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http://www.patientprogram.ca/nares/objectives.htm
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| | New Page 5 |
| | However, he soon found that this drug was highly effective in treating the symptoms of anxiety, and proposed its use with psychotic patients. | | | mast cells contributed to anxiety and chose chlorpromazine based on its known antihistaminergic effects. |
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http://www.macalester.edu/~psych/whathap/UBNRP/Ahschizophrenia/Neurochemistry.htm
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| | [No title] |
| | Proposed mechanisms are their antihistaminergic, serotonergic, dopaminergic or anticholinergic effects. |
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http://www.stjames.ie/ClinicalInformation/NationalMedicinesInformationCentre/NMICBulletin/2002/NewerAtypicalAntipsychoticsinSpecialPopulationsVol8No12002/
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| | Ch. 7 of Depression in Later Life |
| | However, tricyclic antidepressants have several other effects, for example, inhibition of the cholinergic neurotransmitter system, antihistaminergic effects and cardiotoxicity. | | | As the cholinergic system in the aging brain has a reduced capacity, elderly people are vulnerable to drugs with anticholinergic effects. |
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http://www.citalopram.ch/depression/dll_7.html
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| | Nefazodone |
| | Analyses of pooled clinical trial results indicate that nefazodone and imipramine produces similar and significant improvements on anxiety- and agitation-related rating scales compared with placebo in patients with major depression. | | | Compared with SSRIs, nefazodone causes fewer activating symptoms, adverse gastrointestinal effects (nausea, diarrhoea, anorexia) and adverse effects on sexual function, but is associated with more dizziness, dry mouth, constipation, visual disturbances and confusion. | | | Short term tolerability data indicate that nefazodone has a lower incidence of adverse anticholinergic, antihistaminergic and adrenergic effects than imipramine. |
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http://www.greatvistachemicals.com/pharmaceuticals-bulk-drugs/nefazodone.html
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| | Rechtschaffen, A |
| | Blockade of histaminergic outputs by ingestion of antihistaminergic drugs also promotes sleep. | | | The anterior hypothalamus and adjacent basal forebrain region have the most potent sleep-promoting effects seen in the brain. | | | Destruction or chemical inhibition of histaminergic and adjacent neurons in the posterior hypothalamus produces sleep. |
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http://www.npi.ucla.edu/sleepresearch/SleepDream/sleep_dreams.htm
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| | American Family Physician: Atypical laryngeal dystonia caused by an antiemetic |
| | The time-course and treatment-response of this patient's symptoms are highly suggestive of acute dystonia.As opposed to the treatment given in her case, the optimal treatment of an acute dystonic reaction involves administering parenteral benztropine or parenteral diphenhydramine. | | | (3) Once successfully begun, the anticholinergic or antihistaminergic treatment should be continued orally for another two or three days to prevent recurrence. | | | I proffer the term "Hot Cup-Of-Tea Sign" for subtle laryngeal dystonia experienced merely as throat discomfort. |
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http://www.findarticles.com/p/articles/mi_m3225/is_7_69/ai_115319017
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| | nzhtav4n1 |
| | benztropine) and antihistaminergic medications (often administered prophylactically if patients are not hospitalised). | | | Treatment of EPS includes dose reduction or discontinuation of the antipsychotic drug or offering drug treatments, commonly anti-cholinergic (e.g. | | | Whilst diagnosis and treatment of EPS is relatively straightforward for dystonias, it can be more difficult for parkinsonism and akathisia. |
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http://nzhta.chmeds.ac.nz/nzhtav4n1.htm
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| | eMedicine - Fibromyalgia : Article by John Winfield, MD |
| | With respect to treatment of insomnia, do not forget to suggest optimum sleep hygiene. | | | Benzodiazepines (eg, alprazolam, lorazepam, clonazepam), buspirone (BuSpar), trazodone (Desyrel), zolpidem (Ambien), and others in the anticholinergic and antihistaminergic classes are useful. |
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http://www.emedicine.com/med/topic790.htm
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| | The Good Drug Guide : new mood-brighteners and antidepressants |
| | Their functional effects are broadly similar, though Prozac is the most activating, longest-lasting, least selective and most likely to provoke dose-related akathisia ; paroxetine has anticholinergic and sedating antihistaminergic effects; fluvoxamine most commonly induces nausea and has the shortest half-life; and citalopram is the most serotonin selective. | | | The SSRIs all differ in their half-lives, chemical structure and precise specificities. | | | The mood-brightening, resilience-enhancing and anti-anxiety properties of the SSRIs really can make a (very) modest percentage of the population feel "better than well". |
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http://www.biopsychiatry.com/
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| | CIPRAMIL 20 mg Tablets |
| | Citalopram has no effect on the uptake of noradrenaline, dopamine or GABA. | | | After prolonged treatment, the 5-HT- uptake inhibitory efficacy is unchanged and citalopram does not induce changes in the density of neurotransmitter receptors at the recommended dosages. | | | Moreover neither citalopram nor its metabolites have antidopaminergic, antiadrenergic, antiserotoninergic, antihistaminergic or anticholinergic (antimuscarinic) properties. |
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http://home.intekom.com/pharm/lundbeck/cipramil.html
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| | Serotonin Reuptake Blockers and the Treatment of Bulimina -- A Comprehensive Review |
| | Food restrictions such as these make MAOIs impractical in treating a food related disorder. | | | SSRIs, on the other hand, have been shown to be highly effective in treating depression, without the anticholinergic, antihistaminergic, or anti-adrenergic side effects (Fuller and Wong, 1990). | | | In animals, SSRIs cause a decrease in serotonin turnover and a concomitant behavioral decrease in food intake (Fuller and Wong, 1990). |
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http://www.biopsych.net/bulimia%20papers/serotonin%20hypothesis.html
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| | Mirtazapin - Psychoneuroendocrinology |
| | The acute sedative effects of administration of 15 mg mirtazapine which could be demonstrated in each subject can be explained by its antihistaminergic effects. | | | Therefore, it is not surprising that anticholinergic (disturbance of accomodation, obstipation, dry mouth, and urinary retention) and dopaminergic side effects did not occur in the present study. | | | As can be demonstrated in our study, the GH secretion is not influenced by administration of 15 mg mirtazapine PO. |
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http://laakmann.web.med.uni-muenchen.de/mirtpsyn.html
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| | CMC Contents and Abstracts, Vol 6, No. 6 |
| | However, there is an increasing number of case reports on dysrhythmias, like atrial fibrillation or bradycardia and syncope associated with fluoxetine and another SSRI treatment and overdose. | | | In contrast to TCAs, selective serotonin reuptake inhibitors (SSRIs), including fluoxetine and citalopram, are considered to cause less effect on cardiac impulse conduction. | | | In addition, these compounds induced significantly less anticholinergic, antihistaminergic and cardiotoxic side-effects than TCAs. |
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http://www.bentham.org/cmc/vol6-6.html
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| | JMA - |
| | These results point to an immunomodulatory action of fexofenadine independent of its antihistaminergic properties which may be of importance in the treatment of allergic diseases. | | | On the other hand, recent studies have suggested for a variety of antihistaminergic drugs that they may possess additional properties unrelated to the blockage of histamine and its receptor. | | | Especially the effect exerted on the expression of Ox40 can be relevant for the course of allergic diseases as this molecule has been shown to be involved in creating a Th2 immune response. |
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http://eaaci.org/jma/activities/congresses/berlin2001/Abstract/immunology.htm
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| | Outpatient Management of Depression: Evaluating the Various Antidepressants |
| | The antihistaminergic properties of trazodone are in part responsible for its popularity as a sleep aid, but cause significant problems with daytime sedation when it is used as an antidepressant. | | | While they were not rationally developed in the same way as the SSRIs, they were developed because they had less antihistaminergic and less anticholinergic effects in animal models than did their TATCA forerunners ( Figure 6.1). | | | They also do not potently block alpha-1-adrenergic receptors. |
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http://www.preskorn.com/books/omd_s8.html
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| | yawning-serotonergic-modulation |
| | As citalopram is a very selective inhibitor of the 5-HT reuptake mechanisms, practically devoid of inhibitory effects on NA reuptake or on monoamine oxidase, and has only very weak anticholinergic and antihistaminergic properties, its potentiating effect on physostigmine-induced yawning may reasonably be ascribed to | | | This suggestion was strengthened by the results of an experiment with a higher dose of metergoline (10 mg/kg), with which the mean yawning level after physostigmine was decreased to only 3 yawns/hour, that is, to 20 percent of the original level, a result which is highly significant (p<0.001, MannWhitney U test). |
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http://perso.easynet.fr/baillement/melis-ragiolas/serotonergic-modulation.html
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| | Treatment Strategies for Thyroid Dysfunction |
| | As discussed these measures may have little or no role in controlling the drug-induced weight gain, but can help reduce risk factors associated with being overweight. | | | Patients should be encouraged to maximize their daily physical activity to increase their total energy expenditure. | | | Drugs with antihistaminergic properties may cause sedation, resulting in reduced mobility. |
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http://www.continuingeducation.com/pharmtech/weightgain/8_Weight_Gain.html
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| | Untitled1 |
| | Citalopram has no antidopaminergic, antiadrenergic, antiserotoninergic, antihistaminergic or anticholinergic properties and does not inhibit Monoamino oxidase A (MAO). |
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http://www.panacea-biotec.com/products/madam.htm
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| | Re: Effexor Xr and liver function???????????????? » DebbieLynn |
| | Because of mirtazapine's unique pharmacology, antihistaminergic effects predominate at lower doses (drowsiness, sedation), whilst noradrenergic neurotransmission increases with increasing doses, counteracting some of the antihistaminergic effects. | | | Kent, Justine M. SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depression. |
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http://www.dr-bob.org/babble/20010530/msgs/65021.html
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| | Cardiff University - Topics Covered in the Course |
| | To describe the toxicity of psychoactive drugs in normal dose and overdose and management of toxicity | | | To illustrate the toxicity of cholinergic, anticholinergic, antiserotonergic, sympathomimetic and antihistaminergic agents in normal dose and overdose and the management of the toxicity of these agents |
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http://www.cf.ac.uk/medicine/pharmacology/ttc/pge/diptox/topics.htm
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| | All Abstracts for Sydney 2000 |
| | 1 PsoriSol Center for Dermatology and Allergy, Hersbruck, DE 2 Department of Biology, University of Konstanz, Konstanz, DE 3 Invitro GbR, Reichenschwand, DE We and others have previously shown that the new histamine H1 receptor antagonist fexofenadine, a major metabolite of terfenadine, displays several "antiinflammatory" effects independent of its antihistaminergic activity. | | | In vitro investigations with the histamine H1 receptor antagonist fexofenadine on different elements of signal transduction |
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http://www.hogrefe.de/Sydney2000/abstracts/P-780.html
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| | eMJA: Pharmacological approaches to the management of schizophrenia |
| | Salient pharmacodynamic and pharmacokinetic considerations (eg, very short plasma half-lives, long-acting depot formulations, antipsychotics that are loosely bound to dopamine receptors, anticholinergic and antihistaminergic blocking effects) may not be accounted for; | | | Published conversion references used to estimate equivalent doses can differ by as much as 500%, leading to erroneous assumptions about appropriate dosage of the new agent; |
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http://www.mja.com.au/public/issues/178_09_050503/lam10582_fm.html
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| | PHCL 3720 Lecture 13 |
| | Venlafaxine (Effexor®): Though structurally unrelated to the tricyclic antidepressants, venlafaxine does not exhibit a great deal of selectivity in the inhibition of norepinephrine or serotonin re-uptake. | | | However, venlafaxine, like the SSRIs exhibits less receptor cross-over than the tricyclic antidepressants, and therefore exhibits fewer anticholinergic, antihistaminergic, and antiadrenergic ( |
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http://www.neurosci.pharm.utoledo.edu/PHCL3720/Lecture13.htm
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| | [No title] |
| | In a primate model of acute dystonia, clozapine had essentially no associated dystonia, whereas risperidone exhibited dose-dependent effects (5). | | | In addition, clozapine has severalfold greater antimuscarinic and antihistaminergic effects than risperidone (2). | | | Even though both agents have a higher serotonin 5-HT2Ato-dopamine D2 binding ratio-a characteristic shared by the new-generation antipsychotics (1)-clozapine has two orders of magnitude lower affinity for dopamine D2 receptors and substantially lower affinity for 5-HT2A receptors than risperidone (2-4). |
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http://www.psychiatry.ru/focus/article.php4?id=83
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| | Atomoxetine: An New Medication for AD/HD |
| | Their alpha adrenergic effects can cause tremor and changes in blood pressure. | | | Their antihistaminergic effects can cause weight gain and tiredness. | | | Their anticholinergic effects can cause constipation, dry mouth and dry eyes. |
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http://www.ncpamd.com/Strattera.htm
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| | Drowning and near-drowning: a challenge for the anesthesiologist |
| | The inhibition of the reuptake of 5HT is believed to lead to an antidepressant effect by stimulation of the 5HT | | | In addition, they do not have antihistaminergic, anticholinergic, or alpha 1 adrenergic actions and side effects. | | | In addition TCAs have a number of other actions with specific side effects: antihistaminergic, causing drowsiness and weight gain, anticholinergic/antimuscarinic causing constipation, blurred vision, dry mouth and drowsiness, alpha |
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http://www.euroanesthesia.org/education/rc_amsterdam/14rc4.HTM
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| | March 1998 Vol - 43 No 2 Letters to the Editor |
| | The short elimination half-life of nefazodone (2 to 4 hours) may have facilitated the reaction (2,3). | | | The metabolite mCPP has a high affinity for many 5-HT receptors (4). | | | Nefazodone, a 5-HT2A receptor antagonist and serotonin (5-HT) reuptake inhibitor, has minimal anticholinergic, antihistaminergic, and alpha-1-adrenergic antagonist effects (3). |
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http://www.cpa-apc.org/french_site/publications/Archives/CJP/1998/Mar/mar98_leted.htm
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