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| | World Intellectual Property Organization |
 | | It is also an object of the invention to provide agonist therapy in which analgesically effective blood levels of the opioid agonist are maintained over an extended period of time, while also selectively enhancing the analgesic potency of the opioid agonist. | | | opioid agonists have been used to provide pain relief to patients. | | | The slow release of the drugs is brought about through controlled diffusion out of the matrix and/or selective breakdown of the coating of the preparation or selective breakdown of a polymer matrix. |
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http://www.wipo.int/ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/58447.010816&ELEMENT_SET=DECL
(9196 words)
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| | Varenicline: An 42 Nicotinic Receptor Partial Agonist for Smoking Cessation |
| | More recently, efforts to combine nicotine replacement therapy with the nicotinic antagonist mecamylamine were more successful. | | | These were maximal effects for (-)-cytisine and varenicline (1), demonstrating partial agonist behavior. | | | Moreover, varenicline (1) effectively blocks the nicotine response both in vivo and in vitro, demonstrating the appropriate antagonist profile. |
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http://pubs.acs.org/cgi-bin/jcen?jmcmar/48/i10/html/jm050069n.html
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| | The operational model of agonist action |
| | You may measure a "response" even in the absence of agonist. | | | However, Black and Leff derived a "practical" or "operational" equation that encompasses the behavior of all of these unknown biochemical cascades. | | | This form of the equation makes it clear that the maximum effect seen with a particular agonist is not Effect |
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http://www.curvefit.com/operational_model_.htm
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| | Synonyms of agonist |
| | usage: a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist" |
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http://www.infoplease.com/thesaurus/agonist
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| | Winds of Change.NET: Answers About The Agonist |
| | Regarding The Agonist, what he did was wrong. | | | Sure doesn't sound like a great idea to me. Nor can I pass information on to them without saying truthfully where I got it. | | | After all, isn't failing to do that what he got in trouble for? |
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http://www.windsofchange.net/archives/003307.php
(1474 words)
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| | Agonist Watch : |
| | Our picture of our favorite gris-gris woman has practically melted, which really sucks, since we can't remember how to get another one at the moment. | | | He also pointed out the email referenced in a link belowalludes to a conversation between Howard Kurtz of the Washington Post and Kelly. | | | Jim Basset puts "his wrong doing in the same camp as running a gnutella client" |
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http://wcnbdhusicf.blogspot.com
(5827 words)
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| | Lesson 7 |
| | This relationship addressed the observation that some drugs do not elicit a maximal response even at apparently maximal receptor occupancies. | | | Therefore, the agonistic response to a drug that occurs at concentrations different than those that produce antagonism, cannot be ascribed to interaction of the drug with a single receptor. | | | Stephenson introduced the concept of efficacy as a property of the drug to explain the nonlinear relationships between occupancy and response, and for the ability of a group of drugs (partial agonists) to produce equal responses while occupying different proportions of the receptor population. |
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http://www.med.unc.edu/wrkunits/2depts/pharm/receptor/lesson7.htm
(1079 words)
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| | FET without an GnRH Agonist |
| | Based on these results, the authors concluded that, among patients with functioning ovaries, an FET protocol that does not use a GnRH agonist may be appropriate and effective. | | | In an attempt to increase the predictability of FET cycles, many programs have experimented with using a GnRH agonist (e.g., Lupron) in their protocol, as patients using a GnRH agonist are far less likely to experience a spontaneous LH surge. | | | The purpose of the current study was to investigate one such protocol. |
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http://www.inciid.org/article.php?cat=treatment&id=190
(563 words)
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| | Palatin Technologies' Small Molecule Melanocortin Agonist.. |
| | Melanocortin (MC)-based therapeutics are currently one of the fastest growing areas of pharmaceutical research and development. | | | The Company is currently conducting clinical trials with its lead drug candidate, PT-141, an MC receptor agonist, for the treatment of male and female sexual dysfunction. | | | The data were presented today at the 2005 Keystone Symposia on Obesity: Molecular Physiology and Genetics of the Control of Body Weight. |
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http://www.amex.com/newsDetails/CmnNewsDet.jsp?id=XpressFeed_NewsDetails_1107174654985.html
(637 words)
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| | [No title] |
| | Notice how the response does not increase above 50 % even after giving large concentrations of isoproterenol. | | | However, the drug is a partial agonist so it will increase heart rate. | | | 1) To illustrate this interaction, we will study the effect of a partial agonist on the ability of isoproterenol to increase heart rate. |
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http://www.mc.uky.edu/Pharmacology/instruction/pha824mp/partial.htm
(619 words)
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| | The Agonist thoughtful, global, timely |
| | The Agonist - Here is Monday's best from the practitioners of the dismal science: | | | The Agonist - Tom Watson informs us that Judy buried the lead in her own article. | | | Miller generally would not discuss her interactions with editors, elaborate on the written account of her grand jury testimony or allow reporters to review her notes. |
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http://www.agonist.org
(2144 words)
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| | The Agonist Project For International relations |
| | I feel that economics, is another key (underrepresented) component to our national security. | | | As many of you know I announced the Agonist project for international relations. | | | Topic: The Agonist Project For International relations (Read 514 times) |
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http://discuss.agonist.org/yabbse/index.php?board=2;action=display;threadid=18139
(192 words)
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| | Agonist definition - Medical Dictionary definitions of popular medical terms |
| | Dopamine agonists mimic the effects of dopamine in the brain by stimulating dopamine receptors with a lower risk of the uncontrollable and irreversible dyskinesias often associated with levodopa therapy. | | | For example, in treating Parkinson disease, the long-used drug levodopa can cause uncontrollable, jerky body movements called dyskinesias that can inhibit a person's ability to function. | | | Agonists and antagonists are key agents in the chemistry of the human body and important players today in pharmacology. |
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http://www.medterms.com/script/main/art.asp?articlekey=7835
(333 words)
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| | Physiology Basics: Receptors |
| | The term commonly used is efficacy - in other words, if two drugs occupy the same number of receptors on a tissue, and one drug elicits a greater biological response than the other drug (by its action on the receptor) then that drug has greater efficacy. | | | Such theories have to explain the various effects of not only agonists, but also antagonists, partial agonists, and even inverse agonists. | | | Add an inverse agonist instead, and you see the opposite of the effect - for example benzodiazepines like diazepam cause sedation and drowsiness through their agonist effects at the GABA |
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http://www.anaesthetist.com/physiol/basics/receptor/receptor.htm
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| | Cogprints - Optimal Agonist/Antagonist Combinations Maintain Receptor Response by Preventing Rapid beta1-Adrenergic ... |
| | Although the scientific rationale for this remains unclear and because the agonist and antagonist drugs may be administered together in some medical circumstances, it is important to understand the early interactions of beta-agonist drugs with the beta-antagonist drugs at the level of the initial receptor response. | | | Because desensitization is a serious side effect, the beta1-adrenergic agonist drugs are no longer the logical treatment for heart failure and have been replaced by antagonist drugs represented by metoprolol (Lopressor). | | | This study was designed to test a receptor model and a method to optimize agonist/antagonist combinations calculated to prevent receptor desensitization, which has relevance for many important drugs, including the b1-adrenergic agonist drugs. |
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http://cogprints.org/4093
(700 words)
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| | Combined Ipratropium and Beta 2 - Adrenergic Receptor Agonist in Acute Asthma |
| | Nadrenergic receptor agonist (§-agonist) therapy for severe asthma exacerbations (forced expiratory volume in 1 second [FEV | | | Should inhaled anticholinergics be added to beta2 agonists for treating acute childhood and adolescent asthma? | | | Combined Ipratropium and Beta 2 - Adrenergic Receptor Agonist in Acute Asthma |
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http://www.familypractice.com/journal/2000/v13.n01/1301.08/art-1301.08.htm
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| | CD Baby: AGONIST: Infinite Resistance |
| | Aaron's admiration for David Bowie, Jimi Hendrix, and Dream Theater has much to do with the bands prog and emo elements. | | | From the beginning, the band's members all contributed their personal influences and styles to the music to begin the evolution of Agonist's unique sound. | | | This twelve-track freshman effort is mostly an exercise in the heavier side of classic rock with the metal, prog, and psychodelic elements that would later come to define Agonist budding on several tracks throughout the disc. |
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http://www.cdbaby.com/cd/agonist
(686 words)
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| | Agonist-Induced Increase in Apparent {beta} -adrenergic Receptor Size -- Limbird and Lefkowitz 75 (1): 228 -- ... |
| | However, the low concentrations of agonist that are capable of altering apparent receptor size and the sensitivity of this effect to guanyl nucleotides suggest that these phenomena may be intimately involved in eliciting the physiological effects of ß -adrenergic catecholamines at the molecular level. | | | The precise molecular interactions responsible for the agonist-induced increase in apparent ß -adrenergic receptor size are still unresolved. | | | This article has been cited by other articles in HighWire Press-hosted journals: |
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http://www.pnas.org/cgi/content/abstract/75/1/228
(375 words)
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| | Agonist-antagonists |
| | It is commonly used with acepromazine to provide a relatively long acting sedation and analgesia in dogs and cats after painful procedures. | | | It seems to have some agonist properties at the mu receptor and antagonist activity at the kappa receptor but the onset of action is rather slow, 20 to 30 minutes. | | | Buprenorphine is used for analgesia when a longer duration of action (6-8 hours) is required. |
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http://cvm.msu.edu/services/aneth/docs/analges/agonist-.htm
(230 words)
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| | Li, Lintong (2002-07-22) The tethered agonist approach to mapping ion-channel proteins: toward a structural model for ... |
| | Li, Lintong (2002-07-22) The tethered agonist approach to mapping ion-channel proteins: toward a structural model for the agonist-binding site of the nicotinic acetylcholine receptor. | | | The tethered agonist approach to mapping ion-channel proteins: toward a structural model for the agonist-binding site of the nicotinic acetylcholine receptor | | | In Chapter 3, we report evidence that the N-terminal extracellular domain of nAChR is closely related to acetylcholine binding protein (AChBP), whose crystal structure was solved in May 2001. |
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http://etd.caltech.edu/etd/available/etd-07312002-120928
(485 words)
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| | Wired News: Noted War Blogger Cops to Copying |
| | Kelley's plagiarism was first brought to light by a blogger who goes by the name General Roy. | | | "Many postings on the (Agonist) pages I looked at are word-for-word verbatim," said Stratfor chief analyst Matthew Baker. | | | Later that day, The Agonist reported a number of specifics about the capture of the An Najaf airfield. |
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http://www.wired.com/news/conflict/0,2100,58346,00.html
(669 words)
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| | The Agonist and bloggers' ethics - CyberJournalist.net - The Agonist and bloggers' ethics |
| | The Agonist and bloggers' ethics - CyberJournalist.net - The Agonist and bloggers' ethics | | | Some people seem to be taking a view like this: "OK, The Agonist plagiarized material from another site - but he aggregated war news conveniently, quickly, and accurately all the same. | | | 0 Weblogs reference 'The Agonist and bloggers' ethics' |
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http://www.cyberjournalist.net/news/000144.php
(1188 words)
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| | The Agonist: Thoughtful, global, plagiarized? (Signifying Nothing: Tell 'em about it, Joe-Joe!) |
| | He has since apologized and, according to him, worked out an arrangement with Stratfor that allows him to continue posting some of their proprietary content. | | | The Agonist has been a high-profile, high-visibility blogger since the start of the war. | | | The Agonist, has apparently plagiarized some of his war updates from Stratfor’s paid reports. |
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http://blog.lordsutch.com/?entryid=363
(920 words)
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| | The Agonist and bloggers' ethics |
| | ABSTRACT: After the publisher of a popular war Weblog admitted to plagiarizing from other news sites, the blogging community began debating the ethical responsibility of bloggers. | | | You are here: Fairness.com > Resources > The Agonist and bloggers' ethics | | | QUOTE: The blogging community has been abuzz with talk about the actions of Sean-Paul Kelley, a Texas blogger who admitted to plagiarizing Stratfor for his popular war blog, The Agonist. |
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http://www.fairness.com/resources/one?resource_id=5662
(153 words)
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| | Strategic Armchair Command |
| | The Agonist, which has skyrocketed to popularity in part by offering inside breaking news about the war before the mainstream media reports it, and which has been touted by the likes of Will Femia's Weblog Central and Nick Denton.org, appears to have an 'interesting' relationship with Stratfor and its US-Iraq War site. | | | While perhaps in one out of twenty times Stratfor is credited, 95% of the time, the reports somewhat infer they are inside information directly from its own sources. | | | In fact, approximately 50% of The Agonist's posts, almost all those not credited to a mainstream media source -- which are the ones that have mostly made it shine -- appear to be identical to Stratfor sitrep, intel, and combat reports! |
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http://radio.weblogs.com/0120495/2003/04/01.html
(1340 words)
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| | The Agonist: Debunking The Debunkers |
| | It seems he's caught Snopes changing some things around on their site. | | | Why did the cache of this page mysteriously disappear? | | | In the meantime The Agonist has sent this email to Google: |
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http://www.agonist.org/archives/007922.html
(399 words)
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| | The Agonist: Moderation Policy |
| | Warn you by private message and give you a chance to rectify the situation. | | | Not allowed: abusing or vilifying other agonist members. | | | If you violate any of the Agonist rules, a moderator may: |
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http://agonist.got.net/moderation.html
(314 words)
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| | The Agonist |
| | May 13The Agonist - Yesterday I spent some time going over this post and re-reading the pertinent sections of Henry A. Kissinger's "A World Restored." Here's what I came up with: Read more at scoop.agonist.org |
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http://www.redtailcanyon.com/default.aspx?content=showChannel&nodeId=24348
(2563 words)
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