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| | Redflagsweekly.com |
 | | Boveri’s aneuploidy theory of cancer is as valid today as it was in 1914. | | | If the medical profession and biotechnology industries were to embrace the aneuploidy theory of cancer, cancer research and the flood of new technologies would at last become biologically and clinically relevant. | | | The fundamental difference between the aneuploidy theory and the reigning gene-mutation theory may be put this way. |
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http://www.redflagsweekly.com/features/rasnickP.htm
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| | Duesberg.com - Book Review - Oncogenes, Aneuploidy and AIDS: A Scientific Life & Times of Peter H. Duesberg. |
| | Oncogenes, Aneuploidy and AIDS has other global themes such as how science should be done, and the prominent role of metaphoric language in popular and professional scientific writing. | | | In this authoritative and elegantly written book, Harvey Bialy exposes a microcosm of today’s medical science in a blistering analysis of the history of modern cancer and AIDS research. | | | In its modern metamorphosis at the hands of Duesberg and his colleagues, this explanation of cancer has begun to receive serious and well deserved attention. |
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http://www.duesberg.com/books/oncogenes.html
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| | Bisphenol A Exposure Causes Meiotic Aneuploidy in the Female Mouse Current Biology, v.13, 1apr03 |
| | Our initial studies were consistent with this expectation; the level of hyperploidy in 415 metaphase II control oocytes was 0.7%. | | | In the course of meiotic studies of mouse oocytes conducted in 1998, we observed a sudden and dramatic change in congression failure levels. | | | Specifically, they are consistent with the hypothesis that endocrine changes affecting oocyte growth underlie human age-related increases in nondisjunction. |
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http://www.mindfully.org/Plastic/Plasticizers/BPA-Mouse1apr03.htm
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| | Detection of aneuploidy for chromosomes 4, 6, 7, 8, 9, 10, 11, 12, 13, 17, 18, 21, X and Y by fluorescence in-situ ... |
| | The aneuploidy found in our OAT patients' gametes does not show | | | An alternative technique for aneuploidy determination is FISH | | | upon the method used to estimate the mean aneuploidy frequency, |
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http://humrep.oxfordjournals.org/cgi/content/full/14/5/1266
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| | Human Sperm Aneuploidy - Genetic and Environmental Causes |
| | Collectively, the results of this study will not only allow us to provide the first quantitative estimate of the role of genetic factors in the incidence of aneuploidy, but could also provide important insight for designing human mutagen screening tests, and providing genetic counseling to families having a child with an aneuploid condition. | | | This will be done by scoring the levels of aneuploidy in human sperm from identical and fraternal twins using a multi-color fluorescence in situ hybridization (FISH) technique. | | | Based on these observations one can postulate that humans are similar to other eukaryotes in that genetic factors cause some cases of nondisjunction. |
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http://www.vipbg.vcu.edu/hg/grant/HD33527.shtml
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| | Aneuploidy, or What're A Few Chromosomes, More or Less?. In the Pipeline: |
| | Where things start to get messy, is when you try to figure out where those changes are coming from, and if they're always associated with cancer. | | | As a medicinal chemist, what I'm interested in are new drug targets. | | | Aneuploidy is found in a wide range of cancer cells - but is it a cause of cancer, or is it an effect? |
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http://www.corante.com/pipeline/archives/2002/08/27/aneuploidy_or_whatre_a_few_chromosomes_more_or_less.php
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| | Intrauterine diagnosis of sex chromosome aneuploidy -- Linden et al. 87 (3): 468 -- Obstetrics & Gynecology |
| | CONCLUSION: Information about sex chromosome aneuploidy can assist obstetricians in providing accurate and comprehensive genetic counseling to parents of affected fetuses, and thereby facilitate the process of making an informed decision about pregnancy management. | | | Points addressed for each of the aneuploid karyotypes included expected phenotype, reproductive competence, developmental risks, and intervention therapies. | | | OBJECTIVE: To provide current information on sex chromosome aneuploidies to obstetricians who encounter such diagnoses and who counsel prospective parents faced with the prenatal diagnosis of a sex chromosome aneuploidy. |
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http://www.greenjournal.org/cgi/content/abstract/87/3/468
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| | Variegated aneuploidy related to premature centromere division (PCD) |
| | Mosaic variegated aneuploidy with microcephaly: a new human mitotic mutant? | | | For comments and suggestions or contributions, please contact us | | | variegated aneuploidy has also been described in patients without PCD and patients with Roberts syndrome |
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http://www.infobiogen.fr/services/chromcancer/Kprones/VariegAneuplPCDID10069.html
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| | Our Stolen Future: Bisphenol A causes aneuploidy |
| | These results open up a dramatic new front on the study of human aneuploidy and point toward possible interventions that may help avoid many human birth defects. | | | Aneuploidy is a condition in which cells have the wrong number of chromosomes. | | | Patricia Hunt and Terry Hassold are two of the world's leading researchers on aneuploidy, and in using animal experiments to understand the causes and impacts of aneuploidy in people. |
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http://www.ourstolenfuture.org/newscience/oncompounds/bisphenola/2003/2003-0401huntetal.htm
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| | Polyploidy and Aneuploidy |
| | The risk of an aneuploid pregnancy leads many individuals and couples to seek genetic counseling; | | | Chromosomal aneuploidy may lead to infertility, pregnancy loss - such as miscarriage or stillbirth - the death of a child, as well as a number of birth defects, genetic syndromes, and /or mental retardation; | | | The aneuploidies most often seen in liveborns tend to be of smaller chromosomes such as 13, 18, 21, or the sex chromosomes. |
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http://www.mc.edu/campus/users/rbuckley/leslie.htm
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| | Our Stolen Future: What is aneuploidy and why is it important? |
| | Our Stolen Future: What is aneuploidy and why is it important? | | | Far less is understood about the biological mechanisms that cause it. | | | One explanation currently under study is that the hormonal environment of the cells surrounding the developing oocyte is involved in directing meiosis and ensuring that it unfolds normally. |
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http://www.ourstolenfuture.org/newscience/oncompounds/bisphenola/2003/2003-0328aneuploidy.htm
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| | Detection of Aneuploidy in Human Spermatozoa of Normal Semen Donors by Fluorescence in Situ Hybridization |
| | Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. | | | The results give background information on the incidence of hyperploid spermatozoa in unexposed men and encourage the use of this novel technique for future studies on genetic effects in men exposed to potentially aneuploidogenic agents. | | | The possible age-related increase in aneuploidy frequencies was assessed. |
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http://ehp.niehs.nih.gov/docs/1996/Suppl-3/lahdetie.html
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| | Isolation of DNA probes specific for rat chromosomal regions 19p, 19q and 4q and their application for the analysis of ... |
| | Laboratory of Health Effects Research, National Institute of Public Health and Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands | | | Isolation of DNA probes specific for rat chromosomal regions 19p, 19q and 4q and their application for the analysis of diethylstilbestrol-induced aneuploidy in binucleated rat fibroblasts | | | Isolation of DNA probes specific for rat chromosomal regions 19p, 19q and 4q and their application for the analysis of diethylstilbestrol-induced aneuploidy in binucleated rat fibroblasts -- de Stoppelaar et al. |
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http://mutage.oupjournals.org/cgi/content/abstract/15/2/165
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| | Aging and aneuploidy in human oocytes and follicular cells. |
| | Previous reports of aneuploidy in human ovary and other somatic cell types suggest that follicular cells behave differently in their response to aging. | | | Aging and aneuploidy in human oocytes and follicular cells. | | | A significant difference between the percentage of granulosa cell aneuploidy in the 25 to 34 years group and all other age groups was found, suggesting a decrease of the tendency for granulosa cells to exhibit aneuploidy in older age groups. |
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http://www.arclab.org/medlineupdates/abstract_3745811.html
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| | Aneuploidy |
| | Somatic aneuploidy and its resulting mosaics are often observed in association with cancer. | | | However, CML patients often show aneuploidy in addition to the Philadelphia chromosome. | | | In another study of 15 patients with intestinal tumors, 12 had cells with abnormal chromosomes, at least some with trisomy for chromosome 8, 13, 15, 17, or 21. |
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http://www.ncbi.nlm.nih.gov/books/bv.fcgi?db=Books&rid=iga.section.3080
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| | Aneuploidy and cancer—the vintage wine revisited - Nature Biotechnology |
| | In light of this, numerous investigators have proposed that "epigenetic mechanisms" might be responsible for drug and multidrug resistance in cancer cells, although before now no specific mechanism had been suggested. | | | Continuous chromosome reassortment, catalyzed by aneuploidy, as Duesberg and his colleagues argue in their most recent paper, is a likely mechanism to explain the high mutation rates of cancer cells. | | | , aneuploidy as the functional genetic basis of cancer passes both these tests in ways that should be of interest to biotechnologists of a variety of stripes. |
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http://www.nature.com/nbt/journal/v19/n1/full/nbt0101_22.html
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| | Aneuploidy and Deletions |
| | Aneuploidy is the condition of having less than or more than the normal diploid number of chromosomes, and is the most frequently observed type of cytogenetic abnormality. | | | The two most commonly observed forms of aneuploidy are monosomy and trisomy: | | | In other words, it is any deviation from euploidy, although many authors restrict use of this term to conditions in which only a small number of chromosomes are missing or added. |
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http://arbl.cvmbs.colostate.edu/hbooks/genetics/medgen/chromo/aneuploidy.html
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| | Changes in Chromosome Number |
| | Studies in the jimsonweed, Datura stramonium, provide a classical example of the effects of aneuploidy and polyploidy. | | | Changes in chromosome number are of two basic types: changes in whole chromosome sets (resulting in a condition of aberrant euploidy) and changes in parts of chromosome sets (resulting in aneuploidy). | | | For example, the study of persons trisomic for only part of human chromosome 21 has made it possible to localize determinants specific to Down syndrome to various regions of chromosome 21, hinting that some aspects of the phenotype might be due to trisomy for single major genes in these chromosomal regions. |
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http://www.ncbi.nlm.nih.gov/books/bv.fcgi?db=Books&rid=mga.section.1179
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| | Peter H. Duesberg |
| | Aneuploidy versus gene mutation hypothesis of cancer: recent study claims mutation, but is found to support aneuploidy. | | | Instability of chromosome structure increases exponentially with degrees of aneuploidy. | | | Aneuploidy, the somatic mutation that makes cancer a species of its own. |
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http://mcb.berkeley.edu/faculty/BMB/duesbergp.html
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| | Guardian Unlimited The Guardian Preventing accidents of growth |
| | Aneuploidy could be responsible for up to 20% of all birth defects. | | | Aneuploidy screening is yet another way to offer hope to couples who take IVF treatment - and to make sure of healthy children when a "test tube" embryo is successfully implanted. | | | In most cases, these cause spontaneous miscarriage - the mother never knows she was pregnant - but in a smaller number of cases, a baby may be born with Down's syndrome or other conditions. |
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http://www.guardian.co.uk/uk_news/story/0,3604,979698,00.html
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| | plating assay for aneuploidy in N. crassa |
| | A new allele of the mei-1 gene was responsible for some of the high aneuploidy. | | | In an attempt to quantify better the effect of methylation on aneuploidy we developed a simple plate assay for aneuploid sexual progeny. | | | This suggestion grew from anecdotal observations of aneuploidy at frequencies higher than was expected based on literature values. |
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http://www.fgsc.net/fgn44/hagemann.html
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| | Aneuploidy Screen - FISH Analysis |
| | The aneuploidy FISH analysis is performed on interphase nuclei. | | | Prenatal aneuploidy screening by FISH can be performed on patients in need of rapid preliminary results due to an abnormal ultrasound examination or advanced gestational age. | | | Please note: Chromosome analysis is required on every patient sample referred for aneuploidy screening by FISH. |
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http://www.bcm.edu/geneticlabs/tests/cyto/aneuploidy.html
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| | Cell & Chromosome Full text MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation ... |
| | Mailhes JB: Important biological variables that can influence the degree of chemical-induced aneuploidy in mammalian oocyte and zygotes. | | | Although numerous hypotheses have been proposed to describe the etiology of aneuploidy in human gametes, the only steadfast association remains maternal age [1,2]. | | | Although these findings support a relationship between disturbed proteasomal activity and chromosome segregation, considerable additional data are needed to further investigate the roles of proteasome-mediated proteolysis and other potential molecular mechanisms on chromosome segregation during OM. |
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http://www.cellandchromosome.com/content/1/1/2
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| | Variation in Chromosome Number |
| | As was mentioned above the effects of aneuploidy are not as severe in plants. | | | The best known condition is probably Down's Syndrome which results from an extra copy of chromosome 21. | | | An important point to remember is that aneuploidy is usually lethal in animals, but can be tolerated to a greater extent in plants. |
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http://www.cc.ndsu.nodak.edu/instruct/mcclean/plsc431/chromnumber/number3.htm
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| | Fluorescence In-Situ Hybridization (FISH-Prenatal-Aneuploidy/Microdeletion), Amniocytes, Chorionic Villi |
| | This test can be used as an adjunct to chromosomal analysis for aneuploidy screening on interphase nuclei and on chromosomes for detection of submicroscopic/cryptic rearrangements in certain congenital disorders. | | | Note: The information contained in this handbook is for use by personnel of University of Iowa Health Care. | | | For submicroscopic rearrangement, preliminary results will be reported in eight days and the final written report will be available in two weeks. |
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http://www.medicine.uiowa.edu/Path_Handbook/handbook/test818.html
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