Interleukin 2<

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Topic: Interleukin 2<

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Leukemia Inhibitory Factor, <bb>>Interleukinb>bb>> 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury -- Gadient and Patterson 17 (3): 127 -- Stem Cells

Recombinant human <bb>>interleukinb>bb>> 11 decreases arthritis in HLA-B27 transgenic rats.
<bb>>Interleukinb>bb>> 6, but not ciliary neurotrophic factor or leukaemia inhibitory factor, is responsible for the acute phase response to turpentine-induced myositis.
Neurologic disease induced in transgenic mice by cerebral overexpression of <bb>>interleukinb>bb>> 6.

http://stemcells.alphamedpress.org/cgi/content/full/17/3/127 (6319 words)



Serum <bb>>interleukinb>bb>> 10 and <bb>>interleukinb>bb>> 11 in patients with acute pancreatitis -- Chen et al. 45 (6): 895 -- Gut

<bb>>Interleukinb>bb>> 10 reduces the severity of acute pancreatitis in rats.
<bb>>Interleukinb>bb>> 10 prevents necrosis in murine experimental acute pancreatitis.
Serum <bb>>interleukinb>bb>> 10 and <bb>>interleukinb>bb>> 11 in patients with acute pancreatitis

http://gut.bmjjournals.com/cgi/content/full/45/6/895 (2575 words)



Melanoma Center - Types of Treatment - Biological Therapy - Immunotherapy - <bb>>Interleukinb>bb>>-2

High-dose recombinant <bb>>interleukinb>bb>> 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993.
One type, <bb>>interleukinb>bb>>-2, causes the immune system's T-cells to multiply and perform a variety of functions, including killing cancer cells.
Like interferons, interleukins are cytokines, naturally produced proteins of the immune system.

http://www.melanomacenter.org/treatment/interleukin.html (319 words)



Medical Acupuncture Online Journal, Volume 14 #1, Article 2

For 10 patients, needles were inserted 5 cm from the midline, to a depth of 1.25 cm, at the levels of the vertebrae above and below the dermatome of the pain area.
Wu et al57 reported that daily microwave acupuncture to SP 10 and BL 17 was effective for raising the leukocyte count of patients receiving chemotherapy although they did not have a control group in their study.
During the final 10 days of treatment, analgesia (complete or partial pain relief) was the same in all groups (approximately 95% immediate and 80% long-term effects) although the percentage of patients who experienced complete long-term pain relief was significantly higher in the 2 acupuncture groups (approximately 50%) than in the drug treatment group (34%).

http://www.medicalacupuncture.org/aama_marf/journal/vol14_1/article2.html (319 words)



RM-10 Immune System Food

12.) A 57 year old obese female with bilateral knee pain and candidiasis, experienced rapid improvement with the use of RM- 10 in her systemic yeast infection, and modest improvement in her knee pain.
His cholesterol dropped 15 percent and triglycerides by 20 percent within four weeks.
These interleukins are anticancer cytokines that are secreted by activated macrophages.

http://www.crohns-disease-probiotics.com/RM-10.html (319 words)



Cancer: Gene Therapies, Stem Cells, Telomeres, And Cytokines - Abstracts : Online Reference For Health Concerns

Interleukins (IL) are a heterogeneous class of cytokines involved in activation of T lymphocytes (IL-1, 2, 4, 6 and 7), <bb>>Bb>bb>> lymphocytes (IL-1, 2, 4, 5, 6 and 7), and macrophages (IL-1 and 4), and hematopoiesis (IL-1, 2, 3, 4, 5, 6 and 7), acting either by themselves, or as co-stimulator factors.
Our previous study showed that high-grade astrocytomas often expressed high <bb>>interleukinb>bb>> (IL)-1beta production.
<bb>>Interleukinb>bb>> (IL) -6 and IL-8 are cytokines that have been shown to play a role in several pancreatic diseases, including acute pancreatitis, chronic pancreatitis, and pancreatic adenocarcinoma.

http://www.lef.org/protocols/abstracts/abstr-150.html (319 words)



CancerGuide: Nutritional Supplements and <bb>>Interleukinb>bb>>-2

Marcus SL, Petrylak DP, Dutcher JP, Paietta E, Ciobanu N, Strauman J, Wiernik PH, Hutner SH, Frank O, Baker H. Hypovitaminosis C in patients treated with high-dose <bb>>interleukinb>bb>> 2 and lymphokine-activated killer cells.
Marcus SL, Dutcher JP, Paietta E, Ciobanu N, Strauman J, Wiernik PH, Hutner SH, Frank O, Baker H. Severe hypovitaminosis C occurring as the result of adoptive immunotherapy with high-dose <bb>>interleukinb>bb>> 2 and lymphokine-activated killer cells.
Effects of <bb>>interleukinb>bb>> 2 therapy on lymphocyte magnesium levels.

http://www.cancerguide.org/rcc_il2supplements.html (1470 words)



Leukemia Inhibitory Factor, <bb>>Interleukinb>bb>> 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury -- Gadient and Patterson 17 (3): 127 -- Stem Cells

Recombinant human <bb>>interleukinb>bb>> 11 decreases arthritis in HLA-B27 transgenic rats.
<bb>>Interleukinb>bb>> 6, but not ciliary neurotrophic factor or leukaemia inhibitory factor, is responsible for the acute phase response to turpentine-induced myositis.
Neurologic disease induced in transgenic mice by cerebral overexpression of <bb>>interleukinb>bb>> 6.

http://stemcells.alphamedpress.org/cgi/content/full/17/3/127 (6319 words)



Thiourea (CICADS 49, 2003)

Adult and sexually immature Sprague-Dawley rats were given Evans-Blue dye intravenously at 60 mg/kg body weight, followed by 10 or 100 mg thiourea/kg body weight, and sacrificed after 2 h.
The concentration of 2.0 mg/ml proved to be ineffective in this regard.
Thiourea was administered to Sprague-Dawley rats (10 per sex per dose group) at concentrations of 0, 0.02, 0.1, 0.5, or 2.5 mg/litre (0, 0.0028, 0.014, 0.070, or 0.350 mg/kg body weight per day) in the drinking-water for 13 weeks (Hazleton, 1987).

http://www.inchem.org/documents/cicads/cicads/cicad49.htm (6319 words)



<bb>>Interleukinb>bb>>

Materials and Methods: Sixty-one CHC patients who were treated by fixed protocol of IFN therapy (IFN [alpha] 9-10 mega U/day for 2 weeks followed by 3 times/week for 22 weeks) and showed similar clinical activities were carefully chosen from 542 IFN-treated CHC and enrolled in this study.
The aim of this study was determine the immunoregulatory functions of <bb>>Interleukinb>bb>> 12 (IL-12) with regard to local cytokine production in human liver.
Th1 (<bb>>interleukinb>bb>> (IL)-2) and Th2 (IL-6) cytokines and monokines (IL-1 =DF, IL-1 receptor antagonist (RA)) were studied during IFN therapy.

http://www.hepatitis-c.de/interleu.htm (1158 words)



<bb>>Interleukinb>bb>>-4 augments acetylated LDL-induced cholesterol esterification in macrophages -- Cornicelli et al. 41 (3): 376 -- Journal of Lipid Research

Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential

http://www.jlr.org/cgi/content/abstract/41/3/376 (493 words)



<bb>>Interleukinb>bb>>-1 Receptor Antagonist Gene Polymorphism and Circulating Levels of Human Immunodeficiency Virus Type 1 RNA in Brazilian Women -- Witkin et al. 75 (13): 6242 -- The Journal of Virology

The majority of our subjects (90.6%) were classified as having either stage A1 or stage A2 HIV disease (1).
Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and <bb>>interleukinb>bb>> 1 receptor antagonist gene polymorphisms and severe malaria in a west African population.
<bb>>Interleukinb>bb>> 1 receptor antagonist gene polymorphism in women with vulvar vestibulitis.

http://jvi.asm.org/cgi/content/full/75/13/6242 (1593 words)



<bb>>Interleukinb>bb>> 1 Trials in Cancer Patients: A Review of the Toxicity, Antitumor and Hematopoietic Effects -- Veltri and Smith 1 (4): 190 -- The Oncologist

Phase I study with recombinant human <bb>>interleukinb>bb>> 1ß in patients undergoing autologous bone marrow transplant for acute myelogenous leukemia.
<bb>>Interleukinb>bb>> 1 induces <bb>>interleukinb>bb>> 6 production in peripheral blood monocytes.
The cell surface receptors for <bb>>interleukinb>bb>> 1 alpha and <bb>>interleukinb>bb>> 1 beta are identical.

http://theoncologist.alphamedpress.org/cgi/content/full/1/4/190 (4880 words)



Response of human intestinal lamina propria T lymphocytes to <bb>>interleukinb>bb>> 12: additive effects of <bb>>interleukinb>bb>> 15 and 7 -- Monteleone et al. 43 (5): 620 -- Gut

<bb>>Interleukinb>bb>> 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells.
Cells were cultured with <bb>>interleukinb>bb>> (IL) 12 (100 pg/ml final concentration) or anti-CD28 (1 µ g/ml final concentration) or anti-CD2 (1:1000 final dilution) antibody in the presence or absence of IL-7 (10 ng/ml final concentration) or IL-15 (10 ng/ml final concentration).
<bb>>Interleukinb>bb>> 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.

http://gut.bmjjournals.com/cgi/content/full/43/5/620 (4880 words)



Arterial Inflammation in Mice Lacking the <bb>>Interleukinb>bb>> 1 Receptor Antagonist Gene -- Nicklin et al. 191 (2): 303 -- The Journal of Experimental Medicine

Potential therapeutic uses of <bb>>interleukinb>bb>> 1 receptor antagonists in human diseases
Key Words: <bb>>interleukinb>bb>> 1, vasculitis, aorta, arteritis, chronic disease
Arterial Inflammation in Mice Lacking the <bb>>Interleukinb>bb>> 1 Receptor Antagonist Gene -- Nicklin et al.

http://www.jem.org/cgi/content/abstract/191/2/303 (1470 words)



Low-Dose Prolonged Intermittent <bb>>Interleukinb>bb>>-2 Adjuvant Therapy: Results of a Randomized Trial among Human Immunodeficiency Virus Positive Patients with Advanced Immune Impairment (<200 CD4s)

A higher incidence of HIV-related clinical events was observed among patients receiving HAART alone (3/10) than among subjects receiving HAART plus IL-2 (0/12).
These 3 patients tolerated IL-2 treatment well, and none of them was lost to follow-up because of clinical events, nor were they excluded from the study because of a bad response to IL-2 therapy.
In particular, 1 patient was monitored up to week 34 but then moved to another city; 2 patients were monitored until week 10, and after that 1 moved to another city and 1 went to jail.

http://www.natap.org/2002/september/090902_4.htm (1596 words)



Hereditary predisposition to low <bb>>interleukinb>bb>>-10 production in children with extended oligoarticular juvenile idiopathic arthritis -- Crawley et al. 40 (5): 574 -- Rheumatology

Regulation of <bb>>interleukinb>bb>> 10 release by tumor necrosis factor in humans and chimpanzees.
<bb>>Interleukinb>bb>> 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.
One of the key anti-inflammatory cytokines is <bb>>interleukinb>bb>> 10

http://rheumatology.oxfordjournals.org/cgi/content/full/40/5/574 (2601 words)



Therapy with a Combination of Low Doses of <bb>>Interleukinb>bb>> 12 and Chloroquine Completely Cures Blood-Stage Malaria, Prevents Severe Anemia, and Induces Immunity to Reinfection -- Mohan et al. 67 (2): 513 -- Infection and Immunity

Successful therapy of chronic, nonhealing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued <bb>>interleukinb>bb>>-12 production.
A functional <bb>>interleukinb>bb>> 12 receptor complex is composed of two beta-type cytokine receptor subunits.
The role of <bb>>interleukinb>bb>> 12 in the immune response, disease and therapy.

http://iai.asm.org/cgi/content/full/67/2/513 (2601 words)



<bb>>Interleukinb>bb>> 12: Basic Biology and Potential Applications in Cancer Treatment -- Robertson and Ritz 1 (1): 88 -- The Oncologist

B7-1 and <bb>>interleukinb>bb>> 12 synergistically induce effective antitumor immunity.
Multiple effects on peripheral hematology following administration of recombinant human <bb>>interleukinb>bb>> 12 to nonhuman primates.
Inhibition of angiogenesis in vivo by <bb>>interleukinb>bb>> 12.

http://theoncologist.alphamedpress.org/cgi/content/full/1/1/88 (2601 words)



Point-pricking Bleeding Therapy, <bb>>Interleukinb>bb>>-4 & IgE

The rats in the point-pricking bleeding group were bled at Ying Xiang (LI 20), He Gu (LI 4), Qu Chi (LI 11), and Zu San Li (St 36).

http://www.bluepoppy.com/press/journal/issues/articles/jul03/jul03_ezine_bleeding_allergicrhin.cfm (641 words)



Lessons From Genetically Engineered Animal Models: XII. IL-10-deficient (IL-10-/-) mice and intestinal inflammation -- Rennick and Fort 278 (6): 829 -- AJP - Gastrointestinal and Liver Physiology

<bb>>interleukinb>bb>>; counterregulation by IL-10; proinflammatory cytokines; Th1-mediated intestinal disease; IL-10 therapy
MAb was very effective and often completely ablated established
Our current studies are focused on identifying late-acting

http://ajpgi.physiology.org/cgi/content/full/278/6/G829 (641 words)



Human Pulmonary Fibroblasts Exhibit Altered <bb>>Interleukinb>bb>>-4 and <bb>>Interleukinb>bb>>-13 Receptor Subunit Expression in Idiopathic Interstitial Pneumonia -- Jakubzick et al. 164 (6): 1989 -- American Journal of Pathology

Interaction with <bb>>interleukinb>bb>> 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15.
Debinski W, Obiri NI, Pastan I, Puri RK: A novel chimeric protein composed of <bb>>interleukinb>bb>> 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for <bb>>interleukinb>bb>> 13 and <bb>>interleukinb>bb>> 4.
Wallace WA, Howie SE: Immunoreactive <bb>>interleukinb>bb>> 4 and interferon-gamma expression by type II alveolar epithelial cells in interstitial lung disease.

http://ajp.amjpathol.org/cgi/content/full/164/6/1989 (6613 words)



<bb>>Interleukinb>bb>>-12 from Intrinsic Cells Is an Effector of Renal Injury in Crescentic Glomerulonephritis -- TIMOSHANKO et al. 12 (3): 464 -- Journal of the American Society of Nephrology

Trinchieri G: <bb>>Interleukinb>bb>>-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.
Manetti R, Parronchi P, Giudizi MG, Piccinni MP, Maggi E, Trinchieri G, Romagnani S: Natural killer cell stimulatory factor (<bb>>interleukinb>bb>> 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
1.2 ± 0.1 c/gcs; sham chimeras, 1.1 ± 0.05 c/cgs)

http://www.jasn.org/cgi/content/full/12/3/464 (6613 words)



Journal of Venomous Animals and Toxins including Tropical Diseases - <<bb>>Bb>bb>>>Correlation between cytokine serum levels, number of CD4⁺ T cells/mm³ and viral load in HIV-1 infected individuals with or without antiretroviral therapyb>bb>>Bb>bb>>>

It is in part due to the blood trafficking these cells, which were sequestered in the lymphatic compartment (24), also to the increased production rate of circulating lymphocytes resulting from the expansion of peripheral T cells (10), apoptosis suppression, and new T cell production (9).
The biggest problem for those treating HIV-1/AIDS patients is obtaining information on the functional state of immune response; they need other markers to see if there is immunological recovery or not (13,33).
To help interpret patient immune response during antiretroviral therapy, mainly HAART, and verify if immunity regeneration is occurring, other progression markers should be used with CD4

http://www.scielo.br/scielo.php?pid=S1678-91992004000300008&script=sci_arttext&tlng=en (6613 words)



Polarized Distribution of <bb>>Interleukinb>bb>>-1 Receptors and Their Role in Regulation of Serotonin Transporter in Placenta -- Kekuda et al. 292 (3): 1032 -- Journal of Pharmacology And Experimental Therapeutics

Osborn L, Kunkel S and Nabel GJ (1989) Tumor necrosis factor alpha and <bb>>interleukinb>bb>> 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa <bb>>Bb>bb>>. Proc Natl Acad Sci USA 86: 2336-2340
Cunningham ET, Jr and De Souza EB (1993) <bb>>Interleukinb>bb>> 1 receptors in the brain and endocrine tissues.
Corbett JA, Sweetland MA, Lancaster JR, Jr and McDaniel ML (1993) A 1-hour pulse with IL-1 beta induces formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans: Evidence for a tyrosine kinase signaling mechanism.

http://jpet.aspetjournals.org/cgi/content/full/292/3/1032 (6149 words)



Proceedings of the Oklahoma Academy of Science

Of the many procedures available, adherence to nylon wool columns has been used most frequently, with varying degrees of success, to separate unpurified lymphocyte preparations into T-cell (nonadherent) and <bb>>Bb>bb>>-cell (adherent) subpopulations in laboratory mice (2) and rats (3), chickens (4), sheep (5), and humans (6).
2) in the nonadherent subpopulation, indicating this subtype is adhering to the nylon wool.
2), indicates that the nonadherent subpopulation is enriched in PNA+ splenocytes.

http://digital.library.okstate.edu/OAS/oas_htm_files/v75/p31_37nf.html (2739 words)



Particle Diameter Influences Adhesion under Flow -- Patil et al. 80 (4): 1733 -- Biophysical Journal

In certain experiments, the P-selectin-coated surface was treated with mAbs to P-selectin (10 µg/ml) 15 min prior to the adhesion
( C) BSA microspheres were allowed to settle onto P-selectin under no flow conditions for 10 min.
Immediately after reinitiation of flow, the number of 19.ek.Fc microspheres remaining bound to the surface was determined.

http://www.biophysj.org/cgi/content/full/80/4/1733 (2739 words)



IL2 - <bb>>Interleukinb>bb>> 2 - aka: TCGF - Cancer GeneticsWeb

Recombinant <bb>>interleukinb>bb>>-2-based treatments for advanced melanoma: the experience of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group.
Medline Search: <bb>>interleukinb>bb>> 2 AND cancer AND gene therapy (PubMed)
<bb>>Interleukinb>bb>> 2 gene therapy of colorectal carcinoma with autologous irradiated tumor cells and genetically engineered fibroblasts: a Phase I study.

http://www.cancerindex.org/geneweb/IL2.htm (457 words)



Circulating <bb>>Interleukinb>bb>> 6 Levels, Blood Pressure, and Insulin Sensitivity in Apparently Healthy Men and Women -- Fernandez-Real et al. 86 (3): 1154 -- Journal of Clinical Endocrinology & Metabolism

levels of <bb>>interleukinb>bb>> 6 are reduced in serum and subcutaneous adipose
Circulating <bb>>Interleukinb>bb>> 6 Levels, Blood Pressure, and Insulin Sensitivity in Apparently Healthy Men and Women -- Fernandez-Real et al.
<bb>>INTERLEUKINb>bb>> 6 (IL-6) IS a cytokine produced by many different

http://jcem.endojournals.org/cgi/content/full/86/3/1154 (4827 words)



Targeted Anti-<bb>>Interleukinb>bb>>-6 Monoclonal Antibody Therapy for Cancer: A Review of the Rationale and Clinical Evidence -- Trikha et al. 9 (13): 4653 -- Clinical Cancer Research

Badache A., Hynes N. <bb>>Interleukinb>bb>> 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells.
Bataille R., Jourdan M., Zhang X. G., Klein <bb>>Bb>bb>>. Serum levels of <bb>>interleukinb>bb>> 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.
Novick D., Shulman L. M., Chen L., Revel M. Enhancement of <bb>>interleukinb>bb>> 6 cytostatic effect on human breast carcinoma cells by soluble IL-6 receptor from urine and reversion by monoclonal antibody.

http://clincancerres.aacrjournals.org/cgi/content/full/9/13/4653 (8622 words)

Topic: <b>Interleukin</b> <b>2<

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