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| | Prostate Cancer Resources and Information OncoLink |
 | | Antiandrogens are used in prostate cancer as part of combined androgen blockade (CAB) therapy. | | | This pain may be eased by the use of a pain reliever (such as aspirin or acetaminophen). | | | This type of therapy, also called maximal androgen blockade (MAB), involves a combination of an antiandrogen and an LHRH analog or orchiectomy. |
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http://www.oncolink.upenn.edu/types/article.cfm?c=16&s=57&ss=449&id=5988
(1563 words)
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| | Environmental Health Perspectives: Perinatal exposure to low levels of the environmental antiandrogen vinclozolin ... |
| | In this study we examined the effects of exposure to the antiandrogenic fungicide vindozolin (Vz) on the development of two sex-differentiated behaviors that are organized by the perinatal actions of androgens. | | | Antiandrogens could therefore affect the reproductive success of a wide range of animal species by altering male copulatory behavior. | | | Other antiandrogens such as procymidone, prochloraz, and linuron also affect the development of the BC muscle (Lambright et al. |
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http://www.findarticles.com/p/articles/mi_m0CYP/is_6_113/ai_n14816421
(1247 words)
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| | PCAW - Prostate Cancer Awareness Week - Tolerability of Nonsteroidal Antiandrogens in the Treatment of Advanced ... |
| | In one study of antiandrogen plus medical or surgical castration in patients with advanced prostate cancer, 20 of the patients were originally randomized to nilutamide, but the occurrence of visual side effects in 70% led to an early change to flutamide and the use of flutamide as the antiandrogen in all subsequent patients | | | One of the first antiandrogens to be used in clinical practice as a component of CAB was the steroidal antiandrogen cyproterone acetate. | | | Clinical hepatotoxicity has also been associated with all three nonsteroidal antiandrogens, but there are differences among the three drugs with respect to the nature and severity of the reported conditions. |
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http://www.pcaw.com/info_articles/articles/archives/tolerability.asp
(5880 words)
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| | [No title] |
| | A kit for treating a human male comprising: a means for necrosing prostate tissue; a therapeutically effective amount of an antiandrogen drug; and a means for administering the antiandrogen drug. | | | The means for administering the antiandrogen drug is determined by the manner of delivering the antiandrogen drug. | | | The syringes 86 and 88 may then be used to deliver the ethanol and antiandrogen drug through the needle 25 (shown in Fig. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=03/05889.030123&ELEMENT_SET=DECL
(9083 words)
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| | [No title] |
| | Three series of patients in which various antiandrogen medications were withdrawn were summarized, including data from Kelly and Scher, Nieh and Dawson and McLeod from NCI. | | | Due to the slower elimination halflife of Casodex from the body, the onset of an AAWR may take up to 4 to 8 weeks with this antiandrogen. | | | They defined response by a PSA decline of 50% or more (range 37% to 89% decline. |
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http://www.prostatepointers.org/library/aawr.txt
(1343 words)
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| | Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial |
| | After cessation of antiandrogen therapy at 9 months, women in the flutamide-treated group showed a much slower return of hirsutism compared with those in the spironolactone group. | | | This resistance to antiandrogenic therapy was not correlated with any endocrine or other evaluated parameters. | | | Despite these limitations, it is clear that spironolactone does not offer sufficient antiandrogenic coverage to sustain significant improvement of androgen-sensitive skin disorders and that long-term administration of the drug is limited because of adverse side effects. |
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http://www.fernand.labrie.crchul.ulaval.ca/flabrie/pub/241.htm
(3154 words)
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| | Effect of Androgen Deficiency on the Human Meibomian Gland and Ocular Surface -- Krenzer et al. 85 (12): 4874 -- ... |
| | Influence of antiandrogen therapy on the anterior segment | | | Impact of antiandrogen therapy on the appearance of the tear film meniscus. | | | Secretions (n = 2 samples/individual) were obtained from the left and right eyes of patients (n = 5) taking antiandrogen therapy and their age-related controls (n = 6) and analyzed (n = 10–12 samples/group) on the same column for the content of cholesterol, cholesterol esters, wax esters, diglycerides, triglycerides, and squalene. |
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http://jcem.endojournals.org/cgi/content/full/85/12/4874
(4746 words)
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| | Androgenetic Alopecia - Biopsy-proven cases respond to oral antiandrogen; regrowth possible - DermatologyTimes |
| | Sinclair noted his research is based on the assumptions that androgenetic alopecia and chronic telogen effluvium are distinct diseases and that the former can be differentiated from the latter by biopsy. | | | In addition, we believe this is the first study to objectively demonstrate oral antiandrogen treatment can improve hair density in women with androgenetic alopecia rather than merely halt further loss. | | | He observed that a number of previous studies of oral antiandrogens, including finasteride, failed to find any therapeutic benefit in women thought to have androgenetic alopecia. |
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http://www.dermatologytimes.com/dermatologytimes/article/articleDetail.jsp?id=45681
(789 words)
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| | Re: RU58841, flutamide, or castration: which is more effect... |
| | Marty Saway herself said in her antiandrogen article about the different antiandrogens, that the different antiandrogens are more/less effective in different human conditions. | | | Bryan my point is a very good point because castration has some effects that antiandrogen therapy does. | | | The same applies for castration, which like antiandrogen therapy, reduces androgen. |
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http://www.hairsite5.com/m408ru7/_disc408/00000091.htm
(398 words)
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| | REVIEW ARTICLE |
| | While both objective and symptomatic improvements can be achieved with these approaches, their efficacy in patients who have already been treated with an antiandrogen is not known. | | | An important point to be made about this trial is that it was, by design, a crossover trial that allowed patients with progressive disease who had been on the placebo arm to then add flutamide to their regimen. | | | The efficacy of corticosteroids in the treatment of advanced prostate cancer has long been appreciated and was recently reviewed.[15] The exact mechanism(s) of action are not fully known, but almost certainly there is an anti-inflammatory effect, as evidenced by the capacity of corticosteroids to palliate pain from bone metastases. |
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http://www.prostatepointers.org/prostate/esmall/es2.html
(4241 words)
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| | Hair Loss Forums :: View topic - Treatment of female pattern hair loss with oral antiandrogen |
| | Objectives: To evaluate the efficacy of oral antiandrogen therapy in the management of women with FPHL using standardized photographic techniques (Canfield Scientific), and to identify clinical and histological parameters predictive of clinical response. | | | The only significant predictor was midscalp clinical grade, with higher-scale values associated with a greater response (P = 0·013). | | | High midscalp clinical grade was the only predictor of response identified. |
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http://www.morphollica.com/forums/viewtopic.php?p=1359
(539 words)
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| | When Flutamide Stops Working |
| | In 1998 Chang found molecular evidence of how antiandrogen drugs, which up to a point can halt the disease, under certain conditions can spur prostate-cancer cells to grow. | | | This work, which earned an award from the American Urological Association, is described in the November 1 issue of the journal Cancer Research. | | | Finding out exactly how this happens is a key step to prevention and better treatment. |
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http://www.psa-rising.com/med/hormonal/flut-kinase1102.shtml
(1078 words)
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| | Indications for Antiandrogen Use : BC Cancer Agency |
| | During neoadjuvant therapy prior to radical radiation therapy, an antiandrogen will be added if there is a PSA rise, or if an inadequate PSA response is observed (defined as failure to achieve a PSA of <1 ng/ml after 4 months of adequate therapy as defined by castrate testosterone levels). | | | Maximal androgen blockade utilizing continuous antiandrogen therapy with medical or surgical castration does not significantly prolong survival and is therefore no longer indicated [Crawford et al with SWOG, ASCO proceedings, 1997]. | | | Second-line treatment should not be continued in the face of progressive disease although permanent castration (surgical or medical) is recommended to avoid stimulation by androgens. |
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http://www.bccancer.bc.ca/HPI/CancerManagementGuidelines/Genitourinary/Prostate/Management/SystemicManagementofProstateCancer/IndicationsforAntiandrogenUse.htm
(349 words)
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| | Virginia Prostate Center- Editorial |
| | This observation underscores the necessity to conduct clinical trials in man. In man, both Eulexin and CASODEX are less effective as monotherapy than medical or surgical castration at doses tested so far. | | | However, prospective double blinded randomized clinical trials like the one yielding the results summarized in the figure will continue to provide the pertinent human clinical evidence necessary to physicians and patients for informed treatment decisions. | | | CASODEX does not cross the blood brain barrier in the rat. |
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http://www.evms.edu/vpc/editorial.html
(931 words)
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| | The role of antiandrogen monoth |
| | This study shows that the antiandrogen monotherapy is a temporary alternative to castration in dogs with BPH. | | | The role of antiandrogen monotherapy in the treatment of benign prostatic hyperplasia in the dog | | | Various therapy were proposed as surgical castration and an alternative treatment option is steroidal antiandrogen monotherapy. |
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http://www.ordineveterinarimantova.it/ECM/Bigliardi2.htm
(237 words)
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| | [No title] |
| | Recently, antiandrogens such as hydroxyflutamide (HF) in combination with surgical or medical castration have been widely used for the treatment of prostate cancer. | | | Data were expressed in relative luciferase activity as compared to an internal luciferase positive control. | | | Because this syndrome often leads to the failure of androgen-ablative therapy, it is desirable to develop better antiandrogens without agonist activity. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=03/88927.031030&ELEMENT_SET=DECL
(5695 words)
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| | Women's Hair Loss Treatments |
| | A more complete review of these antiandrogen treatments for women's hair loss can be found in the following article written by Dr. Marty Sawaya, one of the leading researchers in women's hair loss. | | | Because of this, it is vital that you work together with your dermatologist to determine the benefits and drawbacks of each of the following antiandrogens. | | | Antiandrogen Treatment: Since Androgenetic Alopecia is by nature a byproduct of elevated androgen levels in your body, the most common treatment for it is an Antiandrogen. |
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http://www.hairlosstalk.com/research/women/step3wom.htm
(1778 words)
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| | Prostate Cancer (Chemotherapy) Page 2 |
| | Prostate specific antigen (PSA) response was defined as a > 50% fall in PSA from baseline that was maintained for at least 8 weeks. | | | Scher HI, Kelly WK Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021. | | | Mild skin toxicity was observed in 20% of patients. |
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http://www.lef.org/protocols/abstracts/abstr-136a.html
(6800 words)
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| | Hairsite4.com - Viewing topic #22936 - A topical antiandrogen, cyproterone |
| | For a thorough discussion of that, see: "Preliminary Pharmacokinetics and Metabolism of Novel Non-steroidal Antiandrogens in the Rat: Relation of their Systemic Activity to the Formation of a Common Metabolite", Cousty-Berlin et al, J Steroid Biochem Molec Biol, Vol. | | | I did mean that they were not performed in humans but maybe that is not so important. | | | Topically applied sexual steroids in combination with liposomes are as effective as oral antiandrogen medication in acne treatment, while reducing the risk of adverse effects and avoiding high serum cyproterone acetate concentrations. |
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http://www.hairsite4.com/dc/dcboard.php?az=show_topic&forum=8&topic_id=22936&mode=full
(3033 words)
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| | Re: RU58841, flutamide, or castration: which is more effect... |
| | >The creature subject and/or the condition/location as well as the antiandrogen are all very important factors when it comes to the outcome of antiandrogen therapy. | | | You continue to evade the point, which is that even if I'm wrong about castration being the MOST powerful "antiandrogen", it is still right up there NEAR the top. | | | The point is the direct comparison of three different antiandrogenic treatments, and which of those three treatments is the most powerful.>>>< |
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http://www.hairsite5.com/m408ru7/_disc408/00000031.htm
(475 words)
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| | Postgraduate Medicine: Hirsutism in Women |
| | Studies have found that finasteride, flutamide, and cyproterone acetate are equal in effectiveness (29,36-38). | | | Discontinuation of antiandrogen therapy has resulted in recurrence of hirsutism within 6 months (29). | | | However, antiandrogen comparative studies have not been reported, and use of ketoconazole is considered an alternative antiandrogen therapy. |
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http://www.postgradmed.com/issues/2000/06_00/bergfeld.htm
(2863 words)
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| | CIPLADOC - Publications - The ginette times |
| | The development of a formulation containing an antiandrogen, for the treatment of PCOS in women, was based on the following principles: | | | Relative efficacy of antiandrogens in the treatment of acne in hyper-androgenic women5 | | | Androgens are known to cause the development of these skin conditions (SAHA) in PCOS. |
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http://www.cipladoc.com/publications/ginette/ginetttimes_Isu01.htm
(1175 words)
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| | The Canadian Prostate Health Council |
| | The effects of second line antiandrogen therapy in HRPC on survival remain unknown. | | | The antiandrogen withdrawal response occurs in practice 15% to 30% of the time (5,10,11). | | | If a patient has not been on antiandrogens previously, a trial of an antiandrogen may result in a PSA response (>50% decline) in 15% to 80% of cases; however, the median duration of response is only 4 months (15-17). |
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http://www.canadian-prostate.com/ver_01/eng/updates/cpv5no11.htm
(5637 words)
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| | ScienceDaily.com Content: State-of-the-art strategies for managing HRPC |
| | Over the last decade, several investigators have observed that biochemical (PSA) responses as well as symptomatic and objective responses can be achieved in HRPC patients upon withdrawal of antiandrogen therapy. | | | An antiandrogen withdrawal response occurs in approximately 15% to 30% of patients (Table 1). | | | Generally, an antiandrogen response is observed within 2 to 4 weeks after withdrawal of the antiandrogen. |
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http://sciencedaily.mediwire.com/main/Content.aspx?ArticleID=112831
(486 words)
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| | Protocol Information: S9426 |
| | except that specified in SWOG-8894 OR medical castration (Lupron, Zoladex, etc) or surgical castration and antiandrogen, no concomitant chemo, hormone, or biologic response modifier therapy, except LHRH analogues. | | | A Phase II Trial of Antiandrogen Withdrawal In Patients with Progressive Prostate Cancer | | | Pts must be taking an antiandrogen on a regular basis at regis., must have progressive dz at study entry (SWOG-8894 pts must progress by SWOG-8894 criteria), PSA>4 ng/ml, no other therapy w/in 30 days prior to regis. |
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http://www.swog.org/visitors/ViewProtocolDetails.asp?ProtocolID=21
(188 words)
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| | vgn-ext-hidden_Abstract |
| | Preliminary studies assessing dexamethasone (DXM) activity following AAW provided conflicting data on a link between DXM response and prior response to AAW (Urol Int 2000; 65:28; Int J Urol 2001; 8:290). | | | Purpose: Androgen receptor mutations present in prostate cancer patients upon progression to antiandrogen treatment might influence not only the response to antiandrogen withdrawal (AAW) but also to additional treatments such as dexamethasone. | | | There is a trend suggesting that DXM is especially useful in patients unresponsive to AA Associated Presentation(s): |
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http://www.asco.org/ac/1,1003,_12-002636-00_18-0016-00_19-002451,00.asp
(650 words)
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| | What are antiandrogen drugs? - Surgery - DoctorNDTV |
| | Can I have these medicines from a medical shop without prescription? | | | Antiandrogen creams and tablets are available but each have their own side effects and risks. | | | You first have to undergo a proper hormonal evaluation to see the levels of all the different sex hormones and only then any kind of medicines have to be prescribed but after proper consultation with a endocrinologist. |
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http://www.doctorndtv.com/faq/detailfaq.asp?id=6742
(185 words)
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| | HairlossSucks Newsletter - January 2001 |
| | The results of an actual clinical trial on the Kevis product are reviewed here, and the findings may surprise you. | | | Another treatment within this second category of OTC products that make Antiandrogen Claims, is Kevis. | | | Flutamide is discussed pertaining to the quality of its antiandrogenic effects. |
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http://www.hairlosssucks.com/nl12001.htm
(4856 words)
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| | ECCO: Radiotherapy Used to Treat Gynaecomastia and Breast Pain from Antiandrogen Therapy |
| | ECCO: Radiotherapy Used to Treat Gynaecomastia and Breast Pain from Antiandrogen Therapy | | | Title: ECCO: Radiotherapy Used to Treat Gynaecomastia and Breast Pain from Antiandrogen Therapy | | | van Poppel concluded that radiotherapy can be a useful means of treating the symptoms of breast pain and gynaecomastia caused by antiandrogens treatments in patients with prostate cancer. |
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http://www.docguide.com/dg.nsf/PrintPrint/67A8988185C99BAB85256DB2006C478D
(590 words)
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| | Antiandrogen - Wikipedia, the free encyclopedia |
| | Antiandrogens are often indicated to treat severe male sexual disorders, such as hypersexuality (excessive sexual desire) and sexual deviation, specifically paraphilias, as well as use as a antineoplastic agent and palliative, adjuvant or neoadjuvant hormonal therapy in prostate cancer. | | | They are also occasionally used as a male contraceptive agent, to purposefully prevent or counteract masculinisation in the case of transwomen undergoing gender reassignment therapy, and to prevent the symptoms associated with reduced testosterone, such as hot flushes, following castration. | | | The term antiandrogen withdrawal response (AAWR) describes the medical course taken when cancer cells adapt to feed on the antiandrogens rather than androgen, so that treatment must be halted in order to starve those cells thriving on the antiandrogens. |
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http://en.wikipedia.org/wiki/Antiandrogen
(454 words)
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| | Antiandrogen withdrawal in treatment of hormone-refractory PCa, from the Prostate Cancer InfoLink site (preserved at ... |
| | The antiandrogen withdrawal effect was first noted in patients who had received the nonsteroidal antiandrogen flutamide (Eulexin) as part of their combined hormonal therapy. | | | As a consequence it was initially known as the "flutamide withdrawal syndrome." When the PSA level rose to about 20 ng/ml and it was clear that combined hormonal therapy was failing, some physicians would stop the patients' flutamide on the ground that there was no point to continuing this form of therapy. | | | However, it can prolong the period of effective therapy with orchiectomy or LHRH agonists by many weeks or months before the patient's PSA level begins to rise again. |
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http://www.phoenix5.org/Infolink/refractory/antiandrogenwithdrawal.html
(729 words)
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| | PCAW - Prostate Cancer Awareness Week - Long-Term Follow-Up of Four Patients with Advanced Prostate Cancer Treated With ... |
| | Mild antiandrogenic effects and nausea, reversible interstitial pneumonitis in one patient and supraclavicular lymph node enlargement in another patient were the only side effects. | | | Due to different mechanisms of action, one antiandrogen may be effective in the treatment of patients in whom another antiandrogen or antiandrogen withdrawal has failed. | | | Standard treatment of patients who have failed combined androgen blockade is discontinuation of the antiandrogen. |
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http://www.pcaw.com/info_articles/articles/follow-up.asp
(1518 words)
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| | Management of hormone-refractory prostate cancer, from the Prostate Cancer InfoLink site (preserved at Phoenix5) |
| | For the patient who has received combined hormonal therapy with an LHRH agonist and an antiandrogen or with an orchiectomy and an antiandrogen, there is the option of antiandrogen withdrawal (stopping the antiandrogen). | | | This can be achieved either by maintaining the patient on the LHRH agonist or by giving the patient an orchiectomy. | | | It is generally considered that for the patient who begins to fail hormonal therapy there are two immediate possible opportunities, depending upon the form of therapy he has previously been receiving: |
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http://www.phoenix5.org/Infolink/refractory/overview.html
(1388 words)
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| | Early or Delayed Hormonal Therapy Following RP |
| | Immediate antiandrogen therapy after radical prostatectomy and pelvic lymphadenectomy improves survival and reduces the risk of recurrence in patients with node-positive prostate cancer. | | | Because the optimal timing of the institution of antiandrogen therapy for prostate cancer is controversial, we compared immediate and delayed treatment in patients who had minimal residual disease after radical prostatectomy. | | | However, patients receiving combined therapy for more than 3 months had a significantly lower risk of PSA failure than those treated with radical prostatectomy alone. |
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http://www.cancer.prostate-help.org/carphte.htm
(4119 words)
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