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| | ADRENERGIC RECEPTOR REGULATION IN POSTTRAUMATIC STRESS DISORDER ::::::::::: Welcome to Child Trauma Academy ::::::::::: |
 | | Adrenergic and noradrenergic systems and their receptors are involved in the mediation and recovery from the observed behavioral changes following IS (Anisman et al. | | | Brain noradrenergic and adrenergic systems and their receptors, then, play key roles in a variety of important affective and behavioral changes associated with the stress response. | | | These changes are felt to reflect homeostatic changes resulting from the increased activity of the adrenergic and noradrenergic systems mediating the CNS stress response (Stolk et al. |
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http://www.childtrauma.org/CTAMATERIALS/adrenergic.asp
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| | Beta-blockers for heart failure-time to think the unthinkable? -- Davies and Bashir 92 (11): 673 -- QJM |
| | Pharmacological and morphological aspects of the isoproterenol induced lesion in the rat Langendorff heart. | | | Hasenfuss G, Holubarsch C, Hermann H-P, Astheimer K, Pieske B, Just H. Influence of the force-frequency relationship on haemodynamics and left ventricular function in patients with non-failing hearts and in patients with dilated cardiomyopathy. | | | Jahns R, Boivin V, Siegmund C, Inselmann G, Lohse MJ, Boege F. Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. |
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http://qjmed.oupjournals.org/cgi/content/full/92/11/673
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| | BBC NEWS Health 'Made to measure' heart drug hope |
| | However, Professor Liggett says, in some patients, adding in a beta-blocker does little to help and may actually cause more problems through side-effects, or through interfering with the other medications the individual is on. | | | Professor Liggett predicts that by 2010, it will be possible for doctors to tailor an individual patient's treatment according to their genes. | | | Half of the patients were given a beta-blocker called bucindolol and the other half received a dummy drug. |
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http://news.bbc.co.uk/go/newsFeedXML/moreover/-/1/hi/sci/tech/4277597.stm
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| | Genes Influence How Heart Failure Patients Respond To Drugs |
| | So UF researchers set out to determine whether variations in an individual's genetic code might influence how well a patient tolerates beta-blockers once therapy is begun. | | | "This raises the possibility that the clinical response to at least some beta-blocking agents can be substantially enhanced by selection of patients who have the 'hyper-responsive' Arg389Arg beta-1 adrenergic receptor gene variant," Bristow said. | | | The research findings suggest that the gene variants that determine initial tolerability to beta-blockers and the heart's structural and functional response to the treatment also might affect outcomes long term, said Michael Bristow, M.D., Ph.D., co-director of the University of Colorado Cardiovascular Institute in Aurora, Colo. |
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http://www.sciencedaily.com/releases/2005/05/050508210347.htm
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| | A beta 2 Adrenergic Receptor Signaling Complex Assembled with the Ca2+ Channel Cav1.2 -- Davare et al. 293 (5527): 98 ... |
| | Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates {beta}-1 Adrenergic Receptor Endocytosis through Different Pathways. | | | Spatial and Temporal Regulation of RACK1 Function and N-methyl-D-aspartate Receptor Activity through WD40 Motif-mediated Dimerization. | | | Direct Interaction and Functional Coupling between Metabotropic Glutamate Receptor Subtype 1 and Voltage-sensitive Cav2.1 Ca2+ Channel. |
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http://www.sciencemag.org/cgi/content/abstract/293/5527/98
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| | Alpha2-adrenergic receptor blockade |
| | Alpha2-adrenergic receptor blockade markedly potentiates duloxetine- and fluoxetine-induced increases in noradrenaline, dopamine, and serotonin levels in the frontal cortex of freely moving rats | | | In contrast, the selective alpha2-adrenergic receptor antagonists atipamezole (0.16 mg/kg, s.c.) and 1-(2-pyrimidinyl)piperazine (1-PP; 2.5 mg/kg, s.c.) increased levels of NAD (by 180 and 185%, respectively) and DA (by 130 and 90%, respectively), without affecting 5-HT levels. | | | Concomitant alpha2-adrenergic receptor antagonism and inhibition of monoamine uptake may thus provide a mechanism allowing for a marked increase in the efficacy of AD agents. |
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http://www.biopsychiatry.com/alp2ant.htm
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