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| | DMT - TheSite.org |
 | | DMT can cause your heart rate and blood pressure to increase suddenly, so those with heart problems or high blood pressure should give this drug a wide berth. | | | Most individuals taking DMT do so with a partner, to take hold of the pipe once the experience begins. | | | People who smoke DMT have described feeling rapidly propelled into an intense alternate reality. |
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http://www.thesite.org.uk/drinkanddrugs/drugsafety/drugsatoz/dmt
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| | D. M. Turner - DMT |
| | The dosage for 5-MeO-DMT is 5 to 10 mg. | | | DMT acts as a catalyst to awaken this realm of movement by exercising the muscles involved and realigning the underlying energies. | | | A DMT tryp tends to be out of body, out of personality, and sometimes outside of the mind. |
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http://www.lavondyss.com/donut/guide/dmt.html
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| | DMT article: 2. DMT Usage |
| | This breakdown may be prevented by the ingestion of an MAO-inhibitor, allowing the DMT to act within the brain without being metabolized by the homeostatic mechanisms normally present. | | | Another method of administering DMT which does not involve fire is injection, but since this requires the use of a needle it is not for everyone. | | | There is a certain art to smoking DMT to produce a significant effect which is only acquired with practice. |
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http://www.serendipity.li/dmt/dmtart02.html
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| | MAPS - Volume 4 Number 2 - Tryptamines, Beta-carbolines and You |
| | During this time, one can take DMT (0.5 mg/kg) or 5-MeO-DMT (0.1 mg/kg) orally to induce an interesting psychedelic state which is similar, but qualitatively different, from smoking either of the two tryptamines alone. | | | DMT is a very potent psychedelic chemical when smoked or injected, but is orally inactive. | | | Even at high doses (5 mg/kg), the best one can expect from harmaline would be intense nausea, diarrhea, nystagmus and perhaps the sound of rushing water. |
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http://www.maps.org/news-letters/v04n2/04230cal.html
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| | 5meoabst.txt |
| | From the present results it is suggested that the relative potencies of DMT and 5-MeODMT in other behavioral measures may relate to the role of brain (equipotent) or spinal (5-MeODMT more potent than DMT) sites of action for the various behaviors. | | | In contrast, the difference in the effects of DMT and 5-MeODMT on acoustic startle is related to the spinal excitatory effects of 5-MeODMT which DMT does not possess. | | | In another series of studies, the effects of systemically-administered DMT and 5-MeODMT on the "startle" elicited by electrical stimulation of the nucleus reticularis pontis caudalis (RPC) were determined. |
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http://www.tacethno.com/info/5meodmt/5meoabst.txt
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| | Reports of 5-MeO-DMT Experiences |
| | My first experience with 5-MeO DMT was several months ago. | | | If there is some way for the body's natural supply of DMT to leak or flow into the bloodstream, that could easily explain what are commonly thought of as "near-death experiences" and "alien abductions". | | | Some scientists believe the pineal gland and DMT to be a gateway to the other world, a means of exiting from one's current body, to move into the afterlife (whatever your personal religious thoughts are of an afterlife, if you believe in such). |
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http://www.serendipity.li/dmt/1st5meo.html
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| | TiHKAL #38 5-MEO-DMT |
| | A true academic challenge exists with the many studies of 5-methoxy-DMT (as has been mentioned under DMT, different drug, same problem) which have involved drug mixtures. | | | Overall comparison to DMT, more potent, slightly faster, but like DMT is largely a simple, stoning drug with no sensory contribution, no intellectual contribution. | | | For me it was like adding the MDMA experience to DMT. |
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http://www.psiconautica.org/Tihkal/tihkal38.html
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| | Pharmanopo-Psychonautics |
| | This generally holds for oral ingestion as well, with the provison that orally, DMT (at least up to a 1.0 g dose) requires activation by MAOI, whereas in sufficient dosage, both bufotenine and 5-MeO-DMT (Ott In press) are impressively active orally by themselves. | | | DMT free-base from hexane likewise exists as at least three isoforms, melting points from 44-74'C having been reported, and Fish, Johnson and Horning (1956) replicated the irreversible transformation of a lower-melting-point isoform (47-49°C) into a highermelting-point isoform (71-73'C). | | | De Smet (1983) bioassayed doses as high as 125 mg DMT (as less than 185 mg bioxalate salt in 15 ml water; ca. |
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http://www.tacethno.com/info/bufotenine/pharmanopo.html
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| | Mycotopian Web Board: QT's DMT Extraction for Students |
| | Even avid psychedelic users have had frightening experiences with DMT on their first encounter with the drug. | | | both mimosa and phalaris have just dmt, not bufo so they are safe choices. | | | DMT is naturally formed in the body and has been found in abnormal levels in the body fluids of persons suffering from schizophrenia. |
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http://www.mycotopia.net/discus/messages/5/20142.html?1042467012
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| | Extracting DMT from Phalaris |
| | DMT causes intense visual hallucinations and other psychedelic phenomena. | | | The main drug of interest here is DMT. | | | Even though DMT is found naturally in your brain and many other common occuring substances, possession of it is illegal in many parts of the world. |
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http://www.futurehi.net/docs/DMT_from_Phlaris.html
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| | _912.html |
| | The fact is, 5-MeO-DMT and DMT both share these characteristics, and yet both are psychoactive. | | | The following was observed: (1) tingling from head and neck to extremities; (2) constriction of the chest; (3) color hallucinations and visual disturbances; (4) mental confusion and mild disorientation; (5) purpling of skin in head and neck as "the diluted color of eggplant"; and (6) nausea, retching, vomiting, nystagmus (Lyttle et al. | | | So already, according to Ciprian-Ollivier and Cetkovich-Bakmas, bufotenine has "strong hallucinogenic properties." In the LSD-trained rat study, bufotenine elicited an LSD stimulus response only 25.80f the time (Helsley et al. |
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http://sulcus.berkeley.edu/mcb/165_001/papers/manuscripts/_912.html
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| | DMT |
| | As to spectra, the EI-MS of DMT presents no surprises. | | | In the early clinical studies of DMT and DET, frequent use was made of schizophrenic patients, in the belief that if these drugs imitate the mental disorder in normal subjects, the use of schizophrenic population might be especially informative, either through some enhanced response or a loss of effect. | | | DMT is the only psychedelic tryptamine that has recently been taken through the Kafkaesque processes for approval for human studies (via the FDA, the DEA, and the other Health agencies of the Government) and is one of the few Schedule I drug that is being looked at clinically in this country today. |
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http://www.dimethyltryptamine.com/synthesis.html
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| | tryptamines: pharmacology |
| | DMT is explicitly named as a Schedule I drug in the Federal Controlled Substances Act; registry number 7435 (United States of America). | | | DMT was first synthesized in 1931, and demonstrated to be hallucinogenic in 1956. | | | In the UK, DMT is classified as a Class A drug. |
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http://bluezoo.org/tryptamines/pharmacology.html
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| | Breathe - 5-MeO-DMT |
| | It felt very at home in my brain and body, much like DMT did. | | | I'm sure many of you recognize the significance of the numerals 5 and 23, and those numbers have always played a special part in my life (ever since I read Illuminatus and the Principia Discordia). | | | It was a very positive energy and it put me into a hyperaware, very sensitive state. |
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http://www.lycaeum.org/archive/psychonaut/dmt/dmt2.htm
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| | trip! |
| | Without an MAOI, DMT/5-meo DMT may be smoked (i.e. | | | The dosage range for DMT is 90-60mg, and is somewhat less for 5-meo-DMT, at around 2-20mg per dose. | | | In the 1950’s, both DMT and 5-meo-DMT were isolated as the psychoactive constituents of the Colombian Cohoba snuff. |
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http://www.tripproject.ca/march/drugContent.php?info=researchchemicals
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| | The Truth About Toad Licking! |
| | That is what it's like when you inhale about 5 milligrams (the recommended dose) of 5-MeO-DMT. | | | I was in limbo for those 5 minutes. | | | Actually, it was his face, reproduced 5 times, hovering around the central image of his REAL face. |
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http://www.geocities.com/Area51/Labyrinth/9624/thetoad.html
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| | 5MEO |
| | 5-MeO-DMT is a short acting tryptamine very similar in nature to DMT. | | | Some individuals have world-shattering effects with less than 5 mg. | | | It is built on experience, research and submissions. |
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http://www.clearwhitelight.org/hatter/5meo.htm
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| | Ask Dr. Shulgin Online November 18, 2002 |
| | Two additional 5-substituted dimethyltryptamines are also well known; these are bufotenine with an HO- group (a hydroxy group) and 5-MeO-DMT with a MeO- group (a methoxy group) at this position. | | | But to answer your question, there must be human experimentation to establish human activity and, to my knowledge, 5-Me-DMT has never been tried in man. | | | I have been unable to find any information regarding the compound that has a methyl group at the 5-position of DMT. |
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http://www.cognitiveliberty.org/shulgin/adsarchive/5Me_DMT.htm
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| | GanjaTalk.com - powered by XMB |
| | posted on 4-7-2005 at 06:15 AM if the drug ingested is just DMT, an enzyme called monoamine oxidase will destroy most of the chemical before it is ablo to pass through the blood brain barrier. | | | I don't know anything about DMT so if some one can help me out that would be appreciated as well but I was reading it is an extraordinary hallucinogen. | | | The only reason I don't believe they would work in a drink is that the DMT type chemicals wouldn't be absorbed quickly enough. |
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http://www.ganjatalk.com/forum/viewthread.php?tid=3013
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| | Tryptamine Carriers FAQ |
| | Methyl transferases that catalyze the synthesis of tryptamines, including DMT, 5-MeO-DMT and bufotenine, are found in human lung, brain, cerebrospinal fluid, liver and heart (McKenna and Towers 1984). | | | A potent inhibitor of INMT, which is a necessary enzyme for the synthesis of DMT and 5-MeO-DMT, is found in particularly high concentrations in the pineal gland. | | | Because of this, inhibitors of the MAO enzyme (MAOIs) can be used to potentiate the effects of tryptamines and to make DMT and 5-MeO-DMT orally active. |
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http://userpages.umbc.edu/~jfreed1/lsdrecords/trypfaq.htm
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| | eMedicine - Hallucinogens : Article by Scott Cameron, MD |
| | DMT is a potent psychedelic with a brief duration of action (15-60 min). | | | DMT is only active when smoked or snorted. | | | Do not assume that a patient who is quiet but who was violently agitated 5 minutes ago is just resting. |
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http://www.emedicine.com/med/topic3407.htm
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| | Lycaeum > Leda > 5-MEO-DMT information extracted from the Pharmacotheon by Jonathon Ott |
| | The asymmetrical isopropyl analogue of 5-MeO-DMT, 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MIPT) is active orally at a 5 mg dose, but like the DMT analogue MIPT produces amphetamine like stimulation and not entheogenic effects (Repke et al. | | | Shulgin conducted experiments with nine subjects, finding that smoking 6-10 mg of the free base of 5-MeO-DMT produced an entheogenic effect starting in less than 60 seconds, reaching a peak in two to three minutes and lasting about twenty minutes (Shulgin in DeSmet 1983). | | | It would appear that in general 5-MeO-DMT and DMT are the principal entheogenic constituents of epena and related snuffs. |
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http://leda.lycaeum.org/?ID=16772
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| | _515.html |
| | Also, detailed research elucidating the pharmacological and/or neuromolecular mechanisms of 5-MeO-DMT in exerting its psychoactive/psychedelic effects in humans are difficult to find in the literature because it is an analog of DMT, which is listed as a Schedule I drug. | | | This might be due to the extra hydroxy (-OH) group at the number 5 position on bufotenine, which contributes polarity to the molecule. | | | However, the exact pharmacological and/or toxicological mechanisms of components like bufotenine in causing its toxic physiological effects in animals and humans are still unclear. |
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http://sulcus.berkeley.edu/mcb/165_001/papers/manuscripts/_515.html
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| | L E G A L H I G H S |
| | Contraindications: Excessive dose may cause headache and confusion during first 5 minutes. | | | These include 5- and 6-fluorotryptamine and 5- and 6-fluorotryptophan. | | | Physical pain or discomfort may be amplified during first 10 minutes. |
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http://www.entheogen.st/legal.html
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| | Extraction of DMT and 5-MeO-DMT |
| | Good starting dose for smoked DMT is 15-20mg, and 5-MeO-DMT 3 or 4 mg, so start low, especially if you think you've got your hands on good aquatica-extract (because of the butenine factor). | | | You now have extracted DMT, 5-MeO-DMT and some other alkaloids from the plants. | | | The two extraction receipts below are basically using the same method to produce DMT but I have included both as the different approach in describing the process might help to clarify any particular steps that you might be confused about. |
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http://dmt.lycaeum.org/extract/extractiondmt.html
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| | Lycaeum > Leda > 5-MeO-DMT |
| | TiHKAL states that experiments have shown 5-MeO-DMT to be active in the 10-25 mg range following harmaline. | | | Like DMT, has not been found to be orally active by itself. |
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http://leda.lycaeum.org/Chemicals/5-MeO-DMT.3488.shtml
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| | V72 - 5MeO-DMT |
| | The primary effects of 5-MeO-DMT last approximately 5-20 minutes when smoked, 30-45 minutes when insufflated. | | | 5-MeO-DMT has been called just "5MEO", but as other "5-MeO" (methoxy group on the 5 position, such as 5-MeO-DiPT) psychoactives have become known this shortened name is slowly losing its usefulness. | | | In the other parts of the world, including the U.S., 5-MeO-DMT is mostly encountered as a crystalline chemical and smoked, snorted, or swallowed for recreation and/or insight. |
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http://www.v72.org/5MeODMT.html
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| | The Lycaeum Forums : "Goodbye ecstasy, hello 5-Meo-DMT: new designer drugs are just a click away " |
| | However, it's much harder with DMT and 5meoDMT - so they resort to such statements as: "not uncommon for those who take large amounts to suffer psychological and emotional difficulties for weeks afterwards" (I think that was lifted straight off Erowid), and in DMT's case, it feels kinda like dying. | | | A more powerful sister compound of DMT, occurring naturally in the venom of the Bufo alvarius toad but generally smoked in synthesised form. | | | Not uncommon for those who take large amounts to suffer psychological and emotional difficulties for weeks afterwards. |
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http://forums.lycaeum.org/cgi-bin/ultimatebb.cgi?ubb=get_topic&f=8&t=000916
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