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| | Adrenoleukodystrophy |
 | | Further studies are needed to determine the long-term safety and effectiveness of this treatment for individuals with Adrenoleukodystrophy. | | | Genetic counseling for families of people with Adrenoleukodystrophy is suggested. | | | Symptoms often first appear in boys between the ages of 4 and 8 years and may include: behavioral changes such as poor memory; increasingly poor school work; loss of emotional control; and/or dementia. |
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http://hw.healthdialog.com/kbase/nord/nord43.htm
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| | Prognosis of Adrenoleukodystrophy - WrongDiagnosis.com |
| | Prognosis for Adrenoleukodystrophy: Prognosis for patients with ALD is generally poor except after successful bone marrow transplantation. | | | About prognosis: The 'prognosis' of Adrenoleukodystrophy usually refers to the likely outcome of Adrenoleukodystrophy. | | | Naturally, such forecast issues are by their nature unpredictable. |
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http://www.wrongdiagnosis.com/a/adrenoleukodystrophy/prognosis.htm
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| | MedlinePlus Medical Encyclopedia: Adrenoleukodystrophy |
| | This is a very significant development but one that can be adequately treated with corticosteroids. | | | The child may live in this condition for as much as ten years until death occurs. | | | Updated by: Daniel Rauch, MD, FAAP, Director, Pediatric Hospitalist Program, Associate Professor of Pediatrics, NYU School of Medicine, New York, NY. |
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http://www.nlm.nih.gov/medlineplus/ency/article/001182.htm
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| | Adrenoleukodystrophy; "Lorenzo's Oil" and Teaching |
| | Moser, H.W. Adrenoleukodystrophy: phenotype, genetics, pathogenesis and therapy. | | | Moser, H.W. Clinical and therapeutic aspects of adrenoleukodystrophy and adrenomyeloneuropathy. | | | Uziel, G., Bertini, E., Bardelli, P., Rimoldi, M., Gambetti, M. Experience on therapy of adrenoleukodystrophy and adrenomyeloneuropathy. |
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http://carbon.cudenver.edu/~bstith/loren.htm
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| | X-Linked Adrenoleukodystrophy |
| | Moser HW (1997) Adrenoleukodystrophy: phenotype, genetics, pathogenesis and therapy. | | | The authors' work is supported by the National Institutes of Health and the Food and Drug Administration. | | | Takano H, Koike R, Onodera O, Sasaki R, Tsuji S (1999) Mutational analysis and genotype-phenotype correlation of 29 unrelated Japanese patients with X-linked adrenoleukodystrophy. |
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http://www.geneclinics.org/profiles/x-ald/details.html
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| | Adrenoleukodystrophy and Myelin: Where's the Connection? |
| | In the last decade there has been some amazing research done in conjunction with this disease and the few others who, like it, occur as a result from the breakdown or loss of myelin in the brain. | | | Because they have gathered such an extensive group of researchers who share similar ideas and beliefs concerning the practice both of medicine and research, they have been able to make progress at a very promising pace. | | | According to the fact sheet put out by the National Institute of Health in Bethesda, MD in 1997, "ALD is a rare, genetic disorder characterized by the breakdown or loss of the myelin sheath surrounding nerve cells in the brain and progressive dysfunction of the adrenal gland" (1). |
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http://serendip.brynmawr.edu/bb/neuro/neuro99/web3/Kirbyglatkowski.html
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| | Adrenoleukodystrophy - Wikipedia, the free encyclopedia |
| | This condition occurs with a similar frequency in all populations. | | | The prevalence of X-linked adrenoleukodystrophy is approximately 1 in 20,000 individuals. | | | This page was last modified 23:06, 2 May 2006. |
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http://en.wikipedia.org/wiki/Adrenoleukodystrophy
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| | The Human and Scientific Story of Adrenoleukodystrophy |
| | At the age of five, a normally happy, well-behaved Lorenzo Odone began to have problems focusing in school and controlling his emotions. | | | Testing revealed that Lorenzo had childhood cerebral x-linked adrenoleukodystrophy (ALD), a rare, basically ignored genetic demyelinating disease that shows symptoms between the ages 5 and 12 (3). |
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http://serendip.brynmawr.edu/bb/neuro/neuro00/web1/Arnaudo.html
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| | MedlinePlus: Leukodystrophies |
| | Genetics Home Reference: X-linked adrenoleukodystrophy (National Library of Medicine) | | | Adrenoleukodystrophy (National Institute of Neurological Disorders and Stroke) - Short Summary |
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http://www.nlm.nih.gov/medlineplus/leukodystrophies.html
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| | Adrenoleukodystrophy |
| | MCW HealthLink - Adrenoleukodystrophy: Information sheet from the Medical College of Wisconsion about Adrenoleukodystrophy. | | | Gourt :: Health :: Conditions and Diseases :: Neurological Disorders :: Demyelinating Diseases :: Leukodystrophy :: Adrenoleukodystrophy | | | Human and Scientific Story of Adrenoleukodystrophy: Description, discussion of treatments, and links. |
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http://www.gourt.com/Health/Conditions-and-Diseases/Neurological-Disorders/Demyelinating-Diseases/Leukodystrophy/Adrenoleukodystrophy.html
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| | [No title] |
| | Adrenoleukodystrophy Foundation - Obtain educational material, research, contacts and memorials. | | | BOTW Directory - Health > Conditions and Illness > Genetic Disorders > Adrenoleukodystrophy - Submit Site | | | Loren's Adrenoleukodystrophy Page - Features information about the disorder and examines the relationships between the condition and a popular film, Lorenzo's Oil. |
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http://botw.org/top/Health/Conditions_and_Illness/Genetic_Disorders/Adrenoleukodystrophy
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| | Adrenoleukodystrophy (ALD): A Case Study
Using the Film "Lorenzo's Oil" |
| | This is an interdisciplinary study that could be used on several levels and with a variety of classes, for example: Biology, Chemistry, Genetics, Ethics, Health, Neurology, Nutrition, Pathology, Psychology and Anatomy. | | | Adrenoleukodystrophy (ALD) is a rare inherited metabolic disorder characterized by the loss of the fatty covering (myelin sheath) on nerve fibers within the brain and progressive degeneration of the adrenal gland. | | | The basic defect is the impaired capacity to degrade very long chain fatty acids that are found in the blood plasma and tissues of the body. |
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http://www.accessexcellence.org/AE/AEPC/WWC/1994/adreno.html
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| | Adrenoleukodystrophy - ALDS |
| | Both are characterized by varying degrees of adrenal involvement and demyelination. | | | Adrenoleukodystrophy (ALD) is a serious genetic disorder which progressively affects the adrenal gland, along with the white matter of the nervous system. | | | The term adrenoleukodystrophy encompasses two distinct genetic disorders; X-linked adrenoleukodystrophy and neonatal ALD. |
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http://www.alds.org.au/ald.html
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| | Demyelinating Diseases |
| | Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. | | | Adrenoleukodystrophy - Alexander Disease - Canavan Disease - Demyelinating Diseases - Diffuse Cerebral Sclerosis of Schilder - Leukodystrophy, Globoid Cell - Leukodystrophy, Metachromatic - Multiple Sclerosis - Neuromyelitis Optica - | | | Devic's disease: bridging the gap between laboratory and clinic [Gold and Linington] - Brain, Jul 2002 |
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http://www.mic.ki.se/Diseases/C10.314.html
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| | X-linked adrenoleukodystrophy - United Leukodystrophy Foundation |
| | Other clinical names you might encounter for X-ALD include: | | | What are the clinical symptoms of X-linked adrenoleukodystrophy? | | | There are a wide range of clinical severities of X-linked adrenoleukodystrophy (X-ALD), and these have been classified into six broad categories: childhood cerebral ALD, adolescent cerebral ALD, adult cerebral, adrenomyeloneuropathy, adrenal insufficiency-only, and symptomatic heterozygotes. |
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http://www.ulf.org/types/XALD.html
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| | Treatment of Adrenoleukodystrophy |
| | There are many experimental therapies being used, but no concrete information is available yet about the effectiveness of bone marrow transplants, gene therapy or “Lorenzo’s Oil” combined with a low fat diet. | | | Having low levels of very long chain fatty acids in the body will help to slow and minimize the effects of the disease by preventing them from accumulating in the body. | | | Lorenzo’s Oil is a mixture of oleic and erucic acids, that helps to normalize the levels of very long chain fatty acids in boys with adrenoleukodystrophy. |
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http://www.ikm.jmu.edu/Buttsjl/ISAT493/Adrenoleukodystrophy/aldtreatment.html
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| | Adrenoleukodystrophy |
| | Radiologically selective visual pathway involvement in adult onset cerebral adrenoleukodystrophy | | | T2 Relaxation Measurements in X-linked Adrenoleukodystrophy Performed Using Dual-echo Fast Fluid-attenuated Inversion Recovery MR Imaging | | | Diffusion Tensor Imaging in Cases of Adrenoleukodystrophy: Preliminary Experience as a Marker for Early Demyelination? |
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http://www.gfmer.ch/genetic_diseases_v2/gendis_detail_list.php?cat3=13
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| | Adrenoleukodystrophy |
| | Adrenoleukodystrophy (Addison-Schilder syndrome, Fanconi-Prader syndrome, Siemerling-Creutzfeldt syndrome, bronze Schilder disease) |
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http://www.bdid.com/adrenoleukodystrophy.htm
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| | MedFriendly.com: Adrenoleukodystrophy |
| | The increased ACTH level is what causes increased skin coloring in some patients. | | | NEONATAL ADRENOLEUKODYSTROPHY: This form of ALD is often abbreviated as NALD. | | | Even early on in the disease, the brains of patients with ALD may have significant abnormalities even if the signs of the disease are mild. |
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http://www.medfriendly.com/adrenoleukodystrophy.html
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| | Kennedy Krieger Institute: Adrenoleukodystrophy (ALD) |
| | Adrenoleukodystrophy (ALD) is a rare, genetic disorder characterized by the breakdown or loss of the myelin sheath surrounding nerve cells in the brain and progressive dysfunction of the adrenal gland. | | | Neonatal adrenoleukodystrophy (NALD) is a disorder that is totally distinct from X-linked adrenoleukodystrophy. | | | ALD is one of a group of genetic disorders called the leukodystrophies that cause damage to the myelin sheath, the fatty covering, on nerve fibers in the brain. |
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http://www.kennedykrieger.org/kki_diag.jsp?pid=1069
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| | Kennedy Krieger Institute: Hugo W. Moser, M.D. |
| | Patients are physician-referred and included only if preliminary clinical and laboratory studies have shown that the patient has a peroxisomal disorder. | | | Neurogenetics Research and Peroxisomal Disease Diagnostic Laboratory This unit, which is headed by Dr. Hugo Moser, is concerned with the study, diagnosis and treatment of peroxisomal disorders, including X-linked adrenoleukodystrophy, the Zellweger syndrome, neonatal adrenoleukodystrophy, infantile Refsum syndrome and rhizomelic chondrodysplasia punctata. | | | There are 15 peroxisomal disorders that lead to mental retardation and nervous system disabilities. |
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http://www.kennedykrieger.org/kki_staff.jsp?pid=1841
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| | Adrenoleukodystrophy AHealthyMe.com |
| | Adrenoleukodystrophy is a rare genetic disease characterized by a loss of myelin surrounding nerve cells in the brain and progressive adrenal gland dysfunction. | | | Adrenoleukodystrophy (ALD) is a member of a group of diseases, leukodystrophies, that cause damage to the myelin sheath of nerve cells. | | | You are here: Home > Health A to Z > Adrenoleukodystrophy |
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http://www.ahealthyme.com/topic/topic100586401
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| | Museum of Pathology |
| | These specimens are from a patient suffering from adrenoleukodystrophy. | | | Adrenoleukodystrophy is a familial progressive demyelinating disorder affecting the cerebral white matter. | | | There is no clear line of demarcation between normal and abnormal white matter. |
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http://museum.med.monash.edu.au/spec/index.cfm?spec=WQ4
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| | Adrenoleukodystrophy |
| | A description of adrenoleukodystrophy is provided, and available treatments, prognosis, and current research activities are all discussed. | | | This condition is one of a group of genetic disorders called the leukodystrophies, that results in damage to the myelin sheath (the fatty covering on the nerve cells in the brain) which Lorenzo's oil, a mixture of glyceryl trioleate and glyceryl trierucate, attempts to reduce. | | | This Web resource on adrenoleukodystrophy (a rare genetic disorder) is produced by the National Institute of Neurological Disorders and Stroke (NINDS). |
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http://omni.ac.uk/browse/mesh/D000326.html
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| | GeneReviews: Adrenoleukodystrophy, X-Linked |
| | GeneReviews are expert-authored, peer-reviewed, current disease descriptions that apply genetic testing to the diagnosis, management, and genetic counseling of patients and families with specific inherited conditions. | | | Your browser does not support HTML frames so you must view Adrenoleukodystrophy, X-Linked in a slightly less readable form. |
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http://www.geneclinics.org/profiles/x-ald
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| | Help with ALD (adrenoleukodystrophy) |
| | Adrenoleukodystrophy (ALD) is a rare, genetic disease for which there is no effective treatment or cure. | | | All of the proceeds of the Run For ALD will benefit the Kennedy Krieger Institute, a non-profit hospital dedicated to treating, preventing and ultimately curing ALD and other neurogenetic diseases. | | | It is best known as the disease portrayed in the 1993 movie "Lorenzos Oil" starring Nick Nolte and Susan Sarandon. |
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http://www.run4ald.org
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| | BBC - Health - Conditions - Adrenoleukodystrophy |
| | A steady deterioration in brain function may then occur as the disease follows a relentless course towards death, which usually occurs within ten years of onset of symptoms and often much sooner. | | | Without the myelin sheath the nerves don't work as they should.There are several different types of ALD, which may be inherited in two different ways. | | | Adrenoleukodystrophy (ALD) is a rare inherited disorder that leads to progressive brain damage, failure of the adrenal gland, and eventually death. |
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http://www.bbc.co.uk/health/conditions/adrenoleukodystrophy1.shtml
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| | Adrenoleukodystrophy, X-linked |
| | X-linked adrenoleukodystrophy (X-ALD) is a rare disorder characterized by progressive demyelinization of the central nervous system (CNS) (brain and/or spinal cord) and peripheral adrenal insufficiency (Addison's disease). | | | The minimum frequency of hemizygotes identified in the United States would be 1:42,000 and that of hemizygotes plus heterozygotes 1:16,800. |
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http://www.orpha.net/static/GB/adrenoleukodystrophy.html
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| | Facts on X-Linked Adrenoleukodystrophy (X-ALD) |
| | X-ALD is a peroxisomal storage disease whereby abnormal function of peroxisomes leads to the accumulation of very long-chain fatty acids (VLCFA) in tissues of the body, especially the brain and the adrenal glands. | | | Stephan Kemp, Ph.D and Hugo Moser, M.D. Adrenoleukodystrophy (X-ALD) is a serious progressive, genetic disorder, which affects the adrenal glands and the white matter of the nervous system. | | | It was first recognized in 1923 and has been known as Schilder's disease and sudanophilic leukodystrophy. |
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http://www.x-ald.nl/facts.htm
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| | Adrenoleukodystrophy |
| | Never disregard professional medical advice or delay in seeking it because of something you have read on The Tyler Medical Clinic Site! | | | Adrenoleukodystrophy (ALD) is a rare X-linked disease characterized by accumulation of long fatty acid chains in the adrenal glands, brain, plasma and fibroblasts. |
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http://www.tylermedicalclinic.com/adrenoleukodystrophy.htm
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| | What is Adrenoleukodystrophy? |
| | Adrenoleukodystrophy (ALD) falls into a group of disorders known as leukodystrophies. | | | This disease is diagnosed with a plasma test to determine the level of very long chain fatty acids, regardless of symptomatology. | | | The figure above shows the location of the Adrenoleukodystrophy gene on the x chromosome. |
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http://www.ikm.jmu.edu/Buttsjl/ISAT493/Adrenoleukodystrophy/aldintro.html
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| | PharmGKB: Adrenoleukodystrophy |
| | This work is supported by the NIH/NIGMS Pharmacogenetics Research Network and Database (U01GM61374). | | | ALD (Adrenoleukodystrophy); ALDs (Adrenoleukodystrophy); Adrenoleukodystrophies; Adrenoleukodystrophies, X-linked; Adrenoleukodystrophy, X-linked; Adrenomyeloneuropathies; Adrenomyeloneuropathy; Schilder Addison Complex; Schilder-Addison Complex; X linked Adrenoleukodystrophy; X-linked Adrenoleukodystrophies; X-linked Adrenoleukodystrophy |
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http://www.pharmgkb.org/do/serve?objId=PA443288&objCls=Disease
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| | Role of ALDP (ABCD1) and Mitochondria in X-Linked Adrenoleukodystrophy -- McGuinness et al. 23 (2): 744 -- Molecular ... |
| | Role of ALDP (ABCD1) and Mitochondria in X-Linked Adrenoleukodystrophy -- McGuinness et al. | | | Asheuer, M., Bieche, I., Laurendeau, I., Moser, A., Hainque, B., Vidaud, M., Aubourg, P. Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy. | | | Oezen, I., Rossmanith, W., Forss-Petter, S., Kemp, S., Voigtlander, T., Moser-Thier, K., Wanders, R. J., Bittner, R. E., Berger, J. Accumulation of very long-chain fatty acids does not affect mitochondrial function in adrenoleukodystrophy protein deficiency. |
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http://mcb.asm.org/cgi/content/abstract/23/2/744
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| | References |
| | Boehm, Corinne D., Moser, Ann B., and Moser, Hugo W. “X-Linked Adrenoleukodystrophy.” |
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http://www.ikm.jmu.edu/Buttsjl/ISAT493/references.html
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