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| | Flecainide - Wikipedia, the free encyclopedia |
 | | This risk is probably increased when flecainide is co-administered with other class Ic antiarrhythmics, such as encainide. | | | Morganroth J. Early and late proarrhythmia from antiarrhythmic drug therapy. | | | A full list of drug interactions with flecainide can be obtained from the manufacturer. |
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http://en.wikipedia.org/wiki/Flecainide
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| | [No title] |
| | This study consisted of 100 patients who were not being treated with other antiarrhythmic drugs. | | | These patients were hemodynamically stable and were not being treated with any other antiarrhythmic drugs. | | | After comparing amiodarone, ibutilide and sotalol in terms of efficacy, side effect profiles, and cost, it seems apparent that ibutilide should be the intravenous drug of choice for pharmacological conversion of atrial fibrillation or flutter. |
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http://www.courses.ahc.umn.edu/pharmacy/5822/GPamiod.html
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| | RSD1000: A Novel Antiarrhythmic Agent with Increased Potency under Acidic and High-Potassium Conditions -- Yong et al. ... |
| | Abraham S, Beatch GN, MacLeod BA and Walker MJ (1989) Antiarrhythmic properties of tetrodotoxin against occlusion-induced arrhythmias in the rat: A novel approach to the study of the antiarrhythmic effects of ventricular sodium channel blockade. | | | The antiarrhythmic action of RSD1000 against ischemia-induced arrhythmias in intact rats is summarized for all arrhythmias | | | Lazzara R and Scherlag BJ (1984) Current concepts of the genesis of ischemic arrhythmias and sudden coronary death, in Clinical Pharmacology of Antiarrhythmic Therapy (Lucchesi BR, Dingell JV andSchwarz RP, Jr eds) pp 9-23, Raven Press, New York. |
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http://jpet.aspetjournals.org/cgi/content/full/289/1/236
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| | Body |
| | Torsade de pointes — (Twisting of the points) A unique form of ventricular tachycardia that can be congenital in origin or can result from antiarrhythmic or psychotropic drug therapy, hypocalcemia, or acute myocardial infarction. | | | Echocardiography — A noninvasive test using ultrasound to visualize the structure of the heart, the contractile function of the chambers (ejection fraction) and information on blood flow velocity (Doppler flow analysis). | | | Angina Pectoris — (Latin = suffocation — chest) Chest pain or feeling of tightness due to lack of blood supply to the heart muscle because of obstruction or constriction of the coronary arteries (CAD). |
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http://www.txai.org/edu/glossary/glossary.htm
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| | A guide to recently approved cardiovascular medications - Patient Care |
| | While many primary care physicians may not initiate treatment with dofetilide, most are likely to see patients who are taking it, making it important for them to have a working knowledge of this medication. | | | Note that this restriction was carried forward from the clinical studies of dofetilide, all of which used in-hospital drug administration. | | | Therapeutic role in primary care Ezetimibe, the first in a new class of compounds, has an indication for lipid lowering as monotherapy or in combination therapy. |
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http://www.patientcareonline.com/patcare/article/articleDetail.jsp?id=119752
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| | Society of Cardiovascular Anesthesiologists |
| | The difficulty with this extreme view is that, for many practitioners, antiarrhythmic drugs are a measure of last resort when a patient remains pulseless following repeated external cardioversion attempts and CPR. | | | Given these caveats, what is the role of IV amiodarone in the management of patients experiencing life-threatening VT or VF during, or immediately after, surgery? | | | How compelling are these data, and how should the findings influence our treatment of sustained ventricular arrhythmias in perioperative settings? |
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http://www.scahq.org/sca3/newsletters/nov_res.shtml
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| | (Print Version) Arrhythmia (Cardiac) Page 2 |
| | These results suggest that intravenous magnesium sulfate may be effective in the acute management of cardiac arrhythmias in patients with a low serum iMg2+ level. | | | In this study we demonstrate that each of these ligands suppresses many of the phenotypic correlates of endothelin-induced hypertrophy in a cultured neonatal rat cardiac ventriculocyte model. | | | Simulation is then used to investigate how the drugs affect reentrant rhythms in the neighborhood of the CRS. |
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http://www.lef.org/protocols/abstracts/abstr-txt/t-abstr-012a.html
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| | Myocardial infarction: class of antiarrhythmic agent affects mortality. |
| | McAlister FA, and Teo KK: Antiarrhythmic therapies for the prevention of sudden cardiac death. | | | Patients at risk from sudden cardiac death who are given class I antiarrhythmics, are more likely to die than those given a control (NNH = 163 at unknown). | | | Class IV antiarrhythmics (calcium channel antagonists) have no clear effect. |
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http://www.eboncall.org/CATs/500.htm
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| | Clinical Trial: Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE) |
| | The CASCADE Study: randomized antiarrhythmic drug therapy in survivors of cardiac arrest in Seattle. | | | For those patients refractory to medical therapy, ventricular resection or implantation of pacemakers has been employed. | | | A total of 113 patients were randomized to amiodarone and 115 patients to conventional therapy with other antiarrhythmic agents which included procainamide, quinidine, disopyramide, tocainide, mexiletine, encainide, flecainide, propafenone, moricizine, or combination therapy in that order. |
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http://clinicaltrials.gov/ct/show/NCT00000464?order=36
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| | Antiarrhythmic agent - Wikipedia, the free encyclopedia |
| | Blocking this channel depresses the phase 0 depolarization (reduces V | | | Antiarrhythmic agents may be considered the first-line therapy in the prevention of sudden death in certain forms of structural heart disease, and failure of these agents to suppress arrhythmias may lead to implantation of an implantable cardioverter-defibrillator (ICD). | | | Class I agents are grouped by what effect they have on the Na channel, and what effect they have on cardiac action potentials. |
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http://en.wikipedia.org/wiki/Antiarrhythmic_agent
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| | [No title] |
| | Therefore the interactions between bretylium and other drugs (including other antiarrhythmic drugs) is primarily through the pharmacodynamic mechanism.Dofetilide is metabolised by CYP3A4 and excreted by the renal cation transport system. | | | These agents are effective for the management of various types of cardiac arrhythmias both atrial and ventricular in origin.Class III antiarrhythmic drugs may interact with other drugs by two major processes: pharmacodynamic and pharmacokinetic interactions. | | | The pharmacodynamic interaction occurs when the pharmacological effects of the object drug are stimulated or inhibited by the precipitant drug. |
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http://www.cis.upenn.edu/~mamandel/Annotators/cyp/set03/pm12692891.cyp
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| | Amiodarone ENIOSSA.COM - Drugs and Medications Directory |
| | In a meta-analysis of 18 RCTs, amiodarone was similar to other antiarrhythmic drugs in its ability to convert patients to normal sinus rhythm (72.1 percent for amiodarone compared with 71.9 percent for other antiarrhythmic drugs). | | | Use of these drugs would be most appropriate in patients with recurrent hemodynamically unstable atrial fibrillation. | | | Although the U.S. Food and Drug Administration (FDA) has labeled amiodarone only for the treatment of life-threatening ventricular arrhythmias, the drug also is used to treat atrial fibrillation. |
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http://fentanyl.eniossa.com/A/Amiodarone.html
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| | HighBeam Research: Library Search: Results |
| | Pharmacologic control of ventricular rate *: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. | | | Antiarrhythmic drug Dofetilide Closely monitor patients for dangerous... | | | Agents that are proarrhythmic, such as dofetilide, or agents that are contraindicated in... |
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http://highbeam.com/library/search.asp?q=Dofetilide&refid=healthcyclopedia
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| | Wyeth: News & Announcements |
| | A critical appraisal of the scientific literature supports the administration of Cordarone I.V. before lidocaine in the management of cardiac arrest due to VF/pulseless VT. This represents a significant change to the long-standing practice of administering lidocaine as the first antiarrhythmic to virtually everyone suffering cardiac arrest. | | | Cordarone I.V. is the most widely studied antiarrhythmic agent among those included in the 2000 ACLS guidelines and is the only ACLS antiarrhythmic drug to be studied in randomized, placebo-controlled trials. | | | Although lidocaine remains an acceptable treatment according to the 2000 ACLS guidelines, the guidelines state that the evidence to support its use as a first-line antiarrhythmic in the acute treatment of ventricular fibrillation (VF) remains poor and methodologically weak. |
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http://www.wyeth.com/news/Pressed_and_Released/pr05_08_2001.asp?archive=2001
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| | 1H-NMR determination of the enantiomeric excess of the antiarrhythmic drug Mexiletine by using mandelic acid analogues ... |
| | Mexiletine (1a, Figure 1) is a chiral therapeutically relevant compound, clinically used as an antiarrhythmic, | | | H-NMR determination of the enantiomeric composition of Mexiletine [1-(2,6-dimethylphenoxy)-2-propanamine], a chiral, orally effective antiarrhythmic agent, and some of its derivatives. | | | 1H-NMR determination of the enantiomeric excess of the antiarrhythmic drug Mexiletine by using mandelic acid analogues as chiral solvating agents |
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http://www.arkat-usa.org/ark/journal/2004/I05_Tortorella/VT-850L/VT-850L.asp
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| | Dofetilide: A New Class III Antiarrhythmic |
| | Dosing, Administration, and Monitoring: If the patient is devoid of all contraindications, dofetilide may be initiated. | | | Lastly, agents that cause hypokalemia or hypomagnesemia, such as diuretics, should also be used with caution. | | | pulmonary fibrosis, thyroid and hepatic dysfunction), these agents are not suitable for all patients. |
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http://clevelandclinicmeded.com/medical_info/pharmacy/septoct2000/pharm.htm
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| | [No title] |
| | Review Questions on Antiarrhythmic Drugs Cardiac arrhythmias are disorders of heart rate and rhythm which may arise from changes in 1) automaticity of pacemaker cells and/or 2) conduction of the impulse through the heart. | | | Antiarrhythmic which causes hypotension and bone marrow depression | | | Verapamil is excreted by the kidneys, and has a biexponential elimination with a fast early distribution phase and a slower terminal elimination phase. |
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http://www.kumc.edu/research/medicine/pharmacology/CAI/webCAI/blk2/ab85.wbc
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| | MedForumsLive.com - propafenone, Rythmol |
| | PRESCRIBED FOR: Propafenone is an antiarrhythmic agent and is only approved for use in patients with life-threatening ventricular arrhythmias, such as ventricular tachycardia. | | | The primary mechanism of action is blocking channels which transport sodium across cell borders, which prolongs the beginning of the phase during which heart muscle cells become electrically stimulated (action potential). | | | Propafenone is at least as effective as any other type I agent in converting atrial fibrillation to sinus rhythm. |
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http://www.medforumslive.com/drugs/p/propafenone.html
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| | Effects of the antiarrhythmic agent tedisamil on cardiac potassium currents in humans |
| | Tedisamil is a new antiarrhythmic drug with predominantly class III action. | | | Effects of the antiarrhythmic agent tedisamil on cardiac potassium currents in humans | | | The aim of the present study was to investigate the effects of the compound on potassium currents in human cardiac myocytes isolated from either right atrial appendages or explanted left ventricles. |
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http://www.pulsus.com/europe/02_01/rav2_ed.htm
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| | Antiarrhythmic agent - definition of Antiarrhythmic agent in the Medical dictionary - by the Free Online Medical ... |
| | This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. | | | Antiarrhythmic agent - definition of Antiarrhythmic agent in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia. | | | Preventing or alleviating irregularities in the force or rhythm of the heart. |
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http://medical-dictionary.thefreedictionary.com/Antiarrhythmic+agent
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| | (WO 99/64050) NOVEL POTASSIUM CHANNEL DRUGS AND THEIR USES [Repub: 20.04.2000] |
| | The manner of linking the ligands together is such that the multibinding agents thus formed demonstrate an increased biologic and/or therapeutic effect as compared to the same number of unlinked ligands made available for binding to the K | | | The invention also relates to methods of using such compounds and to methods of preparing them. |
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http://wipo.int/cgi-pct/guest/getbykey5?KEY=99/64050.000420&ELEMENT_SET=DECL
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| | Business Wire: WYETH-AYERST LABORATORIES TO INTRODUCE NEW ANTI... @ HighBeam Research |
| | Wyeth-Ayerst Laboratories is a major research-oriented pharmaceutical company with leading products in the areas of women's health care, cardiovascular and metabolic disease therapies, central nervous system drugs, anti-inflammatory agents, vaccines, infant nutritionals and generic pharmaceuticals. | | | With its introduction in the U.S., Cordarone I.V. will now be available in more than 100 countries, The oral form of Cordarone has been on the market in the U.S. since 1985. |
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http://www.highbeam.com/library/doc0.asp?docid=1G1:17118251&refid=ink_tptd_np
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| | Procainamide - Psychology Central |
| | Procainamide(proe-KANE-a-mide) (trade names Pronestyl®, Procan®, Procanbid®) is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias, classified by the Vaughan Williams classification system as class Ia. It blocks open sodium (Na) channels and prolongs the cardiac action potential (outward potassium (K | | | This results in slowed conduction, and ultimately the decreased rate of rise of the action potential, which may result in widening of QRS on electrocardiogram (EKG). |
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http://psychcentral.com/psypsych/Procainamide
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| | Research & Development - Business Opportunities - Safer Antiarrhythmic Agent |
| | The Cardiac Arrhythmias Suppression Trials (CAST) have shown that Class I anti-arrhythmic drugs like Flecainide, Enacinide and Morizicine were associated with increased rather than decreased all-cause mortality and sudden cardiac death, in spite of their ability to suppress arrhythmia. | | | TRC-30X has an improved therapeutic anti-arrhythmic efficacy as compared to pure class II or pure class III agents especially in patients with IHD or impaired LVSF. | | | This has led to a change in focus towards class III and class II anti-arrhythmic agents. |
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http://www.torrentpharma.com/biz_safer.php
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| | Antiarrhythmic increases time to recurrence |
| | Pooled findings from three randomized, placebo-controlled trials with a total of 1,091 patients (958 with AF, atrial flutter or both, and 133 with paroxysmal supraventricular tachycardia) were presented at the XXIst Annual Meeting of the European Society of Cardiology. | | | BARCELONA, Spain - Trials of azimilide (Procter and Gamble), an investigational class III antiarrhythmic agent for prevention of atrial fibrillation (AF) or flutter, revealed efficacy but some safety questions remain unanswered. | | | Data from three trials evaluated efficacy of azimilide for AF, flutter. |
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http://www.cardiologytoday.com/200001/recurrence.asp
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| | [No title] |
| | Bodor N., Farag H., Polgar P. “A Tryptamine Analog with High Affinity to the Heart Tissues in a Potential Antiarrhythmic Agent.” Journal of Pharmacy and Pharmacology, 53(6):889-894 (2001). |
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http://www.cop.ufl.edu/faculty/PC/Bodor.htm
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