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| | NYU - Antiepileptic Drug Therapy |
 | | Antiepileptic drugs are the principal therapy for epilepsy. | | | Antiepileptic drugs interact with each other and with other drugs, and other drugs interact with antiepileptic drugs. | | | Unfortunately, steady-release antiepileptic drugs are not widely available, and we must work with the drugs we have. |
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http://www.neurologychannel.com/nyu/antiepileptic.html
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| | American Family Physician: Antidepressants and antiepileptic drugs for chronic non-cancer pain |
| | Specific antiepileptic drugs are effective in the treatment of patients with neuropathic pain. | | | Neuropathic pain typically is treated with medications that influence neurotransmitters (e.g., antidepressants, antiepileptic drugs), and treatment with opioids is reserved for patients with refractory neuropathic pain. | | | Antiepileptic drugs act at several sites that may be relevant to pain, but the precise mechanism of their analgesic effect remains unclear. |
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http://www.findarticles.com/p/articles/mi_m3225/is_3_71/ai_n11836585
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| | Children's Epilepsy Program : Antiepileptic Medications |
| | Not all antiepileptic medications need to be monitored with drug levels (eg valproate, lamotrigine, gabapentin, topiramate, tiagabine), as there is not a good correlation between drug level and effect. | | | Prescription of antiepileptic medication is only done by a doctor with knowledge of antiepileptic medication and epilepsy in children. | | | The secondary aims are to identify if certain antiepileptic medications, or combinations of medications, are associated with a higher overall incidence of fetal outcomes or specific types of malformations. |
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http://www.rch.org.au/cep/treatments/index.cfm?doc_id=3242
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| | New antiepileptic drugs |
| | These drugs are used as add-on therapy in patients whose epilepsy is not controlled by established treatments. | | | Given the overlap in clinical indications, choice of one of the newer antiepileptic drugs is often based on known adverse effects, interactions (see box) and familiarity with using a particular drug. | | | Beydoun A. Monotherapy trials of new antiepileptic drugs. |
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http://www.australianprescriber.com/magazines/vol22no3/antiepileptic.htm
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| | DMR Medical Advisory 98-6 |
| | When possible, the choice of antiepileptic drug should be directed by the specific epilepsy syndrome. | | | Each person should be encouraged to learn to identify each of his or her medications and know the dosing schedule. | | | Factors to be considered when choosing or using an antiepileptic drug include the pharmacokinetics of absorption, distribution, and elimination. |
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http://www.dmr.state.ct.us/publications/centralofc/hcs_ma98-6.htm
(2669 words)
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| | eMedicine - Antiepileptic Drugs: An Overview : Article by Juan G Ochoa, MD |
| | Antiepileptic drugs can be grouped according to their major mechanism of action. | | | Some antiepileptic drugs work by acting on a combination of channels and/or some unknown mechanism of action. | | | The major clinical problem of this drug is the development of tolerance; sedation tolerance is more evident than antiepileptic tolerance. |
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http://www.emedicine.com/neuro/topic692.htm
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| | Post-Marketing Antiepileptic Drug Survey (PADS) |
| | Patients who are started on new antiepileptic drugs or devices. | | | The survey records demographic data for each patient, as well as data on past behavioral and psychiatric disturbances and current or past antiepileptic drug use. | | | Data will be collected on any patient that is placed on new antiepileptic drugs or devices and entered into a database maintained by the International Epilepsy Consortium at Virginia Commonwealth University. |
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http://www.people.vcu.edu/~jhighsmi
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| | The effects of antiepileptic medications on thinking and behavior |
| | Neuropsychological abilities before and after 5 years of stable antiepileptic drug therapy. | | | Cognitive adverse effects of antiepileptic drugs: incidence, mechanisms and therapeutic implications. | | | The effects of antiepileptic medications on thinking and behavior |
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http://www.nyumc.net/public_html/epilepsy_20031016/aed_thinking_effects.html
(1434 words)
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| | Causes and Treatments of Seizures |
| | Convulsions that stop with etiology-specific therapy and those that are brief and infrequent may not warrant antiepileptic drugs. | | | Phenobarbital is the drug of choice to treat convulsions in neonates. | | | Antiepileptic drugs are not indicated in all neonates with convulsions. |
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http://pediatricneuro.com/alfonso/pg58.htm
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| | Side Effects of Newer Antiepileptic Drugs |
| | Their main benefit is an improved side-effect profile, said David Weintraub, Research Coordinator for the Columbia Antiepileptic Drug Database Study and coinvestigator with Dr. Hirsch on three studies. | | | Such results have important implications for how neurologists and other clinicians should be treating —or altering their treatment of—patients with epilepsy, said Lawrence J. Hirsch, MD, principal investigator of the Columbia Antiepileptic Drug Database study. | | | “Our data allow head-to-head comparisons of all the newer antiepileptic drugs with regard to overall effectiveness and tolerability or with regard to specific side effects,” Dr. Hirsch said. |
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http://www.neurologyreviews.com/jun04/nr_jun04_AEDside.html
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| | News - Antiepileptic Use Linked To Reduced Ocular Perfusion |
| | Patients who take antiepileptic drugs have reduced blood flow in their ocular area, which may have an impact on their visual functioning. | | | A DGReview of :"Epilepsy Patients Treated with Antiepileptic Drug Therapy Exhibit Compromised Ocular Perfusion Characteristics." | | | Focus on Monitoring Antiepileptic Drugs and Analyzing Contributing Factors of Sudden Unexplained Death in Epilepsy |
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http://docguide.com/news/content.nsf/news/8525697700573E1885256C6D00214383
(388 words)
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| | Guidelines Clarify Role of New Antiepileptic Drugs |
| | “If you are treating a chronic comorbid condition, such as hypertension, diabetes, or depression, and you are taking an antiepileptic drug that accelerates the elimination of the other drugs, you may be limiting the other drugs&; efficacy by accelerating their elimination. | | | Andres Kanner, MD, Professor of Neurology, Rush University Medical Center, Chicago, observed, “Old antiepileptic drugs can yield complete seizure control with no adverse events in a large number of patients,” but certain clinical situations require consideration of the new antiepileptic drugs. | | | Drug interactions are a particularly important issue for the elderly, Dr. Kanner observed. |
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http://www.neurologyreviews.com/jul04/nr_jul04_epilepsy.html
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| | Epilepsy Drugs and Medications |
| | This is because monotherapy is associated with fewer side effects than adjunctive therapy, and avoids the problem of potential interactions between antiepileptic drugs. | | | There are a number of antiepileptic drugs available from which your physician can choose. | | | You may be asked to give a blood sample at regular intervals so that the level of drug in your body can be monitored, or to enable your Neurologist to check for adverse effects of the drug on the function of your body (e.g. |
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http://www.trileptal.com/info/treating/epilepsy-drug-therapy.jsp
(420 words)
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| | Antiepileptic Medications |
| | The bloodstream is the pathway to the brain and, therefore, leads medication to the centres of the brain in which seizures begin. | | | Modern science has greatly improved antiepileptic (anticonvulsant) drugs, which have dramatically changed the lives of people with epilepsy. | | | It is important to follow the doctor’s instructions very carefully as to when and how much medication should be taken. |
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http://www.epilepsy.ca/eng/content/antiepi.html
(2217 words)
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| | Amazon.com: Antiepileptic Drugs : Combination Therapy and Interactions: Books: Jerzy Majkowski,Blaise F. D. ... |
| | The book consists of five sections covering the general concepts and advantages of combination therapies, the principles of drug interactions, the mechanisms of interactions, drug interactions in specific populations or in patients with co-morbid health conditions, and concludes with a look at the future directions for this field of research. | | | This book reviews the use of antiepileptic drugs focusing on the interactions between these drugs and between antiepileptics and other drugs. | | | Antiepileptic Drugs : Combination Therapy and Interactions (Hardcover) |
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http://www.amazon.com/exec/obidos/tg/detail/-/052182219X?v=glance
(463 words)
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| | Hypnotic and antiepileptic effects of cannabidiol (Journal of Clinical Pharmacology, 1981; 21: 417S-427S) |
| | Three other placebo patients (1, 4, and 5) remained under treatment for 12, 12, and eight weeks, respectively, after which they were withdrawn from the experiment and underwent a change in the prescribed antiepileptic drugs in an attempt to improve their condition. | | | One week later, each group began to receive placebo or cannabidiol capsules in a double-blind procedure in addition to the antiepileptic drugs they were already receiving. | | | Anticonvulsant activity of delta-9-THC compared to three other drugs. |
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http://www.thecompassionclub.org/library/epilepsy2.html
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| | Discontinuing Antiepileptic Drugs |
| | Antiepileptic drugs may not have to be taken for a lifetime. | | | However, like so much in epilepsy treatment, the risks vary between individuals and between types of epilepsy. | | | Answer Place > Medical Aspects > Treatment > Medications > Discontinuing Antiepileptic Drugs |
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http://www.epilepsyfoundation.org/answerplace/Medical/treatment/medications/discontinuing.cfm
(389 words)
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| | Amazon.com: Antiepileptic Drugs: Books: Rene H. Levy,Richard H. Mattson,Brian S. Meldrum |
| | Coverage begins with a thorough grounding in general principles, including pharmacokinetics, mechanisms of action and toxicology, and selection and use of drugs for specific patient populations. | | | Comprehensive reference for clinical neurologists and researchers on the actions, interactions, toxicity, and other extensive information about antiepileptic drugs. | | | The book then explores specific drugs, including phenytoin, phenobarbital and other barbiturates, primidone, carbamazepine, valproic acid, ethosuximide, oxazolidinedione, and benzodiazepines. |
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http://www.amazon.com/exec/obidos/tg/detail/-/0781723213?v=glance
(653 words)
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| | Seizure induced by antiepileptic drugs |
| | The mechanism of the antiepileptic activity of this drug is not clear. | | | The choice of antiepileptic drug by clinicians should be based on precise diagnosis. | | | Exacerbation of generalized non-convulsive seizure with ethosuximide therapy. |
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http://www.kfshrc.edu.sa/annals/203_204/99-161R.htm
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| | Topamax Drug Description - Topiramate - HealthScout |
| | Topiramate is a sulfamate-substituted monosaccharide that is intended for use as an antiepileptic drug. | | | To find more information on specific conditions, please visit our partner sites: |
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http://www.healthscout.com/rxdetail/1/69/1/main.html
(265 words)
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| | Antiepileptic drug developed at Hebrew University to undergo phase three clinical trials |
| | Bialer's research team, which included his former doctoral student, Dr. Salim Hadad, worked to develop a glycine derivative which would penetrate the blood-brain barrier and would subsequently be cleared out of the body by a pre-designed elimination pathway in order to avoid undesirable side effects which may be caused by toxic metabolic substances (metabolites). | | | Antiepileptic drug developed at Hebrew University to undergo phase three clinical trials | | | Additionally, the drug is also to be tested for its possible beneficial effects on patients suffering from manic-depression, as well as for treatment of neuropathic pain. |
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http://www.eurekalert.org/pub_releases/2003-10/huoj-add100103.php
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| | New Antiepileptic Drugs for the Treatment of Epilepsy |
| | Despite continued improvements in surgical techniques the fact the surgery is only effective for localization related epilepsy, requires extensive and expensive evaluation, and is irreversible leaves anticonvulsant treatment the preferred modality. | | | With the seeming plethora of antiepileptic drugs (AED), one might wonder why new ones are desirable. | | | New Antiepileptic Drugs for the Treatment of Epilepsy |
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http://www.seizures.net/articles_epilepsy/New_AED3_03.html
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| | TOPAMAX Antiepileptic Drug Cleared by FDA |
| | There was a 1.5 percent incidence of kidney stones; nearly 80 percent of patients experiencing stones continued TOPAMAX therapy. | | | TOPAMAX will be available by prescription in late January and will be competitively priced with other newer antiepileptic drugs. | | | Approximately 30 percent of people with epilepsy in the United States -- at least 650,000 patients -- continue to experience seizures despite treatment with currently available medications. |
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http://www.pslgroup.com/dg/f662.htm
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| | Properties of Antiepileptic Medication |
| | The most comprehensive reference on the properties of antiepileptic drugs is Antiepileptic Drugs, Fourth Edition Levy, R.H.; Mattson, R.H.; and Meldrum, B.S.; Raven Press, 1995. | | | Ethosuximide has little or no effect on the pharmacokinetics of other antiepileptic drugs | | | Comment: Optimal individual maintenance doses will be determined by clinical response; initial doses are lower; pharmacokinetic interactions may affect dosage requirements. |
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http://www.fesb.hr/~dpopovic/epi/aed.htm
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| | Epilepsy Fdn.-Video News Release: New Data Released on Pre-Pregnancy Use of Anti-Seizure Drugs |
| | The convergence of statistically-significant data from antiepileptic drug pregnancy registries from around the world is beginning to provide clear guidance to women and their physicians about the use of antiepileptic drugs during pregnancy and the risk of birth defects to the woman's child. | | | Antiepileptic drug use is growing, as they are increasingly used for treatment of several non-epileptic neurological pain symptoms such as migraines and tremor, and for psychiatric disorders such as mood and bipolar disorders. | | | This information is relevant to a growing number of patients in the population—and the physicians who treat them—as more than 56 million antiepileptic drugs were prescribed to women in the 12-month period ending September 2004. |
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http://www.epilepsyfoundation.org/aboutus/pressroom/vnr20021207.cfm
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| | ANTIEPILEPTIC DRUGS |
| | Coatsworth, J.J. Studies on the Clinical Efficacy of Marketed Antiepileptic Drugs, NINDS Monograph No. 12, 1971. | | | Woodbury, D.M., Penry, J.K, and Schmidt, R.P. Antiepileptic Drugs, Raven Press, NY, 1972. |
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http://w3.ouhsc.edu/neuro/division/cope/aed.htm
(392 words)
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| | NGC - NGC Summary |
| | Effectiveness of New Antiepileptic Drugs (AEDs) in Refractory Partial Epilepsy as Adjunctive Therapy | | | Efficacy and tolerability of the new antiepileptic drugs for treatment of refractory epilepsy: AAN guideline summary for patients and their families. | | | The guideline subcommittee recognizes that these drugs are not antiepileptic but antiseizure drugs. |
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http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=5183&nbr=3565
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| | Antiepileptic Pill: Chinese Herbal Medicine |
| | In such circumstances, it is best discussed with the doctor so that patients can be aware of all the options. | | | For others it may be necessary to take antiepileptic drugs for a period of years, even if seizures have stopped, as the underlying cause of the seizures may still be there. | | | It is a brain disorder in which clusters of nerve cells, or neurons, in the brain sometimes signal abnormally. |
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http://www.damo-qigong.net/treat/epilepsy
(1190 words)
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