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| | Aminoglycoside dosing review |
 | | Controversies in antimicrobial therapy: Pitfalls in monitoring aminoglycoside therapy. | | | Achieving therapeutic serum levels of aminoglycosides early in the course of treatment is critical to therapeutic success. | | | Most strains of enterococcus are resistant to aminoglycosides alone, however when used in combination with penicillins they are often effective in enterococcal endocarditis due to synergistic antimicrobial mechanisms. |
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http://www.rxkinetics.com/amino.html
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| | [Frontiers in Bioscience 4, d9-21, January 1, 1999] |
| | Aminoglycoside kinases which phosphorylate aminoglycosides at positions other than the 3’- and 5"- hydroxyls are widely distributed and some play important roles in conferring clinical resistance to these antibiotics. | | | Thus aminoglycosides are water soluble, basic in nature, and generally positively charged at physiological pH. | | | Since aminoglycoside therapy is primarily administered in a clinical setting, most aminoglycoside resistance determinants have been isolated from nosocomial pathogens. |
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http://bioscience.org/1999/v4/d/wright/fulltext.htm
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| | Aminoglycoside - Wikipedia, the free encyclopedia |
| | Blood drug levels and creatinine are monitored during the course of therapy. | | | Streptomycin was the first effective drug in the treatment of tuberculosis, though the role of aminoglycosides such as streptomycin and amikacin have been eclipsed (because of their toxicity and inconvenient route of administration) except for multiple drug resistant strains. | | | The most frequent use of aminoglycosides is empiric therapy for serious infections such as septicemia, complicated intraabdominal infections, complicated urinary tract infections, and nosocomial respiratory tract infections. |
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http://en.wikipedia.org/wiki/Aminoglycoside
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| | Indian Journal of Medical Research: Aminoglycoside resistance in enterococci isolated from paediatric septicaemia in a ... |
| | Though the treatment regime with vancomycin would be effective but would not be practicable in our country as the drug is expensive and would be beyond the reach of most patients. | | | Over the years, enterococci have become increasingly resistant to antibiotics in terms of both the multiplicity of resistance and the level of resistance to particular drugs', and have emerged as important nosocomial agents due to their colonizing ability and multi drug resistance2,3. | | | Methods: Blood of paediatric cases with a clinical diagnosis of septicaemia was cultured to isolate and identify enterococci. |
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http://www.findarticles.com/p/articles/mi_qa3867/is_200405/ai_n9450693
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| | BioMed Central Full text Aminoglycoside antibiotics and autism: a speculative hypothesis |
| | It should be stressed, however, that at this stage no direct evidence supports our speculative hypothesis and that its main purpose is to initiate development of new ideas that, eventually, would improve our understanding of the pathobiology of autism. | | | For example, aminoglycoside antibiotics are currently being considered for treatment of Duchenne's muscular dystrophy patients who carry a nonsense mutation in the dystrophin gene [8] as well as for the treatment of cystic fibrosis (CF) patients [9]. | | | Thus, our hypothesis that aminoglycoside antibiotics may precipitate autism in genetically susceptible individuals would be supported if a link could be established between amynoglicosides and the onset of autism symptoms, or if it could be found in a post-hoc analysis of existing clinical data from a larger pool of autism patients. |
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http://www.biomedcentral.com/1471-244X/1/5
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| | Preparation of 1-N-[.omega.-amino-.alpha.-hydroxyalkanoyl]aminoglycoside polysilylated antibiotics and products ... |
| | When utilizing such compounds, those skilled in the art will appreciate that any reductive techniques which would reduce the double bond should be avoided. | | | A process of claim 7 wherein the polysilylated aminoglycoside is polysilylated gentamicin B.sub.1 and n is 0. | | | Polysilylated aminoglycosides containing the desired number of silyl groups may be prepared either by utilizing an amount of silylating agent which is only sufficient to add the desired number of silyl groups or by utilizing excess silylating agent to persilylate the aminoglycoside and then partially desilylating by hydrolysis or solvolysis. |
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http://www.freepatentsonline.com/4347354.html
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| | OtoDx Aminoglycoside Hypersensitivity Test |
| | A single dose of aminoglycosides may be ototoxic to these patients. | | | Identifying patients who have this mutation is critical, since the hearing loss can be prevented in most patients if aminoglycoside antibiotics are avoided. | | | Identify hypersensitive patients before they are placed at risk of hearing loss |
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http://www.athenadiagnostics.com/hearingloss/otodx_amino.asp
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| | General Strategies of Pyranmycins against Drug Resistant Microorganisms |
| | However, several problems are often associated with these designs. | | | However, one article did provide a potential strategy for a desirable chemical design that may be used to counteract drug resistance. | | | Numerous efforts have been devoted to the development of new aminoglycosides that may avoid these enzyme-catalyzed modifications, for example, using deoxygenation or fluoro-substitution to avoid the inactivation from phosphorylation or acetylation. |
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http://www.chem.usu.edu/~tchang/Research/details_general_strategies.htm
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| | Aminoglycoside Levels |
| | Levels are indicated to determine if the correct dose is being administered, as per the patient's weight and volume of distribution, and if the dosing interval is appropriate for the patient's renal function. | | | Draw "post" aminoglycoside level precisely 30 minutes post completion of infusion (eg. | | | If an infusion is started just prior to drawing the post level, falsely high peak serum concentrations could be obtained. |
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http://www.lhsc.on.ca/critcare/ucicu/procs/aminolgy.htm
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| | aminoglycoside - definition of aminoglycoside by the Free Online Dictionary, Thesaurus and Encyclopedia. |
| | This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. | | | Any of a group of broad-spectrum antibiotics, such as streptomycin, derived from species of Streptomyces or Micomonospora bacteria and used to treat infections caused by gram-negative bacteria. | | | aminoglycoside - definition of aminoglycoside by the Free Online Dictionary, Thesaurus and Encyclopedia. |
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http://www.thefreedictionary.com/aminoglycoside
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. | | | Energy Citations Database (ECD) Document #6867713 - Factors potentially influencing aminoglycoside use and expenditure |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=6867713
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