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| | Alpha-1-Antitrypsin Deficiency |
 | | In recent studies, a protease-to-protease inhibitor imbalance in patients with alpha 1-antitrypsin deficiency was thought to be a mechanism contributing to the development of chronic pancreatitis. | | | Alpha 1-Antitrypsin deficiency predisposes to pulmonary emphysema, liver cirrhosis and hepatocellular carcinoma. | | | Alpha 1-antitrypsin deficiency is a genetic disorder commonly associated with pulmonary and hepatic injury. |
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http://www.thedoctorsdoctor.com/diseases/a1at_deficiency.htm
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| | Alpha 1 Antitrypsin Disorder |
| | Should doubts or concerns about your own health arise, a medical professional should be contacted to acquire the most accurate and up-to-date information about Alpha 1 Antitrypsin Disorder/Deficiency. | | | Alpha 1 Antitrypsin Disorder/Deficiency is caused by having two of the defective genes (Phenotype ZZ). | | | "Genetic Emphysema" is caused by Alpha 1 Antitrypsin Disorder/Deficiency and effects the lower half of the lungs. |
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http://www.geocities.com/kens_a1ad
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| | Alpha 1-antitrypsin deficiency - Wikipedia, the free encyclopedia |
| | Alpha 1-antitrypsin (AAT) is produced in the liver, and one of its functions is to protect the lungs from the neutrophil elastase enzyme. | | | Alpha 1-antitrypsin deficiency (A1AD or Alpha-1) is a genetic disorder caused by reduced levels of alpha 1-antitrypsin in the blood. | | | Four percent carry the PiZ allele; between 1 in 625 and 1 in 2000 are homozygous. |
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http://en.wikipedia.org/wiki/Alpha_1-antitrypsin_deficiency
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| | Alpha 1-antitrypsin deficiency - Wikipedia, the free encyclopedia |
| | Symptoms of alpha-1 antitrypsin deficiency include shortness of breath, recurring respiratory infections, or obstructive asthma that does not respond to treatment. | | | Alpha 1-antitrypsin (AAT) is produced in the liver, and one of its functions is to protect the lungs from the neutrophil elastase enzyme. | | | Alpha 1-antitrypsin deficiency (A1AD or Alpha-1) is a genetic disorder caused by reduced levels of alpha 1-antitrypsin in the blood. |
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http://en.wikipedia.org/wiki/Alpha_1-antitrypsin_deficiency
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| | Alpha-1 Antitrypsin Deficiency (AATD), Cincinnati Children's Hospital Medical Center |
| | Alpha-1 antitrypsin deficiency is the most common genetic cause of liver disease in children and is the most common genetic disease for which liver transplantation is done. | | | Alpha-1 antitrypsin's job is to protect tissues in the body from being digested by enzymes released from inflammatory cells. | | | Alpha-1 antitrypsin is a protein that is made in the liver and then released into the bloodstream. |
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http://www.cincinnatichildrens.org/svc/alpha/l/liver/diseases/alpha-1-antitrypsin.htm
(954 words)
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| | Alpha-1-Antitrypsin Deficiency |
| | In recent studies, a protease-to-protease inhibitor imbalance in patients with alpha 1-antitrypsin deficiency was thought to be a mechanism contributing to the development of chronic pancreatitis. | | | Alpha 1-Antitrypsin deficiency predisposes to pulmonary emphysema, liver cirrhosis and hepatocellular carcinoma. | | | Alpha 1-antitrypsin deficiency is a genetic disorder commonly associated with pulmonary and hepatic injury. |
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http://www.thedoctorsdoctor.com/diseases/a1at_deficiency.htm
(13359 words)
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| | eMedicine - Alpha1-Antitrypsin Deficiency : Article by Sarah Catherine Lyman Hellewell, MD |
| | In addition, the AlphaNet and the Alpha 1 Foundation, organizations that provide services to patients and a research focus. | | | Remember the 4 stages in the process of helping patients become nonsmokers: (1) Ask about smoking habits; (2) Advise about health effects; (3) Assist the patient with encouragement, education, and nicotine replacement; and (4) Arrange follow-up. | | | A patient could claim that (1) the physician failed to establish a diagnosis even though diagnostic testing was readily available and inexpensive, (2) that appropriate treatment was delayed, (3) that specific educational and counseling opportunities were missed, and (4) that all of these harmed the patient. |
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http://www.emedicine.com/med/topic108.htm
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| | CHEST: Bronchiectasis in patients with alpha-1-antitrypsin deficiency: a rare occurrence? |
| | The clinical symptoms and chest radiographic findings of seven patients with [alpha.sub.1]-antitrypsin deficiency were summarized in Table 1. | | | However, with the wide availability of detection technique, a strong suspicion now exists that the number of patients with asymptomatic [alpha.sub.1]-antitrypsin deficiency is greater than those who develop symptomatic emphysema. | | | The initial diagnosis of [alpha.sub.1]-antitrypsin deficiency, was made by measurement of its concentration in serum by either electrophoresis or nephelometry.[3] The serum [alpha.sub.1]-antitrypsin levels of these seven patients were less than 10 to 15 percent of the normal and often near zero. |
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http://www.findarticles.com/p/articles/mi_m0984/is_n5_v104/ai_14636153
(1173 words)
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| | Alpha 1 Antitrypsin Disorder |
| | Should doubts or concerns about your own health arise, a medical professional should be contacted to acquire the most accurate and up-to-date information about Alpha 1 Antitrypsin Disorder/Deficiency. | | | Alpha 1 Antitrypsin Disorder/Deficiency is caused by having two of the defective genes (Phenotype ZZ). | | | "Genetic Emphysema" is caused by Alpha 1 Antitrypsin Disorder/Deficiency and effects the lower half of the lungs. |
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http://www.geocities.com/kens_a1ad
(988 words)
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| | ALPHA-1 ANTITRYPSIN DEFICIENCY Pediatric Oncall |
| | Individuals diagnosed as alpha-1 antitrypsin deficient should undergo pulmonary function tests, blood gas analysis, chest X-Ray, electrocardiogram and graded exercise test. | | | A: In alpha l deficient persons there is insufficient amount of alpha-1 antitrypsin circulating in the blood, hence the destructive effect of neutrophil elastase goes unchecked and lung tissue is destroyed causing emphysema, asthma, chronic bronchitis and repeated chest infections. | | | Since alpha-1 antitrypsin is the predominant glycoprotein responsible for the a 1 globulin band on routine protein electrophoresis, that band is absent in its deficiency. |
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http://www.pediatriconcall.com/fordoctor/diseasesandcondition/alpha1deficiency.asp
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| | Emphysema |
| | Its technical name is "alpha 1-antitrypsin deficiency (A1AD) related emphysema." It is also sometimes called "early onset emphysema" because it can appear when a person is as young as 30 or 40 years old. | | | A1AD related emphysema is caused by an inherited lack of a protective protein called alpha 1-antitrypsin (AAT). | | | If AAT deficient individuals also smoke, their risk of developing emphysema is much greater than the average person's. |
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http://www.cheshire-med.com/programs/pulrehab/a1atdef.html
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| | Alpha-1-antitrypsin deficiency: what next? -- Stockley 55 (7): 614 -- Thorax |
| | Alpha-1-antitrypsin deficiency is classically associated with the early onset of severe basal emphysema, but is also associated | | | Neutrophil accumulation in the lung in alpha-1-antitrypsin deficiency: spontaneous release of leukotriene B4 by alveolar macrophages. | | | Urinary excretion of desmosine (elastin cross-links) in subjects with Pi ZZ alpha-1-antitrypsin deficiency, a phenotype associated with hereditary predisposition to pulmonary emphysema. |
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http://thorax.bmjjournals.com/cgi/content/full/55/7/614
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| | disability - Alpha-1 Antitrypsin Deficiency |
| | Alpha One Foundation (USA) The Alpha One Foundation is the only national research organization solely dedicated to developing the means to cure and control Alpha1-antitrypsin deficiency and to improve the quality of life for those with the disorder. | | | Alpha-1 National Association (USA)Alpha1 National Association, a non-profit, membership organization, dedicated to improving the lives of individuals and their families affected by alpha1-antitrypsin deficiency. | | | Puerto Rico Alpha 1 Support Group This is the site for the A1AD Spanish Homepage from the Puerto Rico Alpha 1 Support Group organised by Elaine Alfonzo. |
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http://www.ilusa.com/links/disable/Antitryp.htm
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| | Alpha-1-antitrypsin Deficiency |
| | An association for support, education, and research for individuals and their families affected by alpha-1-antitrypsin deficiency (A1AD). |
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http://cpmcnet.columbia.edu/dept/gi/alpha1AT.html
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| | eMedicine - Alpha1-Antitrypsin Deficiency : Article by Sarah Catherine Lyman Hellewell, MD |
| | A small prospective study of 21 patients with AAT deficiency did show improvement in the mean dyspnea score at 3 months after surgery. | | | A patient could claim that (1) the physician failed to establish a diagnosis even though diagnostic testing was readily available and inexpensive, (2) that appropriate treatment was delayed, (3) that specific educational and counseling opportunities were missed, and (4) that all of these harmed the patient. | | | This contrasts with centrilobular emphysema characteristic of cigarette smoking, which predominantly affects the respiratory bronchioles in the central portion of the lobule, initially at the apex of the lung. |
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http://www.emedicine.com/MED/topic108.htm
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| | CHEST: [[Alpha].sub.1]-Antitrypsin Deficiency Therapy |
| | These problems have been largely eliminated since November 1, 1999, by an important and unique drug distribution method: direct patient allocation (Bayer Direct). | | | As recently as 1 year ago, pooled human plasma AAT was in short supply in the United States, with individuals with newly diagnosed conditions precluded from initiating therapy; those already receiving therapy were forced to reduce their doses to amounts likely to be ineffective. | | | Under this system, the drug is distributed directly to each patient and the allocation follows the patient regardless of changes in insurance or location. |
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http://www.findarticles.com/p/articles/mi_m0984/is_3_119/ai_72730246
(1024 words)
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| | Understanding Alpha-1 Antitrypsin Deficiency |
| | Research is being conducted at NIH to learn more about alpha-1 antitrypsin deficiency. | | | Speak with your doctor about alpha-1 antitrypsin replacement therapy | | | Alpha-1 antitrypsin deficiency is an inherited (passed down from parents) disorder that causes low levels of, or no alpha-1 antitrypsin in the blood. |
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http://www.clevelandclinic.org/health/health-info/docs/1100/1138.asp?index=5731
(825 words)
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| | Alpha 1 antitrypsin and cystic fibrosis |
| | Opportunities for the use of aerosolised a 1 anti-trypsin for the treatment of cystic fibrosis. | | | Although anti-proteases remain therapeutically promising much research needs to be completed in this area and their efficacy and safety needs to be fully established before they will become available in routine clinical use. |
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http://www.cysticfibrosismedicine.com/CFdocs/CFText/alph1.htm
(260 words)
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| | ALPHA 1-ANTITRYPSIN DEFICIENCY |
| | A specific enzyme (alpha 1 antitrypsinase) that when absent genetically can result in panacinar emphysema (lung disease) and liver disease. | | | The incidence is approximate 1 in 10,000 people. | | | There is no specific treatment for this condition other than supportive care for the liver and lung complications. |
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http://www.medhelp.org/glossary2/new/GLS_0242.HTM
(92 words)
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| | Chest: Clinical implications of gene therapy for alpha-1-antitrypsin deficiency.@ HighBeam Research |
| | Recent developments in treatment options for patients with [[alpha].sub.1]-antitrypsin ([[alpha].sub.1]AT) deficiency represent a classic example of the direct benefits that can be achieved f rom basic investigation. | | | Chest: Clinical implications of gene therapy for alpha-1-antitrypsin deficiency.@ HighBeam Research | | | Clinical implications of gene therapy for alpha-1-antitrypsin deficiency. |
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http://www.highbeam.com/library/doc0.asp?DOCID=1G1:16669159&refid=ip_encyclopedia_hf
(193 words)
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| | ALPHA-1 ANTITRYPSIN DEFICIENCY Pediatric Oncall |
| | Individuals diagnosed as alpha-1 antitrypsin deficient should undergo pulmonary function tests, blood gas analysis, chest X-Ray, electrocardiogram and graded exercise test. | | | A: In alpha l deficient persons there is insufficient amount of alpha-1 antitrypsin circulating in the blood, hence the destructive effect of neutrophil elastase goes unchecked and lung tissue is destroyed causing emphysema, asthma, chronic bronchitis and repeated chest infections. | | | Since alpha-1 antitrypsin is the predominant glycoprotein responsible for the a 1 globulin band on routine protein electrophoresis, that band is absent in its deficiency. |
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http://www.pediatriconcall.com/fordoctor/diseasesandcondition/alpha1deficiency.asp
(1257 words)
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| | Environmental Occupational, and Genetic Risk Factors for Alpha-1 Antitrypsin Deficiency |
| | Participants agreed that new research initiatives in these areas represent an opportunity to benefit both basic science, through enhanced understanding of gene-environment interaction, and the AAT deficiency patient community, through innovative new approaches to disease management and treatment. | | | The goals of this workshop were to a) assess the present state of knowledge regarding environmental and occupational risk factors contributing to AAT deficiency morbidity and mortality, b) define future research needs in this area, and c) explore collaborative opportunities to advance understanding of risk factors affecting the progression of AAT deficiency-related disease. | | | Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. |
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http://ehp.niehs.nih.gov/docs/2003/6325/abstract.html
(429 words)
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| | Alpha-1 antitrypsin deficiency |
| | Alpha-1 antitrypsin replacement therapy is not currently available in the UK. | | | Specific therapy for alpha-1 antitrypsin deficiency is difficult. | | | Alpha-1 antitrypsin deficiency is thought to be one of the commonest genetic deficiencies in Caucasian (or white) populations. |
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http://www.netdoctor.co.uk/diseases/facts/alpha1def.htm
(1848 words)
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| | Understanding Alpha-1 Antitrypsin Deficiency |
| | Research is being conducted at NIH to learn more about alpha-1 antitrypsin deficiency. | | | Speak with your doctor about alpha-1 antitrypsin replacement therapy | | | Alpha-1 antitrypsin deficiency is an inherited (passed down from parents) disorder that causes low levels of, or no alpha-1 antitrypsin in the blood. |
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http://www.clevelandclinic.org/health/health-info/docs/1100/1138.asp?index=5731&src=news
(825 words)
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| | disability - Alpha-1 Antitrypsin Deficiency |
| | Alpha One Foundation (USA) The Alpha One Foundation is the only national research organization solely dedicated to developing the means to cure and control Alpha1-antitrypsin deficiency and to improve the quality of life for those with the disorder. | | | Alpha-1 National Association (USA)Alpha1 National Association, a non-profit, membership organization, dedicated to improving the lives of individuals and their families affected by alpha1-antitrypsin deficiency. | | | Puerto Rico Alpha 1 Support Group This is the site for the A1AD Spanish Homepage from the Puerto Rico Alpha 1 Support Group organised by Elaine Alfonzo. |
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http://www.ilusa.com/links/disable/Antitryp.htm
(415 words)
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| | ALPHA-1 - ANTITRYPSIN DEFICIENCY |
| | Gastroenterology Consultants, PC Alpha-1 - antitrypsin deficiency is a hereditary disease that may lead to hepatitis and cirrhosis. | | | The protein alpha-1 - antitrypsin is a substance made in the liver. | | | It plays an important role preventing the breakdown of enzymes in various organs of the body. |
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http://www.gastro.com/html/liverdisease/antitrypsin_deficiency.shtml
(530 words)
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| | Open Directory - Health: Conditions and Diseases: Genetic Disorders: Alpha-1 Antitrypsin Deficiency |
| | Alpha 1 Awareness Alliance - A site where members of the medical professions and the public can find information about alpha 1-antitrypsin- deficiency. | | | Understanding Alpha-1 Antitrypsin Deficiency - Information on signs and symptoms of this disorder, as well as risk factors and treatment. | | | MedicineNet - An Alpha-1 antitrypsin deficiency article with details such as what it is, normal lungs and how they work, smoking, risk factors, how it is inherited, signs, symptoms and treatment. |
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http://dmoz.org/Health/Conditions_and_Diseases/Genetic_Disorders/Alpha-1_Antitrypsin_Deficiency
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| | Alpha-1 Antitrypsin Deficiency / Family Village Library |
| | The mission of this association is to improve, through support, education, and research, the quality of life of those affected by alpha1-antitrypsin deficiency. | | | It is a powerful tool for support and education concerning Alpha-1 Antitrypsin Deficiency Disorder. | | | Available services include: offering support and education to patients with A1AD, the general public, and the medical community; acting as a clearinghouse of information to assist healthcare professionals and individuals with A1AD; acting as an advocate for people with A1AD; and aiding in support of research of A1AD. |
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http://www.familyvillage.wisc.edu/lib_alph.htm
(144 words)
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| | Amazon.com: Books: Alpha 1 - Antitrypsin Deficiency (Lung Biology in Health and Disease) |
| | Clinical and basic research on the comparatively new lung disease, alpha 1-antitrypsin deficiency. | | | Alpha 1-antitrypsin (1AT) deficiency is a common hereditary disorder characterized by a reduction of serum levels of 1AT, emphysema, and liver disease (1-8). | | | Providing a broad overview of basic and clinical aspects of alpha 1-antitrypsin (a 1AT) deficiency, this up-to-date reference discusses the complex pathobiological processes underlying the pathogenesis of a1AT deficiency, describes the a1AT gene and its promoter, and details specific therapies to prevent the major clinical manifestations of the disorder. |
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http://www.amazon.com/exec/obidos/tg/detail/-/0824788486?v=glance
(416 words)
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| | CHEST: Lung transplantation for alpha-1-antitrypsin deficiency emphysema - Alpha-1-Antitrypsin: A World View |
| | Between 1963 and 1973, 36 patients underwent lung transplantation in medical centers throughout the world.[1,2] COPD was the primary indication for transplantation in nine of these patients and was a coexistent condition in five or six others. | | | The moribund condition of some recipients before the operation undoubtedly contributed to the disappointing results, but respiratory failure, pneumonia, rejection, and airway complications were the main causes of death. | | | The differences in survival appear relatively early and probably reflect the greater complexity of transplantation for diseases such as pulmonary hypertension and cystic fibrosis. |
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http://www.findarticles.com/p/articles/mi_m0984/is_n6_v110/ai_18999146
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