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| Â | Aquatic Life Criteria: Silver - U.S. EPA |
 | | CerioFAST™: An acute toxicity test based on Ceriodaphnia dubia feeding behavior. | | | Development and assessment of acute bioassay techniques for the littoral rotifer, ( Philodina acuticornis). | | | Relationships among observed metal concentrations, criteria, and benthic community structural responses in 15 streams. |
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http://www.epa.gov/waterscience/criteria/silver/silref.html
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| Â | F. Acute Toxicity Studies: The Search for Refinement Endpoints |
| | Schlede's approach to the determination of humane endpoints in acute oral toxicity testing was to examine the results of numerous tests performed in various laboratories. | | | The method of utilizing specific clinical signs in the determination of humane endpoints and progress in the development of alternative methods is discussed. | | | Eva Schlede's paper discusses the issue of humane endpoints as a method of refinement in acute oral toxicity, skin and eye irritation and corrosion and skin sensitization studies. |
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http://www.hsus.org/ace/11440
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| Â | Toxicity of Pesticides |
| | A living system can be many things: a human body, or parts of the body (such as the lungs or the respiratory system); a pond, a forest and those creatures that live there. | | | Understand what toxicity is and how it affects humans. | | | However, due to some differences between the way our bodies and the bodies of animals work, results of animal tests cannot always be applied or "extrapolated" to humans. |
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http://pmep.cce.cornell.edu/facts-slides-self/core-tutorial/module04
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| Â | eMedicine - Toxicity, Vitamin : Article by Mark Rosenbloom, MD, MBA, FACEP |
| | Acute toxicity effects are prostaglandin-mediated and include flushing, pruritus, wheezing, vasodilation, headache, increased intracranial blood flow, and headache. | | | One study of acute or chronic overdoses, with more than 40,000 exposures, reported 1 death and 8 major adverse outcomes. | | | A study of 40,000 acute and chronic overdoses reported only 1 fatality and 8 major adverse outcomes. |
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http://www.emedicine.com/emerg/topic638.htm
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| Â | Case Report: Visual Toxicity in Acute Isoniazid Overdose |
| | Chronic therapy leads to peripheral neuropathies, toxic encephalopathy, ataxia, stupor, memory impairment, toxic psychosis, optic neuritis and optic atrophy (4). | | | While acute depletion of pyridoxine is the etiology of seizures, chronic depletion is thought to produce peripheral neuropathies through nerve demyelination and a softening of the grey matter in the spinal cord. | | | In 1959, Money documented a patient who was on isoniazid therapy and developed acute retrobulbar neuropathy with visual blurring which responded to pyridoxine (16). |
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http://www.ijmt.net/4_3/4_3_21.htm
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| Â | Smoking addiction Quit smoking Toxicity of cytisine [www.tabex.net] |
| | When applied orally to mice for 45 days and to rats and dogs for 180 days, Tabex does not cause any toxic changes in the hemopoiesis and in the internal organs, except different degrees of dystrophic changes in the liver. | | | When given orally to rats for 30 and 90 days, Tabex shows no toxic changes in the hemopoiesis and internal organs of the experimental animals. | | | The chronic toxicity was studied on Wistar rats and on dogs treated orally with aqueous solution for the rats and substance in the feed - for dogs, at the following terms and doses: |
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http://www.bpg.bg/tabex/toxicity.html
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| Â | THE MERCK MANUAL, Sec. 22, Ch. 302, Drug Toxicity |
| | For many drugs, a frequency of 1 in 10,000 or 1 in 50,000 may be clinically relevant and can be determined only with postmarketing surveillance after NDA approval. | | | However, the role of in vitro studies in drug development has expanded. | | | At the end of the study, the animals are killed, and pathologic examinations are performed to identify affected organs. |
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http://www.merck.com/pubs/mmanual/section22/chapter302/302a.htm
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| Â | eMedicine - Toxicity, Mercury : Article by Barry Diner, MD |
| | The blood level correlation with chronic methylmercury toxicity is more variable. | | | If no such history exists, clinical suspicion can be confirmed by laboratory analysis. | | | Documented hypersensitivity; peanut allergy; concurrent iron supplementation therapy; methylmercury toxicity |
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http://www.emedicine.com/emerg/topic813.htm
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| Â | In Vitro Page |
| | The scientific workshop, In Vitro Methods for Assessing Acute Systemic Toxicity, was held October 17-20, 2000, at the Hyatt Regency Crystal City Hotel in Arlington, VA. Background review materials have been archived. | | | Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity, NIH Publication No. 01-4499. | | | Transmittal Letter on Acute Systemic Toxicity from Dr. Kenneth Olden to the Agency Heads (with visible link boxes to enclosures) [ PDF ] |
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http://iccvam.niehs.nih.gov/methods/invitro.htm
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| Â | digoxin |
| | - kayexalate therapy has little role to play during the acute management phase (* the total body potasium is not increased in acute digoxin intoxication - digoxin only causes a redistribution of potassium from the intracellular to the extracellular compartment) | | | - a patient with an acute ingestion requires therapy to decrease further GI absorption of the drug, selective management of cardiac arrhythmias and Fab fragment therapy prn | | | - potassium is only used in the management of arrhythmias associated with chronic digoxin toxicity in order to maintain the serum potassium > 3.5 meq/L, and preferably in the high-normal range |
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http://www.emguidemaps.homestead.com/files/digoxin.html
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| Â | Development of Alternatives to Animal Use for Safety Testing and Hazard Assessment |
| | Shouldn’t we focus on them ?”) and the methodologies which will be used to assess toxicity (“Significant doubt exists about the validity of animal testing results when applied to humans,” he said. | | | As historian John Parascandola has noted, “although pressure from the animal rights movement has played a key role in stimulating interest in alternatives to animal experimentation and testing, scientific and economic considerations have also figured prominently in these developments.” (Parascandola, 1991). | | | Traditional toxicology is based upon the assumption that physiological processes in mammals are much the same and that a substance which is toxic to a small mammal like a rodent is likely to prove equally toxic to a human being, if the quantity of the substance is adjusted according to body weight and other factors. |
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http://www.solutions-site.org/artman/publish/article_67.shtml
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| Â | Treating acute and/or chronic metal toxicity - CB Post - Oct.11, 2003 |
| | This acute toxic metal exposure could have pushed chronically affected personnel over their total body burden. | | | Blood test for metals at this point in time is also useless. | | | Chelation therapy using appropriate agents is then used to treat the chronic metal toxicity. |
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http://www.safecleanup.com/jag/p1011032.htm
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| Â | SchoolIPM - Technical Information - Pesticides - Toxicitiy of Pesticides |
| | Acute toxicity may be measured as acute oral (through the mouth), acute dermal (through the skin) and acute inhalation (through the lungs or respiratory system). | | | These adverse effects may range from slight symptoms such as headaches to severe symptoms like coma, convulsions, or death. | | | Poisons work by altering normal body functions, consequently toxicity can occur in as many ways as there are body functions. |
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http://schoolipm.ifas.ufl.edu/techp14.htm
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| Â | Introduction - Methods for Measuring the Acute Toxicity of Effluents and Receiving Waters to Freshwater and Marine ... |
| | 1.7 These methods are restricted to use by, or under the supervision of, analysts experience in the use or conductof, and interpretation of data from, aquatic toxicity tests. | | | Each analyst must demonstrate the ability to generate acceptable test results with the methods using the procedures described in this methods manual. | | | Data can also be used to predict potential acute and chronic toxicity in the receiving water, based on the LC50 and appropriate dilution, application, and persistence factors. |
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http://www.epa.gov/waterscience/WET/disk2/intro2.htm
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| Â | PPD Preclinical Cancer Research: Acute Toxicity and PK |
| | Bioavailability and acute toxicology evaluation are critical components of early preclinical drug development. | | | Piedmont Research Center offers basic services in bioavailability, pharmacokinetics and toxicity analysis. | | | PPD Preclinical Cancer Research: Acute Toxicity and PK Advanced |
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http://www.ppdi.com/PPD_DIS_2_1_4.htm
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| Â | Oncologic Acute Toxicity Unit: Development of a new tool in the oncologic clinical practice. |
| | Oncologic Acute Toxicity Unit: Development of a new tool in the oncologic clinical practice. | | | Objetives: To analyze the characteristics of patients who contact the OATU and their outcome. | | | Introduction: We have developed an Oncologic Acute Toxicity Unit (OATU) to attend specifically and promptly the acute symptoms secondary to chemotherapy. |
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http://www.esmo.org/reference/abstracts00/psc/680.htm
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| Â | Alternative tests with better results and less use of animals |
| | This approach requires the dimensions of a transnational integrated project, and the involvement of prominent toxicity research groups in the European Union, strict supervision and the introduction of the regulating community and professional handling. | | | Its aim is to develop a simple and robust in vitro testing strategy for the prediction of acute human systemic toxicity, which can substitute the tests for acute animal toxicity currently used as regulators. | | | The aim is to reduce the time for and cost of studies for the development of new active elements and reduce the number of experimental animals. |
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http://www.innovations-report.com/html/reports/life_sciences/report-35268.html
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| Â | Woody Ornamentals - Acute Toxicity & Effects |
| | As little as a few drops of such a material taken orally could be fatal to a 150-pound person. | | | In addition, the effect of the chemical as an irritant to the eyes and skin is examined under laboratory conditions. | | | Acute toxicity of a pesticide refers to the chemical’s ability to cause injury to a person or animal from a single exposure, generally of short duration. |
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http://woodypestguide.cas.psu.edu/Pesticides/Acute.html
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| Â | Cancer Issues-The Fallout From Breast Cancer Therapy |
| | Indeed, little is known about the pattern of recovery after the end of treatment," write the study authors. | | | "In general, oncology clinicians prepare women for the acute toxicity of breast cancer treatments, but clinicians have had only limited data on the physical and psychosocial sequelae of primary treatments. | | | These are particularly pronounced in women who've had chemotherapy or mastectomies, says the study in the March 3 issue of the Journal of the National Cancer Institute. |
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http://www.cancerissues.org/ms/news/517659/main.html
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| Â | Terms Beginning With "A" |
| | Adaptation: Changes in an organism's physiological structure or function or habits that allow it to survive in new surroundings. | | | Acute Exposure: A single exposure to a toxic substance which may result in severe biological harm or death. | | | Acute exposures are usually characterized as lasting no longer than a day, as compared to longer, continuing exposure over a period of time. |
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http://www.epa.gov/OCEPAterms/aterms.html
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| Â | Acute Toxicity in mice and rats |
| | Drugs are given by acute systemic administration, i.e. | | | The acute toxicity is assessed on the basis of a 24-hour, 48-hour and 7-day mortality. | | | Test to determine the acute toxicity of a compound. |
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http://www.sams-dodd.com/tds/T-G00154-00000.htm
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| Â | Acute toxicity |
| | You have come across our Acute toxicity article. | | | Unfortunately, work on Acute toxicity has not finished and we are still working on the contents. | | | Please come back to this page in the future when more definitive content is published on Acute toxicity. |
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http://www.bambooweb.com/articles/a/c/Acute_toxicity.html
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| Â | Acute Toxicity Working Group |
| | In Vitro Methods for Assessing Acute Systemic Toxicity | | | Acute toxicity studies provide information on the health hazards likely to arise from short term exposure and are usually an initial step in the evaluation of the toxic characteristics of a substance. | | | The committee pointed out that acute toxicity tests are helpful in classifying and labeling hazards, in guiding treatment on acute intoxication, standardizing biological products, providing comparative information on dose response, and serving as a standard for evaluating alternative test procedures. |
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http://iccvam.niehs.nih.gov/groups/atwg.htm
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| Â | MST-16, a Novel Bis-dioxopiperazine Anticancer Agent, Ameliorates Doxorubicin-induced Acute Toxicity While Maintaining ... |
| | Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan | | | induced by anthracyclines in an acute phase (31, 35, 36). | | | Articles by Yoshida, M. Articles by Sugimachi, K. Clinical Cancer Research Vol. |
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http://clincancerres.aacrjournals.org/cgi/content/full/5/12/4295
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| Â | EPA: Pesticides - Test Guidelines/Acute Toxicity |
| | Crosswalk of Paragraphs: OPPTS 870.1100 versus OECD 425 Acute Oral Toxicity: Up-and-Down Procedure - (13 KB, PDF) | | | > International Issues > Test Guidelines/Acute Toxicity - Acute Oral Toxicity Up-And-Down-Procedure | | | The acute oral toxicity portion of this page is being updated. |
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http://www.epa.gov/oppfead1/harmonization
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| Â | Re-examination of acute toxicity of fluoride |
| | In acute fluoride poisoning, diarrhea and abdominal pain are regarded as minor transient side effects, and only severe symptoms and critical conditions in which patients need hospitalization are counted among toxic symptoms of fluoride. | | | Fluoride mouth rinsing is considered a drug treatment that should be strictly controlled. | | | SUMMARY: The acute toxic dose of fluoride has been believed to be 2 to 5 mg or 8 mg/kg of body weight. |
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http://www.fluoride-journal.com/97-30-2/302-89.htm
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| Â | The MSDS HyperGlossary: Acute toxicity |
| | Evaluation of acute toxicity data should include the relationship, if any, between the exposure of animals to the test substance and the incidence and severity of all abnormalities, including behavioral and clinical abnormalities, the reversibility of observed abnormalities, gross lesions, body weight changes, effects on mortality, and any other toxic effects. | | | Acute toxicity differs from chronic toxicity, which describes the adverse health effects from repeated (lower level) exposures to a substance over a longer period (months to years). | | | Acute toxicity helps workers understand the health consequences from a single exposure to a chemical. |
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http://www.ilpi.com/msds/ref/acutetoxicity.html
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| Â | Chronic toxicity |
| | Chronic toxicity is a property of a substance that has toxic effects on a living organism, when that organism is exposed to the substance continuously or repeatedly. |
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http://www.worldhistory.com/wiki/c/chronic-toxicity.htm
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| Â | Low acute toxicity with prostate IRMT |
| | Using the Radiation Therapy Oncology Group toxicity scale, 39% of patients were diagnosed with grade 1, and 27% with grade 2 gastrointestinal toxicity during the study. | | | Research supports the use of intensity-modulated radiotherapy (IMRT) as a primary treatment for prostate cancer, with low levels of acute toxicity. | | | In addition, grade 3 genitourinary toxicity was diagnosed in 7% of patients during IRMT, with grade 1 and grade 2 symptoms occurring in 36% and 47% of patients, respectively. |
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http://hcp.prostateline.com/news/3274.aspx
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| Â | Determination of Acute Reference Exposure Levels for Airborne Toxicants March 1999 ACUTE TOXICITY SUMMARY HYDROGEN ... |
| | Acute effects from inhalation of HCN are characterized by altered sense of smell, headache, tachypnea, nausea, loss of coordination, loss of consciousness, palpitations, convulsions, respiratory distress, and asphyxiation... | | | Acute Toxicity to Humans Cyanide toxicity results from cytochrome oxidase inhibition which prevents cellular utilization of oxygen. | | | Acute Toxicity Exposure Levels (for a 1-hour exposure) Inhalation reference... |
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http://smealsearch2.psu.edu/47130.html
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| Â | Acute and Chronic Toxicity Testing of Ammonia with Hyalella azteca (Amphipod) |
| | Hyalella azteca were exposed under flow-through conditions to measured concentrations of ammonia in a flow-through system for 96 hours to determine the acute toxicity of ammonia to Hyalella. | | | Acute and Chronic Toxicity Testing of Ammonia with Hyalella azteca (Amphipod) | | | Secondly, the chronic toxicity of ammonia was determined by exposing Hyalella azteca for 40-days to measured concentrations of ammonia in a flow-through system. |
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http://www.glec-online.com/gl03016.htm
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| Â | 423. Natamycin (Pimoricin(R)) (WHO Food Additives Series 10) |
| | Repeated patch tests on 102 patients with various forms of eczema failed to demonstrate any sensitizing potential with pimaricin (Malten, 1968). | | | Special studies on degradation products (1) Acute toxicity Recent studies indicate that similar breakdown products of pimaricin occur in simulated gastric juice, 0.5% citric acid and urine and it appears likely that breakdown products in stored apples | | | Summary of the results of acute and chronic toxicity tests. |
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http://www.inchem.org/documents/jecfa/jecmono/v10je09.htm
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| Â | 192: Acute toxicity due to adenovirus versus cell-mediated immune response to the transgene in human argininosuccinate ... |
| | Acute toxicity due to adenovirus versus cell-mediated immune response to the transgene in human argininosuccinate synthetase gene transfer. | | | 192: Acute toxicity due to adenovirus versus cell-mediated immune response to the transgene in human argininosuccinate synthetase gene transfer. | | | In conclusion, our data suggest toxicity associated with the FGV, rather than neoantigencity of the intracellular transgene, as an important determinant for gene transfer in urea cycle disorders in our animal models. |
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http://www.faseb.org/genetics/ashg02s/f192.htm
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| Â | Acute toxicity |
| | The duration of an acute aquatic toxicity test is generally 4 days or less and mortality is the response measured. | | | For clarity, the length of the exposure (short, medium, or long) and the nature of the effect end point (lethal or nonlethal) should be specified. |
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http://al.umces.edu/biol615/lecture1/sld026.html
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| Â | Hepatitis B Basic Study on Immune Function, Acute Toxicity |
| | The dissection and histological study on the major organs also showed no toxic reactions or pathological changes. | | | Vitalliver was used in Kunming white mice for acute toxicity test: the general condition of animal was good, pathology observation showed no significant change, indicated that Vitalliver is non toxic and safe for use. | | | Hepatitis B Basic Study on Immune Function, Acute Toxicity |
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http://www.vigconic.com/Vitalliver/eng/research_report.html
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| Â | Wastewater and Industrial Toxicity Testing at Marinco Bioassay Laboratory |
| | In these tests, carefully chosen indicator organisms are exposed to whole effluent and/or effluent dilutions for a pre-determined time period in order to observe the effluent's effect on the organisms, and thereby, approximate it's potential to effect organisms within the receiving water. | | | Committing ourselves to developing the best toxicity testing processes meant that we also had to establish a superior aquaculture program. | | | Our experienced staff includes a dedicated project coordinator that is on hand to help you maintain compliance and derive value from our testing services. |
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http://www.biologylab.com
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| Â | Test of acute toxicity in Acne Formula |
| | Information and statements on this site regarding health supplements have not been evaluated by the medical profession and are not intended to diagnose, treat, cure, or prevent any disease. | | | This indicates that Acne Formula has low acute toxicity and it is safe for human consumption. | | | Doses of Acne Formula, with the equivalent dosage of 186 grams of herbs per kilogram of body weight, were administered using gavage method to mice, and were observed continuously for 7 days for clinical signs and mortality. |
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http://www.e2121.com/toxicologyeng.html
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| Â | ACUTE TOXICITY OF PESTICIDES |
| | Because the LD50 is based on animal tests and does not account for individual sensitivity, it does not necessarily represent the toxic dose for an individual human. | | | The LD50 for a chemical is the dose which has been found in controlled experiments to kill 50% of a large number of test animals. | | | In addition to oral or dermal acute toxicity, a pesticide may also carry the DANGER - POISON, or WARNING signal words because of other potential hazards, such as inhalation toxicity or the ability to cause severe eye or skin damage. |
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http://orchard.uvm.edu/uvmapple/pest/9697neapmg/txcty.html
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| Â | Lead Toxicity |
| | Chronically infected birds can have similar symptoms to acute toxicity. | | | This bird has changes consistent with liver disease. | | | The disease is sometimes broken down into acute lead toxicity and chronic lead toxicity. |
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http://www.lbah.com/Avian/lead.htm
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| Â | Iron toxicity, acute |
| | Acute symptoms are characterized by vomiting, diarrhea, mild lethargy, upper abdominal pain, pallor, and hyperglycemia with more severe clinical findings including cyanosis, stupor, acidosis, hematemesis, shock, and coma. | | | Serum iron concentrations and symptoms of acute poisoning in children. | | | Toxicity is likely following 60 mg/kg of elemental iron ingestion |
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http://www.5mcc.com/Assets/SUMMARY/TP0492.html
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| Â | Magnesium chloride - toxicity, ecologicial toxicity and regulatory information |
| | Signs and symptoms of poisoning, first aid, and links to treatment information for this chemical. | | | Toxicity to humans, including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, and acute toxicity. | | | To view acute toxicity of individual products, click on 'View Products' link in the ' Chemical Identification ' section above. |
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http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC32916
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| Â | Predicting Chronic Lethality of Chemicals to Fishes from Acute Toxicity Test Data: |
| | Results from 28 data sets having lethality data for both acute and chronic exposures were used to evaluate the method. | | | Statistical models (multiple regression) were developed that utilize acute toxicity data to establish the relation of lethality to toxicant concentration and exposure time for predicting chronic lethality. | | | New methods for predicting chronic toxicity (lethality) from acute lethality data with fishes were developed and assessed. |
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http://www.sogang.ac.kr/~ghlee/mpa1.htm
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