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| | Acetylcholine |
 | | Often the most effective treatments are ligands which inhibit the breakdown of acetylcholine. | | | Over the past several years, a variety of research groups have focused on the development of selective nicotinic agonists. | | | The methyl group also prevents the penetration into the brain. |
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http://www.neurosci.pharm.utoledo.edu/MBC3320/acetylcholine.htm
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| | Semiconductor Devices in Measuring the Acetylcholine Receptor |
| | As desired, the intracellular and the extracellular measurements both showed very little response to carbachol as shown in figure 5 [1]. | | | Since Myasthenia Gravis can be treated, the determination of the disease is vitally important [6]. | | | As more research takes place in this area of microscale and nanoscale biomedical instrumentation, more advancement of biology in both clinical and research applications will take place. |
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http://www.csua.berkeley.edu/~yakura/stuff/mcb165/m165a.html
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| | Acetylcholine - Wikipedia, the free encyclopedia |
| | Blocking, hindering or mimicking the action of acetylcholine has many uses in medicine. | | | Clinically they are used to reverse the action of muscle relaxants, to treat myasthenia gravis and in Alzheimer's disease (rivastigmine, which increases cholinergic activity in the brain). | | | On the other hand, since a shortage of acetylcholine in the brain has been associated with Alzheimer's disease, some drugs that inhibit acetylcholinesterase are used in the treatment of that disease. |
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http://en.wikipedia.org/wiki/Acetylcholine
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| | Activation of the Recombinant Human alpha 7 Nicotinic Acetylcholine Receptor Significantly Raises Intracellular Free ... |
| | Costa, A. Patrick, J. and Dani, J. Improved technique for studying ion channels expressed in Xenopus oocytes, including fast perfusion. | | | Send reprint requests to: Dr. Osvaldo Delbono, Dept. of Physiology and Pharmacology, Bowman Gray School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. | | | McGehee, D. and Role, L. Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. |
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http://jpet.aspetjournals.org/cgi/content/full/280/1/428
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| | acetylcholine receptor antibody |
| | It is also used to monitor reponse to therapy for myasthenia gravis. | | | The acetylcholine receptor antibody test is used to diagnose myasthenia gravis, a condition in which the muscles become tired and weak. | | | The presence of more than.05 nM (nanomoles) of acetylcholine receptors in the blood indicates the person may have myasthenia gravis. |
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http://www.northmemorial.com/healthencyclopedia/content/1013.asp
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| | Single Nucleotide Polymorphisms of the Human M1 Muscarinic Acetylcholine Receptor Gene |
| | Many GPCRs have been found to contain single nucleotide polymorphisms (SNPs) that are involved in disease susceptibility or drug response (for a review, see reference | | | Although the muscarinic receptors are thought to contribute to certain neurological and psychiatric disorders, no sequence variations or alleles have been found that affect susceptibility to these diseases or response to muscarinic agonists. | | | Indeed, for the past 20 years, the cholinergic hypothesis has proposed that loss of cholinergic function is responsible for the cognitive symptoms of Alzheimer's. |
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http://www.aapspharmsci.org/view.asp?art=ps030431
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| | Human Alpha-7 Nicotinic Acetylcholine Receptor: Expression Levels and Promoter Polymorphisms as Predictors/Indicators ... |
| | Through cooperative research initiatives such as these, it is our hope and goal that commercial products will be fully developed and made available to benefit veterans and others. | | | Despite advances in treatment and diagnostic methods, there remains a need for methods to diagnose and treat schizophrenic patients. | | | As schizophrenia runs in families, a molecular diagnostic for the alpha-7 nicotinic receptor provided to other family members may give the opportunity for early intervention. |
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http://www.vard.org/tts/avail/03-102.htm
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| | nicotinic Acetylcholine Receptor antibody [88B] (ab2804) datasheet |
| | Immunohistochemical staining of nAChR in rat skeletal muscle results in strong staining of the motor endplate. | | | Customer reviews (feedback) regarding nicotinic Acetylcholine Receptor antibody [88B] | | | The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine. |
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http://www.abcam.com/?datasheet=2804
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| | Biochemistry of Neurotransmitters |
| | King, Ph.D / IU School of Medicine / miking at iupui.edu | | | The anxiolytic drugs of the benzodiazepine family exert their soothing effects by potentiating the responses of GABA-A receptors to GABA binding. | | | ChE inhibitors have been used as components of nerve gases but also have significant medical application in the treatment of disorders such as glaucoma and myasthenia gravis as well as in terminating the effects of neuromuscular blocking agents such as atropine. |
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http://web.indstate.edu/thcme/mwking/nerves.html
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| | Neuro-Immunology lab -- Acetylcholine Receptor Antibody |
| | Borderline corresponds to levels of precipitation between the mean +2SD and mean +3SD of a group of healthy controls but are less than our low positive (1nmol/liter). | | | This test is aimed at detecting even very low levels of antibodies. | | | We use human antigen and compare precipitation induced by the serum to be tested to that induced by normal sera and a series of standards containing acetylcholine receptor antibodies. |
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http://www.interchg.ubc.ca/neuroimm/mg.html
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| | ARUP: Acetylcholine Receptor Antibodies |
| | Acetylcholine receptors from normal human muscle: concentrations, purification, and use in radioreceptor assays for autoantibodies. | | | Functional activities of autoantibodies to acetylcholine receptors and the clinical severity of myasthenia gravis. | | | Synaptic actions of acetylcholine: problems for future research. |
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http://www.aruplab.com/guides/clt/tests/clt_al20.jsp
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| | NodeWorks - Encyclopedia: Muscarinic acetylcholine receptor |
| | Acetylcholine (ACh) is used as a neurotransmitter within the autonomic nervous system. | | | For example, the drug pirenzepine is a muscinaric antagonist (decreases the effect of ACh) which is much more potent at M1 receptors than it is at other subtypes. | | | A very few parts of the sympathetic system (sweating, for example), do use acetylcholine as a neurotransmitter at this position. |
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http://pedia.nodeworks.com/M/MU/MUS/Muscarinic_acetylcholine_receptor
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| | Acetylcholine receptor antibody Encyclopedia Search - Drug Price Search |
| | Presence of acetylcholinesterase antibody in the blood of patients with symptoms of myasthenia gravis supports the diagnosis, but lack of these antibodies does not rule out this condition. | | | The acetylcholine receptor antibody attacks receptors for the neurotransmitter acetylcholine, which sends signals from nerves to muscles and from nerve to nerve in the brain. | | | This is a diagnostic test for myasthenia gravis. |
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http://www.drug-price-search.com/encyclopedia/?encyclopedia_name_url=87&level=2
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| | KRONUS - Technical Product Information - Neuromuscular |
| | Autoantibodies to the Acetylcholine receptor (AChRAb) can be detected in 80-90% of patients with myasthenia gravis. | | | While the majority of the anti-AChR autoantibodies in the sera of patients with MG recognize the fetal form of the AChR, some MG patient sera contain autantibodies that specifically bind to adult AChR. | | | Lambert-Eaton Myasthenic Syndrome (LEMS) is a disorder of neuromuscular transmission caused by antibodies that impair the presynaptic release of acetylcholine. |
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http://www.kronus.com/technical/neuromuscular.html
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| | NEJM -- Cellular immunity in myasthenia gravis. Response to purified acetylcholine receptor and autologous thymocytes |
| | To determine the potential importance of an immune response directed against the acetylcholine receptor in myasthenia gravis, we studied cell-mediated immunity to receptor as measured by lymphocyte stimulation in 21 myasthenic patients and 21 controls, including five with amyotrophic lateral sclerosis. | | | Our findings are further evidence that autoimmunity to the acetylcholine receptor plays a central part in myasthenia gravis. | | | Peripheral blood lymphocytes from one of three young female myasthenic patients responded to autologous thymocytes but not to receptor; peripheral blood lymphocytes from the other two responded to receptor but not to autologous thymocytes. |
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http://content.nejm.org/cgi/content/short/294/13/694
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| | OriGene - Antibodies - Muscarinic Acetylcholine Receptor M4 |
| | Muscarinic acetylcholine receptor M4 has been reported to be expressed in many regions of the rat brain, particu | | | The clinical relevance of this receptor is unknown. | | | However, mouse studies have linked it to adenylyl cyclase inhibition. |
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http://www.origene.com/antibody/TA200234.aspx
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| | Acetylcholine Receptor Pathway |
| | View a Shockwave™ Animation of an Acetylcholine Receptor Pathway. | | | The sight, smell, and taste of food cause salivation and the stimulation of the vagus nerve to release acetylcholine. | | | When acetylcholine binds to its receptor, the parietal cell's permeability to calcium ions (Ca) is altered so that the ions move into the cell. |
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http://www.gerd.com/intro/noframe/arp.htm
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| | NEJM -- Thymus cells in myasthenia gravis selectively enhance production of anti-acetylcholine-receptor antibody by ... |
| | We investigated the role of the thymus in 16 patients with myasthenia gravis without thymoma by studying the production of anti-acetylcholine-receptor antibody by thymic and blood lymphocytes cultured alone or together. | | | These results suggest that myasthenic thymus contains cell-bound acetylcholine-receptor-like material or specific T cells (or both) that can aid receptor-antibody production. | | | Receptor-antibody production by autologous blood lymphocytes was enhanced by the addition of responders' thymic cells, irradiated to abrogate antibody production and suppression (P less than 0.01). |
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http://content.nejm.org/cgi/content/abstract/305/22/1313
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| | Acetylcholine Receptor Pore |
| | The structure of the acetylcholine receptor pore is described by: | | | Miyazawa A, Fujiyoshi Y, Unwin N. (2003) "Structure and gating mechanism of the acetylcholine receptor pore." Nature 424: 949 PubMed [1OED.pdb] | | | The energetic cost of removing water with apolar side chains in this pore would be prohibitive. |
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http://www.bio.cmu.edu/Courses/BiochemMols/Channels/1oed.htm
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| | Image Of The Week - Nicotinic Acetylcholine Receptor |
| | Some members of this family of receptors in the brain bind nicotine and are targets for the addictive activity of this drug. | | | The electrostatic isopotential surface--a surface representing constant electric potential--for a model of the nicotinic acetylcholine receptor. | | | The model was developed by Igor Tsigelny, Naoya Sugiyama, and Palmer Taylor at the Departments of Pharmacology and Chemistry/Biochemistry at the University of California, San Diego, in collaboration with Steven M. Sine at the Mayo Foundation in Rochester, Minnesota. |
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http://www.sdsc.edu/IOTW/week19.96/iotw.html
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