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Topic: Acute phase reaction


  
 acute phase proteins animals
The acute phase response has been monitored in experimental infections of pigs with the Hp response in particular providing a valuable biomarker and end-point for investigation of infection with Actinobacillus pleuropneumoniae (Hall et al.
Thompson D, Milford-Ward A, Whicher J (1992) The value of acute phase measurements in clinical practice.
In the last several years there has been considerable progress in studies on the acute phase response as it affects animals.
http://www.trideltaltd.com/apranimals.html   (4019 words)

  
 The "Acute Phase" Response and its Aftermath
Kushner I. Regulation of the acute phase response by cytokines.
It is also important to note that the various components of the APR are not so highly orchestrated that they play the same tune in response to every kind of stimulus or in all individuals.
The presumed functions of the acute phase response may be grouped for discussion into tentative categories.
http://homepage.mac.com/juliofigueroa/docs/GRdocs/BobMunford2000/RobertMunford.html   (8844 words)

  
 Kawasaki Syndrome Workshop - Etiology - Office of Rare Diseases
During the convalescent phase of KD, the overrepresentation of V
To address this possibility, a prospective study was conducted to analyze cultures in a blinded manner from patients at the time of presentations.
The latter result may be a point of convergence with the consensus primer approach, which pointed to partial homology with La Crosse virus isolates of the bunyavirus family.
http://rarediseases.info.nih.gov/html/workshops/workshops/KAWASAKI19970513_et.html   (9103 words)

  
 Effects of dialyser and dialysate on the acute phase reaction in clinical bicarbonate dialysis -- Schouten et al. 15 ...
the acute phase response in the clinical situation.
of the acute phase response during clinical bicarbonate HD.
the induction of the acute phase response in clinical HD remains
http://ndt.oupjournals.org/cgi/content/full/15/3/379   (2894 words)

  
 Serum amyloid P component levels are not decreased in patients with systemic lupus erythematosus and do not rise during ...
Because the acute phase response is relatively inadequate in
of the acute phase response, on admission to the ICU, SAP concentrations
not change significantly during an acute phase response.
http://ard.bmjjournals.com/cgi/content/full/63/7/831   (3487 words)

  
 European Colloqium Report
For assessing individual animals, the significance of results increased considerably when values of positive and negative APPs were combined in an acute phase index.
It is concluded that using assays for APPs, at the farm as well as in the abattoir, animal health can be assessed for a wide spectrum of processes.
In veterinary research different approaches have been followed to study performance of animals and outcome of animal production.
http://www.gla.ac.uk/faculties/vet/research/protein/01_glasgow/03_titles_abstracts/paper1.htm   (1537 words)

  
 Expression of serum amyloid A protein in the absence of the acute phase response does not reduce HDL cholesterol or ...
to the induction of the acute phase response with reduction
involved the induction of the acute phase response.
the acute phase response that affect HDL metabolism.
http://www.jlr.org/cgi/content/full/40/4/648   (4074 words)

  
 Particulate air pollution is associated with an acute phase response in men. Results from the MONICA-Augsburg Study -- ...
Particulate air pollution is associated with an acute phase response in men.
Even modest acute phase responses are associated with increased
induction of an acute phase response by exposure to air pollution
http://www.eurheartj.org/cgi/content/abstract/22/14/1198   (974 words)

  
 American Family Physician: Acute rheumatic fever: an update - diagnosis, primary & secondary prevention, treatment, ...
A history of a sore throat within the preceding three months has been found in as few as 20 percent of children; it is rarely mentioned by the patient or the family unless they are specifically questioned about it.
In the absence of a history of preexistent murmur, several auscultatory findings point toward acute carditis: an apical systolic murmur greater than grade 3/6 and lasting at least one-half of systole; any apical diastolic murmur; and muffled, distant heart sounds and the presence f a distolic third heart sound.
The resurgence of acute rheumatic fever is occurring at a time when many physicians may be unfamiliar with its protean manifestations.
http://www.findarticles.com/p/articles/mi_m3225/is_n2_v45/ai_12019313   (1203 words)

  
 Horst Ibelgaufts'COPE: Cytokines Online Pathfinder Encyclopaedia
51-66 (1990); Kushner I et al The acute phase response is mediated by heterogeneous mechanisms.
Hepatology 13: 364-75 (1991); Baumann H and Gauldie J The acute phase response Immunology Today 15: 74-80 (1994); Heinrich PC et al Interleukin 6 and the acute phase response.
An acute phase reaction is characterized, among other things, by fever, and an increase in the numbers of peripheral leukocytes, in particular an increase in the numbers of circulating neutrophils and their precursors.
http://www.copewithcytokines.de/cope.cgi?000229   (788 words)

  
 Inflammation, serum C-reactive protein, and erythropoietin resistance -- Bárány 16 (2): 224 -- Nephrology ...
Trey JE, Kushner I. The acute phase response and the hematopoietic system: the role of cytokines.
process may be acute, leading to transient resistance to epoetin,
acute intercurrent illness or surgery, it would be of interest
http://ndt.oxfordjournals.org/cgi/content/full/16/2/224   (1813 words)

  
 Macrophage inflammatory protein-1{alpha} as a costimulatory signal for mast cell-mediated immediate hypersensitivity ...
(and in what situations) chemokines might contribute to acute
In contrast to the wealth of information on the role of chemokines
the background mouse strain developed clear parameters of acute
http://www.jci.org/cgi/content/full/115/2/434   (4887 words)

  
 Stress Response & its Implications in Surgery & Anaesthesia - Dr. Sanjib, Dr. Mary Korula 
Kehlet H. Acute pain control and accelerated postoperative surgical recovery.
Table 3: Features of the acute phase response.
The classical stress responses (catecholamines, cortisol and glucose) to abdominal surgery such as cholecystectomy are not changed greatly by reducing surgical trauma.
http://www.theiaforum.org/april2004(1).htm   (3797 words)

  
 Braun - Physiologic Reactions during Birth
The authors also monitored body temperature, body weight, and behavioral state in order to investigate whether clinical signs of acute phase reaction were present.
To investigate whether the normal birth process stimulated an acute phase response in healthy infants with physiological changes in the circulating levels of acute phase cytokines and acute phase proteins.
The normal birth process and extra-uterine adaptation stimulates an acute phase reaction in the newborn infant with a release of interleukin-6 and acute phase proteins and a depression of prealbumin.
http://www.braun.com/medical/bodytemperature/infocenter/clinicaltrials/reactions.html   (151 words)

  
 Dorlands Medical Dictionary
pain reaction,   dilatation of the pupil on a feeling of pain.
stress reaction,   any of the biological reactions to adverse stimuli, physical, mental, or emotional, internal or external, that tend to disturb the organism's homeostasis; should these compensating reactions, physiological or psychological, be inadequate or inappropriate, they may lead to disorders.
acute situational reaction,   acute stress reaction,   a transient, self-limiting acute emotional reaction to severe psychological stress; it is variably defined as comprising one or more of the following DSM-IV categories: adjustment disorder, brief reactive psychosis, acute stress disorder, and posttraumatic stress disorder.
http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_r_04zPzhtm   (5194 words)

  
 Acute phase related hyporetinemia in cows around parturition
The physiologic process of parturition is mainly responsible for the observed increase in SAA.
Introduction:Parturition in cows induces an acute phase reaction, characterised by an increase in the positive acute phase protein serum amyloid A (SAA).
In humans, several infections and even inflammatory processes are known to induce an acute phase related hyporetinemia.
http://www.gla.ac.uk/faculties/vet/research/protein/03_doorn_2002/abstracts/Merris.html   (346 words)

  
 Improved specificity of serum albumin determination and estimation of "acute phase reactants" by use of the bromcresol ...
slower (30-min) reaction is a measure of "acute phase reactant(s)" in
Improved specificity of serum albumin determination and estimation of "acute phase reactants" by use of the bromcresol green reaction -- Gustafsson 22 (5): 616 -- Clinical Chemistry
Improved specificity of serum albumin determination and estimation of "acute phase reactants" by use of the bromcresol green reaction
http://www.clinchem.org/cgi/content/abstract/22/5/616   (281 words)

  
 C-Reactive Protein and Erythrocyte Sedimentation Rate in Orthopaedics pg. 13--16
All four procedures had a peak CRP response 2 to 3 days after surgery followed by a biphasic rapid decline.
The clinical use of acute phase proteins is as an aid to diagnosis [15].
ESR is an indirect measure of the acute phase reaction.
http://www.uphs.upenn.edu/ortho/oj/2002/html/oj15sp02p13.html   (2324 words)

  
 Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in ...
Interleukin 6, but not ciliary neurotrophic factor or leukaemia inhibitory factor, is responsible for the acute phase response to turpentine-induced myositis.
and in the bronchoalveolar lavage fluid of patients with acute
Effects of interleukin-6 and leukemia inhibitory factor on the acute phase response and DNA synthesis in cultured rat hepatocytes.
http://stemcells.alphamedpress.org/cgi/content/full/17/3/127   (6361 words)

  
 Annals of Internal Medicine: Article
In contrast, improvements in lean mass without concomitant functional improvements were seen in sarcopenia associated with aging and in chronic obstructive pulmonary disease.
Moore and coworkers reported the results of body composition studies in healthy persons, obese persons, and persons with acute and chronic injury.
However, it must once again be noted that excess breakdown of skeletal muscle protein may be life-sustaining in cases of serious acute illness or injury.
http://enotes.tripod.com/cachexia.htm   (3429 words)

  
 Acute phase response of plasma proteins in analbuminemic rats -- Goto et al. 104 (6): 952 -- Journal of Biochemistry
directly related to those involved in the acute phase response.
Acute phase response of plasma proteins in analbuminemic rats
alpha-2-macroglobulin, the most prominent acute phase protein in rats.
http://jb.oupjournals.org/cgi/content/abstract/104/6/952   (327 words)

  
 Research Interests
Our original observation of this phenomenon has stimulated considerable world wide interest.
Characterisation of the glycosylation pattern on the acute phase proteins, especially a 1 acid glycoprotein and alteration of this pattern during the acute phase response is being studies in collaboration with the University of Strathclyde.
Further development of acute phase protein assays are underway while the applications of proteomics in diagnosis of disease in animals is also being investigated.
http://www.gla.ac.uk/faculties/vet/research/genesandproteins/acutephaselab/research.html   (458 words)

  
 Factor VIII Activity and Thrombophilia (Clotting) Risk @ HEMEX.com
independent of acute phase reactant responses or related to von Willebrand factor (vWF) levels.
This was thought to be related to an acute phase response reaction secondary to
Given the important role of factor VIII in the coagulation pathway, it was speculated that the high levels of factor VIII sometimes in the 250-500% range could be consider ed a risk.
http://www.hemex.com/testmenus/factor_viii_activity_anecdote.htm   (379 words)

  
 Document Archive
The results of our study suggest that the acute phase response may be partly related to a yet unknown primary inflammatory component in unstable angina.
Episodic activation of the coagulation system in unstable angina does not elicit an acute phase reaction
Further studies are needed to elucidate the actual role of inflammation in unstable angina and its relation to activation of the coagulation system.
http://www.u430.bhdc.jussieu.fr/cgi-bin/docarc/public.pl?rm=search&queryfield=docid&query=195&limit=1   (129 words)

  
 Kinetics of the acute-phase reaction in rats after tumor transplantation -- Abd-el-Fattah et al. 41 (6): 2548 -- Cancer ...
during the second phase was much higher in rats bearing Yoshida sarcoma
Copyright © 1981 by the American Association for Cancer Research.
phase, during which serum levels increased continuously as the tumor burden
http://cancerres.aacrjournals.org/cgi/content/abstract/41/6/2548   (214 words)

  
 Study Shows Organic Food Healthier for Animals
The proliferative response of lymphocytes cultured with FCS, and acute
phase proteins showed no difference in organically and conventionally
acute-phase reaction of the liver, both responding to the presence of
http://www.organicconsumers.org/organic/animals120904.cfm   (1014 words)

  
 Acute Phase Proteins
Abstract Presented At The Second European Colloquium on Acute Phase Proteins.University of Bonn, Germany,12 May 2001
The acute phase reaction is induced by various mediators produced by activated monocytes, macrophages, granulocytes, endothelial cells, fibroblasts etc. Among the inflammatory mediators cytokines - hormone-like molecules - play an important role.
Besides fever, pain, leukocytosis, protein catabolism and other reactions of the organism it includes a drastic change in the synthesis of acute-phase proteins (APP) in the liver.
http://www.trideltaltd.com/cytokineapp3.html   (325 words)

  
 MEDLINE Tutorial - How To... - Health Sciences Library - McGill University
If you click on *acute-phase reaction, the system will retrieve all references which contain this subject heading as the main focus, (note the * asterisk), regardless of the subheading.
Note that each part is distinct; that is, the main subject heading, acute-phase reaction, has been separated by a space from the subheading, etiology.
If you click on the subheading et [etiology], the system will search and retrieve all references with this specific main subject heading /subheading combination, that is, *acute-phase reaction / et [etiology].
http://www.health.library.mcgill.ca/help/guides/biomed/medline/display.cfm   (750 words)

  
 Malnutrition and the acute-phase reaction in dialysis patients--how to measure and how to distinguish -- Kaysen 15 ...
Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue TB, Craig WY. Reference distributions for the negative acute-phase serum proteins, albumin, transferrin and transthyretin: a practical, simple and clinically relevant approach in a large cohort.
The acute phase protein response in patients receiving subcutaneous IL-6.
Albumin concentration in dialysis patients is negatively correlated
http://ndt.oxfordjournals.org/cgi/content/full/15/10/1521   (1761 words)

  
 Effects of treatment with a fully human anti-tumour necrosis factor {alpha} monoclonal antibody on the local and ...
Taken together, our results confirm that TNF neutralisation with anti-TNF mAb in RA is very effective in controlling clinical
inflammation and decreasing the acute phase reaction in patients
All patients with RA enrolled in a phase I, single dose, placebo controlled study with D2E7 in our centre were studied.
http://ard.bmjjournals.com/cgi/content/full/60/7/660   (4915 words)

  
 Comparative analysis of lipid composition of normal and acute-phase high density lipoproteins -- Pruzanski et al. 41 ...
Despite induction of the acute phase, no change
reaction (20) and in some chronic inflammatory diseases (21).
It was shown that in the acute phase (9) (10) and in
http://www.jlr.org/cgi/content/full/41/7/1035   (6665 words)

  
 Transcriptional regulation of genes encoding the acute-phase proteins CRP, SAA, and C3 -- Goldberger et al. 138 (11): ...
Inflammation or acute tissue injury results in a programmed change in the
Induction of a sterile inflammatory reaction with intramuscular
These data suggest that the increase in CRP, SAA, and C3 serum concentrations observed during an acute-phase reaction is due to an
http://www.jimmunol.org/cgi/content/abstract/138/11/3967   (299 words)

  
 research report
Therapeutic Drug Monitoring and Phamakokinetics of Protease-inhibitors in antiretroviral therapy of HIV-Infection
A phase IIIb open clinical study to evaluate safety of Tenofovir Disoproxil Fumarate
Preparative Application of Peroxidic Oxidants for Oxygen-Transfer Reactions
http://www.zv.uni-wuerzburg.de/forschungsbericht/FOBE-akt/swe-a.htm   (3469 words)

  
 Induction and Modulation of Acute-Phase Response by Protein Malnutrition in Rats: Comparative Effect of Systemic and ...
process: evidence that alpha-2HS glycoprotein is a negative acute
levels in protein malnourished patients during acute infection.
KEY WORDS: acute phase response · malnutrition · systemic inflammation ·; localized inflammation ·; rats
http://www.nutrition.org/cgi/content/full/128/2/166   (4822 words)

  
 ITIH4 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 4) Is a New Acute-Phase Protein Isolated from Cattle during ...
Serum haptoglobin as an indicator of acute phase response in bovine respiratory disease.
Acute phase response in heifers with experimentally induced mastitis.
ITIH4 serum concentration increases during acute phase processes in human patients and is upregulated by interleukin 6 in hepatocarcinoma HepG2 cells.
http://iai.asm.org/cgi/content/full/72/7/3777   (4576 words)

  
  ACUTE PHASE REACTANTS 
However, an awareness that they are acute phase reactants is of value in the interpretation of results in patients with inflammatory or neoplastic disorders.
Cryofibrinogen may also be present in patients with an acute phase reaction, but this finding has no diagnostic value.
Levels of some proteins may be reduced during an acute phase response, eg albumin, prealbumin, transferrin.
http://www.npg.co.za/RCPA/acute_p2.htm   (192 words)

  
 Prevention of Acute Allergic Conjunctivitis and Late-Phase Inflammation with Immunostimulatory DNA Sequences -- ...
These experiments also raise interesting questions about the
Because neutrophilia is a hallmark of the late-phase reaction
it did not affect the acute-phase reaction with this dose regimen.
http://www.iovs.org/cgi/content/full/41/12/3850   (3195 words)

  
 [No title]
On the other hand, in the context of the wild type promoter they induce a negative response.
Our results suggest that the overall inhibition of apo C-III expression during the acute phase reaction is mediated by cytokine-induced positive factors through the disruption of a stronger transcriptionally active complex, which operates under normal physiological conditions.
Regulation of the apo C-III Gene during the ÒAcute Phase ReactionÓ of the LIver (I. Talianidis, E. Ktistaki, J.-M. Lacorte, V. Zannis)
http://www.imbb.forth.gr/groups/mammals/projects/RegC-III.html   (194 words)

  
 Acute phase protein - Wikipedia, the free encyclopedia
Measurement of acute phase proteins is a useful marker of inflammation in both medical and veterinary clinical pathology.
This response is called the acute phase reaction.
The liver responds by producing a large number of acute phase reactants, most notably:
http://www.wikipedia.org/wiki/Acute_phase_reaction   (132 words)

  
 Tumor necrosis factor - Wikipedia, the free encyclopedia
TNFα is a member of a group of other cytokines that all stimulate the acute phase reaction.
On the liver: stimulating the acute phase response, leading to an increase in C-reactive protein and a number of other mediators.
In medicine, tumor necrosis factor alpha (TNFα, cachexin or cachectin) is an important cytokine involved in systemic inflammation and the acute phase response.
http://en.wikipedia.org/wiki/TNF   (312 words)

  
 Abstract
Our results suggest that in a course of MF a generalised inflammatory reaction, known as acute phase response, is present in all patients.
Acute phase proteins may serve as a laboratory marker of cytokine network function: changes in APP level reflect changes in cytokine balance and are easier to follow analytically.
Microheterogeneity of Selected Acute Phase Proteins in Patients Suffering From Mycosis Fungoides
http://www.blackwellpublishing.com/esdr2004/abstract.asp?id=18664   (376 words)

  
 Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase response
Cancer patients with an acute phase response (C-reactive protein >10 mg l
Keywords: acute phase response; drug metabolism; erythromycin breath-test (EBT)
This indicates that the sub-group of cancer patients with significant acute-phase response have compromised drug metabolism, which may have implications for the safety of chemotherapy in this population.
http://www.nature.com/bjc/journal/v87/n3/abs/6600448a.html   (301 words)

  
 Ferritin - Wikipedia, the free encyclopedia
As ferritin is also an acute phase reactant, it is often elevated in the course of disease.
Ferritin is also used as a marker for iron overload disorders, such as haemochromatosis in which the ferritin level may be abnormally raised.
A normal C-reactive protein can be used to exclude elevated ferritin caused by acute phase reactions.
http://www.wikipedia.org/wiki/Ferritin   (193 words)

  
 Periodontitis in Humans and Non-Human Primates: Oral-Systemic Linkage Inducing Acute Phase Proteins
Acute phase reaction; animal studies; inflammatory response; acute phase proteins; periodontal diseases; Sjögren’s syndrome.
This report describes patient-oriented and non-human primate model studies to determine the effect of periodontal disease on systemic acute phase proteins (APP).
Background: The acute phase response (APR) represents a systemic counterpart to the localized inflammatory response.
http://www.electronicipc.com/JournalEZ/detail.cfm?code=02250020070114&cfid=&cftoken=   (470 words)

  
 Synthesis and regulation of acute phase plasma proteins in primary cultures of mouse hepatocytes -- Baumann et al. 97 ...
of effectors mediating the hepatic acute phase reaction.
and factors that have been proposed to regulate the hepatic acute phase
Synthesis and regulation of acute phase plasma proteins in primary cultures of mouse hepatocytes
http://www.jcb.org/cgi/content/abstract/97/3/866   (367 words)

  
 Iron Saturation of Serum Ferritin in Patients with Adult Onset Still's Disease
We suggest that soluble transferrin receptor is the method of choice in estimating the iron status of patients with an acute phase reaction.
We conclude that the acute phase ferritin in patients with AOSD contains less iron in comparison to ferritin in healthy controls.
Patients with Still's disease show a prominent acute phase reaction.
http://www.jrheum.com/abstracts/abstracts01/2213.html   (206 words)

  
 3606 : Expression of heme oxygenase-1 in rat liver and in rat hepatocytes under inflammatory conditions
Recently, it has been suggested that HO-1 can be involved in acute phase response, a systemic reaction to inflammation and tissue injury.
Conclusions: Our data demonstrate that in rat liver the expression of HO-1 is induced at early time-points under the inflammatory conditions both in vivo, in turpentine oil treated rats, and in vitro, in hepatocytes stimulated with proinflammatory cytokines.
Thus, HO-1 should be considered not only as oxidative stress protein but also as early intracellular positive acute phase protein, and its role in acute phase response has to be further elucidated.
http://www.thieme.de/abstracts/zfg/abstracts2003/daten/3606.html   (308 words)

  
 Respiratory System
Late phase effects: Cytokines released by leukocytes, eosinophils and basophils recruited during the early phase contribute to the late phase effects.
Acute early phase reaction: Exposure of presensitized IgE-coated mast cells to the same or cross-reacting antigens results in an acute early phase reaction from the release of histamine (causes bronchospasm), leukotrienes (attract leukocytes, eosinophils; release mucus), and platelet activating factor (which causes more release of histamine and serotonin from platelets).
Reaction to systemic processes - gram negative septicemia, hemorrhage, pancreatitis, uremia, diabetic ketoacidosis, other metabolic disorders
http://pathcuric1.swmed.edu/PathDemo/resqs/resqs.htm   (3671 words)

  
 Role of Serum Amyloid A During Metabolism of Acute-Phase HDL by Macrophages -- Artl et al. 20 (3): 763 -- ...
The acute phase was induced by injection of a 1% croton
SAA associates rapidly during the acute phase with HDL,
Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins.
http://atvb.ahajournals.org/cgi/content/full/20/3/763   (7000 words)

  
 acute phase reaction - General Practice Notebook
The information provided herein should not be used for diagnosis or treatment of any medical condition.
The acute phase reaction describes the global systemic physiological response to acute insults such as inflammation by:
They are released by peripheral monocytes in direct relation to the level of inflammation, hypothetically to increase the level of acute phase proteins necessary for their activity.
http://www.gpnotebook.co.uk/cache/537264185.htm   (126 words)

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