Androgen antagonist - Medicow
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Topic: Androgen antagonist


  
 Inhibition of Recovery of Spermatogenesis in Irradiated Rats by Different Androgens -- Shetty et al. 143 (9): 3385 -- ...
Weights (wt) of testis (A–D), seminal vesicle (ves.) (E–H), ventral prostate (I–L), and bulbocavernosus (Bulbo cav.) muscle (M–P) in unirradiated control rats, irradiated-only rats, and irradiated (5 Gy) rats treated with GnRH antagonist with or without one of the androgens.
However, in the irradiated rats treated with GnRH antagonists,
Inhibition of Recovery of Spermatogenesis in Irradiated Rats by Different Androgens -- Shetty et al.
http://endo.endojournals.org/cgi/content/full/143/9/3385

  
 Response-Surface Modeling of the Effect of 5{alpha}-Dihydrotestosterone and Androgen Receptor Levels on the Response to ...
to androgen antagonists under conditions of varying androgen
behave as an antagonist at relatively high concentrations and
relationship was significant and antagonistic for the response
http://www.toxsci.oupjournals.org/cgi/content/full/69/2/332

  
 {beta}-Catenin Binds to the Activation Function 2 Region of the Androgen Receptor and Modulates the Effects of the ...
androgen receptor-GST interacted most strongly with the ß-catenin
Therefore, there was demonstrable physical association of androgen
Mulholland also examined the physical interaction of androgen
http://mcb.asm.org/cgi/content/full/23/5/1674

  
 Interaction of Organophosphate Pesticides and Related Compounds with the Androgen Receptor
Of the compounds tested in this study, only methylparathion 3 and ethylfenitrothion 5 demonstrated sufficient AR antagonistic activity to determine potency in dose-shift experiments (Figure 3).
The clear implication is that the X-OH becomes a stronger H-bond donor with the additional CF substituent and therefore, is more likely to enhance the D-ring region interaction necessary to produce agonism.
M interfered with our ability to perform experiments necessary to determine K
http://ehis.niehs.nih.gov/members/2003/5671/5671.html

  
 Growth hormone-releasing hormone (GHRH) antagonists inhibit the proliferation of androgen-dependent and -independent ...
Our findings support the rationale for the clinical use
Thus, GHRH antagonists could be used together with LH-RH agonists or castration as the primary therapy of androgen-dependent
There is a lack of consensus regarding the influence of IGF-I on the etiology of prostate cancer ( 29-34).
http://www.pnas.org/cgi/content/full/100/3/1250

  
 Antiandrogen
Androgens and Anti-Androgen Therapy (Current Topics in Reproductive Endocrinology)
Antiandrogen-Estrogen Therapy for Signs of Androgenization (New Developments in Biosciences ; 3)
Antiandrogens are often indicated to treat severe male sexual disorders, such as hypersexuality (excessive sexual desire) and sexual deviation, specifically paraphilias, as well as use as a antineoplastic agent and palliative, adjuvant or neoadjuvant hormonal therapy in prostate cancer.
http://www.freeglossary.com/Androgen_antagonist

  
 Dynamics of Intracellular Movement and Nucleocytoplasmic Recycling of the Ligand-Activated Androgen Receptor in Living ...
Neumann F 1994 The antiandrogen cyproterone acetate: discovery, chemistry, basic pharmacology, clinical use and tool in basic research.
We have used this approach to explore the intracellular movement
Using p65-GFP as our positive control, we examined the
http://mend.endojournals.org/cgi/content/full/14/8/1162

  
 Suppression of spermatogenesis to azoospermia by combined administration of GnRH antagonist and 19-nortestosterone ...
clinical studies might be the nature of the different androgens,
us to perform a clinical study with the modern GnRH antagonist
Randomized Placebo-Controlled Trial of Androgen Effects on Muscle and Bone in Men Requiring Long-Term Systemic Glucocorticoid Treatment
http://humrep.oupjournals.org/cgi/content/full/16/12/2570

  
 Androgen Antagonist Activity by the Antioxidant Moiety of Vitamin E, 2,2,5,7,8-Pentamethyl-6-chromanol in Human ...
as an effective means of modulating androgenic pathways through
role of androgens in prostate cancer development is emphasized
The activity of androgens is tissue specific and mediated through
http://intl-mct.aacrjournals.org/cgi/content/full/2/8/797

  
 Research
Antagonist: ablative mucosectomy is the procedure of choice to prevent Barrett’s cancer.
A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.
Suet-Fueng Chin was awarded the American Association of Cancer Research-AFLAC Scholar-In-Training award for her contribution to this work, “Isolation and characterization of a novel gene, EMSY, mapped to 11q13.4 found amplified in breast cancers,” April, 2002.
http://www.hutchison-mrc.cam.ac.uk/research.html

  
 Steroid-induced androgen receptor-oestradiol receptor {beta}-Src complex triggers prostate cancer cell proliferation -- ...
Antagonist cross-inhibition of signalling pathway activation by androgen or oestradiol in LNCaP cells
Based on the effects of cell-permeable inhibitors on S-phase
when treated with oestradiol or R1881 and each of the two antagonists
http://embojournal.npgjournals.com/cgi/content/full/19/20/5406

  
 Le Magazine, April 2004 - Report: Resveratrol - Powerful Protection Against Prostate Cancer
Distinct forms of hepatic androgen 6 beta-hydroxylase induced in the rat by indole-3-carbinol and pregnenolone carbonitrile.
Plant-derived 3,3’-diindolylmethane is a strong androgen antagonist in human prostate cancer cells.
Lu R, Serrero G. Resveratrol, a natural product derived from grape, exhibits anti-estrogenic activity and inhibits the growth of human breast cancer cells.
http://www.lef.org/magazine/mag2004/apr2004_report_resver_02.htm

  
 Pharmacology - Medical Encyclopedia
hypnotic, anxiolytic, antipsychotic, antidepressant (including tricyclic antidepressants), anti-emetic, anticonvulsant and antiepileptic, movement disorder drug, CNS stimulant, barbiturate, benzodiazepine, cyclopyrrolone, dopamine antagonist, antihistamine, anticholinergic, emetic, cannabinoids, 5-HT antagonist, amphetamine, monoamine oxidase inhibitor, lithium salt, selective serotonin reuptake inhibitor
(see also Digestive system) antacid, reflux suppressant, antiflatulent, antidopaminergic, antispasmodic, proton pump inhibitor, H2 antagonists, cytoprotectant, prostaglandin analogue, laxative, antidiarrhoeal, bile acids
androgen, antiandrogen, gonadotropin, corticosteroid, growth hormone, insulin, antidiabetic, thyroid hormones, antithyroid drugs, calcitonin, diphosponate, vasopressin analogues
http://www.nursingstudy.com/encyclopedia/Pharmacology.html

  
 Plant derived 3,3'-diindolylmethane is a strong androgen antagonist in human prostate cancer cells -- Le et al., ...
Plant derived 3,3'-diindolylmethane is a strong androgen antagonist in human prostate cancer cells
Plant derived 3,3'-diindolylmethane is a strong androgen antagonist in human prostate cancer cells -- Le et al., 10.1074/jbc.M300588200 -- Journal of Biological Chemistry
Our results indicate that DIM exhibits potent antiproliferative and antiandrogenic properties in androgen dependent human prostate cancer cells.
http://www.jbc.org/cgi/content/abstract/M300588200v1

  
 Natural Hormone Replacement Therapy, Hrt Alternative, Menopause Treatment
Endocrin for Women also contains the correct balance of micro-nutritionals, rare and exotic Chinese Herbs and others such as Saw Palmetto (thought to control androgen excesses in women), plus other cofactors believed to be required by the female body in order to allow healthy physiological hormonal/sexual function and proper balance of biochemical and nutritional necessities.
The micro-nutritional, folliculinum (naturally occurring estrogen) seeks to aid the body in restoring normal estrogen hormonal balance.
Calcitonin (also produced by the thyroid) helps to increase blood calcium levels while promoting the conservation of hard bone matrix, while Parathyroid Hormone (PTH) acts as a direct antagonist; together these two hormones help maintain calcium balance within the bloodstream and keep bones dense and healthy.
http://www.vaxa.com/4005.cfm

  
 Biology of Reproduction -- Sign In Page
Effects of Androgen on Androgen Receptor Expression in Rat Testicular and Epididymal...
Copyright © 2000 by the Society for the Study of Reproduction.
http://www.biolreprod.org/cgi/content/full/63/2/368

  
 NURSA - Nuclear Receptor Signaling Atlas
George F. Allan and Zhihua Sui Therapeutic androgen receptor ligands full text >>
NURSA Hai-Jun Zhou, Sophia Y. Tsai and Ming-Jer Tsai RNA interference in the study of nuclear receptor and coregulator signaling full text >>
http://www.nursa.org/template.cfm?threadId=357

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