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| | Serotonin and Hallucinogens |
 | | We synthesized the quaternary amine derivative of 5-HT, N,N,N-trimethylserotonin, or 5-HTQ, and found it to bind with higher affinity than 5- HT, and to be quite selective for 5-HT3 receptors. | | | These receptors were named 5- HT2F receptors; that is, they displayed similarity with the other two members of the 5-HT2 family of receptors. | | | This, at least in part, explained our findings of more than 15 years earlier that there was a significant correlation between hallucinogenic potency and rat fundus 5-HT receptor affinity. |
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http://www.phc.vcu.edu/rag/serotonin
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| | Serotonin Receptor Subtypes and Ligands |
| | The pharmacological function of 5-HT receptors is currently unknown; it has been speculated that, on the basis of their localization, they may be involved in motor control, feeding, anxiety, depression, learning, memory consolidation, adaptive behavior, and brain development ( | | | 5-HT receptors might be involved in mood and learning, as well as in neuroendocrine and vegetative behaviors. | | | The controversy surrounding the possible existence of 5-HT receptors in rat brain further confounded 5-HT research. |
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http://www.acnp.org/g4/GN401000039/Ch039.html
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| | 5-HT receptor - Wikipedia, the free encyclopedia |
| | 5-HT receptors are located on the cell membrane of nerve cells and other cell types in animals and mediate the effects of serotonin as the endogenous ligand and of a broad range of pharmaceutical and hallucinogenic drugs. | | | In the field of neurochemistry, 5-HT receptors are receptors for the neurotransmitter and peripheral signal mediator serotonin, also known as 5-hydroxytryptamine or 5-HT. | | | Within these general classes of 5-HT receptors, a number of specific types have been characterized: |
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http://en.wikipedia.org/wiki/5-HT_receptor
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| | Serotonin - Wikipedia, the free encyclopedia |
| | The pharmacology of 5-HT is extremely complex, with its actions being mediated by a large and diverse range of 5-HT receptors. | | | From here it is free to diffuse over a relatively large region of space (>20µm) and activate 5-HT receptors located on the dendrites, cell bodies and presynaptic terminals of adjacent neurons. | | | As with all neurotransmitters, the actual effects of 5-HT on the human mood and state of mind, and its role in consciousness, are very difficult to ascertain. |
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http://en.wikipedia.org/wiki/5-HT
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| | Indoleamines: The Role of Serotonin in Clinical Disorders |
| | One of the systems involving 5-HT where some of the neurotransmitters and receptors are better understood involves the systems regulating the control of nausea and emesis (83). | | | The diverse and complex nature of 5-HT involvement in different clinical conditions can be illustrated with 5 clinical examples where the variability in the clinical response to 5-HT based treatments across widely different clinical conditions reflects the complexity of the underlying 5-HT systems. | | | Figure 5 illustrates the robust positive results from 4 studies of sumatriplin in headache (7). |
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http://www.acnp.org/G4/GN401000045/CH.html
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| | Effects of ECS on 5-HT-1A Receptor Sensitivity in Hypothalamus: In Vivo Studies |
| | Increased serotonergic transmission mediated by an increase in the sensitivity of post-synaptic 5-HT-1A receptors in the hippocampus has been proposed as a mechanism of action for electroconvulsive shock (ECS) in animals, and by inference for electroconvulsive therapy (ECT) in humans. | | | We conclude that in contrast to the effects of ECS on 5-HT-1A receptor in the hippocampus in animals, ECT in humans does not induce an increase in sensitivity of post-synaptic 5-HT-1A receptors in the hypothalamus. | | | Since activation of these receptors reduces firing of serotonergic neurons and 5-HT release, reduction in their sensitivity would be associated with increased 5-HT release and, hence, an increase in serotonergic transmission in the hypothalamus. |
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http://www.hadassah.org.il/Atarim/biopsych/abstracts/5.html
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| | Dept. of Neuroscience thesis |
| | Mutant 5-HT,B receptors were constructed and the importance of specific amino acid residues in agonist and antagonist binding as well as G protein coupling was investigated by radioligand binding and functional assays on receptors stably expressed in Chinese hamster ovary cells. | | | The 5-hydroxytryptamine (5-HT, serotonin) B receptor is one of thirteen G protein-coupled 5-HT receptors. | | | The presynaptic S-HT~B receptor, which is broadly distributed throughout brain of mammals, regulates 5-HT release and may be involved in depression and anxiety disorders. |
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http://www.neuro.uu.se/spikblad/granas.html
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| | 5-hydroxytryptamine-moduline, a new endogenous cerebral peptide, controls the serotonergic activity via its specific interaction with 5- hydroxytryptamine1B/1D receptors -- Massot et al. 50 (4): 752 -- Molecular Pharmacology |
| | 5-hydroxytryptamine-moduline, a new endogenous cerebral peptide, controls the serotonergic activity via its specific interaction with 5- hydroxytryptamine1B/1D receptors -- Massot et al. | | | Articles by Massot, O. Articles by Fillion, G. 5-hydroxytryptamine-moduline, a new endogenous cerebral peptide, controls the serotonergic activity via its specific interaction with 5- hydroxytryptamine1B/1D receptors | | | Pharmacol., March 5, 2003; 138(5): 795 - 800. |
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http://molpharm.aspetjournals.org/cgi/content/abstract/50/4/752?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext="5-ht-moduline"&searchid=1030440595250_477&stored_search=&FIRSTINDEX=&fdate=1/1/1965&tdate=8/31/2002&jc=all
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| | Drugs With Prominent 5-HT Receptor Activity |
| | This slide lists drugs that interact with 5-HT receptors. | | | There are seven families of 5-HT receptors (5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7), and at least 15 subpopulations have been cloned. | | | Giving & Support © 2005 NYU Medical Center |
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http://www.med.nyu.edu/psych/psychiatrist/depression/slides/sld012.html
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| | Canadian Journal of Psychiatry - In Review (Feb 2001) |
| | Neuropharmacological research into 5-HT receptors is likely to continue to be of significant interest to general psychiatry and to the evaluation and treatment of sexual disorders. | | | Perhaps mutations of the 5-HT receptor or subreceptor structures will be found to play a role in a variety of psychiatric disorders (3). | | | It is also possible that other 5-HT receptor subtypes will be isolated or that further variations in receptor subtypes will be found. |
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http://www.cpa-apc.org/Publications/Archives/CJP/2001/Feb/Inreview2.asp
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| | Serotonin 5-HT(6) receptor antagonists and memory |
| | ATIONALE: 5-HT(6) receptors are predominantly located in the brain and may be involved in cognitive processes. | | | The aim of this study was to assess the effects of two potent and selective 5-HT(6) receptor antagonists, SB-271046-A and SB-357134-A, on learning and memory in the rat. | | | These data indicate that 5-HT(6) receptor antagonism may be involved in cognitive function. |
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http://www.nootropic.com/5-ht6
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| | 5-HT7 Receptor Research -- Neurotransmitter.net |
| | When LH release was suppressed by 5 microg oestradiol benzoate, SB-269970-A (0.5 and 2 microg) did not elevate levels, indicating it is unlikely that 5-HT7 receptors mediate a tonic inhibition on release but rather are involved in terminating the pre-ovulatory LH surge. | | | As both 8-OH-DPAT and ritanserin have moderate activity at the 5-HT7 receptor subtype, the possibility that this subtype might mediate their effects in the zona incerta has been investigated. | | | In rat tissues, three 5-HT7 isoforms, here called 5-HT7(a), 5- HT7(b), and 5-HT7(c), are found. |
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http://www.neurotransmitter.net/seven.html
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| | Serotonin Receptor Subtypes and Ligands |
| | 5-HT receptors might be involved in mood and learning, as well as in neuroendocrine and vegetative behaviors. | | | The pharmacological function of 5-HT receptors is currently unknown; it has been speculated that, on the basis of their localization, they may be involved in motor control, feeding, anxiety, depression, learning, memory consolidation, adaptive behavior, and brain development ( | | | Although 5-HT receptors represent ion channel receptors, whereas 5-HT receptors represent G-protein coupled receptors, much of the early work in 5-HT research was facilitated by 5-HT ligands; that is, a number of 5-HT ligands were shown to be active at 5-HT receptors. |
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http://www.acnp.org/G4/GN401000039/Ch039.html
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| | Serotonin Receptor Subtypes and Ligands |
| | Evidence was subsequently provided suggesting that 5-HT receptors exist in a high-affinity state and a low-affinity state; under normal conditions, this equilibrium is heavily in favor of the low-affinity state, and the tritiated antagonist ketanserin binds at both states with comparable affinity. | | | For example, ketanserin, the most widely used 5-HT antagonist, has been reported to bind with as little as 2-fold to as much as 140-fold selectivity for 5-HT vs. 5-HT receptors. | | | With the subsequent discovery of 5-HT receptors and the finding that many 5-HT ligands bind nearly equally well at both types of receptors, came the realization that some of the roles attributed to 5-HT receptors may in fact be mediated by 5-HT receptors. |
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http://www.acnp.org/G4/GN401000039/Ch039.html
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| | Electrophysiology of Serotonin Receptor Subtypes and Signal Transduction Pathways |
| | For example, while 5-HT agonists are directly inhibitory upon serotonergic neurons in the raphe nuclei (possibly at doses insufficient to affect postsynaptic 5-HT receptors), the net effect of this inhibition may be disinhibitory for postsynaptic neurons that express 5-HT receptors and simultaneously disfacilitatory for postsynaptic neurons that express 5-HT, and 5-HT receptors. | | | With few exceptions (e.g., facial nucleus and the nucleus tractus solitarius), relatively low concentrations of 5-HT receptors or mRNA expression are found in the brainstem. | | | In brain slices of the nucleus prepositus hypoglossi, focal electrical stimulation evokes inhibitory postsynaptic potentials which have been shown to be mediated by endogenous 5-HT acting on 5-HT receptors to activate a K |
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http://www.acnp.org/g4/GN401000043/Ch043.html
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| | The Selective Serotonin2A Receptor Antagonist, MDL100,907, Elicits a Specific Interoceptive Cue in Rats |
| | Millan MJ, Peglion J-L, Lavielle G, Perrin-Monneyron S (1997): 5-HT receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists. | | | Interest in 5-HT receptors has been reinforced by evidence that their blockade may contribute to the distinctive functional profile of the "atypical" antipsychotic, clozapine, and, possibly, other novel agents employed for management of psychotic states (Roth and Meltzer 1995). | | | 1998), and employing the 5-HT antagonist, SB206,553, and the selective 5-HT antagonist, SB242,084, it was shown that 5-HT receptors likewise mediate DS properties of the novel, mixed 5-HT agonist, RO60,0175 ((S)-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine; Dekeyne et al. |
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http://www.nature.com/npp/journal/v26/n4/full/1395832a.html
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| | 5-HT modulates multiple conductances in immature rat rostral ventrolateral medulla neurones in vitro -- Hwang and Dun 517 (1): 217 -- The Journal of Physiology Online |
| | To minimize the potential interference by subtypes of 5-HT receptors coexisting in a single RVLM neurone, experiments were conducted in the presence of the 5-HT receptor antagonist PBD or the 5-HT receptor antagonist ketanserin to isolate the specific response. | | | To eliminate possible contamination by the activation of undesired 5-HT receptors, the 5-HT receptor antagonist ketanserin or the 5-HT receptor antagonist PBD was included in the perfusing solution so that the conductances underlying I | | | The following compounds were used: TTX, pindobind-5-HT (PBD) and ketanserin from Research Biochemicals Inc.; 5-HT creatinine sulfate and other chemicals from Sigma. |
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http://jp.physoc.org/cgi/content/full/517/1/217
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| | The Selective Serotonin2A Receptor Antagonist, MDL100,907, Elicits a Specific Interoceptive Cue in Rats |
| | 1998), and employing the 5-HT antagonist, SB206,553, and the selective 5-HT antagonist, SB242,084, it was shown that 5-HT receptors likewise mediate DS properties of the novel, mixed 5-HT agonist, RO60,0175 ((S)-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine; Dekeyne et al. | | | Further, several 5-HT antagonists failed to generalize to pizotifen, which interacts with many other sites, including histaminergic receptors, which play a major role in its DS properties (Minnema et al. | | | In distinction, the selective 5-HT antagonist, SB204,741 (0.63 and 10.0 mg/kg), the 5-HT antagonist, SB206,553 (0.16 and 2.5 mg/kg) and the selective 5-HT antagonists, SB242,084 (2.5 and 10.0 mg/kg,) and RS102221 (2.5 and 10.0 mg/kg), did not significantly generalize. |
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http://www.nature.com/npp/journal/v26/n4/full/1395832a.html
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| | Serotonin Receptor [Definition] |
| | Note that there is no 5-HT receptor since, after the receptor was cloned and further characterised, it was found to have more in common with the 5-HT family of receptors and was redesignated as the 5-HT receptor. | | | [click for more], 5-HT receptors are receptors for the neurotransmitter Neurotransmitters are chemicals that are used to relay, amplify and modulate electrical signals between a presynaptic and a postsynaptic neuron. | | | 5-HT receptors are located on the cell membrane A component of every biological cell, the selectively permeable cell membrane (or plasma membrane) is a thin and structured bilayer of phospholipid and protein molecules that envelopes the cell. |
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http://www.wikimirror.com/Serotonin_receptor
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| | Serotonin Receptors |
| | Chronic or repeated administration of antidepressant drugs, such as MAO inhibitors or inhibitors of serotonin uptake, or 5-HT receptor agonists to laboratory rats results in a desensitization of behavioral and electrophysiological responses believed to be mediated by 5-HT receptors. | | | The 5-HT receptor originally was described in cultured murine collicular neurons as a serotonin receptor coupled to the stimulation of adenylyl cyclase activity, possessing pharmacological characteristics distinct from those of the 5-HT or 5-HT receptors. | | | The 5-HT receptor in rats and mice and the 5-HT receptor in bovine and human brain are located in high density in the basal ganglia, particularly in the globus pallidus and the substantia nigra (Table 13-2). |
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http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=bnchm.section.963
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| | Serotonin-induced muscular activity in Schistosoma mansoni larval stages: importance of 5-HT transport and role in daughter sporocyst production. |
| | Serotonin-induced motility of in vitro-derived sporocysts is not inhibited by antidepressant compounds, e.g., fluoxetine, that block 5-HT transport, suggesting that the receptors responsible for motility responses to 5-HT are surface exposed. | | | In the present study, we investigated the importance of 5-HT transporter activity in the manifestation of these 5-HT-induced motility changes, and further examined the role of 5-HT in the development of daughter sporocysts in vitro. | | | Moreover, we demonstrate a strong correlation between endogenous 5-HT levels and basal mother sporocyst muscle activity. |
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http://counsellingresource.com/medications-research/2005/08/21/serotonin-induced-muscular-activity-in-schistosoma-mansoni-larval-stages-importance-of-5-ht-transport-and-role-in-daughter-sporocyst-production
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